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Important success

Important success

You´ll find the current important results of the scientists from all the laboratories of our Institute in this section (chronological order):

Clock in the choroid plexus in the brain are sensitive to disruption of the daily regime but resistant to inflammatory conditions

The ability to transport K+ cations and hence the physiological role of Na+/H+ antiporters is influenced by the composition of their hydrophilic C-termini

A new method for quantification of information transmission reliability between neurons

How does 14-3-3 protein block CaMKK protein kinase activity?

Risk factors for cardiovascular and metabolic diseases are associated with misaligned sleep schedules

How do the cells gain enough potassium?

Heat from skeletal muscle can protect not only against cold but also against obesity

Take a pill in the morning or in the evening? The mood stabilizer lithium affects the brain differently depending on the time of day

Heat or cold? New insights into the functioning of temperature-sensitive ion channels obtained in collaboration with Lund University

Unravelling novel regulatory mechanisms in the human Na+/H+ antiporter NHA2

Characterization of novel antidiabetic drug with less side effects on bone metabolism

The structure of steroids fundamentally affects their effect at the N-methyl-D-aspartate receptors

Ion channel TRPC5 as a target for treating neuropathic pain

ew lipid classes in human breastmilk

Maternal rhythmic behavior supports the development of the fetal biological clock

New findings on the structure of the FOXO4: p53 complex - a key factor in senescence regulation

Metabolomics atlas of a mouse

The effectivity of opioid analgesics is reduced by CCL2 chemokine

Gliflozins - more than just antidiabetics

Targeted modulation of NMDA receptors is a key for the effective treatment of neurological and neurodevelopmental diseases

Structural basis of heat-induced opening of TRP channels

New findings may help to improve diagnostic methods for breast cancer

Palmitoylation controls NMDA receptor susceptibility to neurosteroids

Clove oil alleviates cold-induced toothache by blocking the TRPC5 ion channel

Nanocellulose as a promising cell carrier for applications in regenerative medicine

Antidiabetic lipid mediators as neutral lipase substrates

Mitochondrial cardiolipin in adipose tissue as a novel target for treatment of cardiac cachexia

Neurosteroid pregnenolone sulfate - revealing of its site of action at the N-methyl-D-aspartate receptor

Dietary supplementation with Krill oil as a novel strategy to improve insulin sensitivity and reduce liver fat accumulation in obesity

Novel mechanism of insulin secretion highlights the importance of redox signalization

Losartan attenuates neuroinflammation and neuropathic pain in paclitaxel-induced peripheral neuropathy

Signalling bias as the way to side-effect-free medication

Lipokine 5-PAHSA is Regulated by Adipose Triglyceride Lipase and Primes Adipocytes for de novo Lipogenesis in Mice

Elucidation of TRPA1 activation mechanisms may help to understand the pathophysiology of chronic pain

Innovative method of the Forhkead transcription factor FOXO3 regulation

Transcription factor Hif-1a is required for the correct development of the sympathetic nervous system and innervation of the heart

The resistance of pancreatic beta cells to oxidative stress, which accompanies diabetes type 2, can be increased by mitochondria-targeted antioxidants

A promising pharmacological approach in cardiovascular disease prevention

Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure

The effect of gut microbiome on expression of genes involved in regulation of stress response in chronic stress

Alignment of mother and offspring body clock could prevent diseases such as heart disease and obesity

Anti-epileptic drug gabapentin decreases blood pressure through the attenuation of sympathetic nerve transmission

Antioxidants and their possible use for epilepsy treatment

n-3 PUFA differentially modulate adipose tissue endocannabinoid levels and glucose metabolism in obese mice and type 2 diabetic subjects

Uncovering of signaling pathway regulating changes in energy metabolism during development of pulmonary hypertension

Sensor domain of TRPA1 channel contributes to detection of painful stimuli

Elucidation of molecular basis of 14-3-3 protein-dependent activation of trehalase Nth1 in yeast cells

Axon zippering and its control by tension forces

Cellular and molecular basis of memory

Correlation between resistance to obesity and lipid synthesis in adipose tissue

Role of Plzf gene in regulation of metabolic and cardiac traits

Mitochondria´a role in heart damage due to myocardial infarction

TMEM70 disease

Mitochondria dysfunction and Fanconi syndrome

Prolactin-releasing peptide: a new tool for obesity treatment

Cancer cachexia can reflect aberrant metabolism of adipose tissue

Oxidative stress and its consequences

The new findings revealing coupling of mitochondrial structure and function

Physiological and molecular changes during the progression cardiac failure

A new model of obsessive-compulsive disorder (OCD)

Structural motifs within the TRPA1 receptor contribute to detection of painful stimuli

Anti-inflammatory effects of omega-3 PUFA are mediated by new lipid mediators from adipose tissue

Why some people have dental caries?

Enzyme associated with the development of Alzheimer's disease controls neuronal growth during embryogenesis

Adaptation of the aural neuron code to statistics of stimulus

New animal model of Alzheimer's disease may help to verify the effectiveness of a therapeutic approaches in the future

Testing of new possibilities for the treatment of obesity

A detailed explanation of insulin secretion stimulated by fatty acids help in diagnosing of type 2 diabetes

Gender differences and atherosclerosis

How do the Alzheimer disease patients orient in space?

Chemotherapy induced neuropathic pain

The consequences of brain damage could worse increased body temperature

Epileptic seizure and what influences it?

The aim of the research is a less invasive medical diagnostics

Nanotechnology helps in the development of advanced bone implants

The new findings make life with bipolar disorder easier

Chillies can reduce the pain

Bile acids prevents the development of obesity

Bowel functionality of the newborn is influenced also by the mother's timing system

Differences in the sensitivity of the heart muscle to lack of oxygen between males and females

Biomaterials and Tissue Engineering

Cognitive deficit - symptom of many of neuropsychiatric disorders

Surface adjustment of hip arthroplasty

Everyday Jet Lag

Tissue substitution