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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Our laboratory as a partner in EU projects


Our laboratory has been a partner in EU projects supported through Cooperation program of the European Community (FP7 and H2020) – BIOCLAMS (2010–2015), DIABAT (2011–2015), and FOIE GRAS.

The Department of Adipose Tissue Biology  is involved in extensive cooperation among excellent European laboratories in order to:

  1. identify markers of healthy development (BIOCLAIMS project; 11 partners);
  2. describe mechanisms which could increase energy expenditure in adipose tissue and prevent fat accumulation in the body (DIABAT project; 20 partners); and
  3. analyze the effect of omega-3 administered as phospholipids from Krill oil on non-alcoholic fatty liver disease (FOIE GRAS project; 10 partners).

 

Especially the DIABAT project corresponds with the long-term strategy of the Department (see Kopecky J et al. 1995 J. Clin. Invest. 96:2914-2923 and review Flachs P et al. 2013. BBA). All projects involve dietary and/or pharmacological experiments on laboratory mice. To reach to goals of these projects, we use complex in vivo phenotyping of animals (including an indirect calorimetry system, hyperinsulinemic-euglycemic clamps, in vivo analysis of body composition, and various tolerance and behavioral tests), advanced analytical tools (metabolipidomic analysis and gene expression screens), and cell culture studies.