Intranet Campus web

Laboratory of Experimental Hypertension

Laboratory of Experimental Hypertension

The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure  regulation and end-organ damage in rats with different types of experimental hypertension.

Our research is focused mainly on:

  • Cardiovascular effects of new antidiabetics – gliflozins in  model of experimental hypertension and chronic heart failure
  • Central and peripheral mechanisms of blood pressure regulation
  • Role of sympathetic and parasympathetic nervous system  in cardiovascular diseases
  • Cardiovascular effects  of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).

Projects

Achievements

Publications

Zicha; Josef - Řezáčová; Lenka - Vaněčková; Ivana . Nitric Oxide and Salt Resistance in Dahl Rats: No Role of Inducible NO Synthase . Physiological Research. 2023; 72(1); 123-127 . IF = 2.1 [ASEP] [ doi ]
Valovič; Pavol - Behuliak; Michal - Vaněčková; Ivana - Zicha; Josef . Impaired vascular ?-adrenergic relaxation in spontaneously hypertensive rats: The differences between conduit and resistance arteries . European Journal of Pharmacology. 2023; 958(5 November); 176045 . IF = 5.0 [ASEP] [ doi ]
Strnadová; V. - Karnošová; A. - Blechová; M. - Neprašová; B. - Holá; L. - Němcová; A. - Myšková; A. - Sýkora; D. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies . Neuropeptides. 2023; 98(April)); 102319 . IF = 2.9 [ASEP] [ doi ]
Rauchová; Hana - Hojná; Silvie - Kadlecová; Michaela - Vaněčková; Ivana - Chao; YM. - Chan; J. Y. H. - Zicha; Josef . Sex differences in blood pressure; free radicals and plasma cholesterol fractions in Ren-2 transgenic rats of various ages . Physiological Research. 2023; 72(2); 167-175 . IF = 2.1 [ASEP] [ doi ]
Piťha; J. - Vaněčková; Ivana - Zicha; Josef . Hypertension after the Menopause: What Can We Learn from Experimental Studies? . Physiological Research. 2023; 72(Suppl.2); 91-112 . IF = 2.1 [ASEP] [ doi ]
Pelantová; H. - Tomášová; P. - Šedivá; B. - Neprašová; B. - Mráziková; L. - Kuneš; Jaroslav - Železná; B. - Maletínská; L. - Kuzma; M. Metabolomic Study of Aging in fa/fa Rats: Multiplatform Urine and Serum Analysis . Metabolites. 2023; 13(4)); 552 . IF = 4.1 [ASEP] [ doi ]
Myšková; A. - Sýkora; D. - Kuneš; Jaroslav - Maletínská; L. Lipidization as a tool toward peptide therapeutics . Drug Delivery. 2023; 30(1); 2284685 . IF = 6.0 [ASEP] [ doi ]
Mráziková; L. - Hojná; Silvie - Vaculová; P. - Strnad; Š. - Vrkoslav; V. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance . Nutrients. 2023; 15(2)); 280 . IF = 5.9 [ASEP] [ doi ]
Mengr; A. - Strnadová; V. - Strnad; Š. - Vrkoslav; V. - Pelantová; H. - Kuzma; M. - Comptdaer; T. - Železná; B. - Kuneš; Jaroslav - Galas; M. C. - Pačesová; A. - Maletínská; L. Feeding High-Fat Diet Accelerates Development of Peripheral and Central Insulin Resistance and Inflammation and Worsens AD-like Pathology in APP/PS1 Mice . Nutrients. 2023; 15(17); 3690 . IF = 5.9 [ASEP] [ doi ]
Kuneš; Jaroslav - Hojná; Silvie - Mráziková; L. - Montezano; A. - Touyz; R.M. - Maletínská; L. Obesity; Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms . Physiological Research. 2023; 72(Suppl.2); 73-90 . IF = 2.1 [ASEP] [ doi ]
