{"id":24822,"date":"2024-07-18T20:23:54","date_gmt":"2024-07-18T18:23:54","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/research-and-laboratories\/research-departments\/biologicke-rytmy\/"},"modified":"2026-01-29T14:53:03","modified_gmt":"2026-01-29T13:53:03","slug":"laboratory-of-biological-rhythms","status":"publish","type":"page","link":"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research-departments\/laboratory-of-biological-rhythms\/","title":{"rendered":"Laboratory of Biological Rhythms"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"24822\" class=\"elementor elementor-24822 elementor-17575\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22f0716 e-flex e-con-boxed e-con e-parent\" data-id=\"22f0716\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2f4f528 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"2f4f528\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad6ff43 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ad6ff43\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Laboratory of Biological Rhythms<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3306453 e-con-full e-flex e-con e-parent\" data-id=\"3306453\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f2ab90 elementor-absolute elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"6f2ab90\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"708\" height=\"789\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp\" class=\"attachment-large size-large wp-image-51089\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp 708w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3-269x300.webp 269w\" sizes=\"(max-width: 708px) 100vw, 708px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-62ed919 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"62ed919\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-50924c1 elementor-widget elementor-widget-heading\" data-id=\"50924c1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Content of this page<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8d206bc elementor-toc--content-ellipsis elementor-widget elementor-widget-table-of-contents\" data-id=\"8d206bc\" data-element_type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;marker_view&quot;:&quot;bullets&quot;,&quot;icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-toc__8d206bc\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3c81cea e-con-full e-flex e-con e-child\" data-id=\"3c81cea\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a371a1f elementor-widget elementor-widget-image\" data-id=\"a371a1f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1483\" height=\"752\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/24-uvodni.png\" class=\"attachment-1536x1536 size-1536x1536 wp-image-21078\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/24-uvodni.png 1483w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/24-uvodni-300x152.png 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/24-uvodni-1024x519.png 1024w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/24-uvodni-768x389.png 768w\" sizes=\"(max-width: 1483px) 100vw, 1483px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-211aab2 e-con-full e-flex e-con e-child\" data-id=\"211aab2\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-650442e elementor-widget elementor-widget-heading\" data-id=\"650442e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">About the Laboratory<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4f9d8b elementor-widget elementor-widget-text-editor\" data-id=\"b4f9d8b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/docs.google.com\/forms\/d\/e\/1FAIpQLSdbKChvNzgXea_b7Lh4mRUuiH85yPcEDV6ILgtXHFjqF1zeuQ\/viewform?usp=sf_link\" target=\"_blank\" rel=\"noopener\">Please, consider filing out anonymous questionnaire regarding your chronotype and social jet lag.<\/a><\/p><p><span style=\"text-decoration: underline;\"><strong>GitHub<\/strong><\/span><\/p><p>In the center of our interest is the endogenous time-keeping system, circadian clock of mammals, including humans. The system temporally regulates rhythmic processes in our body so that they take place at the proper time of day and are optimally synchronized relative to each other.<\/p><p>A failure of the temporal regulation has a negative impact on human health. Using in vivo and in vitro models, we study the molecular mechanisms underlying the circadian clock as well as the resulting physiological and behavioral rhythms.<\/p><p>We focus on the following questions:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b55d025 elementor-widget elementor-widget-text-editor\" data-id=\"b55d025\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li>What are the mechanisms for entraining (synchronizing) the circadian system and what are the consequences of its failure?<\/li><li>How does the circadian system develop and how is it being entrained during ontogeny?<\/li><li>How is the circadian system of humans entrained in real life conditions, both in health and in disease?<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9324150 elementor-widget elementor-widget-image\" data-id=\"9324150\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"614\" height=\"307\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/scn-e17-and-p1-ms.gif\" class=\"attachment-large size-large wp-image-17581\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bbd9ce0 elementor-widget elementor-widget-text-editor\" data-id=\"bbd9ce0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\">Fig. PER2 protein in the prenatal and early postnatal SCN, ex vivo luminescence microscopy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e720055 e-con-full e-flex e-con e-child\" data-id=\"e720055\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b62862a elementor-widget elementor-widget-heading\" data-id=\"b62862a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d01bd7 elementor-grid-1 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"0d01bd7\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:26040,&quot;columns&quot;:1,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:1,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t<style id=\"loop-26040\">.elementor-26040 .elementor-element.elementor-element-004a4b0{--display:flex;--flex-direction:column;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:initial;--container-widget-flex-grow:0;--container-widget-align-self:initial;--flex-wrap-mobile:wrap;--justify-content:space-between;--align-items:flex-start;--gap:15px 15px;--row-gap:15px;--column-gap:15px;border-style:solid;--border-style:solid;border-width:1px 1px 1px 1px;--border-top-width:1px;--border-right-width:1px;--border-bottom-width:1px;--border-left-width:1px;border-color:var( --e-global-color-d64be13 );--border-color:var( --e-global-color-d64be13 );--border-radius:10px 10px 10px 10px;box-shadow:0px 6px 10px 0px rgba(0, 0, 0, 0.1);--margin-top:0px;--margin-bottom:0px;--margin-left:0px;--margin-right:0px;--padding-top:20px;--padding-bottom:20px;--padding-left:20px;--padding-right:20px;}.elementor-26040 .elementor-element.elementor-element-004a4b0:not(.elementor-motion-effects-element-type-background), .elementor-26040 .elementor-element.elementor-element-004a4b0 > .elementor-motion-effects-container > .elementor-motion-effects-layer{background-color:var( --e-global-color-bbae344 );}.elementor-widget-heading .elementor-heading-title{font-family:var( --e-global-typography-primary-font-family ), Sans-serif;font-weight:var( --e-global-typography-primary-font-weight );line-height:var( --e-global-typography-primary-line-height );color:var( --e-global-color-primary );}.elementor-26040 .elementor-element.elementor-element-429f813 .elementor-heading-title{font-family:\"Barlow Condensed\", Sans-serif;font-size:24px;font-weight:600;text-transform:none;text-decoration:none;line-height:1.1em;}.elementor-widget-button .elementor-button{background-color:var( --e-global-color-accent );font-family:var( --e-global-typography-accent-font-family ), Sans-serif;font-size:var( --e-global-typography-accent-font-size );font-weight:var( --e-global-typography-accent-font-weight );text-decoration:var( --e-global-typography-accent-text-decoration );line-height:var( --e-global-typography-accent-line-height );}.elementor-26040 .elementor-element.elementor-element-1c3c2d8 .elementor-button{background-color:#00000000;fill:var( --e-global-color-primary );color:var( --e-global-color-primary );transition-duration:0.3s;border-style:solid;border-width:0px 0px 1px 0px;border-color:var( --e-global-color-text );border-radius:0px 0px 0px 0px;padding:0px 0px 5px 0px;}.elementor-26040 .elementor-element.elementor-element-1c3c2d8 .elementor-button:hover, .elementor-26040 .elementor-element.elementor-element-1c3c2d8 .elementor-button:focus{background-color:#00000000;color:var( --e-global-color-8d600d2 );border-color:var( --e-global-color-8d600d2 );}.elementor-26040 .elementor-element.elementor-element-1c3c2d8 .elementor-button-content-wrapper{flex-direction:row-reverse;}.elementor-26040 .elementor-element.elementor-element-1c3c2d8 .elementor-button .elementor-button-content-wrapper{gap:6px;}.elementor-26040 .elementor-element.elementor-element-1c3c2d8 .elementor-button:hover svg, .elementor-26040 .elementor-element.elementor-element-1c3c2d8 .elementor-button:focus svg{fill:var( --e-global-color-8d600d2 );}@media(min-width:768px){.elementor-26040 .elementor-element.elementor-element-004a4b0{--width:100%;}}@media(max-width:1024px){.elementor-26040 .elementor-element.elementor-element-004a4b0{--padding-top:20px;--padding-bottom:20px;--padding-left:20px;--padding-right:20px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-26040 .elementor-element.elementor-element-429f813 .elementor-heading-title{font-size:24px;}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}@media(max-width:767px){.elementor-26040 .elementor-element.elementor-element-004a4b0{--padding-top:20px;--padding-bottom:20px;--padding-left:20px;--padding-right:20px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-26040 .elementor-element.elementor-element-429f813 .elementor-heading-title{font-size:22px;}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}\/* Start custom CSS for heading, class: .elementor-element-429f813 *\/.elementor-26040 .elementor-element.elementor-element-429f813 a {\r\n    text-decoration: none;\r\n}\/* End custom CSS *\/\n\/* Start custom CSS for container, class: .elementor-element-004a4b0 *\/.elementor-26040 .elementor-element.elementor-element-004a4b0 {\n    height: 100%;\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-38728 post-38728 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-biological-rhythms stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/circadian-clock-of-the-choroid-plexus\/\">Circadian clock of the choroid plexus<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/circadian-clock-of-the-choroid-plexus\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-30166 post-30166 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-biological-rhythms stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/the-ontogenesis-of-the-biological-clock-of-laboratory-rat\/\">The ontogenesis of the biological clock of laboratory rat<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/the-ontogenesis-of-the-biological-clock-of-laboratory-rat\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-30162 post-30162 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-biological-rhythms stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/circadian-clock-and-mechanisms-of-entrainment\/\">Circadian clock and mechanisms of entrainment<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/circadian-clock-and-mechanisms-of-entrainment\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-27204 post-27204 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-biological-rhythms stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/the-biological-timing-system-in-healthy-volunteers-and-patients-with-neuropsychiatric-disorders\/\">The biological timing system in healthy volunteers and patients with neuropsychiatric disorders<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/the-biological-timing-system-in-healthy-volunteers-and-patients-with-neuropsychiatric-disorders\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dc25d5b e-con-full e-flex e-con e-child\" data-id=\"dc25d5b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8595551 elementor-widget elementor-widget-heading\" data-id=\"8595551\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Achievements<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e366542 custom_accordion  elementor-widget elementor-widget-accordion\" data-id=\"e366542\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2381\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2381\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=8.2): Tert Deletion Impairs Circadian Regulation of Blood Pressure in Male Spontaneously Hypertensive Rats. Hypertension (2026)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2381\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2381\"><p>Kateryna Semenovykh, Michal Pravenec, Ivana Van\u011b\u010dkov\u00e1, Pavel Houdek, Martin Sl\u00e1dek, Miroslava \u0160im\u00e1kov\u00e1, Petr Mlejnek, Saba Selvi, Jan \u0160ilhav\u00fd, Franti\u0161ek Li\u0161ka, Dmytro Semenovykh, Silvie Hojn\u00e1, Alena Sumov\u00e1. Hypertension, 83(2): 579\u2013590.&nbsp;doi: 10.1161\/HYPERTENSIONAHA.125.25510<\/p><p>Telomere shortening is associated with the aging process. We have created a new genetic rat model with deletion of the\u00a0<em>Tert<\/em>\u00a0gene in which the F3 generation showed shortened telomeres in various tissues. We used spontaneously hypertensive rats, which develop hypertension and are closely associated with higher susceptibility to circadian dysregulation. The rats exhibited signs of accelerated aging at the behavioral level although the circadian regulation of locomotor activity was not impaired. In the rostral ventromedial medulla of the brainstem, the number of TH (tyrosine hydroxylase)-immunopositive cells was reduced, indicating a decrease in sympathetic tone. Importantly, the day\/night rhythmicity of clock gene expression in the heart and other peripheral tissues was modulated in constant darkness, which was reflected in the complete abolition of the daily rhythm of heart rate and blood pressure. This is the first study to show the effects of deletion of\u00a0<em>Tert<\/em>\u00a0on peripheral circadian clocks and regulation of cardiovascular function at a systemic level.<\/p><p><a href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2026\/01\/hypertensionaha12525510fig05-edited.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-53950\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2026\/01\/hypertensionaha12525510fig05-edited.jpg\" alt=\"-\" width=\"1600\" height=\"1697\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2026\/01\/hypertensionaha12525510fig05-edited.jpg 1600w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2026\/01\/hypertensionaha12525510fig05-edited-283x300.jpg 283w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2026\/01\/hypertensionaha12525510fig05-edited-965x1024.jpg 965w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2026\/01\/hypertensionaha12525510fig05-edited-768x815.jpg 768w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2026\/01\/hypertensionaha12525510fig05-edited-1448x1536.jpg 1448w\" sizes=\"(max-width: 1600px) 100vw, 1600px\" \/><\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2382\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2382\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Alena Sumov\u00e1, head of our Laboratory of Biological Rhythms, was selected by Forbes magazine for its list of Top Female Scientists in the Czech Republic 2025<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2382\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2382\"><p><a href=\"https:\/\/forbes.cz\/lists\/top-vedkyne-ceska-2025\/alena-sumova\/\" target=\"_blank\" rel=\"noopener\">Link to the article<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2383\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2383\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=7.2): Maternal food-derived signals oscillate in the fetal suprachiasmatic nuclei before its circadian clock develops. PLoS Biology (2025)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2383\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2383\"><p>Martin Sl\u00e1dek, Pavel Houdek, Tom\u00e1\u0161 \u010cajka, Alena Sumov\u00e1. PLoS Biol 23(9): e3003404.&nbsp;doi: 10.1371\/journal.pbio.3003404<\/p><p>The development of the circadian clock in the suprachiasmatic nucleus (SCN) and its dependence on maternal cues remain poorly understood. We examined SCN ontogenesis in rats from late fetal to post-weaning stages, combining daily gene expression with time-resolved metabolomic and lipidomic profiling. Canonical clock gene rhythms (<em>Per2, Nr1d1, Bmal1<\/em>) were absent at E19 and gradually emerged by P10, while <em>Dbp<\/em> rhythmicity matured later (P20-28). Strikingly, before the SCN molecular clockwork established, metabolism-sensitive gene <em>E4bp4<\/em> as well as essential amino acids and several other maternal food-derived metabolites displayed rhythmicity in the fetal SCN. The temporal coherence of the fetal SCN metabolome and lipidome declines markedly and its rhythmicity disappears immediately after birth, but reappears later in the postnatal period. Our findings uncover a previously unrecognized mechanism by which maternal metabolic signals provide temporal information to the fetal SCN before its circadian clock develops.<\/p><p><a href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/09\/fig-plosbiol-small.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-49081 aligncenter\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/09\/fig-plosbiol-small.png\" alt=\"-\" width=\"956\" height=\"895\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/09\/fig-plosbiol-small.png 956w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/09\/fig-plosbiol-small-300x281.png 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/09\/fig-plosbiol-small-768x719.png 768w\" sizes=\"(max-width: 956px) 100vw, 956px\" \/><\/a><\/p><p>Fig. (A) Development of clock gene expression in the suprachiasmatic nucleus (SCN) analyzed by RT qPCR at various ontogenetic ages shows differences in their sensitivity to maternal rhythmic cues. (B) Amount of correlations between metabolites and lipids decrease after birth. (C) Number of rhythmic compounds decreases after birth and dramatically increases after weaning. (D) Essential amino acids are rhythmic with a similar phase in the SCN before birth.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2384\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2384\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=7.7): Feeding regime synchronizes circadian clock in choroid plexus - insight into a complex mechanism. Cell Mol Life Sci (2025)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2384\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2384\"><p>Tereza Do\u010dkal, Pavel Houdek, Kateryna Semenovykh, Revan Rangotis, Martin Sl\u00e1dek, Alena Sumov\u00e1. Feeding regime synchronizes circadian clock in choroid plexus &#8211; insight into a complex mechanism. Cell Mol Life Sci. 2025 Jun 23;82(1):247.