Metabolic disturbances in obesity are associated with dysregulation of the endocannabinoid (EC) system. We have shown in mice fed an obesogenic high-fat diet that metabolic effects of long-chain omega-3 fatty acids were stronger when supplied in the phospholipid form (omega-3 PL) as compared with triacylglycerols (Rossmeisl et al. 2012. PloS One). These effects were associated with a more efficient modulation of major EC molecules in white adipose tissue (WAT).
In this project, we will characterize
Our results will help to clarify, how modulation of the EC system by omega-3 contributes to their beneficial effects in obesity.
Supported by the CSF projects (no. 14-09347S; 2014-2016; and no. 17-11027S, 2017-2019) PI: Martin Rossmeisl, MD, PhD.