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Laboratory of Developmental Cardiology

Laboratory of Developmental Cardiology

Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:

  • high cardiac tolerance to injury early ontogeny,
  • increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
  • permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
  • and altered cardiac tolerance associated with various pathological states.

Further we study heart development with special emphasis on the cardiac conduction system. Our current research is focused on the following projects:

  • elucidating cardiac conduction system formation with phylogenetic approaches,
  • dynamic imaging methods for cardiac conduction system,
  • and development of new methods for quantitative analysis of fibrous structures to study branching patterns of the coronary vessels and cardiac conduction system.

13th conference New Frontiers in Basic Cardiovascular Research


Developmental aspects of cardiac ischemic tolerance

The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance. More

Cardiac ischemic tolerance in systemic hypertension

Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance. More

Cardioprotective mechanism of chronic hypoxia

Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury. More


Semenzato; M. - Kohr; M. J. - Quirin; Ch. - Menab?; R. - Alánová; Petra - Alán; L. - Pellattiero; A. - Murphy; E. - Di Lisa; F. - Scorrano; L. Oxidization of optic atrophy 1 cysteines occurs during heart ischemia-reperfusion and amplifies cell death by oxidative stress . Redox Biology. 2023; 63(July)); 102755 . IF = 11.4 [ASEP] [ doi ]
Ošťádal; Bohuslav - Kolář; František - Ošťádalová; Ivana - Sedmera; David - Olejníčková; Veronika - Hlaváčková; Markéta - Alánová; Petra . Developmental Aspects of Cardiac Adaptation to Increased Workload . Journal of cardiovascular development and disease. 2023; 10(5)); 205 . IF = 2.4 [ASEP] [ doi ]
Jutrić; D. - Dikić; D. - Boroš; Almoš - Odeh; D. - Gračan; R. - Beletić; A. - Jurčević; I. L. Combined effects of valproate and naringin on kidney antioxidative markers and serum parameters of kidney function in C57BL6 mice . Arhiv za Higijenu Rada i Toksikologiju. 2023; 74(3); 218-223 . IF = 2.1 [ASEP] [ doi ]
Husková; Z. - Kikerlová; S. - Miklovič; M. - Kala; P. - Papoušek; František - Neckář; Jan . Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension . Frontiers in Physiology. 2023; 14(14 June)); 1151308 . IF = 4.0 [ASEP] [ doi ]
Hrabalová; Petra - Bohuslavová; Romana - Matějková; Kateřina - Papoušek; František - Sedmera; David - Abaffy; Pavel - Kolář; František - Pavlínková; Gabriela . Dysregulation of hypoxia-inducible factor 1 alpha in the sympathetic nervous system accelerates diabetic cardiomyopathy . Cardiovascular Diabetology. 2023; 22(1); 88 . IF = 9.3 [ASEP] [ doi ]
Benák; Daniel - Kolář; František - Zhang; L. - Devaux; Y. - Hlaváčková; Markéta . RNA modification m6Am: the role in cardiac biology . Epigenetics. 2023; 18(1); 2218771 . IF = 3.7 [ASEP] [ doi ]
Benák; Daniel - Benáková; Štěpánka - Plecitá-Hlavatá; Lydie - Hlaváčková; Markéta . The role of m6A and m6Am RNA modifications in the pathogenesis of diabetes mellitus . Frontiers in Endocrinology. 2023; 14(July); 1223583 . IF = 5.2 [ASEP] [ doi ]
Semenovykh; Dmytro - Benák; Daniel - Holzerová; Kristýna - Černá; B. - Telenský; P. - Vavříková; Tereza - Kolář; František - Neckář; Jan - Hlaváčková; Markéta . Myocardial m6A regulators in postnatal development: effect of sex . Physiological Research. 2022; 71(6); 877-882 . IF = 2.1 [ASEP] [ doi ]
Sedmera; David . HLHS: Power of the Chick Model . Journal of cardiovascular development and disease. 2022; 9(4)); 113 . IF = 2.4 [ASEP] [ doi ]
Sedmera; David . Mass cytometry imaging in physiology . Acta Physiologica. 2022; 235(2)); e13822 . IF = 6.3 [ASEP] [ doi ]


Prof. RNDr. František Kolář, CSc.
 Head of the Laboratory
RNDr. Jan Neckář, Ph.D.
Senior Researcher
Prof. MUDr. David Sedmera, DSc.
Senior Researcher
Prof. MUDr. Bohuslav Ošťádal, DrSc.
Senior Researcher
MUDr. Ivana Ošťádalová, CSc.
Senior Researcher
Ing. František Papoušek, CSc.
Senior Researcher
RNDr. Markéta Hlaváčková, Ph.D.
Senior Researcher
  Olga Nováková
Senior Researcher
RNDr. Petra Alánová, Ph.D.
Research Assistant
RNDr. Martina Gregorovičová, Ph.D.
Postdoctoral Fellow
  Mgr. Petra Kolesová, Ph.D.
Postdoctoral Fellow
MVDr. Veronika Olejníčková, Ph.D.
Postdoctoral Fellow

RNDr. Kristýna Holzerová, Ph.D.
Postdoctoral Fellow

Mgr. Jaroslav Hrdlička, Ph.D.
Postdoctoral Fellow
Mgr. Daniel Benák
PhD Student
Mgr. Barbora Opletalová
PhD Student

MUDr. Tereza Vavříková
PhD Student

Ing. Miloslava Marková
Milana Pešková
Jarmila Svatůňková