Localization of the enzyme 11β-hydroxysteroid dehydrogenase type 1 in mouse colon stained with anti-11HSD1 antibody (A) and negative control (B).
Our research focuses on gastrointestinal (GI) physiology and pathophysiology and on understanding how complex GI functions are influenced by hormonal (corticosteroids) and environmental factors (stress, food, microbiota). Our work uses various strains of rats and mice, including germ-free animals and animal models of colitis and acute and chronic stress. In particular, we address the questions:
- Host - gut microbiome interactions in neuroendocrine regulatory pathways
- Regulation of intestinal transport
- Local metabolism of glucocorticoids
Projects
Publications
Vagnerová; Karla - Jágr; M. - Mekadim; Chahrazed - Ergang; Peter - Sechovcová; Hana - Vodička; Martin - Olša Fliegerová; Kateřina - Dvořáček; V. - Mrázek; Jakub - Pácha; Jiří
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Profiling of adrenal corticosteroids in blood and local tissues of mice during chronic stress
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Scientific Reports. 2023; 13(1)); 7278
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IF = 4.6
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doi
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Soták; M. - Casselbrant; A. - Rath; E. - Zietek; T. - Strömstedt; M. - Adingupu; D. D. - Karlsson; D. - Fredin; M. F. - Ergang; Peter - Pácha; Jiří - Batorsky; A. - Alpers; Ch. E. - Börgeson; E. - Hansen; P. B. L. - Ericsson; A. - Granqvist; A. B. - Wallenius; V. - Fändriks; L. - Unwin; R. J.
Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity
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Life Sciences. 2021; 267(Feb 15)); 118974
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IF = 6.780
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doi
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Pácha; Jiří - Balounová; Kateřina - Soták; M.
Circadian regulation of transporter expression and implications for drug disposition
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Expert Opinion on Drug Metabolism & Toxicology. 2021; 17(4); 425-439
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IF = 4.936
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doi
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Krausová; Alžběta - Burešová; Petra - Sarnová; Lenka - Oyman-Eyrilmez; Gizem - Škarda; J. - Wohl; P. - Bajer; L. - Sticová; E. - Bartoňová; L. - Pácha; Jiří - Koubková; Gizela - Procházka; Jan - Sporrer; M. - Durrbeck; C. - Stehlíková; Zuzana - Vít; M. - Ziolkowska; N. - Sedláček; Radislav - Jirák; D. - Kverka; Miloslav - Wiche; G. - Fabry; B. - Kořínek; Vladimír - Gregor; Martin
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Plectin ensures intestinal epithelial integrity and protects colon against colitis
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Mucosal Immunology. 2021; 14(3); 691-702
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IF = 9.020
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doi
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Ergang; Peter - Vagnerová; Karla - Hermanová; Petra - Vodička; Martin - Jágr; M. - Šrůtková; Dagmar - Dvořáček; V. - Hudcovic; Tomáš - Pácha; Jiří
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The Gut Microbiota Affects Corticosterone Production in the Murine Small Intestine
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International Journal of Molecular Sciences. 2021; 22(8)); 4229
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IF = 6.208
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doi
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Zemanová; N. - Anzenbacher; P. - Zapletalová; I. - Jourová; L. - Hermanová; Petra - Hudcovic; Tomáš - Kozáková; Hana - Vodička; Martin - Pácha; Jiří - Anzenbacherová; E.