&nbsp;doi: 10.1007\/s00018-025-05798-3<\/p><p>The circadian clock in the choroid plexus (CP) controls a number of physiological processes important for its function, but the signals that synchronize this clock have not yet been thoroughly investigated. In our study, we found that the clock in the ChP in the fourth ventricle (4V) is more robust than the clock in the lateral ventricle (LV). We were therefore interested in whether this clock uses the time of food intake as a signal to synchronize, and whether this signal has a different effect in the ChP in 4V and LV.<\/p><p>To understand this mechanism, we exposed mPer2Luc mice for ten days to a regimen during which food was present for only 6 hours, during the light (resting) phase. This resulted in a shift in the clock phase in both the 4V and LV ChP. We confirmed this by monitoring the rhythm of bioluminescence in isolated ChP tissues as well as changes in diurnal clock gene expression directly in mice. In contrast, clocks in other brain regions (e.g. DMH, ARC, LHb) were not shifted by this regime. That is, the biological clock in the choroid plexus synchronizes with the new regime in food intake, while the clocks in other parts of the brain remain set by light. ChP in 4V responded more strongly to the changed feeding time than ChP in LV.<\/p><p>The mechanism involves a food-induced increase in insulin, glucose and body temperature levels that directly affect the molecular clock. The effect of glucose was partially blocked by OSMI-1, suggesting that a protein modification called O-GlcNAc may play a role in the process.<\/p><p>It turns out that the choroid plexus is not only sensitive to signals from the light-driven central clock, but can also rapidly readjust its rhythm according to the timing of food intake.<\/p><p><a href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/fig.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-46420 size-full\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/fig.png\" alt=\"-\" width=\"839\" height=\"661\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/fig.png 839w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/fig-300x236.png 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/fig-768x605.png 768w\" sizes=\"(max-width: 839px) 100vw, 839px\" \/><\/a><\/p><p><strong>Fig.<\/strong> Restricting food intake to 6 hours during the day is associated with a shift in the phase of the clock in the choroid plexus. The mechanism of the shift involves food-induced increases in insulin, glucose and body temperature, which directly affect the molecular clock mechanism.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2385\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2385\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=6.4): Chronodisruption that dampens output of the central clock abolishes rhythms in metabolome profiles and elevates acylcarnitine levels in the liver of female rats. Acta Physiologica (2025)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2385\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2385\"><p>Shiyana Arora, Pavel Houdek, Tom\u00e1\u0161 \u010cajka, Tereza Do\u010dkal, Martin Sl\u00e1dek, Alena Sumov\u00e1. Acta Physiologica. 2025 Jan 13.&nbsp;doi: 10.1111\/apha.14278<\/p><p>Exposure to light at night and meal time misaligned with the light\/dark (LD) cycle &#8211; typical features of daily life in modern 24\/7 society &#8211; are associated with negative effects on health. To understand the mechanism, we developed a novel protocol of complex chronodisruption (CD) in which we exposed female rats to four weekly cycles consisting of 5-day intervals of constant light and 2-day intervals of food access restricted to the light phase of the 12:12 LD cycle. We showed that CD attenuated the rhythmic output of the central clock in the suprachiasmatic nucleus via Prok2 signaling, thereby disrupting locomotor activity, the estrous cycle, sleep patterns, and mutual phase relationship between the central and peripheral clocks. In the periphery, CD abolished Per1,2 expression rhythms in peripheral tissues and worsened glucose homeostasis. In the liver specifically, it impaired the expression of NAD+, lipid and cholesterol metabolism genes and abolished most of the high-amplitude rhythms of lipids and polar metabolites. Interestingly, CD abolished the circadian rhythm of Cpt1a expression and increased the levels of long-chain acylcarnitines (ACar 18:2, ACar 16:0), indicating enhanced fatty acid oxidation in mitochondria. Our data show the widespread effects of CD on metabolism and point to ACars as biomarkers for CD due to misaligned sleep and feeding patterns.<\/p><p><a href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/01\/novy-uspech-publikace-fig.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-38702 size-full\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/01\/novy-uspech-publikace-fig.png\" alt=\"-\" width=\"1455\" height=\"883\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/01\/novy-uspech-publikace-fig.png 1455w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/01\/novy-uspech-publikace-fig-300x182.png 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/01\/novy-uspech-publikace-fig-1024x621.png 1024w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/01\/novy-uspech-publikace-fig-768x466.png 768w\" sizes=\"(max-width: 1455px) 100vw, 1455px\" \/><\/a><\/p><p>Fig. A. Representative mean activity profiles of female rats from CTRL (left) or chronodisrupted (CD, right) groups with green rectangles and green stars depicting increased activity during estrus phase. B. Heatmap and Venn diagram of lipids and polar metabolites identified as significantly rhythmic in CTRL (left) or CD (right) liver samples. C. Circadian phase of Rev-Erb\u03b1 mRNA in the suprachiasmatic nucleus (SCN), dorsomedial hypothalamus (DMH) and peripheral tissues from CTRL (black) and CD (orange) group calculated by cosinor. Notice the effect of CD on phase relationship between the SCN and periphery. D. Blood glucose was significantly higher (t-test, P = 0.0047) in CD group. E. Intraperitoneal glucose tolerance test (IPGTT) showed significantly slower clearance of injected glucose load (elevated levels 15 and 30 min after the glucose injection, 2-way ANOVA with Sidak\u2019s test, P = 0.0055 and P = 0.0075, respectively).<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2386\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-2386\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=7.3): The circadian clock in the choroid plexus drives rhythms in multiple cellular processes under the control of the suprachiasmatic nucleus. Fluids and Barriers of the CNS (2024)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2386\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-2386\"><div><p>Martin Sl\u00e1dek, Pavel Houdek, Jihwan Myung, Kateryna Semenovykh, Tereza Do\u010dkal, Alena Sumov\u00e1. Fluids Barriers CNS. 2024 May 27;21(1):46.&nbsp;doi: 10.1186\/s12987-024-00547-3.<\/p><\/div><p>Choroid plexus (ChP), the brain structure primarily responsible for cerebrospinal fluid production, contains a robust circadian clock with unknown function. We used genetic mouse models (WT, mPer2Luc, ChP-specific Bmal1 knockout) combined with surgical lesion of the SCN (SCNx), time-resolved transcriptomics, and single cell luminescence microscopy. We found that the ChP clock regulates cerebrospinal fluid circadian secretome, precisely times endoplasmic reticulum stress response, and controls genes involved in neurodegenerative diseases. In ChP of SCNx mice, the rhythms were severely dampened to a comparable extent as in mice with ChP-specific Bmal1 knockout; they were restored by daily injections of dexamethasone. Our data demonstrate that the ChP clock controls tissue-specific gene expression and is strongly dependent on the presence of a functional connection with the SCN. The results may contribute to the search for a novel link between ChP clock disruption and impaired brain health.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/fig.jpg\" alt=\"-\" width=\"2029\" height=\"1444\" title=\"\"><\/p><p>Fig: A. Workflow. B. Period of locomotor activity in Control and SCNx mice. C. SCN after sham surgery and after lesion. D. Rhythms in SCNx ChP are dampened to similar extent as rhythms in ChP from tissues-specific\u00a0<em>Bmal1<\/em>-KO. E. Rhythmic genes in Control (left) or SCNx (right) ChP samples. F. Phase histogram of genes Control (left) or SCNx (right) ChP samples. G. PER2::LUCIFERASE rhythms in single-cell sized ROIs across an explanted ChP from either Control or SCNx mice.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2387\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-2387\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=15): Circadian clock in choroid plexus is resistant to immune challenge but dampens in response to chronodisruption. Brain Behav Immun (2024)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2387\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-2387\"><div><p>Milica Drap\u0161in, Tereza Do\u010dkal, Pavel Houdek, Martin Sl\u00e1dek, Kateryna Semenovykh, Alena Sumov\u00e1. Brain Behav Immun. 2024 Jan 25:S0889-1591(24)00229-0.&nbsp;doi: 10.1016\/j.bbi.2024.01.217.