{"id":24872,"date":"2024-07-15T07:34:39","date_gmt":"2024-07-15T05:34:39","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/research-and-laboratories\/research-departments\/experimentalni-hypertenze\/"},"modified":"2025-12-29T12:15:48","modified_gmt":"2025-12-29T11:15:48","slug":"laboratory-of-experimental-hypertension","status":"publish","type":"page","link":"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research-departments\/laboratory-of-experimental-hypertension\/","title":{"rendered":"Laboratory of Experimental Hypertension"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"24872\" class=\"elementor elementor-24872 elementor-5287\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22f0716 e-flex e-con-boxed e-con e-parent\" data-id=\"22f0716\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2f4f528 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"2f4f528\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad6ff43 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ad6ff43\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Laboratory of Experimental Hypertension<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3306453 e-flex e-con-boxed e-con e-parent\" data-id=\"3306453\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f2ab90 elementor-absolute elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"6f2ab90\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"708\" height=\"789\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp\" class=\"attachment-large size-large wp-image-51089\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp 708w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3-269x300.webp 269w\" sizes=\"(max-width: 708px) 100vw, 708px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-62ed919 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"62ed919\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-50924c1 elementor-widget elementor-widget-heading\" data-id=\"50924c1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Content of this page<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8d206bc elementor-toc--content-ellipsis elementor-widget elementor-widget-table-of-contents\" data-id=\"8d206bc\" data-element_type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;marker_view&quot;:&quot;bullets&quot;,&quot;icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-toc__8d206bc\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3c81cea e-con-full e-flex e-con e-child\" data-id=\"3c81cea\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a371a1f elementor-widget elementor-widget-image\" data-id=\"a371a1f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1080\" height=\"720\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/25-uvodni.jpg\" class=\"attachment-1536x1536 size-1536x1536 wp-image-21071\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/25-uvodni.jpg 1080w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/25-uvodni-300x200.jpg 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/25-uvodni-1024x683.jpg 1024w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/25-uvodni-768x512.jpg 768w\" sizes=\"(max-width: 1080px) 100vw, 1080px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-211aab2 e-con-full e-flex e-con e-child\" data-id=\"211aab2\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-650442e elementor-widget elementor-widget-heading\" data-id=\"650442e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">About the Laboratory<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4f9d8b elementor-widget elementor-widget-text-editor\" data-id=\"b4f9d8b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.<\/p><p><b>Our research is focused mainly on:<\/b><\/p><ul><li>Cardiovascular effects of new antidiabetics \u2013 gliflozins in model of experimental hypertension and chronic heart failure<\/li><li>Central and peripheral mechanisms of blood pressure regulation<\/li><li>Role of sympathetic and parasympathetic nervous system in cardiovascular diseases<\/li><li>Cardiovascular effects of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e720055 e-con-full e-flex e-con e-child\" data-id=\"e720055\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b62862a elementor-widget elementor-widget-heading\" data-id=\"b62862a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d01bd7 elementor-grid-1 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"0d01bd7\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:26040,&quot;columns&quot;:1,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:1,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t<style id=\"loop-26040\">.elementor-26040 .elementor-element.elementor-element-004a4b0{--display:flex;--flex-direction:column;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:initial;--container-widget-flex-grow:0;--container-widget-align-self:initial;--flex-wrap-mobile:wrap;--justify-content:space-between;--align-items:flex-start;--gap:15px 15px;--row-gap:15px;--column-gap:15px;border-style:solid;--border-style:solid;border-width:1px 1px 1px 