The role of the microbiome and psychosocial stress in the expression and activity of drug metabolizing enzymes in mice
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Scientific Reports. 2020; 10(1)); 8529
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IF = 4.379
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doi
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Vodička; Martin - Vavřínová; Anna - Mikulecká; Anna - Zicha; Josef - Behuliak; Michal
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Hyper-reactivity of HPA axis in Fischer 344 rats is associated with impaired cardiovascular and behavioral adaptation to repeated restraint stress
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STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS. 2020; 23(6); 667-677
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IF = 3.493
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doi
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Kroupová; Petra - van Schothorst; E. M. - Keijer; J. - Bunschoten; A. - Vodička; Martin - Irodenko; Ilaria - Oseeva; Marina - Žáček; P. - Kopecký; Jan - Rossmeisl; Martin - Horáková; Olga
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Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice
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Nutrients. 2020; 12(7)); 2037
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IF = 5.717
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doi
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Balounová; Kateřina - Soták; Matúš - Ergang; Peter - Vodička; Martin - Vagnerová; Karla - Pácha; Jiří
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Effects of aging and tumorigenesis on coupling between the circadian clock and cell cycle in colonic mucosa
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Mechanisms of Ageing and Development. 2020; 190(Sep)); 111317
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IF = 5.432
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doi
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Vavřínová; Anna - Behuliak; Michal - Bencze; Michal - Vodička; Martin - Ergang; Peter - Vaněčková; Ivana - Zicha; Josef
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Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors
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Hypertension Research. 2019; 42; 1872-1882
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IF = 2.941
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doi
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Vagnerová; Karla - Vodička; Martin - Hermanová; Petra - Ergang; Peter - Šrůtková; Dagmar - Klusoňová; Petra - Balounová; Kateřina - Hudcovic; Tomáš - Pácha; Jiří
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Interactions Between Gut Microbiota and Acute Restraint Stress in Peripheral Structures of the Hypothalamic–Pituitary–Adrenal Axis and the Intestine of Male Mice
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Frontiers in Immunology. 2019; 10); 2655
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IF = 5.085
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[
doi
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Vagnerová; Karla - Ergang; Peter - Soták; Matúš - Balounová; Kateřina - Kvapilová; Pavlína - Vodička; Martin - Pácha; Jiří
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Diurnal expression of ABC and SLC transporters in jejunum is modulated by adrenalectomy
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Comparative Biochemistry and Physiology Part C. 2019; 226(Dec)); 108607
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IF = 2.892
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doi
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Jágr, Michal - Ergang, Peter - Pataridis, Statis - Kolrosová, M. - Bartoš, M. - Mikšík, Ivan
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Proteomic analysis of dentin-enamel junction and adjacent protein-containing enamel matrix layer of healthy human molar teeth
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European Journal of Oral Sciences 2019, 127(2), 112-121
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IF = 2.220
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doi
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Vodička, Martin - Ergang, Peter - Hrnčíř, Tomáš - Mikulecká, Anna - Kvapilová, Pavlína - Vagnerová, Karla - Šestáková, Blanka - Fajstová, Alena - Hermanová, Petra - Hudcovic, Tomáš - Kozáková, Hana - Pácha, Jiří
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Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress
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Brain Behavior and Immunity 2018, 73(Oct 2018), 615-624
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IF = 6.170
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doi
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Kolínská, Jiřina - Zákostelecká, Marie - Zemanová, Zdeňka - Lisá, Věra - Goliáš, Jaroslav - Kozáková, Hana - Dvořák, B.
Cellular differentiation of non-transformed intestinal epithelial cells is regulated by Lactobacillus rhamnosus and L. casei strains
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Physiological Research 2018, roč. 67, 2, p. 261-273
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IF = 1.701
[ASEP]
Ergang, Peter - Mikulecká, Anna - Vodička, Martin - Vagnerová, Karla - Mikšík, Ivan - Pácha, Jiří
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Social defeat stimulates local glucocorticoid regeneration in lymphoid organs
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Endocrine Connections 2018, 7(12), 1389-1396
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IF = 2.474
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[
doi
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Polidarová, Lenka - Houdek, Pavel - Sládek, Martin - Novosadová, Zuzana - Pácha, Jiří - Sumová, Alena
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Mechanisms of hormonal regulation of the peripheral circadian clock in the colon
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Chronobiology International. 2017, roč. 34, 1, p. 1-16
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IF = 2.643
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doi
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Ergang, Peter - Vodička, Martin - Vagnerová, Karla - Moravec, Martin - Kvapilová, Pavlína - Kment, M. - Pácha, Jiří
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Inflammation regulates 11 beta-hydroxysteroid dehydrogenase type 1 differentially in specific compartments of the gut mucosal immune system
