Metabolický syndrom je definován jako současný výskyt několika rizikových faktorů diabetu 2. typu a kardiovaskulárních chorob: jedná se hlavně o obezitu, inzulinovou rezistenci, vysoké hladiny triglyceridů a LDL cholesterolu a hypertenzi. Tyto rizikové faktory jsou podmíněny mnoha geny s malými účinky a jejich interakcemi s faktory prostředí. Celogenomové asociační studie zatím odhalily jen malou část heritability komplexních patofyziologických znaků u lidí. Analýzy zvířecích modelů lidských komplexních chorob tak mohou představovat užitečnou alternativu. Výzkum oddělení je zaměřen na tyto projekty:
- Odhalení genů regulujících hemodynamické a metabolické znaky u kmene SHR.
- Analýza mechanismů vývinu vysokého krevního tlaku při zvýšeném příjmu soli.
Aktuální projekty
Publikace
Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Malínská; H. - Marková; I. - Hüttl; M. - Miklánková; D. - Mušálková; D. - Stránecký; V. - Kmoch; S. - Sticová; E. - Vrbacký; Marek - Mráček; Tomáš - Pravenec; Michal
.
Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat
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Physiological Genomics. 2024; 56(1); 65-73
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IF = 4.6
[ASEP]
[
doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Marková; I. - Malínská; H. - Hüttl; M. - Kazdová; L. - Kazantsev; D. - Mancini; M. - Novotný; J. - Pravenec; Michal
.
CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study
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PLoS ONE. 2023; 18(4)); e0283276
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IF = 3.7
[ASEP]
[
doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Malínská; H. - Marková; I. - Hüttl; M. - Miklánková; D. - Kazdová; L. - Vrbacký; Marek - Pecinová; Alena - Mráček; Tomáš - Pravenec; Michal
.
Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome
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Metabolites. 2023; 13(2)); 192
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IF = 4.1
[ASEP]
[
doi
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Kurtz; T. W. - Morris Jr.; R. C. - Pravenec; Michal - Lujan; H. L. - DiCarlo; S. E.
Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced Increases in Vascular Resistance With Reductions in Cardiac Output
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Hypertension. 2023; 80(5); 1077-1091
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IF = 8.3
[ASEP]
[
doi
]
Hüttl; M. - Marková; I. - Miklánková; D. - Zapletalová; I. - Kujal; P. - Šilhavý; Jan - Pravenec; Michal - Malínská; H.
Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model
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Frontiers in Pharmacology. 2023; 14(3 Apr)); 1117683
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IF = 5.6
[ASEP]
[
doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Kubovčiak; Jan - Sticová; E. - Pravenec; Michal
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Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension
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Biomedicines. 2022; 10(2)); 376
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IF = 4.7
[ASEP]
[
doi
]
Senko; A. N. - Overall; R. W. - Šilhavý; Jan - Mlejnek; Petr - Malínská; H. - Hüttl; M. - Marková; I. - Fabel; K. S. - Lu; L. - Stuchlík; Aleš - Williams; R. W. - Pravenec; Michal - Kempermann; G.
Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose
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PLoS Genetics. 2022; 18(4)); e1009638
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IF = 4.5
[ASEP]
[
doi
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Marković; Aleksandra - Tauchmannová; Kateřina - Šimáková; Miroslava - Mlejnek; Petr - Kaplanová; Vilma - Pecina; Petr - Pecinová; Alena - Papoušek; František - Liška; František - Šilhavý; Jan - Mikešová; Jana - Neckář; Jan - Houštěk; Josef - Pravenec; Michal - Mráček; Tomáš
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Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat
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Biomedicines. 2022; 10(2)); 276
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IF = 4.7
[ASEP]
[
doi
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Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana
.
Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
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Biomedicines. 2022; 10(9)); 2066
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IF = 4.7
[ASEP]
[
doi
]
Lusk; R. - Hoffman; P.L. - Mahaffey; S. - Rosean; S. - Smith; H. - Šilhavý; Jan - Pravenec; Michal - Tabakoff; B. - Saba; L. M.
Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel
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Frontiers in genetics. 2022; 13(Mar 15)); 821026
.
IF = 3.7
[ASEP]
[
doi
]
Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Do conclusions drawn from spot urine sodium measurements agree with the conclusions drawn from the 24-h urine measurements?
.
Journal of Hypertension. 2022; 40(11); 2316-2317
.
IF = 4.9
[ASEP]
[
doi
]
Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Will Food and Drug Administration Guidance to Reduce the Salt Content of Processed Foods Reduce Salt Intake and Save Lives?
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Hypertension. 2022; 79(4); 809-812
.
IF = 6.0
[ASEP]
[
doi
]
Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension
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Clinical science. 2022; 136(8); 599-620
.
IF = 8.3
[ASEP]
[
doi
]
Dahale; S. - Ruiz-Orera; J. - Šilhavý; Jan - Hübner; N. - van Heesch; S. - Pravenec; Michal - Atanur; S. S.
Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertension
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Life Science Alliance. 2022; 5(4)); e202101234
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IF = 4.4
[ASEP]
[
doi
]
Witte; F. - Ruiz-Orera; J. - Mattioli; C. C. - Blachut; S. - Adami; E. - Schulz; J. F. - Schneider-Lunitz; V. - Hummel; O. - Patone; G. - Mücke; M. B. - Šilhavý; Jan - Heinig; M. - Bottolo; L. - Sanchis; D. - Vingron; M. - Chekulaeva; M. - Pravenec; Michal - Hubner; N. - van Heesch; S.
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion
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Genome Biology. 2021; 22(1)); 191
.
IF = 18.010
[ASEP]
[
doi
]
Pravenec; Michal - Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Mráček; Tomáš - Pecinová; Alena - Tauchmannová; Kateřina - Hüttl; M. - Malínská; H. - Kazdová; L. - Neckář; Jan - Kolář; František - Žurmanová; J. - Novotný; J. - Houštěk; Josef
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Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat
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Physiological Research. 2021; 70(Suppl.4); S471-S481
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IF = 2.139
[ASEP]
[
doi
]
Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František
.
Excess ischemic tachyarrhythmias trigger protection infarction in rats
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Clinical science. 2021; 135(17); 2143-2163
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IF = 6.876
[ASEP]
[
doi
]
Mihola; Ondřej - Landa; Vladimír - Pratto; F. - Brick; K. - Kobets; Tetyana - Kusari; Fitore - Gašić; Srdjan - Smagulova; F. - Grey; C. - Flachs; Petr - Gergelits; Václav - Třešňák; Karel - Šilhavý; Jan - Mlejnek; Petr - Camerini-Otero; R.D. - Pravenec; Michal - Petukhova; G.V. - Trachtulec; Zdeněk
.
Rat PRDM9 shapes recombination landscapes; duration of meiosis; gametogenesis; and age of fertility
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BMC BIOLOGY. 2021; 19(1)); 86
.
IF = 7.364
[ASEP]
[
doi
]
Kurtz; T. W. - DiCarlo; S. E. - Pravenec; Michal - Morris Jr.; R. C.
No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines
.
American Journal of Physiology-Heart and Circulatory Physiology. 2021; 320(5); H1903-H1918
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IF = 5.125
[ASEP]
[
doi
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Křížová; J. - Hůlková; M. - Čapek; V. - Mlejnek; Petr - Šilhavý; Jan - Tesařová; M. - Zeman; J. - Hansíková; H.
Microarray and qPCR Analysis of Mitochondrial Metabolism Activation during Prenatal and Early Postnatal Development in Rats and Humans with Emphasis on CoQ(10) Biosynthesis
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BIOLOGY-BASEL. 2021; 10(5)); 418
.
IF = 5.168
[ASEP]
[
doi
]
Krijt; J. - Sokolová; J. - Šilhavý; Jan - Mlejnek; Petr - Kubovčiak; Jan - Liška; František - Malínská; H. - Hüttl; M. - Marková; I. - Křížková; M. - Stipanuk; M. H. - Křížek; T. - Ditroi; T. - Nagy; P. - Kožich; V. - Pravenec; Michal
.
High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats
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Physiological Research. 2021; 70(5); 687-700
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IF = 2.139
[ASEP]
[
doi
]
Junková; K. - Mirchi; L. F. - Chylíková; B. - Janků; M. - Šilhavý; Jan - Hüttl; M. - Marková; I. - Miklánková; D. - Včelák; J. - Malínská; H. - Pravenec; Michal - Šeda; O. - Liška; František
.
Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation
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Nutrients. 2021; 13(5)); 1462
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IF = 6.706
[ASEP]
[
doi
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Šilhavý; Jan - Malínská; H. - Hüttl; M. - Marková; I. - Oliyarnyk; O. - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Kazdová; L. - Moravcová; R. - Novotný; J. - Pravenec; Michal
.
Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats
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ANTIOXIDANTS. 2020; 9(12)); 1179
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IF = 6.312
[ASEP]
[
doi
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Kurtz; T. W. - Pravenec; Michal - DiCarlo; S. E.
Strategies Are Needed to Prevent Salt-Induced Hypertension That Do Not Depend on Reducing Salt Intake
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American Journal of Hypertension. 2020; 33(2); 116-118
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IF = 2.689
[ASEP]
[
doi
]
Tan, A. L. M. - Langley, S. R. - Tan, Ch. F. - Chai, J. F. - Khoo, CH. M. - Leow, M. K.-S. - Khoo, E. Y. H. - Moreno-Moral, A. - Pravenec, Michal - Rotival, M. - Sadananthan, S. A. - Velan, S. S. - Venkataraman, K. - Chong, Y. S. - Lee, Y. S. - Sim, X. - Stunkel, W. - Liu, M. H. - Tai, E. S. - Petretto, E.
Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore
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Journal of Clinical Endocrinology and Metabolism 2019, 104(2), 465-486
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IF = 5.399
[ASEP]
[
doi
]
Svoboda; Petr - Křížová; E. - Šestáková; Š. - Vápenková; K. - Knejzlík; Z. - Rimpelová; S. - Rayová; D. - Volfová; N. - Křížová; I. - Rumlová; M. - Sýkora; D. - Kizek; R. - Haluzík; M. - Zídek; Václav - Zídková; J. - Škop; V.
Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells; and its inhibition slows cell growth
.
Journal of Biological Chemistry. 2019; 294(22); 8676-8689
.
IF = 4.238
[ASEP]
[
doi
]
Olson; E. - Pravenec; Michal - Landa; Vladimír - Koh-Tan; H.H.C. - Dominiczak; A. F. - McBride; M. W. - Graham; D.
Transgenic overexpression of glutathione S-transferase mu-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat
.
Journal of Hypertension. 2019; 37(5); 985-996
.
IF = 4.171
[ASEP]
Nedvědová, I. - Kolář, D. - Neckář, Jan - Kalous, M. - Pravenec, Michal - Šilhavý, Jan - Korenková, Vlasta - Kolář, František - Žurmanová, J.M.
Cardioprotective Regimen of Adaptation to Chronic Hypoxia Diversely Alters Myocardial Gene Expression in SHR and SHR-mt(BN) Conplastic Rat Strains
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Frontiers in Endocrinology 2019, 9(Jan 22)), 809
.
IF = 3.644
[ASEP]
[
doi
]
Morris Jr., R. C. - Pravenec, Michal - Šilhavý, Jan - DiCarlo, S. E. - Kurtz, T. W.
Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure
.
Hypertension 2019, 73(5), 1042-1048
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IF = 7.713
[ASEP]
[
doi
]
Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Morris, R. C.
Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity
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Hypertension Research 2019, 42(1), 6-18
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IF = 2.941
[ASEP]
[
doi
]
Chen; H. - Moreno-Moral; A. - Pesce; F. - Devapragash; N. - Mancini; M. - Heng; E. L. - Rotival; M. - Srivastava; P. K. - Harmston; N. - Shkura; K. - Rackham; O. J. L. - Yu; W.-P. - Sun; X. M. - Tee; N. G. Z. - Tan; E. L. S. - Barton; P. J. R. - Felkin; L. E. - Lara-Pezzi; E. - Angelini; G. - Beltrami; C. - Pravenec; Michal - Schafer; S. - Bottolo; L. - Hubner; N. - Emanueli; C. - Cook; S. A. - Petretto; E.
WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
.
Nature Communications. 2019; 10(Aug 9)); 3616
.
IF = 12.121
[ASEP]
[
doi
]
Šilhavý, Jan - Mlejnek, Petr - Šimáková, Miroslava - Vaněčková, Ivana - Behuliak, Michal - Kuda, Ondřej - Sticová, E. - Jirsa, M. - Pravenec, Michal
.
Acute toxic effects of telmisartan in spontaneously hypertensive rats fed a high fructose diet
.
Physiological Research 2018, 67(6), 851-856
.
IF = 1.701
[ASEP]
Šilhavý, Jan - Krijt, J. - Sokolová, J. - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Škop, V. - Trnovská, J. - Oliyarnyk, O. - Marková, I. - Hüttl, M. - Malínská, H. - Kazdová, L. - Liška, F. - Kožich, V. - Pravenec, Michal
.
Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats
.
Physiological Research 2018, 67(4), 657-662
.
IF = 1.701
[ASEP]
Pravenec, Michal - Saba, L. M. - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šilhavý, Jan - Šimáková, Miroslava - Strnad, Hynek - Trnovská, J. - Škop, V. - Hüttl, M. - Marková, I. - Oliyarnyk, O. - Malínská, H. - Kazdová, L. - Smith, H. - Tabakoff, B.
Systems genetic analysis of brown adipose tissue function
.
Physiological Genomics 2018, roč. 50, 1, p. 52-66
.
IF = 2.581
[ASEP]
[
doi
]
Pravenec, Michal - Leung, K.-Y. - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Kožich, V. - Greene, N. D. E.
Genetically Determined Folate Deficiency Is Associated With Abnormal Hepatic Folate Profiles in the Spontaneously Hypertensive Rat
.
Physiological Research 2018, roč. 67, 3, p. 417-422
.
IF = 1.701
[ASEP]
Nedvědová, I. - Kolář, D. - Elsnicová, B. - Horníková, D. - Novotný, J. - Kalous, M. - Pravenec, Michal - Neckář, Jan - Kolář, František - Žurmanová, J.M.
Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia
.
Physiological Genomics 2018, roč. 50, 7, p. 532-541
.
IF = 2.581
[ASEP]
[
doi
]
Melčová, M. - Száková, J. - Mlejnek, Petr - Zídek, Václav - Fučíková, A. - Praus, L. - Zídková, J. - Mestek, O. - Kaňa, A. - Mikulík, Karel - Tlustoš, P.
The effect of zinc and/or vitamin E supplementation on biochemical parameters of selenium-overdosed rats
.
POLISH JOURNAL OF VETERINARY SCIENCES 2018, 21(4), 731-740
.
IF = 0.802
[ASEP]
[
doi
]
Manakov, D. - Kolář, D. - Žurmanová, J. - Pravenec, Michal - Novotný, J.
Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36
.
Journal of Physiology and Biochemistry 2018, roč. 74, 3, p. 479-489
.