1px;--border-top-width:1px;--border-right-width:1px;--border-bottom-width:1px;--border-left-width:1px;border-color:var( --e-global-color-d64be13 );--border-color:var( --e-global-color-d64be13 );--border-radius:10px 10px 10px 10px;box-shadow:0px 6px 10px 0px rgba(0, 0, 0, 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.elementor-element-004a4b0 *\/.elementor-26040 .elementor-element.elementor-element-004a4b0 {\n    height: 100%;\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-33686 post-33686 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension poskytovatel-centres-of-excellence stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/vyvoj-novych-syntetickych-analogu-prirozenych-neuropeptidu-jako-leciv-obezity-a-diabetu-2-typu-spoluprace-s-uochb\/\">Development of new synthetic analogues of natural neuropeptides as drugs for obesity and type 2 diabetes (collaboration with UOCHB)<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/vyvoj-novych-syntetickych-analogu-prirozenych-neuropeptidu-jako-leciv-obezity-a-diabetu-2-typu-spoluprace-s-uochb\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-33696 post-33696 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension poskytovatel-centres-of-excellence stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/mechanism-of-therapeutic-effects-of-gliflozins-on-heart-failure\/\">Mechanism of therapeutic effects of gliflozins on heart failure<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/mechanism-of-therapeutic-effects-of-gliflozins-on-heart-failure\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-33678 post-33678 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension poskytovatel-centres-of-excellence stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/the-role-of-neuro-humoral-factors-in-the-development-of-heart-failure\/\">The role of neuro-humoral factors in the development of heart failure<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/the-role-of-neuro-humoral-factors-in-the-development-of-heart-failure\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-29689 post-29689 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/obesity-type-2-diabetes-and-neurodegeneration-crosstalk-new-therapeutic-potential-of-prolactin-releasing-peptide-analogs\/\">Obesity, type 2 diabetes and neurodegeneration crosstalk: New therapeutic potential of prolactin-releasing peptide analogs &#8220;completed project&#8221;<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/obesity-type-2-diabetes-and-neurodegeneration-crosstalk-new-therapeutic-potential-of-prolactin-releasing-peptide-analogs\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-29692 post-29692 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/role-of-brain-angiotensin-ii-nitric-oxide-and-reactive-oxygen-species-in-blood-pressure-control-the-importance-in-contrasting-forms-of-hypertension\/\">Role of Brain Angiotensin II, Nitric Oxide and Reactive Oxygen Species in Blood Pressure Control: The Importance in Contrasting Forms of Hypertension &#8220;completed project&#8221;<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/role-of-brain-angiotensin-ii-nitric-oxide-and-reactive-oxygen-species-in-blood-pressure-control-the-importance-in-contrasting-forms-of-hypertension\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-29695 post-29695 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/central-and-peripheral-modulation-of-vascular-tone-and-sodium-excretion-the-role-of-brain-and-kidney-in-pathophysiology-of-hypertension\/\">Central and peripheral modulation of vascular tone and sodium excretion: the role of brain and kidney in pathophysiology of hypertension &#8220;completed project&#8221;<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/central-and-peripheral-modulation-of-vascular-tone-and-sodium-excretion-the-role-of-brain-and-kidney-in-pathophysiology-of-hypertension\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-29698 post-29698 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/stress-induced-modulation-of-baroreflex-sensitivity-in-spontaneously-hypertensive-rats-the-role-of-renin-angiotensin-system-and-glucocorticoids\/\">Stress-induced modulation of baroreflex sensitivity in spontaneously hypertensive rats: the role of renin-angiotensin system and glucocorticoids &#8220;completed project&#8221;<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/stress-induced-modulation-of-baroreflex-sensitivity-in-spontaneously-hypertensive-rats-the-role-of-renin-angiotensin-system-and-glucocorticoids\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-29701 post-29701 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-experimental-hypertension stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/bilateral-mobility-project-with-polish-academy-of-sciences\/\">Bilateral Mobility Project with Polish Academy of Sciences &#8220;completed project&#8221;<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/bilateral-mobility-project-with-polish-academy-of-sciences\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dc25d5b e-con-full e-flex e-con e-child\" data-id=\"dc25d5b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8595551 