Karnošová; A. - Strnadová; V. - Železná; B. - Kuneš; Jaroslav - Kašpárek; P. - Maletínská; L. NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose . Clinical science. 2023; 137(10); 847-862 . IF = 6.0 [ASEP] [ doi ]
Kala; P. - Vaňourková; Z. - Škaroupková; P. - Kompanowska - Jezierska; E. - Sadowski; J. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L. Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula . Biomedicine & Pharmacotherapy. 2023; 158(February)); 114157 . IF = 7.5 [ASEP] [ doi ]
Kala; P. - Gawrys; O. - Miklovic; M. - Vaňourková; Z. - Škaroupková; P. - Jíchová; Š. - Sadowski; J. - Kompanowska - Jezierska; E. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L. Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension . Journal of Hypertension. 2023; 41(1); 99-114 . IF = 4.9 [ASEP] [ doi ]
Freitas-Lima; L. C. - Pačesová; A. - Staňurová; J. - Šácha; P. - Marek; A. - Hubálek; M. - Kuneš; Jaroslav - Železná; B. - Maletínská; L. GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript peptide . European Journal of Pharmacology. 2023; 949(15 June)); 175713 . IF = 5.0 [ASEP] [ doi ]
Zicha; Josef - Řezáčová; Lenka - Behuliak; Michal - Vaněčková; Ivana . Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension . Physiological Research. 2022; 71(6); 763-770 . IF = 2.1 [ASEP] [ doi ]
Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef . Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats . Hypertension Research. 2022; 45(3); 414-423 . IF = 5.4 [ASEP] [ doi ]
Pačesová; A. - Holubová; M. - Hrubá; L. - Strnadová; V. - Neprašová; B. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Age-related metabolic and neurodegenerative changes in SAMP8 mice . Aging. 2022; 14(18); 7300-7327 . IF = 5.2 [ASEP] [ doi ]
Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances . Nutrition & Diabetes. 2022; 12(1)); 26 . IF = 6.1 [ASEP] [ doi ]
Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana . Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein . Biomedicines. 2022; 10(9)); 2066 . IF = 4.7 [ASEP] [ doi ]
Chao; YM. - Rauchová; Hana - Chan; J. Y. H. Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic l-NAME Treatment in Rats . Biomedicines. 2022; 10(9)); 2232 . IF = 4.7 [ASEP] [ doi ]
Holá; L. - Železná; B. - Karnošová; A. - Kuneš; Jaroslav - Fehrentz; J. A. - Denoyelle; S. - Cantel; S. - Blechová; M. - Sýkora; D. - Myšková; A. - Maletínská; L. A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin . Journal of Pharmacology and Experimental Therapeutics. 2022; 383(2); 129-136 . IF = 3.5 [ASEP] [ doi ]
Hojná; Silvie - Kotsaridou; Zoe - Vaňourková; Z. - Rauchová; Hana - Behuliak; Michal - Kujal; P. - Kadlecová; Michaela - Zicha; Josef - Vaněčková; Ivana . Empagliflozin Is Not Renoprotective in Non-Diabetic Rat Models of Chronic Kidney Disease . Biomedicines. 2022; 10(10)); 2509 . IF = 4.7 [ASEP] [ doi ]
Andelová; K. - Szeiffová Bačová; B. - Sýkora; M. - Pavelka; Stanislav - Rauchová; Hana - Tribulová; N. Cardiac Cx43 Signaling Is Enhanced and TGF-beta 1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHRM . Biomedicines. 2022; 10(7)); 1707 . IF = 4.7 [ASEP] [ doi ]
Zicha; Josef - Behuliak; Michal - Vavřínová; Anna - Dobešová; Zdenka - Kuneš; Jaroslav - Rauchová; Hana - Vaněčková; Ivana . Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats . Hypertension Research. 2021; 44(9); 1067-1078 . IF = 5.525 [ASEP] [ doi ]