IF = 2.523
[ASEP]
[
doi
]
Lusk, R. - Saba, L. M. - Vanderlinden, L. A. - Zídek, Václav - Šilhavý, Jan - Pravenec, Michal - Hoffman, P.L. - Tabakoff, B.
Unsupervised, Statistically Based Systems Biology Approach for Unraveling the Genetics of Complex Traits: A Demonstration with Ethanol Metabolism
.
Alcoholism-Clinical and Experimental Research 2018, roč. 42, 7, p. 1177-1191
.
IF = 3.235
[ASEP]
[
doi
]
Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Morris, R. C.
Functional foods for augmenting nitric oxide activity and reducing the risk for salt-induced hypertension and cardiovascular disease in Japan
.
Journal of Cardiology 2018, roč. 72, 1, p. 42-49
.
IF = 2.289
[ASEP]
[
doi
]
Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Morris Jr., R. C.
Mechanisms of salt sensitivity of blood pressure: an unbiased approach to skinning a cat Reply
.
Journal of Hypertension 2018, roč. 36, 3, p. 703-704
.
IF = 4.209
[ASEP]
[
doi
]
Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Morris Jr., R. C.
The pivotal role of renal vasodysfunction in salt sensitivity and the initiation of salt-induced hypertension
.
Current Opinion in Nephrology and Hypertension 2018, roč. 27, 2, p. 83-92
.
IF = 3.013
[ASEP]
[
doi
]
Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Ježek, F. - Šilar, J. - Kofránek, J. - Morris Jr., R. C.
Testing Computer Models Predicting Human Responses to a High-Salt Diet: Implications for Understanding Mechanisms of Salt-Sensitive Hypertension
.
Hypertension 2018, 72(6), 1407-1416
.
IF = 7.017
[ASEP]
[
doi
]
Kuda, Ondřej - Březinová, Marie - Šilhavý, Jan - Landa, Vladimír - Zídek, Václav - Dodia, Ch. - Kreuchwig, F. - Vrbacký, Marek - Balas, L. - Durand, T. - Hübner, N. - Fisher, A. B. - Kopecký, Jan - Pravenec, Michal
.
Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid
.
Diabetes 2018, roč. 67, 6, p. 1190-1199
.
IF = 7.199
[ASEP]
[
doi
]
Hahnová, K. - Brabcová, I. - Neckář, Jan - Weissová, Romana - Svatoňová, Anna - Nováková, O. - Žurmanová, J. - Kalous, M. - Šilhavý, Jan - Pravenec, Michal - Kolář, František - Novotný, J.
beta-Adrenergic signaling, monoamine oxidase A and antioxidant defence in the myocardium of SHR and SHR-mtBN conplastic rat strains: the effect of chronic hypoxia
.
Journal of Physiological Sciences 2018, roč. 68, 4, p. 441-454
.
IF = 3.341
[ASEP]
[
doi
]
Adriaens, M. E. - Lodder, E. M. - Moreno-Moral, A. - Šilhavý, Jan - Heinig, M. - Glinge, Ch. - Belterman, Ch. - Wolswinkel, R. - Petretto, E. - Pravenec, Michal - Remme, C. A. - Bezzina, C. R.
Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction
.
Journal of the American Heart Association 2018, 7(21)), e009243
.
IF = 4.660
[ASEP]
[
doi
]
Trnovská, J. - Šilhavý, Jan - Kuda, Ondřej - Landa, Vladimír - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Strnad, Hynek - Škop, V. - Oliyarnyk, O. - Kazdová, L. - Haluzík, M. - Pravenec, Michal
.
Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls
.
PLoS ONE. 2017, roč. 12, 6, článku e0179063
.
IF = 2.766
[ASEP]
[
doi
]
Šeda, Ondřej - Liška, F. - Pravenec, Michal - Vernerová, Z. - Kazdová, L. - Křenová, D. - Zídek, Václav - Šedová, Lucie - Krupková, M. - Křen, V.
Connexin 50 Mutation Lowers Blood Pressure in Spontaneously Hypertensive Rat
.
Physiological Research. 2017, roč. 66, 1, p. 15-28
.
IF = 1.324
[ASEP]
Svoboda, Petr - Křížová, E. - Čeňková, K. - Vápenková, K. - Zídková, J. - Zídek, Václav - Škop, V.
Visfatin Is Actively Secreted In Vitro From U-937 Macrophages, but Only Passively Released From 3T3-L1 Adipocytes and HepG2 Hepatocytes
.
Physiological Research. 2017, roč. 66, 4, p. 709-714
.
IF = 1.324
[ASEP]
Rýdlová, M. - Růnová, K. - Száková, J. - Fučíková, A. - Hakenová, A. - Mlejnek, Petr - Zídek, Václav - Tremlová, J. - Mestek, O. - Kaňa, A. - Zídková, J. - Melčová, M. - Truhlářová, K. - Tlustoš, P.