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Steroids. 2017, roč. 126, Oct 2017, p. 66-73
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IF = 2.523
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doi
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Soták, Matúš - Bryndová, Jana - Ergang, Peter - Vagnerová, Karla - Kvapilová, Pavlína - Vodička, Martin - Pácha, Jiří - Sumová, Alena
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Peripheral circadian clocks are diversely affected by adrenalectomy
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Chronobiology International. 2016, roč. 33, 5, p. 520-529
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IF = 2.562
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doi
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Szczurowska, Ewa - Ergang, Peter - Kubová, Hana - Druga, Rastislav - Salaj, M. - Mareš, Pavel
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Influence of early life status epilepticus on the developmental expression profile of the GluA2 subunit of AMPA receptors
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Experimental Neurology. 2016, roč. 283, Part A, p. 97-109
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IF = 4.706
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doi
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Ergang, Peter - Vodička, Martin - Soták, Matúš - Klusoňová, Petra - Behuliak, Michal - Řeháková, Lenka - Zach, P. - Pácha, Jiří
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Differential impact of stress on hypothalamic–pituitary–adrenal axis: Gene expression changes in Lewis and Fisher rats
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Psychoneuroendocrinology. 2015, Vol. 53, Mar 2015, p. 49-59
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IF = 4.704
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doi
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Behuliak, Michal - Vavřínová, Anna - Bencze, Michal - Polgárová, Kamila - Ergang, Peter - Kuneš, Jaroslav - Vaněčková, Ivana - Zicha, Josef
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Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar–Kyoto and spontaneously hypertensive rats
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Journal of Hypertension. 2015, Vol. 33, 12, p. 2443-2454
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IF = 5.062
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doi
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Vodička, Martin - Ergang, Peter - Mikulecká, Anna - Řeháková, Lenka - Klusoňová, Petra - Makal, J. - Soták, Matúš - Musílková, Jana - Zach, P. - Pácha, Jiří
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Regulation of 11 beta-Hydroxysteroid Dehydrogenase Type 1 and 7 alpha-Hydroxylase CYP7B1 during Social Stress
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PLoS ONE 2014, roč. 9, 2, e89421. ISSN 1932-6203.
IF = 3.234
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doi
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Soták, Matúš - Sumová, Alena - Pácha, Jiří
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Cross-talk between the circadian clock and the cell cycle in cancer
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Annals of Medicine 2014, roč. 46, 4, p. 221-232. ISSN 0785-3890.
IF = 3.886
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[
doi
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Polidarová, Lenka - Olejníková, Lucie - Paušlyová, Lucia - Sládek, Martin - Soták, Matúš - Pácha, Jiří - Sumová, Alena
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Development and entrainment of the colonic circadian clock during ontogenesis
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American Journal of Physiology-Gastrointestinal and Liver Physiology 2014, roč. 306, 4, g346-g356. ISSN 0193-1857.
IF = 3.798
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doi
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Moravec, Martin - Švec, Jiří - Ergang, Peter - Mandys, V. - Řeháková, Lenka - Zádorová, Z. - Hajer, J. - Kment, M. - Pácha, Jiří
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Expression of 11 beta-hydroxysteroid dehydrogenase type 2 is deregulated in colon carcinoma
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Histology and Histopathology 2014, roč. 29, 4, p. 489-496. ISSN 0213-3911.
IF = 2.096
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Mikšík, Ivan - Ergang, Peter - Pácha, Jiří
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Proteomic analysis of chicken eggshell cuticle membrane layer
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Analytical and Bioanalytical Chemistry 2014, roč. 406, 29, p. 7633-7640. ISSN 1618-2642.
IF = 3.436
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doi
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Hudcová, T. - Bryndová, Jana - Fialová, K. - Fiala, J. - Karabín, M. - Jelínek, L. - Dostalek, P.
Antiproliferative effects of prenylflavonoids from hops on human colon cancer cell lines
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Journal of the Institute of Brewing. 2014, roč. 120, 3, p. 225-230. ISSN 0046-9750.
IF = 1.24
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doi
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Ergang, Peter - Kuželová, A. - Soták, Matúš - Klusoňová, Petra - Makal, J. - Pácha, Jiří
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Distinct Effect of Stress on 11 beta-Hydroxysteroid Dehydrogenase Type 1 and Corticosteroid Receptors in Dorsal and Ventral Hippocampus
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Physiological Research 2014, roč. 63, 2, p. 255-261. ISSN 0862-8408.
IF = 1.293
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Soták, Matúš - Polidarová, Lenka - Ergang, Peter - Sumová, Alena - Pácha, Jiří
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An association between clock genes and clock-controlled cell cycle genes in murine colorectal tumors
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International Journal of Cancer, 2013, Vol. 132, 5, p. 1032-1041
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IF = 6.198
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doi
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Isolated colonic crypt of rat.
Intracellular pH response in isolated colonic crypts of rat. The crypts were exposed to intracellular alkalinization by addition of NH4Cl followed by acidification after washing out the ammonium pulse.