elementor-widget elementor-widget-heading\" data-id=\"8595551\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Achievements<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e366542 custom_accordion  elementor-widget elementor-widget-accordion\" data-id=\"e366542\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2381\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2381\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Our latest publications<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2381\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2381\"><p><strong>Renoprotective Effects of Endothelin A receptor blockade in experimental models of heart failure<\/strong><\/p><p>Heart failure (CHF) in combination with chronic kidney disease (CKD) or hypertension worsens the patient&#8217;s&nbsp;prognosis and results in poor survival rate. In collaboration with colleagues from the Institute for Clinical and Experimental Medicine (Prague), we examined if the addition of endothelin type A (ETA) receptor antagonist to the angiotensin-converting enzyme inhibitor (ACEi) will bring additional beneficial effects in experimental model of volume overload HF that was combined either with chronic kidney disease (induced by 5\/6 renal mass reduction &#8211; 5\/6 NX) in normotensive Hannover Sprague Dawley rats or with hypertension in heterozygous TGR. The treatment with ET<sub>A<\/sub>\u00a0receptor antagonist alone or ACEi alone and the combined treatment similarly improved the survival and cardiac function. However, the combined treatment exerted the best renoprotection, causing additional decrease in albuminuria and reducing renal glomerular and tubulointerstitial injury as compared with ACE inhibition alone.<\/p><p><u>Kala P, et al. Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5\/6 nephrectomized rats with aorto-caval fistula. Biomed Pharmacother. 2023 Feb;158:114157<\/u><\/p><p><u>Kala P, et al. Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension. J Hypertens. 2023 Jan 1;41(1):99-114.<\/u><\/p><p><strong>Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance<\/strong><\/p><p>In collaboration with dr. Malet\u00ednsk\u00e1 group from IOCB, we explored the glucose intolerance, prediabetes, liver steatosis and insulin resistance-related changes, as well as neuroinflammation in the brain of Wistar Kyoto (WKY) rats fed a HF diet for 52 weeks. Old obese WKY rats showed robust glucose intolerance that was attenuated by palm<sup>11<\/sup>-PrRP31, but not by liraglutide treatment. On the contrary, liraglutide had a beneficial effect on insulin resistance parameters. Despite obesity and prediabetes, WKY rats did not develop steatosis following to HF diet feeding, even though liver lipogenesis was enhanced. Plasma triglycerides and cholesterol were not increased by HFD feeding. The liver lipid profile was significantly altered by a HF diet but remained unaffected by palm<sup>11<\/sup>-PrRP31 or liraglutide treatment. The HF-diet-fed WKY rats revealed astrogliosis in the brain cortex and hippocampus, which was attenuated by treatment. In conclusion, this study suggested multiple beneficial anti-obesity-related effects of palm<sup>11<\/sup>-PrRP31 and liraglutide in both the periphery and brain.<\/p><p><u>Mr\u00e1zikov\u00e1 L et al. Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance. Nutrients. 2023;15(2):280.<\/u><\/p><p><strong>Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic L-NAME Treatment in Rats<\/strong><\/p><p>In cooperation with colleagues from the Institute for Translational Research in Biomedicine (Kaohsiung, Taiwan) we analyzed whether tissue oxidative stress in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, plays an active role in age-dependent susceptibility to hypertension in response to nitric oxide (NO) deficiency induced by systemic L-NAME treatment, and to decipher the underlying molecular mechanisms. Systemic L-NAME also evoked oxidative stress in RVLM of adult, but not young rats, accompanied by augmented enzyme activity of NADPH oxidase and reduced mitochondrial electron transport enzyme activities. The mRNA microarray analysis revealed that four genes involved in ROS production and clearance were differentially expressed in RVLM in an age-related manner. These data suggest that hypertension induced by systemic L-NAME treatment in young rats is mediated primarily by NO deficiency that occurs both in vascular smooth muscle cells and RVLM. In contrast, enhanced augmentation of oxidative stress in RVLM may contribute to the heightened susceptibility of adult rats to hypertension induced by systemic l-NAME treatment.<\/p><p><u>Chao YM, et al. Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic l-NAME Treatment in Rats. Biomedicines. 2022;10(9):2232.