The Response of Macro- and Micronutrient Nutrient Status and Biochemical Processes in Rats Fed on a Diet with Selenium-Enriched Defatted Rapeseed and/or Vitamin E Supplementation
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BioMed Research International. 2017, roč. 2017, 2017, článku 6759810
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IF = 2.583
[ASEP]
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Pravenec, Michal - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šilhavý, Jan - Šimáková, Miroslava - Trnovská, J. - Škop, V. - Marková, I. - Malínská, H. - Hüttl, M. - Kazdová, L. - Bardová, Kristina - Tauchmannová, Kateřina - Vrbacký, Marek - Nůsková, Hana - Mráček, Tomáš - Kopecký, Jan - Houštěk, Josef
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Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity
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Physiological Research.. 2017, roč. 66, 6, p. 917-924
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IF = 1.324
[ASEP]
Neckář, Jan - Svatoňová, Anna - Weissová, Romana - Drahota, Zdeněk - Zajíčková, Pavlína - Brabcová, I. - Kolář, D. - Alánová, Petra - Vašinová, Jana - Šilhavý, Jan - Hlaváčková, Markéta - Tauchmannová, Kateřina - Milerová, Marie - Ošťádal, Bohuslav - Červenka, L. - Žurmanová, J. - Kalous, M. - Nováková, Olga - Novotný, J. - Pravenec, Michal - Kolář, František
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Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats
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Clinical science. 2017, roč. 131, 9, p. 865-881
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IF = 5.220
[ASEP]
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Liška, F. - Landa, Vladimír - Zídek, Václav - Mlejnek, Petr - Šilhavý, Jan - Šimáková, Miroslava - Strnad, Hynek - Trnovská, J. - Škop, V. - Kazdová, L. - Starker, C.G. - Voytas, D.F. - Izsvák, Z. - Mancini, M. - Šeda, O. - Křen, V. - Pravenec, Michal
.
Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat
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Hypertension. 2017, roč. 69, 6, p. 1084-1091
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IF = 6.823
[ASEP]
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doi
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Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Morris Jr., R. C.
An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure
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Journal of the American Heart Association. 2017, roč. 6, 4, článku e005653
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IF = 4.450
[ASEP]
[
doi
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Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Morris Jr., R. C.
The American Heart Association Scientific Statement on salt sensitivity of blood pressure: Prompting consideration of alternative conceptual frameworks for the pathogenesis of salt sensitivity?
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Journal of Hypertension. 2017, roč. 35, 11, p. 2214-2225
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IF = 4.092
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doi
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Coan, P. M. - Hummel, O. - Diaz, A. G. - Barrier, M. - Alfazema, N. - Norsworthy, P. J. - Pravenec, Michal - Petretto, E. - Hübner, N. - Aitman, T. J.
Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
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Disease Models & Mechanisms. 2017, roč. 10, 3, p. 297-306
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IF = 4.398
[ASEP]
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Liška, F. - Chylíková, B. - Janků, M. - Šeda, Ondřej - Vernerová, Z. - Pravenec, Michal - Křen, Vladimír
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Splicing mutation in Sbf1 causes nonsyndromic male infertility in the rat
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Reproduction. 2016, roč. 152, 3, p. 215-223
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IF = 3.100
[ASEP]
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doi
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Abdelmagid, N. - Bereczky-Veress, B. - Atanur, S. - Musilová, Alena - Zídek, Václav - Saba, L. - Warnecke, A. - Khademi, M. - Studahl, M. - Aurelius, E. - Hjalmarsson, A. - Garcia-Dias, A. - Denis, C. V. - Bergström, N. - Sköldenberg, B. - Kockum, I. - Aitman, T. - Hübner, N. - Olsson, T. - Pravenec, Michal - Diez, M.
Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis
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PLoS ONE. 2016, roč. 11, 5, e0155832
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IF = 2.806
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Malínská, H. - Oliyarnyk, O. - Škop, V. - Šilhavý, Jan - Landa, Vladimír - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Strnad, Hynek - Kazdová, L. - Pravenec, Michal
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Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
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PLoS ONE. 2016, roč. 11, 3, e0150924
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IF = 2.806
[ASEP]
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doi
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Šedová, Lucie - Pravenec, Michal - Křenová, D. - Kazdová, L. - Zídek, Václav - Krupková, M. - Liška, F. - Křen, Vladimír - Šeda, Ondřej
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Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model
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PLoS ONE. 2016, roč. 11, 3, článku e0152708
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IF = 2.806
[ASEP]
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doi
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Liška, F. - Peterková, Renata - Peterka, Miroslav - Landa, Vladimír - Zídek, Václav - Mlejnek, Petr - Šilhavý, Jan - Šimáková, Miroslava - Křen, Vladimír - Starker, C.G. - Voytas, D.F. - Izsvák, Z. - Pravenec, Michal
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Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats
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PLoS ONE. 2016, roč. 11, 10, e0164206
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IF = 2.806
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Škop, V. - Trnovská, J. - Oliyarnyk, O. - Marková, I. - Malínská, H. - Kazdová, L. - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šimáková, Miroslava - Kůdela, M. - Pravenec, Michal - Šilhavý, Jan
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Hepatotoxic effects of fenofibrate in spontaneously hypertensive rats expressing human C-reactive protein
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Physiological Research. 2016, roč. 65, 6, p. 891-899
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IF = 1.461
[ASEP]
Pravenec, Michal - Landa, Vladimír - Zídek, Václav - Mlejnek, Petr - Šilhavý, Jan - Mir, S.A. - Vaingankar, S. M. - Wang, J. - Kurtz, T. W.