Zicha; Josef . Contribution of Sympathetic Nervous System to High Blood Pressure in Salt Hypertensive Dahl Rats . Physiological Research. 2021; 70(2); 117-118 . IF = 2.139 [ASEP] [ doi ]
Vavřínová; Anna - Behuliak; Michal - Vaněčková; Ivana - Zicha; Josef . The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure . Physiological Research. 2021; 70(3); 307-326 . IF = 2.139 [ASEP] [ doi ]
Rauchová; Hana . Coenzyme Q10 Effects in Neurological Diseases . Physiological Research. 2021; 70(Suppl.4); S683-S714 . IF = 2.139 [ASEP] [ doi ]
Pražienková; V. - Funda; Jiří - Pirník; Z. - Karnošová; A. - Hrubá; L. - Kořínková; L. - Neprašová; B. - Janovská; Petra - Bencze; Michal - Kadlecová; Michaela - Blahoš; J. - Kopecký; Jan - Železná; B. - Kuneš; Jaroslav - Bardová; Kristina - Maletínská; L. GPR10 gene deletion in mice increases basal neuronal activity; disturbs insulin sensitivity and alters lipid homeostasis . Gene. 2021; 774(Mar 30)); 145427 . IF = 3.913 [ASEP] [ doi ]
Pirník; Z. - Kořínková; L. - Osacká; J. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Cholecystokinin System Is Involved in the Anorexigenic Effect of Peripherally Applied Palmitoylated Prolactin-Releasing Peptide in Fasted Mice . Physiological Research. 2021; 70(4); 579-590 . IF = 2.139 [ASEP] [ doi ]
Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František . Excess ischemic tachyarrhythmias trigger protection infarction in rats . Clinical science. 2021; 135(17); 2143-2163 . IF = 6.876 [ASEP] [ doi ]
Mráziková; L. - Neprašová; Barbora - Mengr; A. - Popelová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models . Frontiers in Pharmacology. 2021; 12(Nov 18)); 779962 . IF = 5.988 [ASEP] [ doi ]
Mengr; A. - Hrubá; L. - Exnerová; A. - Holubová; M. - Popelová; A. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated Prolactin-releasing Peptide Reduced A? Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study . Current Alzheimer Research. 2021; 18(8); 607-622 . IF = 3.040 [ASEP] [ doi ]
Karnošová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10; NPFF-R2 and NPFF-R1 Receptors: In Vitro Study . International Journal of Molecular Sciences. 2021; 22(16)); 8904 . IF = 6.208 [ASEP] [ doi ]
Kacířová; M. - Železná; B. - Blažková; M. - Holubová; M. - Popelová; A. - Kuneš; Jaroslav - Šedivá; B. - Maletínská; L. Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22 . Journal of Neuroinflammation. 2021; 18(1)); 141 . IF = 9.587 [ASEP] [ doi ]
Hüttl; M. - Marková; I. - Miklánková; D. - Zapletalová; I. - Poruba; M. - Haluzík; M. - Vaněčková; Ivana - Malínská; H. In a Prediabetic Model; Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia . International Journal of Molecular Sciences. 2021; 22(21)); 11513 . IF = 6.208 [ASEP] [ doi ]

Article photogallery

The entire photogallery

People

     RNDr. Ivana Vaněčková, DSc.
Head of the Laboratory
MUDr. Josef Zicha, DrSc.
Deputy Head of the Laboratory
RNDr. Jaroslav Kuneš, DrSc.
Senior Researcher
MUDr. Hana Rauchová, CSc.
Senior Researcher
  RNDr. Milada Dobiášová, DrSc.
Senior Researcher
Ing. Michaela Kadlecová, Ph.D.
Research Assistant
Mgr. Silvie Hojná, Ph.D.
Research Assistant
RNDr. Lenka Řezáčová, Ph.D.
Research Assistant
Bc. Martina Sabolová
Pregradual student
Alena Charvátová
Technician
Zdeňka Kopecká
Technician