<\/u><\/p><p><strong>Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats<\/strong><\/p><p>Recently, we demonstrated that chronic blockade of the renin-angiotensin system (RAS) lowered the blood pressure (BP) of adult Ren-2 transgenic rats (TGR) mainly through the attenuation of central sympathoexcitation. However, the participation of central and peripheral mechanisms in the development of high BP in immature, 6-week-old TGR males remains unclear. Chronic intraperitoneal (losartan administration (1 or 2 mg\/kg\/day) lowered the BP of immature TGR by reducing both sympathetic and angiotensin II-dependent BP components. Chronic intracerebroventricular administration of a lower losartan dose (1 mg\/kg\/day) reduced only the sympathetic BP component, whereas a higher dose (2 mg\/kg\/day) was required to influence the angiotensin II-dependent BP component. In conclusion, central sympathoexcitation seems to play an important role in hypertension development in immature TGR. Central sympathoexcitation is highly susceptible to inhibition by low doses of RAS-blocking agents, whereas higher doses also affect peripheral angiotensin II-dependent vasoconstriction.<\/p><p><u>\u0158ez\u00e1\u010dov\u00e1 L, et al. Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats. Hypertens Res. 2022;45(3):414-423.<\/u><\/p><p><strong>Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa\/fa rats with leptin signaling disturbances<\/strong><\/p><p>This study, based on the collaboration with colleagues from IOCB tried to describe the relationship between metabolic and neurodegenerative pathologies and to explore if palm<sup>11<\/sup>-PrRP31 could ameliorate them in obese fa\/fa rat model with leptin signaling disruption. Fa\/fa rats developed obesity, mild glucose intolerance, and peripheral insulin resistance but not hypertension while palm<sup>11<\/sup>-PrRP31 treatment neither lowered body weight nor attenuated glucose tolerance but ameliorated leptin and insulin signaling and synaptogenesis in hippocampus.\u00a0We demonstrated that palm<sup>11<\/sup>-PrRP31 had neuroprotective features without anti-obesity and glucose lowering effects in fa\/fa rats. This data suggest that this analog has the potential to exert neuroprotective effect despite of leptin signaling disturbances in this rat model.<\/p><p><u>Mr\u00e1zikov\u00e1 L, Hojn\u00e1 S, et al. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa\/fa rats with leptin signaling disturbances. Nutr Diabetes. 2022;12(1):26.<\/u><\/p><p><strong>Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats, an experimental non-diabetic model of hypertension<\/strong><\/p><p>The new antidiabetic drugs, gliflozins, inhibit sodium-glucose transporter-2 in renal proximal tubules promoting glucose and sodium excretion. We examined whether these beneficial effects can also be achieved in a non-diabetic hypertensive model, namely in Ren-2 transgenic rats (TGR). Empagliflozin had no effect on plasma glucose level but partially reduced blood pressure in TGR. Although food consumption was substantially higher in empagliflozin-treated TGR compared to the untreated animals, their body weight and the amount of epididymal and perirenal fat was decreased. Empagliflozin had no effect on proteinuria, but it decreased plasma urea, attenuated renal oxidative stress and temporarily increased urinary urea excretion. Several metabolic and inflammatory parameters were also improved by empagliflozin treatment. In conclusion, empagliflozin exerted beneficial antihypertensive, anti-inflammatory and metabolic effects also in a non-diabetic hypertensive model. This study was performed in collaboration with dr. Mal\u00ednsk\u00e1 group from the Institute for Clinical and Experimental Medicine (Prague) and dr. Neck\u00e1\u0159 group from our Institute.<\/p><p><u>Hojn\u00e1 S&nbsp;et al. Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats, an experimental non-diabetic model of hypertension. Biomed Pharmacother. 2021;144:112246.<\/u><\/p><p><strong>Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22<\/strong><\/p><p>In collaboration with dr. Malet\u00ednsk\u00e1 group from IOCB, we examined the impact of high-fat (HF) diet-induced obesity on potential neuroinflammation and peripheral IR in males and females of THY-Tau22 mice, a model of tau pathology. Significant sex differences in neurodegenerative signs were found in THY-Tau22. Impaired short-term spatial memory was observed in 11-month-old THY-tau22 males but not in females, which corresponds to the increased neuroinflammation colocalized with pTau(T231) in the hippocampi and amygdalae of THY-Tau22 males. A robust decrease in synaptic and postsynaptic plasticity was observed in 11-month-old females but not in males. HF diet caused peripheral but not central insulin resistance in mice of both sexes.<\/p><p><u>Kac\u00ed\u0159ov\u00e1 M et al. Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22. J Neuroinflammation. 2021 Jun 22;18(1):141<\/u><\/p><p><strong>Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats<\/strong><\/p><p>Salt hypertensive Dahl rats are characterized by sympathoexcitation and relative NO deficiency. We tested whether the increased blood pressure (BP) response to fasudil (Rho kinase inhibitor) in salt hypertensive Dahl rats is due to the augmented calcium sensitization in the salt-sensitive strain\u00a0<s>and\/<\/s>or due to their decreased baroreflex efficiency. Our results demonstrated a substantial contribution of both factors to high BP in salt hypertensive animals. However, the BP response to the calcium channel blocker nifedipine can distinguish SS and SR rats even after calcium sensitization inhibition by fasudil, which was not seen when fasudil was administered to nifedipine-pretreated rats. Thus, the enhanced calcium entry (potentiated by sympathoexcitation) in salt hypertensive Dahl rats is the abnormality that is essential for their BP increase, which was further augmented by increased calcium sensitization in salt-sensitive Dahl rats.