Effects of transgenic expression of dopamine beta hydroxylase (Dbh) gene on blood pressure in spontaneously hypertensive rats
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Physiological Research. 2016, roč. 65, 6, p. 1039-1044
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IF = 1.461
[ASEP]
Pravenec, Michal - Mlejnek, Petr - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Šilhavý, Jan - Strnad, Hynek - Eigner, Sebastian - Eigner-Henke, Kateřina - Škop, V. - Malínská, H. - Trnovská, J. - Kazdová, L. - Drahota, Zdeněk - Mráček, Tomáš - Houštěk, Josef
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Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue
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Physiological Genomics. 2016, roč. 48, 6, p. 420-427
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IF = 3.044
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Wang, M. - Sips, P. - Khin, E. - Rotival, M. - Sun, X. - Ahmed, R. - Widjaja, A. A. - Schafer, S. - Yusoff, P. - Choksi, P. K. - Ko, N. S. J. - Singh, M. K. - Epstein, D. - Guan, Y. - Houštěk, Josef - Mráček, Tomáš - Nůsková, Hana - Mikell, B. - Tan, J. - Pesce, F. - Kolář, František - Bottolo, L. - Mancini, M. - Hubner, N. - Pravenec, Michal - Petretto, E. - MacRae, C. - Cook, S. A.
Wars2 is a determinant of angiogenesis
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Nature Communications. 2016, roč. 7, Jul, p. 12061
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IF = 12.124
[ASEP]
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Harrall, K. K. - Kechris, K. J. - Tabakoff, B. - Hoffman, P.L. - Hines, L. M. - Tsukamoto, H. - Pravenec, Michal - Printz, M. - Saba, L. M.
Uncovering the liver’s role in immunity through RNA co-expression networks
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Mammalian Genome. 2016, roč. 27, 9-10, p. 469-484
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IF = 2.509
[ASEP]
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Kurtz, T. W. - DiCarlo, S. E. - Pravenec, Michal - Schmidlin, O. - Tanaka, M. - Morris Jr., R. C.
An alternative hypothesis to the widely held view that renal excretion of sodium accounts for resistance to salt-induced hypertension
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Kidney International. 2016, roč. 90, 5, p. 965-973
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IF = 7.916
[ASEP]
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Manakov, D. - Ujčíková, Hana - Pravenec, Michal - Novotný, J.
Alterations in the cardiac proteome of the spontaneously hypertensive rat induced by transgenic expression of CD36
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Journal of Proteomics. 2016, roč. 145, Aug 11, p. 177-186
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IF = 3.914
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Pravenec, Michal - Kožich, V. - Krijt, J. - Sokolová, J. - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šilhavý, Jan - Šimáková, Miroslava - Škop, V. - Trnovská, J. - Kazdová, L. - Kajiya, T. - Wang, J. M. - Kurtz, T. W.
Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome
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Hypertension. 2016, roč. 67, 2, p. 335-341
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IF = 6.857
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Myška, A. - Száková, J. - Fučíková, A. - Mlejnek, Petr - Zídek, Václav - Tremlová, J. - Mestek, O. - Koplík, R. - Zídková, J. - Melčová, M. - Tlustoš, P.
Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats
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Czech Journal of Animal Science. 2016, roč. 61, 11, p. 496-505
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IF = 0.741
[ASEP]
Šilhavý, Jan - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Oliyarnyk, O. - Malínská, H. - Kazdová, L. - Mancini, M. - Pravenec, Michal
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Rosuvastatin ameliorates inflammation, renal fat accumulation, and kidney injury in transgenic spontaneously hypertensive rats expressing human C-reactive protein
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Physiological Research. 2015, Vol. 64, 3, p. 295-301
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IF = 1.643
[ASEP]
Trnovská, J. - Šilhavý, Jan - Zídek, Václav - Šimáková, Miroslava - Mlejnek, Petr - Landa, Vladimír - Eigner, Sebastian - Eigner-Henke, Kateřina - Škop, V. - Oliyarnyk, O. - Kazdová, L. - Mráček, Tomáš - Houštěk, Josef - Pravenec, Michal
.
Gender-related effects on substrate utilization and metabolic adaptation in hairless spontaneously hypertensive rat
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Physiological Research. 2015, Vol. 64, 1, p. 51-60
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IF = 1.643
[ASEP]
Schafer, S. - Adami, E. - Heinig, M. - Rodrigues, K. E. C. - Kreuchwig, F. - Šilhavý, Jan - van Heesch, S. - Simaite, D. - Rajewsky, N. - Cuppen, E. - Pravenec, Michal - Vingron, M. - Cook, S. A. - Hubner, N.
Translational regulation shapes the molecular landscape of complex disease phenotypes
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Nature Communications. 2015, Vol. 6, -, p. 7200
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IF = 11.329
[ASEP]
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Kurtz, T. W. - Dominiczak, A. F. - DiCarlo, S. E. - Pravenec, Michal - Morris Jr., R. C.