<\/p><\/div><p>Choroid plexus (ChP) in brain ventricles plays significant role in brain homeostasis. ChP cells contain robust circadian oscillators that control its function. Chronodisruption in the form of exposure to constant light (cLL) and chronic advance of the light-dark cycle (cLD-shifts) impaired the ChP clock due to disrupted signals originating from the SCN involving glucocorticoid signaling. Sleep patterns and immune markers in the brain were also affected. Interestingly, LPS systemic inflammation did not influence the ChP clock, but disrupted the liver clock. The data highlight the role of ChP in protecting the brain from neuroinflammation. Our results provide a novel link between human lifestyle-induced chronodisruption and the impairment of ChP-dependent brain homeostasis.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-31436\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/09\/bbi-figv2.png\" alt=\"-\" width=\"947\" height=\"1062\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/09\/bbi-figv2.png 947w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/09\/bbi-figv2-268x300.png 268w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/09\/bbi-figv2-913x1024.png 913w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/09\/bbi-figv2-768x861.png 768w\" sizes=\"(max-width: 947px) 100vw, 947px\" \/><\/p><p>Fig. Choroid plexus (ChP) chronodisruption. (A) Total locomotor activity, (B) relative amplitude, and (C) sleep duration of mice reared on<\/p><p>normal light-dark regime (LD12:12), on a chronic phase-shifted light-dark (cLD-shifts) cycle regime, or on a constant light (cLL) regime.<\/p><p>(D-E) 6-day luminescence microscopy of the circadian expression of PER2\u00a0protein imaged in ChP explants of analyzed mice,<\/p><p>quantitative analysis of amplitude (F) and period (G) of individual ChP cells. (I) Multiplex analysis of cytokines in plasma of analyzed mice.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2388\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-2388\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\"> New pulblication (IF=6.3): Population-representative study reveals cardiovascular and metabolic disease biomarkers associated with misaligned sleep schedules. Sleep (2023)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2388\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-2388\"><div><p>Martin Sl\u00e1dek, Jan Klus\u00e1\u010dek, Dana Hamplov\u00e1 and Alena Sumov\u00e1. Sleep 2023 Feb 24,\u00a010.1093\/sleep\/zsad037.\u00a0Social jetlag, or chronic misalignment between biological and social time, is the most common disturbance of circadian rhythms in modern society.<\/p><\/div><p>It remains unclear, however, whether social jetlag has any negative health effects. By investigating a unique population-representative dataset, including 1957 blood samples analyzed for nine biomarkers, we report significant associations between sleep phase preference, social jetlag and cardio-metabolic biomarkers. We identify novel factors affecting social jetlag and demonstrate that flexible working schedule efficiently alleviates social jetlag.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/1-graphical-abstract-sleep-2048x997.png\" alt=\"-\" width=\"2048\" height=\"997\" title=\"\"><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2389\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-2389\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=7.4): Lithium affects the circadian clock in the choroid plexus \u2013 A new role for an old mechanism. Biomedicine & Pharmacotherapy (2023)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2389\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-2389\"><p><strong>Karol\u00edna Li\u0161ka , Tereza Do\u010dkal , Pavel Houdek , Martin Sl\u00e1dek, Vendula Lu\u017en\u00e1 , Kateryna Semenovykh , Milica Drap\u0161in and Alena Sumov\u00e1.<\/strong><\/p><p><strong>Lithium affects the circadian clock in the choroid plexus \u2013 A new role for an old mechanism. Biomedicine &amp; Pharmacotherapy 159 (2023), 114292<\/strong><\/p><p>Lithium is an effective mood stabilizer used in the treatment of Bipolar Disorder (BD), but the mechanism of its therapeutic action is not well understood. We investigated the effect of lithium on the circadian clock located in the ventricle barrier complex containing the choroid plexus (CP), a part of the glymphatic system that influences gross brain function via the production of cerebrospinal fluid. Using in vivo and ex vivo methods, analyzing clock gene expression and probing cell-signaling pathways of the CP, we demonstrated that lithium strongly affected the circadian clock in the CP. The effect of lithium was not mediated by GSK3b-exclusive mechanism, but rather by modulation of PKC activity. The effects on the CP clock may be involved in the therapeutic effects of lithium and improve brain function in BD patients by aligning the function of the CP clock-related glymphatic system with the sleep-wake cycle. Importantly, our data argue for personalized timing of lithium treatment in BD patients.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-17610 size-full aligncenter\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/lithium.png\" alt=\"-\" width=\"667\" height=\"676\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/lithium.png 667w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/lithium-296x300.png 296w\" sizes=\"(max-width: 667px) 100vw, 667px\" \/><\/p><p>Fig: Lithium affects the circadian clock in the choroid plexus independently of GSK3, resulting in time-dependent phase shifts that may affect CSF production, brain function and its therapeutic outcome.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23810\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-23810\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=9.6): Early rhythmicity in the fetal suprachiasmatic nuclei in response to maternal signals detected by omics approach. Greiner P, Houdek P, Sl\u00e1dek M, Sumov\u00e1 A (2022) PLoS Biol 20(5): e3001637.<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23810\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-23810\"><div><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/pditc1r27853eyy05pci.png\" width=\"700\" height=\"612\" alt=\"-\" title=\"\"><\/div><div><p>Fig. Maternal signals drive rhythmicity in the fetal suprachiasmatic nuclei before their molecular clock develops.<\/p><\/div><div><div><p>doi:10.1371\/journal.pbio.3001637.g005.\u00a0Our results indicate the importance of a well-functioning maternal biological clock in providing rhythmic environment during the fetal brain development.<\/p><\/div><p>During development in of the fetal suprachiasmatic nuclei, maternal stimuli may substitute for an absent inter-cellular web of synapses and drive cell-population rhythms before the SCN clock fully matures. Distinct maternal signals rhythmically control a variety of neuronal processes in the fetal rat suprachiasmatic nuclei before they begin to operate as the central circadian clock.<\/p><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23811\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-23811\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication (IF=9.3): Misaligned feeding schedule elicits divergent circadian reorganizations in endo- and exocrine pancreas clocks. Honzlov\u00e1 P, Z&nbsp;Novosadov\u00e1, P Houdek, M Sl\u00e1dek and A Sumov\u00e1. Cell Mol Life Sci 2022 May 27;79(6):318<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23811\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-23811\"><div><img loading=\"lazy\" decoding=\"async\" class=\"size-full aligncenter\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/z0w9e4ijlh6d9rmshpu4.jpg\" width=\"700\" height=\"282\" alt=\"-\" title=\"\"><\/div><div>Fig: Feeding aligned with activity status (as occurs in rats under ad libitum conditions) is associated with coupling between the peaks in insulin and corticosterone levels and the phases of the clocks in the endocrine and exocrine parts of the pancreas.<br \/>doi:10.1007\/s00018-022-04354-7. Misaligned meals become a frequent lifestyle transgression related to current societal pressure imposed on behavior.<\/div><div>\u00a0<\/div><div>Here we provide the first evidence in rats and mice that whereas the clock in the endocrine pancreas shifts according to mealtime, the clock in the exocrine pancreas can be severely impaired by incorrect meal timing. Our findings pave a new avenue for future investigation of the relationship between long-term circadian misalignment and a higher risk of development of metabolic disorders.<\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23812\" class=\"elementor-tab-title\" data-tab=\"12\" role=\"button\" aria-controls=\"elementor-tab-content-23812\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">New publication: Modulation of single cell circadian response to NMDA by diacylglycerol lipase inhibition reveals a role of endocannabinoids in light entrainment of the suprachiasmatic nucleus. Sladek, Liska, Houdek, Sumov\u00e1. Neuropharmacology 185 (2021)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23812\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"12\" role=\"region\" aria-labelledby=\"elementor-tab-title-23812\"><p>doi:10.1016\/j.neuropharm.2021.108455. The paper provides new insights into the modulatory role of endocannabinoid signaling during the light entrainment of the SCN.