<\/p><p><u>Zicha J et al. Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats. Hypertens Res. 2021;44(9):1067-1078.<\/u><\/p><p><strong>Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of \u03b2-amyloid pathology<\/strong><\/p><p>In collaboration with colleagues from IOCB, we examined the neuroprotective properties of palm<sup>11<\/sup>-PrRP31 in double transgenic APP\/PS1 mice, a model of AD-like \u03b2-amyloid (A\u03b2) pathology. Both liraglutide and palm<sup>11<\/sup>-PrRP31 treatments reduced the A\u03b2 plaque load in the hippocampus. Palm<sup>11<\/sup>-PrRP31 also significantly reduced hippocampal microgliosis and reduced cortical astrocytosis, similar to the treatment with liraglutide. Moreover, Palm<sup>11<\/sup>-PrRP31 tended to increase neurogenesis. After the treatment with both anorexigenic compounds, we observed a significant decrease in Tau phosphorylation at Thr231, one of the first epitopes phosphorylated in AD. Both liraglutide and palm<sup>11<\/sup>-PrRP31 reduced the levels of caspase 3, which has multiple roles in the pathogenesis of AD. Palm<sup>11<\/sup>-PrRP31 increased protein levels of the pre-synaptic marker synaptophysin, suggesting that palm<sup>11<\/sup>-PrRP31 might help preserve synapses. These results indicate that palm<sup>11<\/sup>-PrRP31 has promising potential for the treatment of neurodegenerative diseases.<\/p><p><u>Holubov\u00e1 M et al. Liraglutide and a lipidized analog of prolactin-releasing peptide show neuroprotective effects in a mouse model of \u03b2-amyloid pathology. Neuropharmacology. 2019 Jan;144:377-387<\/u>.<\/p><p><strong>Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ET<sub>A<\/sub>\u00a0Blockade<\/strong><\/p><p>In cooperation with colleagues from Mossakowski Medical Research Center, Polish Academy of Sciences, we evaluated the effects of hydrochlorothiazide (diuretic) given on top of standard therapy with trandolapril and losartan (RAS blockers) and ET<sub>A<\/sub>\u00a0receptor blockade with atrasentan in a model of chronic kidney disease. A diuretic added to the combined RAS and ET<sub>A<\/sub>\u00a0blockade has late renoprotective effects in CKD induced by partial nephrectomy in Ren-2 transgenic rats. The diuretic treatment improved renal function (evaluated as proteinuria and creatinine clearance), renal morphology (kidney mass, glomerular volume), and histological markers of kidney damage (glomerulosclerosis index, tubulointerstitial injury).<\/p><p><u>Van\u011b\u010dkov\u00e1 I et al. Renoprotection Provided by Additional Diuretic Treatment in Partially Nephrectomized Ren-2 Transgenic Rats Subjected to the Combined RAS and ET<sub>A\u00a0<\/sub>Blockade. Front Physiol. 2019;10:1145.<\/u><\/p><p><strong>Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation<\/strong><\/p><p>We evaluated the contribution of RAS-dependent vasoconstriction and sympathetic vasoconstriction to BP maintenance during chronic systemic or central RAS blockade in adult Ren-2 transgenic (TGR) rats. BP effect of brain RAS blockade was based solely on the reduced sympathetic vasoconstriction, while systemic RAS blockade attenuated both angiotensin II-dependent and sympathetic vasoconstriction. Surprisingly, neither peripheral nor central pressor effects of acute angiotensin II administration were enhanced in TGR compared to HanSD rats. In conclusion, sympathoinhibition represents the main mechanism of BP reduction in heterozygous TGR rats subjected to chronic central or systemic RAS blockade, while peripheral attenuation of angiotensin II-dependent vasoconstriction during systemic RAS blockade is less important.<\/p><p><u>\u0158ez\u00e1\u010dov\u00e1 L et al. Role of angiotensin II in chronic blood pressure control of heterozygous Ren-2 transgenic rats: Peripheral vasoconstriction versus central sympathoexcitation. Biomed Pharmacother. 2019 Aug;116:108996.<\/u><\/p><p><strong>Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats<\/strong><\/p><p>We investigated the hemodynamic response to acute and chronic administration of gabapentin, a ligand of auxiliary \u03b12\u03b4 subunit of VDCCs, in adult SHR with established neurogenic hypertension. The acute gabapentin administration lowered BP and heart rate more in conscious SHR than in Wistar-Kyoto rats. Hypotensive effect of gabapentin was accompanied by a reduction of plasma norepinephrine level, depressor response to ganglionic blocker pentolinium, and low frequency component of systolic BP variability. In conclusion, besides the known L-type VDCCs involvement in the vascular effect of gabapentin, our data revealed the important role of N-type VDCCs in acute gabapentin effect on sympathetic control of BP. Gabapentin-induced changes of sympathetic nerve transmission indicated major hemodynamic mechanism of the acute response to this drug.