Molecular-Based Mechanisms of Mendelian Forms of Salt-Dependent Hypertension Questioning the Prevailing Theory
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Hypertension. 2015, Vol. 65, 5, p. 932-941
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IF = 6.35
[ASEP]
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doi
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Heinig, M. - Colomé-Tatché, M. - Taudt, A. - Rintisch, C. - Schafer, S. - Pravenec, Michal - Hubner, N. - Vingron, M. - Johannes, F.
histoneHMM: Differential analysis of histone modifications with broad genomic footprints
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B M C Bioinformatics. 2015, Vol. 16, Feb 22, p. 60
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IF = 2.435
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Zicha, Josef - Dobešová, Zdenka - Zídek, Václav - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Vaněčková, Ivana - Kuneš, Jaroslav - Pravenec, Michal
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Pharmacogenetic Analysis of Captopril Effects on Blood Pressure: Possible Role of the Ednrb (Endothelin Receptor Type B) Candidate Gene
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Physiological Research 2014, roč. 63, 2, p. 263-265. ISSN 0862-8408.
IF = 1.293
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Zídková, J. - Melčová, M. - Bartošová, K. - Šestáková, Ivana - Zídek, Václav - Száková, J. - Miholová, D. - Tlustoš, P.
Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model
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Czech Journal of Animal Science. 2014, roč. 59, 12, p. 548-556. ISSN 1212-1819.
IF = 1.183
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Vlčková, V. - Malinová, M. - Koubková, B. - Szaková, J. - Zídek, Václav - Fučíková, A. - Zídková, J. - Kolihová, D. - Tlustoš, P.
Long-term effect of diet amended by risk elements contaminated soils on risk element penetration and physiological parameters of rats
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Czech Journal of Animal Science. 2014, roč. 59, 9, p. 416-427. ISSN 1212-1819.
IF = 1.183
[ASEP]
Šilhavý, Jan - Zídek, Václav - Mlejnek, Petr - Landa, Vladimír - Šimáková, Miroslava - Strnad, Hynek - Oliyarnyk, O. - Škop, V. - Kazdová, L. - Kurtz, T. - Pravenec, Michal
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Fumaric Acid Esters Can Block Pro-Inflammatory Actions of Human CRP and Ameliorate Metabolic Disturbances in Transgenic Spontaneously Hypertensive Rats
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PLoS ONE 2014, roč. 9, 7, e101906. ISSN 1932-6203.
IF = 3.234
[ASEP]
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Šilhavý, Jan - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Škop, V. - Oliyarnyk, O. - Kazdová, L. - Mancini, M. - Saar, K. - Schulz, H. - Hübner, N. - Kurtz, T. W. - Pravenec, Michal
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Rosuvastatin Can Block Pro-Inflammatory Actions of Transgenic Human C-Reactive Protein Without Reducing its Circulating Levels
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Cardiovascular Therapeutics 2014, roč. 32, 2, p. 59-65. ISSN 1755-5914.
IF = 2.362
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Rintisch, C. - Heinig, M. - Bauerfeind, A. - Schafer, S. - Mieth, Ch. - Patone, G. - Hummel, O. - Chen, W. - Cook, S. - Cuppen, E. - Colomé-Tatché, M. - Johannes, F. - Jansen, R. C. - Neil, H. - Werner, M. - Pravenec, Michal - Vingron, M. - Hubner, N.
Natural variation of histone modification and its impact on gene expression in the rat genome
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Genome Research 2014, roč. 24, jun, p. 942-953. ISSN 1088-9051.
IF = 14.63
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Pravenec, Michal - Křen, Vladimír - Landa, Vladimír - Mlejnek, Petr - Musilová, Alena - Šilhavý, Jan - Šimáková, Miroslava - Zídek, Václav
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Recent progress in the genetics of spontaneously hypertensive rats
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Physiological Research 2014, roč. 63, suppl.1, s1-s8. ISSN 0862-8408.
IF = 1.293
[ASEP]
Liška, F. - Mancini, M. - Krupková, M. - Chylíková, B. - Křenová, D. - Šeda, O. - Šilhavý, Jan - Mlejnek, Petr - Landa, Vladimír - Zídek, Václav - d´Amati, G. - Pravenec, Michal - Křen, Vladimír
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Plzf as a Candidate Gene Predisposing the Spontaneously Hypertensive Rat to Hypertension, Left Ventricular Hypertrophy, and Interstitial Fibrosis
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American Journal of Hypertension 2014, roč. 27, 1, p. 99-106. ISSN 0895-7061.
IF = 2.852
[ASEP]
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doi
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Landa, Vladimír - Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Trnovská, J. - Kazdová, L. - Pravenec, Michal
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Sterol regulatory element binding protein 2 overexpression is associated with reduced adipogenesis and ectopic fat accumulation in transgenic spontaneously hypertensive rats
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Physiological Research. 2014, roč. 63, 5, p. 587-590
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IF = 1.293
[ASEP]
Johnson, M.D. - Mueller, M. - Adamowicz-Brice, M. - Collins, M. J. - Gellert, P. - Maratou, K. - Srivastava, P. K. - Rotival, M. - Butt, S. - Game, L. - Atanur, S. S. - Silver, N. - Norsworthy, P. J. - Langley, S. R. - Petretto, E. - Pravenec, Michal - Aitman, T. J.