<\/p><p>Suprachiasmatic nucleus (SCN) of the hypothalamus is the master clock that drives circadian rhythms in physiology and behavior and adjusts their timing to external cues. Neurotransmitter glutamate and glutamatergic receptors sensitive to N-methyl-D-aspartate (NMDA) play a dual role in the SCN by coupling astrocytic and neuronal single cell oscillators and by resetting their phase in response to light. Recent reports suggested that signaling by endogenous cannabinoids (ECs) participates in both of these functions. ECs, such as 2-arachidonoylglycerol (2-AG), act via presynaptic CB1 receptors to modulate synaptic activity and affect the SCN response to light-mimicking NMDA stimulus in a time-dependent manner. We demonstrate that circadian clock in the rat SCN regulates expression of 2-AG transport, synthesis and degradation enzymes as well as its receptors. Inhibition of the major 2-AG synthesis enzyme, diacylglycerol lipase, enhances the phase delay and lowers the amplitude of explanted SCN rhythm in response to NMDAR activation. Using PER2 bioluminescence imaging, we show how single cell oscillators reflect the phase response of the whole SCN. Additionally, we present strong evidence that the zero amplitude behavior of the SCN in response to single NMDA stimulus in the middle of subjective night is the result of a loss of rhythm in individual SCN cells. The paper provides new insights into the modulatory role of endocannabinoid signaling during the light entrainment of the SCN.<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-17628\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/rhythmic.gif\" alt=\"-\" width=\"200\" height=\"193\" title=\"\"> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-17626\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/e8-scn1.gif\" alt=\"-\" width=\"200\" height=\"193\" title=\"\"><\/p><p>Fig 1. Explanted SCN from mPer2Luc mouse oscillating in vitro was treated by diacylglycerol lipase inhibitor and NMDA during daytime (left) or in the middle of subjective nighttime (right).<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-17630 size-full\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/single-cell.jpg\" alt=\"-\" width=\"747\" height=\"413\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/single-cell.jpg 747w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/single-cell-300x166.jpg 300w\" sizes=\"(max-width: 747px) 100vw, 747px\" \/><\/p><p>Fig 2. PER2 levels in a single representative neuron from the explants shown in Fig. 2. Red line shows the signal before treatment.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9750c69 e-con-full e-flex e-con e-child\" data-id=\"9750c69\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f1379a3 elementor-widget elementor-widget-heading\" data-id=\"f1379a3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Publications<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ca927b9 e-con-full e-flex e-con e-child\" data-id=\"ca927b9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aad297b elementor-widget__width-auto elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-facetwp-facet\" data-id=\"aad297b\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Publication year                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-rok_vydani facetwp-type-fselect\" data-name=\"rok_vydani\" data-type=\"fselect\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec60511 elementor-widget__width-auto elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-facetwp-facet\" data-id=\"ec60511\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Prestigious publication                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-prestizni_publikace facetwp-type-fselect\" data-name=\"prestizni_publikace\" data-type=\"fselect\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c59e890 elementor-widget__width-auto elementor-widget-tablet__width-inherit elementor-widget-mobile__width-initial elementor-widget elementor-widget-facetwp-facet\" data-id=\"c59e890\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Search publication                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-vyhledavani facetwp-type-search\" data-name=\"vyhledavani\" data-type=\"search\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"facetwp-flyout-open elementor-element elementor-element-2924c80 elementor-hidden-desktop elementor-widget elementor-widget-facetwp-button\" data-id=\"2924c80\" data-element_type=\"widget\" data-widget_type=\"facetwp-button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Filtration<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"facetwp-template facetwp-elementor-widget elementor-element elementor-element-b0db2bb elementor-grid-1 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"b0db2bb\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1140,&quot;columns&quot;:1,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:1,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t<style id=\"loop-1140\">.elementor-1140 .elementor-element.elementor-element-fdfbca6{--display:flex;--flex-direction:row;--container-widget-width:initial;--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--gap:10px 10px;--row-gap:10px;--column-gap:10px;--padding-top:0px;--padding-bottom:0px;--padding-left:0px;--padding-right:0px;}.elementor-widget-icon.elementor-view-stacked .elementor-icon{background-color:var( --e-global-color-primary );}.elementor-widget-icon.elementor-view-framed .elementor-icon, .elementor-widget-icon.elementor-view-default .elementor-icon{color:var( --e-global-color-primary );border-color:var( --e-global-color-primary );}.elementor-widget-icon.elementor-view-framed .elementor-icon, .elementor-widget-icon.elementor-view-default .elementor-icon svg{fill:var( --e-global-color-primary );}.elementor-1140 .elementor-element.elementor-element-01e22d5{width:var( --container-widget-width, auto );max-width:auto;--container-widget-width:auto;--container-widget-flex-grow:0;}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-element{--flex-grow:0;--flex-shrink:0;}.elementor-1140 .elementor-element.elementor-element-01e22d5 .elementor-icon-wrapper{text-align:center;}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-view-framed .elementor-icon{background-color:var( --e-global-color-34f6237 );}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-view-stacked .elementor-icon{color:var( --e-global-color-34f6237 );}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-view-stacked .elementor-icon svg{fill:var( --e-global-color-34f6237 );}.elementor-1140 .elementor-element.elementor-element-01e22d5 .elementor-icon{font-size:14px;padding:8px;border-width:0px 0px 0px 0px;border-radius:100px 100px 100px 100px;}.elementor-1140 .elementor-element.elementor-element-01e22d5 .elementor-icon svg{height:14px;}.elementor-1140 .elementor-element.elementor-element-7f15758{--display:flex;--flex-direction:row;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--justify-content:flex-start;--align-items:flex-start;--gap:2px 30px;--row-gap:2px;--column-gap:30px;--flex-wrap:wrap;--padding-top:0px;--padding-bottom:0px;--padding-left:0px;--padding-right:0px;}.elementor-widget-heading .elementor-heading-title{font-family:var( --e-global-typography-primary-font-family ), Sans-serif;font-weight:var( --e-global-typography-primary-font-weight );line-height:var( --e-global-typography-primary-line-height );color:var( --e-global-color-primary );}.elementor-1140 .elementor-element.elementor-element-d82d22b{width:100%;max-width:100%;margin:-4px 0px calc(var(--kit-widget-spacing, 0px) + 0px) 0px;text-align:left;}.elementor-1140 .elementor-element.elementor-element-d82d22b .elementor-heading-title{font-family:var( --e-global-typography-text-font-family ), Sans-serif;font-size:var( --e-global-typography-text-font-size );font-weight:var( --e-global-typography-text-font-weight );line-height:var( --e-global-typography-text-line-height );color:var( --e-global-color-text );}.elementor-1140 .elementor-element.elementor-element-f26a1ac{margin:0px 0px calc(var(--kit-widget-spacing, 0px) + 0px) 0px;text-align:left;}.elementor-1140 .elementor-element.elementor-element-f26a1ac .elementor-heading-title{font-family:var( --e-global-typography-text-font-family ), Sans-serif;font-size:var( --e-global-typography-text-font-size );font-weight:var( --e-global-typography-text-font-weight );line-height:var( --e-global-typography-text-line-height );color:var( --e-global-color-text );}.elementor-widget-button .elementor-button{background-color:var( --e-global-color-accent );font-family:var( --e-global-typography-accent-font-family ), Sans-serif;font-size:var( --e-global-typography-accent-font-size );font-weight:var( --e-global-typography-accent-font-weight );text-decoration:var( --e-global-typography-accent-text-decoration );line-height:var( --e-global-typography-accent-line-height );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button{background-color:#00000000;font-family:var( --e-global-typography-accent-font-family ), Sans-serif;font-size:var( --e-global-typography-accent-font-size );font-weight:var( --e-global-typography-accent-font-weight );text-decoration:var( --e-global-typography-accent-text-decoration );line-height:var( --e-global-typography-accent-line-height );fill:var( --e-global-color-primary );color:var( --e-global-color-primary );transition-duration:0.3s;border-style:solid;border-width:0px 0px 1px 0px;border-color:var( --e-global-color-text );border-radius:0px 0px 0px 0px;padding:0px 0px 0px 0px;}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:hover, .elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:focus{background-color:#00000000;color:var( --e-global-color-8d600d2 );border-color:var( --e-global-color-8d600d2 );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button-content-wrapper{flex-direction:row-reverse;}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button .elementor-button-content-wrapper{gap:6px;}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:hover svg, .elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:focus svg{fill:var( --e-global-color-8d600d2 );}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button{background-color:#00000000;fill:var( --e-global-color-primary );color:var( --e-global-color-primary );transition-duration:0.3s;border-style:solid;border-width:0px 0px 1px 0px;border-color:var( --e-global-color-text );border-radius:0px 0px 0px 0px;padding:0px 0px 0px 0px;}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:hover, .elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:focus{background-color:#00000000;color:var( --e-global-color-8d600d2 );border-color:var( --e-global-color-8d600d2 );}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button-content-wrapper{flex-direction:row-reverse;}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button .elementor-button-content-wrapper{gap:6px;}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:hover svg, .elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:focus svg{fill:var( --e-global-color-8d600d2 );}@media(max-width:1024px){.elementor-1140 .elementor-element.elementor-element-7f15758{--gap:2px 20px;--row-gap:2px;--column-gap:20px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1140 .elementor-element.elementor-element-d82d22b .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-1140 .elementor-element.elementor-element-f26a1ac .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}@media(max-width:767px){.elementor-1140 .elementor-element.elementor-element-fdfbca6{--flex-direction:row;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--justify-content:flex-start;--align-items:flex-start;--flex-wrap:nowrap;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1140 .elementor-element.elementor-element-d82d22b .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-1140 .elementor-element.elementor-element-f26a1ac .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-53265 post-53265 publikace type-publikace status-publish hentry oddeleni-biological-rhythms typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Marhefkov\u00e1; N. - Sl\u00e1dek; Martin - Klus\u00e1\u010dek; Jan - R\u00f6schov\u00e1; Michaela - Kahle; M. - Roland; R. - Pazdern\u00edk; M. - Wohlfahrt; P. - Novodvorsk\u00fd; P. - Haluz\u00edk; M. - Sumov\u00e1; Alena - Dubsk\u00fd; M.\u00a0<i>Effects of type 1 diabetes on sleep duration and timing \u2013 a comparison within the general population<\/i>. <strong>Sleep Medicine.  2025; 136(December);  106868<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 3.4<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0370913\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1016\/j.sleep.2025.106868\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-49264 post-49264 publikace type-publikace status-publish hentry oddeleni-biological-rhythms typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Do\u010dkal; Tereza - Houdek; Pavel - Semenovykh; Kateryna - Rangotis; Revan - Sl\u00e1dek; Martin - Sumov\u00e1; Alena\u00a0<i>Feeding regime synchronizes circadian clock in choroid plexus insight into a complex mechanism<\/i>. <strong>Cellular and Molecular Life Sciences.  2025; 82(1);  247<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 6.2<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0367995\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1007\/s00018-025-05798-3\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-49265 post-49265 publikace type-publikace status-publish hentry oddeleni-biological-rhythms oddeleni-metabolism-of-bioactive-lipids oddeleni-translational-metabolism typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Rudl Kulhav\u00e1; Lucie - Houdek; Pavel - Nov\u00e1kov\u00e1; Michaela - Hricko; Ji\u0159\u00ed - Pau\u010dov\u00e1; Michaela - Kuda; Ond\u0159ej - Sl\u00e1dek; Martin - Fiehn; O. - Sumov\u00e1; Alena - \u010cajka; Tom\u00e1\u0161\u00a0<i>Circadian ontogenetic metabolomics atlas: an interactive resource with insights from rat plasma; tissues; and feces<\/i>. <strong>Cellular and Molecular Life Sciences.  2025; 82(28 Jun);  264<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 6.2<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0367980\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1007\/s00018-025-05783-w\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-49266 post-49266 publikace type-publikace status-publish hentry oddeleni-biological-rhythms oddeleni-translational-metabolism typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Sl\u00e1dek; Martin - Houdek; Pavel - \u010cajka; Tom\u00e1\u0161 - Sumov\u00e1; Alena\u00a0<i>Maternal food-derived signals oscillate in the fetal suprachiasmatic nucleus before its circadian clock develops<\/i>. <strong>PLOS Biology.  2025; 23(9);  e3003404<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 7.2<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0369830\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1371\/journal.pbio.3003404\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-41319 post-41319 publikace type-publikace status-publish hentry oddeleni-biological-rhythms oddeleni-translational-metabolism typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Arora; Shiyana - Houdek; Pavel - \u010cajka; Tom\u00e1\u0161 - Do\u010dkal; Tereza - Sl\u00e1dek; Martin - Sumov\u00e1; Alena\u00a0<i>Chronodisruption that dampens output of the central clock abolishes rhythms in metabolome profiles and elevates acylcarnitine levels in the liver of female rats<\/i>. <strong>Acta Physiologica.  2025; 241(2);  e14278<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 5.6<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0363409\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1111\/apha.14278\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-34188 post-34188 publikace type-publikace status-publish hentry oddeleni-biological-rhythms typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Sumov\u00e1; Alena - Sl\u00e1dek; Martin\u00a0<i>Circadian Disruption as a Risk Factor for Development of Cardiovascular and Metabolic Disorders \u2013 From Animal Models to Human Population<\/i>. <strong>Physiological Research.  2024; 73(Suppl.1); S321-S334<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 2.0<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0355717\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.33549\/physiolres.935304\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d36008 elementor-widget elementor-widget-facetwp-facet\" data-id=\"3d36008\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                        <div class=\"facetwp-facet facetwp-facet-strankovani facetwp-type-pager\" data-name=\"strankovani\" data-type=\"pager\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-864c9ef e-con-full e-flex e-con e-child\" data-id=\"864c9ef\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba5ec6c elementor-widget elementor-widget-heading\" data-id=\"ba5ec6c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Photogallery<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6441e84 elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"6441e84\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;3&quot;,&quot;slides_to_scroll&quot;:&quot;1&quot;,&quot;slides_to_show_tablet&quot;:&quot;3&quot;,&quot;slides_to_show_mobile&quot;:&quot;1&quot;,&quot;lazyload&quot;:&quot;yes&quot;,&quot;image_spacing_custom_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]}}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-carousel-wrapper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Image Carousel\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper swiper-image-stretch\" aria-live=\"off\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"1 of 7\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"alena-popularizace-2025-11-21-ceny-akademie-ved-fullres-78-res\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTE0MTMsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI1XC8xMVwvYWxlbmEtcG9wdWxhcml6YWNlLTIwMjUtMTEtMjEtY2VueS1ha2FkZW1pZS12ZWQtZnVsbHJlcy03OC1yZXMtc2NhbGVkLmpwZyIsInNsaWRlc2hvdyI6IjY0NDFlODQifQ%3D%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/alena-popularizace-2025-11-21-ceny-akademie-ved-fullres-78-res-scaled.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/alena-popularizace-2025-11-21-ceny-akademie-ved-fullres-78-res-1024x683.jpg\" alt=\"A. Sumov\u00e1 received the Academy of Sciences Award for Popularization, 2025\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">A. Sumov\u00e1 received the Academy of Sciences Award for Popularization, 2025<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"2 of 7\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"66604d6238165velterh-vedy-2024-eng\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDY0MjcsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI1XC8wN1wvNjY2MDRkNjIzODE2NXZlbHRlcmgtdmVkeS0yMDI0LWVuZy5qcGciLCJzbGlkZXNob3ciOiI2NDQxZTg0In0%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/66604d6238165velterh-vedy-2024-eng.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/66604d6238165velterh-vedy-2024-eng-768x1024.jpg\" alt=\"Biological Rhythms at the Science Fair 2024\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Biological Rhythms at the Science Fair 2024<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"3 of 7\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"643e370d42292img-20230417-151637-eng\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDY0MjksInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI1XC8wN1wvNjQzZTM3MGQ0MjI5MmltZy0yMDIzMDQxNy0xNTE2MzctZW5nLmpwZyIsInNsaWRlc2hvdyI6IjY0NDFlODQifQ%3D%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/643e370d42292img-20230417-151637-eng.