<\/p><p><u>Behuliak M et al. Hemodynamic Response to Gabapentin in Conscious Spontaneously Hypertensive Rats. Hypertension. 2018;72(3):676-685.<\/u><\/p><p><strong>Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy<\/strong><\/p><p>We examined the potential neuroprotective effects of palm11-PrRP31, a strong anorexigenic analog with glucose-lowering properties, in THY-Tau22 mice overexpressing mutated human tau, a model of AD-like tau pathology. Treatment with palm11-PrRP31 significantly improved spatial memory. In the hippocampi of palm11-PrRP31-treated THY-Tau22 mice, tau protein phosphorylation was attenuated at Thr231, Ser396, and Ser404, the epitopes linked to AD progression. Furthermore, we observed a significant increase in the amount of postsynaptic density protein PSD95, a marker of increased synaptic plasticity. Thus, palm11-PrRP31 seems to be a potential tool for the attenuation of neurodegenerative disorders in the brain.<\/p><p><u>Popelov\u00e1 A et al. Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy. J Alzheimers Dis. 2018;62(4):1725-1736<\/u><\/p><p><strong>Basal and Activated Calcium Sensitization Mediated by RhoA\/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension<\/strong><\/p><p>We compared basal and activated calcium sensitization in three forms of experimental hypertension with increased sympathetic tone and enhanced calcium entry \u2013 in spontaneously hypertensive rats (SHR), heterozygous Ren-2 transgenic rats (TGR), and salt hypertensive Dahl rats. Activated calcium sensitization was enhanced in all three hypertensive models (due to the hyperactivity of vasoconstrictor systems). In contrast, basal calcium sensitization was reduced in SHR and TGR relative to their controls, whereas it was augmented in salt-sensitive Dahl rats relative to their salt-resistant controls. Similar differences in calcium sensitization were also seen in femoral arteries of SHR and Dahl rats.<\/p><p><u>Behuliak M et al. Basal and Activated Calcium Sensitization Mediated by RhoA\/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension. Biomed Res Int. 2017;2017:8029728.<\/u><\/p><p><strong>The effects of liraglutide in mice with diet-induced obesity studied by metabolomics<\/strong><\/p><p>Although the major modes of liraglutide (glucagon-like peptide-1 receptor agonist) action are well-known, its detailed action at the metabolic level has not been studied. In collaboration with dr. Malet\u00ednsk\u00e1 group from IOCB we explored the effect of 2-week liraglutide treatment in C57BL\/6 male mice with obesity and diabetes induced by 13 weeks of high-fat diet using NMR. NMR spectroscopy identified 11 metabolites significantly affected by liraglutide treatment as compared to high-fat diet-fed control group. These metabolites included those involved in nicotinamide adenine dinucleotide metabolism, \u03b2-oxidation of fatty acids and microbiome changes, with highly interesting changes in creatinine, taurine and trigonelline, which were specific for liraglutide administration.<\/p><p><u>Bug\u00e1\u0148ov\u00e1 et al. The effects of liraglutide in mice with diet-induced obesity studied by metabolomics. J Endocrinol. 2017;233(1):93-104.<\/u><\/p><p><strong>Moderate additive effects of endothelin receptor A blockade in Ren-2<\/strong> transgenic rats subjected to various types of RAS blockade<\/p><p>We analyzed the effects of three different classes of RAS blockers (losartan, captopril or aliskiren) in combination with the endothelin A receptor blocker atrasentan on blood pressure of Ren-2 transgenic rtats. All RAS blockers similarly decreased BP to normotension, their effects being mediated through substantially attenuated RAS-dependent and moderately decreased SNS-dependent vasoconstriction. Atrasentan alone partially lowered BP, while BP was normalized by combination of atrasentan with either RAS blocker. In combination therapies, BP lowering effects resulted from the attenuation of both RAS- and SNS-dependent vasoconstriction. Moreover, atrasentan-treated groups had substantially reduced NO-dependent vasodilation and significantly decreased calcium influx through L-VDCC. In conclusion, although the BP-lowering effect of combined ET<sub>A<\/sub>\u00a0and RAS blockades in TGR is predominantly dependent on the effects exerted by RAS blockade, further effects are attributable to decreased calcium influx due to chronic ET<sub>A<\/sub>\u00a0blockade.<\/p><p><u>Van\u011b\u010dkov\u00e1 I et al. Moderate additive effects of endothelin receptor A blockade in Ren-2 transgenic rats subjected to various types of RAS blockade. Life Sci. 2016;159:127-134.