Genetic Analysis of the Cardiac Methylome at Single Nucleotide Resolution in a Model of Human Cardiovascular Disease
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PLoS Genetics. 2014, roč. 10, 12, e1004813. ISSN 1553-7390.
IF = 7.528
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Ivics, Z. - Mátés, L. - Yau, T. Y. - Landa, Vladimír - Zídek, Václav - Bashir, S. - Hoffmann, O. I. - Hiripi, L. - Garrels, W. - Kues, W. A. - Bösze, Z. - Geurts, A. - Pravenec, Michal - Rülicke, T. - Izsvák, Z.
Germline transgenesis in rodents by pronuclear microinjection of Sleeping Beauty transposons
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Nature Protocols 2014, roč. 9, 4, p. 773-793. ISSN 1754-2189.
IF = 9.673
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doi
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Ivics, Z. - Hiripi, L. - Hoffmann, O. I. - Mátés, L. - Yau, T. Y. - Bashir, S. - Zídek, Václav - Landa, Vladimír - Geurts, A. - Pravenec, Michal - Rülicke, T. - Bösze, Z. - Izsvák, Z.
Germline transgenesis in rabbits by pronuclear microinjection of Sleeping Beauty transposons
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Nature Protocols 2014, roč. 9, 4, p. 794-809. ISSN 1754-2189.
IF = 9.673
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doi
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Ivics, Z. - Garrels, W. - Mátés, L. - Yau, T. Y. - Bashir, S. - Zídek, Václav - Landa, Vladimír - Geurts, A. - Pravenec, Michal - Rülicke, T. - Kues, W. A. - Izsvák, Z.
Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons
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Nature Protocols 2014, roč. 9, 4, p. 810-827. ISSN 1754-2189.
IF = 9.673
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doi
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Houštěk, Josef - Vrbacký, Marek - Hejzlarová, Kateřina - Zídek, Václav - Landa, Vladimír - Šilhavý, Jan - Šimáková, Miroslava - Mlejnek, Petr - Kazdová, L. - Mikšík, Ivan - Neckář, Jan - Papoušek, František - Kolář, František - Kurtz, T. W. - Pravenec, Michal
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Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction
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Physiological Genomics 2014, roč. 46, 18, p. 671-678. ISSN 1094-8341.
IF = 2.374
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Zídek, Václav - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Landa, Vladimír - Kazdová, L. - Pravenec, Michal - Kurtz, T. W.
Tissue-Specific Peroxisome Proliferator Activated Receptor Gamma Expression and Metabolic Effects of Telmisartan
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American Journal of Hypertension, 2013, Vol. 26, 6, p. 829-835
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IF = 3.665
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Pravenec, Michal - Kožich, V. - Krijt, J. - Sokolová, J. - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Šilhavý, Jan - Oliyarnyk, O. - Kazdová, L. - Kurtz, T. W.
Folate Deficiency Is Associated With Oxidative Stress, Increased Blood Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats
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American Journal of Hypertension, 2013, Vol. 26, 1, p. 135-140
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IF = 3.665
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Mancini, M. - Petretto, E. - Kleinert, C. - Scavone, A. - De, T. - Cook, S. - Šilhavý, Jan - Zídek, Václav - Pravenec, Michal - d´Amati, G. - Camici, P.G.
Mapping genetic determinants of coronary microvascular remodeling in the spontaneously hypertensive rat
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Basic Research in Cardiology, 2013, Vol. 108, 1, p. 316
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IF = 5.904
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Langley, S. R. - Bottolo, L. - Kuneš, Jaroslav - Zicha, Josef - Zídek, Václav - Hubner, N. - Cook, S.A. - Pravenec, Michal - Aitman, T. J. - Petretto, E.
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Cardiovascular Research, 2013, Vol. 97, 4, p. 653-665
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Klevstig, M. - Manakov, D. - Kašparová, D. - Brabcová, I. - Papoušek, František - Žurmanová, J. - Zídek, Václav - Šilhavý, Jan - Neckář, Jan - Pravenec, Michal - Kolář, František - Nováková, O. - Novotný, J.
Transgenic rescue of defective Cd36 enhances myocardial adenylyl cyclase signaling in spontaneously hypertensive rats
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Pflugers Archiv - European Journal of Physiology, 2013, Vol. 465, 10, p. 1477-1486
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Katter, K. - Geurts, A.M. - Hoffmann, O. - Mátés, L. - Landa, Vladimír - Hiripi, L. - Moreno, C. - Lazar, J. - Bashir, S. - Zídek, Václav - Popova, E. - Jerchow, B. - Becker, K. - Deveraj, A. - Walter, A. - Grzybowski, M. - Corbett, M. - Rangel, A.F. - Ho
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Transposon-mediated transgenesis, transgenic rescue, and tissue-specific gene expression in rodents and rabbits
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FASEB Journal, 2013, Vol. 27, 3, p. 930-941
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MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension
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Human Molecular Genetics, 2013, Vol. 22, 18, p. 3624-3640
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