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/643e370d42292img-20230417-151637-eng.jpg\" alt=\"Lecture by Prof. Michael Hastings, 2023\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Lecture by Prof. Michael Hastings, 2023<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"4 of 7\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"61681013b4021helena-senat-small-eng\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDY0MzEsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI1XC8wN1wvNjE2ODEwMTNiNDAyMWhlbGVuYS1zZW5hdC1zbWFsbC1lbmcuanBnIiwic2xpZGVzaG93IjoiNjQ0MWU4NCJ9\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/61681013b4021helena-senat-small-eng.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/61681013b4021helena-senat-small-eng.jpg\" alt=\"Prof. Illnerov\u00e1 receives the Silver Medal of the Senate of the Parliament of the Czech Republic, 2021\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Prof. Illnerov\u00e1 receives the Silver Medal of the Senate of the Parliament of the Czech Republic, 2021<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"5 of 7\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"5e4bcdb318505img-20191129-105450-eng\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDY0MzMsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI1XC8wN1wvNWU0YmNkYjMxODUwNWltZy0yMDE5MTEyOS0xMDU0NTAtZW5nLmpwZyIsInNsaWRlc2hvdyI6IjY0NDFlODQifQ%3D%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/5e4bcdb318505img-20191129-105450-eng.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/5e4bcdb318505img-20191129-105450-eng.jpg\" alt=\"Visit of prof. Jihwan Myung, 2022.\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Visit of prof. Jihwan Myung, 2022.<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"6 of 7\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"5e4bcba9952acimg-20200129-114304-eng\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDY0MzUsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI1XC8wN1wvNWU0YmNiYTk5NTJhY2ltZy0yMDIwMDEyOS0xMTQzMDQtZW5nLmpwZyIsInNsaWRlc2hvdyI6IjY0NDFlODQifQ%3D%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/5e4bcba9952acimg-20200129-114304-eng.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/5e4bcba9952acimg-20200129-114304-eng.jpg\" alt=\"A. Sumov\u00e1 receives Honorary Medal for Merit for Popularization of Science, 2020.\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">A. Sumov\u00e1 receives Honorary Medal for Merit for Popularization of Science, 2020.<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"7 of 7\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"5e4bc2e7c3b71menaker-2014-eng\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDY0MzcsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI1XC8wN1wvNWU0YmMyZTdjM2I3MW1lbmFrZXItMjAxNC1lbmcuanBnIiwic2xpZGVzaG93IjoiNjQ0MWU4NCJ9\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/5e4bc2e7c3b71menaker-2014-eng.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/5e4bc2e7c3b71menaker-2014-eng.jpg\" alt=\"invited speaker Michael Menaker, 2014.\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">invited speaker Michael Menaker, 2014.<\/figcaption><\/figure><\/a><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"8\" height=\"12.453\" viewBox=\"0 0 8 12.453\"><g id=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24_5\" data-name=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24 5\" transform=\"translate(-8.959 -6)\"><path id=\"Vector\" d=\"M8.958,12.227,15.445,6l1.513,1.453-4.973,4.774L16.958,17l-1.513,1.453Z\" transform=\"translate(0 0)\" fill=\"#6c90c0\"><\/path><\/g><\/svg>\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"8\" height=\"12.453\" viewBox=\"0 0 8 12.453\"><g id=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24_5\" data-name=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24 5\" transform=\"translate(16.959 18.453) rotate(180)\"><path id=\"Vector\" d=\"M8.958,12.227,15.445,6l1.513,1.453-4.973,4.774L16.958,17l-1.513,1.453Z\" transform=\"translate(0 0)\" fill=\"#6c90c0\"><\/path><\/g><\/svg>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0314aed e-con-full e-flex e-con e-child\" data-id=\"0314aed\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a3c7254 elementor-widget elementor-widget-heading\" data-id=\"a3c7254\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">People<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a133880 e-con-full e-flex e-con e-child\" data-id=\"a133880\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1852f23 dual__bold elementor-widget elementor-widget-heading\" data-id=\"1852f23\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Head of Laboratory<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24c8d53 elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"24c8d53\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1210,&quot;columns&quot;:2,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:2,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t<style id=\"loop-1210\">.elementor-1210 .elementor-element.elementor-element-237f3e9{--display:flex;--flex-direction:row;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--justify-content:flex-start;--align-items:center;--gap:10px 10px;--row-gap:10px;--column-gap:10px;border-style:solid;--border-style:solid;border-width:1px 1px 1px 1px;--border-top-width:1px;--border-right-width:1px;--border-bottom-width:1px;--border-left-width:1px;border-color:var( --e-global-color-d64be13 );--border-color:var( --e-global-color-d64be13 );--border-radius:10px 10px 10px 10px;box-shadow:0px 6px 10px 0px rgba(0, 0, 0, 0.1);--margin-top:0px;--margin-bottom:0px;--margin-left:0px;--margin-right:0px;--padding-top:0px;--padding-bottom:0px;--padding-left:0px;--padding-right:0px;}.elementor-1210 .elementor-element.elementor-element-237f3e9:not(.elementor-motion-effects-element-type-background), .elementor-1210 .elementor-element.elementor-element-237f3e9 > .elementor-motion-effects-container > .elementor-motion-effects-layer{background-color:var( --e-global-color-bbae344 );}.elementor-widget-image .widget-image-caption{color:var( --e-global-color-text );font-family:var( --e-global-typography-text-font-family ), Sans-serif;font-size:var( --e-global-typography-text-font-size );font-weight:var( --e-global-typography-text-font-weight );line-height:var( --e-global-typography-text-line-height );}.elementor-1210 .elementor-element.elementor-element-9ce683f{width:var( --container-widget-width, 90px );max-width:90px;padding:5px 5px 5px 5px;--container-widget-width:90px;--container-widget-flex-grow:0;}.elementor-1210 .elementor-element.elementor-element-9ce683f.elementor-element{--flex-grow:0;--flex-shrink:0;}.elementor-1210 .elementor-element.elementor-element-9ce683f img{width:100%;max-width:80px;height:80px;object-fit:cover;object-position:top center;border-radius:100px 100px 100px 100px;}.elementor-1210 .elementor-element.elementor-element-0040c42{--display:flex;--flex-direction:column;--container-widget-width:100%;--container-widget-height:initial;--container-widget-flex-grow:0;--container-widget-align-self:initial;--flex-wrap-mobile:wrap;--gap:0px 0px;--row-gap:0px;--column-gap:0px;--padding-top:0px;--padding-bottom:0px;--padding-left:5px;--padding-right:0px;}.elementor-1210 .elementor-element.elementor-element-7229714{--display:flex;--gap:0px 0px;--row-gap:0px;--column-gap:0px;--padding-top:5px;--padding-bottom:5px;--padding-left:0px;--padding-right:5px;}.elementor-widget-heading .elementor-heading-title{font-family:var( --e-global-typography-primary-font-family ), Sans-serif;font-weight:var( --e-global-typography-primary-font-weight );line-height:var( --e-global-typography-primary-line-height );color:var( --e-global-color-primary );}.elementor-1210 .elementor-element.elementor-element-d364753{width:100%;max-width:100%;}.elementor-1210 .elementor-element.elementor-element-d364753 .elementor-heading-title{font-family:\"Barlow Condensed\", Sans-serif;font-weight:600;text-transform:none;line-height:1.1em;}.elementor-1210 .elementor-element.elementor-element-ad7a981 .elementor-heading-title{font-family:var( --e-global-typography-74d688f-font-family ), Sans-serif;font-size:var( --e-global-typography-74d688f-font-size );font-weight:var( --e-global-typography-74d688f-font-weight );text-decoration:var( --e-global-typography-74d688f-text-decoration );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-551f794{margin:-1px 0px calc(var(--kit-widget-spacing, 0px) + 0px) 0px;}.elementor-1210 .elementor-element.elementor-element-551f794 .elementor-heading-title{font-family:var( --e-global-typography-74d688f-font-family ), Sans-serif;font-size:var( --e-global-typography-74d688f-font-size );font-weight:var( --e-global-typography-74d688f-font-weight );text-decoration:var( --e-global-typography-74d688f-text-decoration );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-0a8af6b{--display:flex;--flex-direction:row;--container-widget-width:initial;--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--gap:10px 10px;--row-gap:10px;--column-gap:10px;--padding-top:0px;--padding-bottom:5px;--padding-left:0px;--padding-right:5px;}.elementor-1210 .elementor-element.elementor-element-63f4a74 .elementor-heading-title{font-family:var( --e-global-typography-74d688f-font-family ), Sans-serif;font-size:var( --e-global-typography-74d688f-font-size );font-weight:var( --e-global-typography-74d688f-font-weight );text-decoration:var( --e-global-typography-74d688f-text-decoration );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-54c1327 .elementor-heading-title{font-family:var( --e-global-typography-74d688f-font-family ), Sans-serif;font-size:var( --e-global-typography-74d688f-font-size );font-weight:var( --e-global-typography-74d688f-font-weight );text-decoration:var( --e-global-typography-74d688f-text-decoration );line-height:var( --e-global-typography-74d688f-line-height );}@media(max-width:1024px){.elementor-widget-image .widget-image-caption{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1210 .elementor-element.elementor-element-ad7a981 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-551f794 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-0a8af6b{--gap:15px 15px;--row-gap:15px;--column-gap:15px;}.elementor-1210 .elementor-element.elementor-element-63f4a74 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-54c1327 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}}@media(min-width:768px){.elementor-1210 .elementor-element.elementor-element-237f3e9{--width:100%;}}@media(max-width:767px){.elementor-1210 .elementor-element.elementor-element-237f3e9{--gap:0px 0px;--row-gap:0px;--column-gap:0px;--flex-wrap:nowrap;}.elementor-widget-image .widget-image-caption{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-1210 .elementor-element.elementor-element-0040c42{--padding-top:2px;--padding-bottom:2px;--padding-left:5px;--padding-right:0px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1210 .elementor-element.elementor-element-ad7a981 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-551f794 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-0a8af6b{--gap:0px 10px;--row-gap:0px;--column-gap:10px;}.elementor-1210 .elementor-element.elementor-element-63f4a74 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-54c1327 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}}\/* Start custom CSS for image, class: .elementor-element-9ce683f *\/.elementor-1210 .elementor-element.elementor-element-9ce683f a {\n    width: 100%;\n}\/* End custom CSS *\/\n\/* Start custom CSS for container, class: .elementor-element-237f3e9 *\/.elementor-1210 .elementor-element.elementor-element-237f3e9 {\n    height: 100%;\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35848 post-35848 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms typ-pozice-vedouci-oddeleni ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/prof-pharmdr-alena-sumova-dsc\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"60\" height=\"67\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/sumova-af70d8f71c54cd9b724e34fcdae2b280.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21259\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/prof-pharmdr-alena-sumova-dsc\/\">Alena Sumov\u00e1, Prof.  PharmD, DSc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Head of lab.; Senior research scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2528<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: alena.sumova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-43835cf e-con-full e-flex e-con e-child\" data-id=\"43835cf\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9cb31bf dual__bold elementor-widget elementor-widget-heading\" data-id=\"9cb31bf\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Deputy Head of Laboratory<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fd87624 elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"fd87624\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1210,&quot;columns&quot;:2,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:2,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35523 post-35523 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms typ-pozice-zastupce-vedouciho ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-martin-sladek-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"83\" height=\"83\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/martin.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21262\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-martin-sladek-ph-d\/\">Martin Sl\u00e1dek, M.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Deputy head of lab.; Research Scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2609<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: martin.sladek@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8fc34bd e-con-full e-flex e-con e-child\" data-id=\"8fc34bd\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b0f7978 dual__bold elementor-widget elementor-widget-heading\" data-id=\"b0f7978\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Laboratory staff<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-81becf7 elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"81becf7\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1210,&quot;columns&quot;:2,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:2,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35593 post-35593 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-tereza-dockal\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/tereza-small-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21286\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-tereza-dockal\/\">Tereza Do\u010dkal, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">PhD student<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2407<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: tereza.dockal@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-36016 post-36016 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-pavel-houdek\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/3-pavel-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21271\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-pavel-houdek\/\">Pavel Houdek, D.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Research Specialist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2545<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: pavel.houdek@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-27905 post-27905 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms typ-pozice-osobnosti-fgu ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/helena-illnerova-prof-m-sc-d-sc\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"60\" height=\"66\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/1-1-illnerova.png\" class=\"attachment-thumbnail size-thumbnail wp-image-21265\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/helena-illnerova-prof-m-sc-d-sc\/\">Helena Illnerov\u00e1, Prof., M.Sc., D.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Professor Emeritus<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873511<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35662 post-35662 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/msc-cadenato-martinez-de-salinas-pedro-leopoldo\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/01\/msc-cadenato-martinez-de-salinas-pedro-leopoldo-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-image-38699\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/msc-cadenato-martinez-de-salinas-pedro-leopoldo\/\">Cadenato Martinez De Salinas Pedro Leopoldo, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">PhD student<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2407<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: pedro.cadenato@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35232 post-35232 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/kateryna-semenovykh\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/katya-thumb-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21277\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/kateryna-semenovykh\/\">Kateryna Semenovykh<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">PhD student<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2545<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: kateryna.semenovykh@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-34948 post-34948 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-rhythms ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/eva-tlusta\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/1-eva-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21289\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/eva-tlusta\/\">Eva Tlust\u00e1<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Laboratory technician<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2609<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: eva.tlusta@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Content of this page About the Laboratory Please, consider filing out anonymous questionnaire regarding your chronotype and social jet lag. GitHub In the center of our interest is the endogenous time-keeping system, circadian clock of mammals, including humans. The system temporally regulates rhythmic processes in our body so that they take place at the proper [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22745,"parent":24807,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-24822","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/comments?post=24822"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24822\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24807"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/22745"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=24822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}