<\/u><\/p><p><strong>Prolactin-releasing peptide: a new tool for obesity treatment<\/strong><\/p><p>In collaboration with colleagues from the Institute for Organic Chemistry and Biochemistry (IOCB), we published a review dealing with beneficial effects of prolactin-releasing peptide analogs in the treatment of obesity. These lipidized analogs of prolactin-releasing peptide were newly synthetized in IOCB and their cardiovascular effects were analysed in our Laboratory. Acute peripheral administration of myristoylated and palmitoylated PrRP analogs to mice and rats induced strong and long-lasting anorexigenic effects and neuronal activation in the brain areas involved in food intake regulation. Thus, the strong anorexigenic and body weight-reducing effects of palmitoylated PrRP31 and myristoylated PrRP20 make these analogs attractive candidates for antiobesity treatment.<\/p><p><u>Kune\u0161 J et al. Prolactin-releasing peptide: a new tool for obesity treatment. J Endocrinol. 2016 Aug;230(2):R51-8.&nbsp;doi: 10.1530\/JOE-16-0046.<\/u><\/p><div><p><strong>The role of endothelin system in the regulation of blood pressure in Ren-2 transgenic rats<\/strong><\/p><p>Endothelin-1 is a very potent vasoconstrictor. The effects of endothelin receptor A (ETA) blockade on major vasoactive systems contributing to blood pressure regulation was evaluated in Ren-2 transgenic rats, in which hypertension is associated with the insertion of murine Ren-2 gene. We found that blood pressure lowering effect of ETA blockade was mediated by the reduced Ca influx through L-type voltage-dependent calcium channels due to missing ETA receptor-dependent vasoconstriction and attenuated angiotensin II-dependent vasoconstriction.<\/p><\/div><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25255392\" target=\"_blank\" rel=\"noopener\">Van\u011b\u010dkov\u00e1 I\u00a0<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26066975\" target=\"_blank\" rel=\"noopener\">et al:<\/a>\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25255392\" target=\"_blank\" rel=\"noopener\">Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet. J Hypertens. 2015, 33(1): 161-9<\/a><\/p><p><strong>Anti-obesity effects of prolactin-releasing peptide after peripheral administration<\/strong><\/p><p>In cooperation with dr. Lenka Malet\u00ednsk\u00e1 group from the Institute of Organic Chemistry and Biochemistry ASCR, where lipidized analogs of neuropeptide prolactin releasing peptide (PrRP) were synthesized, we studied the properties of these analogs in vitro (binding to receptors, stability in plasma, etc.) and their effect on food intake in rodents after peripheral administration. We found a very strong binding to the cells expressing PrRP receptor. Peripheral administration of palmitoylated PrRP to fasted mice led to long lasting reduction of food intake, which was associated with an increased neuronal activity in brain areas involved in the regulation of food intake. Long-term administration of analogs in obese mice resulted in decreased food intake, weight loss and normalization of some metabolic parameters. The results clearly showed that lipidized analogues of PrRP could become attractive candidates for the treatment of obesity.<\/p><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25771926\" target=\"_blank\" rel=\"noopener\">Malet\u00ednsk\u00e1 L\u00a0<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26066975\" target=\"_blank\" rel=\"noopener\">et al:<\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25771926\" target=\"_blank\" rel=\"noopener\">\u00a0Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration, International Journal of Obesity. 2015, 39(6): 986-993.<\/a><\/p><p><strong>Is calcium sensitization the key player in genetic hypertension development?<\/strong><\/p><p>The role of alterations in Ca<sup>2+<\/sup>\u00a0sensitization (RhoA\/Rho kinase pathway) and Ca<sup>2+<\/sup>\u00a0entry via voltage-gated Ca<sup>2+<\/sup>\u00a0channels were studied in developing spontaneously hypertension rats. Ca<sup>2+<\/sup>\u00a0sensitization is attenuated and Ca<sup>2+<\/sup>\u00a0entry is enhanced from prehypertensive stages. Reduced expression of upstream activators of Rho kinase and lower expression of CPI-17 (endogenous inhibitor of myosin light chain phosphatase) explain changes of Ca<sup>2+<\/sup>\u00a0sensitization during genetic hypertension development.<\/p><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26418671\" target=\"_blank\" rel=\"noopener\">Behuliak M et al: Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens. 2015; 33(12): 2443-2454.<\/a><\/p><p><strong>The role of reactive oxygen species in salt hypertension and genetic hypertension<\/strong><\/p><p>Enhanced production of reactive oxygen species (ROS) in the brain and\/or kidney has been proposed to participate in the pathogenesis of different forms of hypertension. In our studies, we evaluated the production of superoxide radicals by plasma membrane nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase in brain and kidney of hypertensive Dahl salt-sensitive rats and transgenic rats for the murine Ren-2 renin gene. We have found increased ROS production in the kidney of both hypertensive strains, whereas no changes in ROS formation were detected in the brain.<\/p><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26066975\" target=\"_blank\" rel=\"noopener\">Vokurkov\u00e1 M et al: ROS production is increased in the kidney but not in the brain of Dahl rats with salt hypertension elicited in adulthood, Physiol Res. 2015, 64: 303-312<\/a><\/p><p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26713567\" target=\"_blank\" rel=\"noopener\">Vokurkov\u00e1 M et al: NADPH oxidase activity and reactive oxygen species production in brain and kidney of adult male hypertensive Ren-2 transgenic rats, Physiol Res. 2015, 64: 849-856<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2382\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2382\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Positive side effects of medications.<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2382\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2382\"><p><a href=\"https:\/\/www.ceskatelevize.cz\/porady\/1097181328-udalosti\/224411000101122\/cast\/1080941\/?fbclid=IwZXh0bgNhZW0CMTEAAR37nHrYKRwqeJpciIriVwk4TF0RNQ4pgXfUjz63h8V6JIcb908xOt61mTY_aem_fdIYyeEqlNQSmuRQx9H6JQ\" target=\"_blank\" rel=\"noopener\">Ivana Van\u011b\u010dkov\u00e1 appeared on the main news broadcast of Czech Television on Friday (November 22) and explained newly acquired findings regarding the effectiveness of diabetes medications.<\/a> Gliflozins not only have a positive effect in the treatment of diabetes, but they also show a number of beneficial side effects on heart, lung, and liver diseases. Together with her team from the Department of Experimental Hypertension, she focused on how these medications work in rats with combined liver and heart disease.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2383\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2383\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Josef Zicha was granted by the Jan Evangelista Purkinje Medal for the achievements in biomedical sciences (2020)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2383\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2383\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2384\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2384\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Jaroslav Kune\u0161 was granted by the Gregor Johann Mendel Medal for the achievements in natural sciences (2018)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2384\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2384\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2385\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2385\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">15th International Conference on Endothelin organized in Prague in 2017<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2385\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2385\"><div><div><p>The 15<sup>th<\/sup>\u00a0International Conference on Endothelin was organized in Prague (October 4-7, 2017) by Dr. Van\u011b\u010dkov\u00e1 and Prof. Pernow from the Karolinska Intitute (Sweden). More than one hundred participants from the whole world discussed on the role of endothelins (ET-1, ET-2 and ET-3), inhibitors of their receptors, and the molecular mechanisms of their actions (<a href=\"http:\/\/www.endothelins.com\/Conferences\/ET-15\/Welcome\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.endothelins.com\/Conferences\/ET-15\/Welcome\/<\/a>). The important part of the conference was devoted to different diseases, their pathology is connected with endothelin family, such as pulmonary hypertension, chronic kidney disease, diabetes, metabolic syndrome, and obesity. Particular attention was also paid to sex differences, immunity and cancer. Moreover, the results of new clinical trials with endothelin receptor blockers were presented. Selected papers were published in Physiological Research, vol. 67, suppl. 1, 2018.<\/p><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2386\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-2386\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">IOCB Prague and Institute of Physiology have signed license agreement with Novo Nordisk<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2386\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-2386\"><p>Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.<\/p><p>Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.<\/p><p>Compounds were developed in the laboratory of Dr. Lenka Malet\u00ednsk\u00e1 (IOCB Prague) whose team focused on synthesis and study of modified analogues of endogenous neuropeptides. In cooperation with Dr. Kune\u0161 (Dept. Experimental Hypertension, IP AS CR) these compounds are tested in various models of rats and mice.<\/p><p>Both Institutes have signed research collaborative and license agreements with major pharmaceutical company Novo Nordisk which will develop and prepare these compounds for preclinical testing on animal models followed by clinical trials if successful.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2387\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-2387\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Successfull presentation at 26th International Meeting of International Society of Hypertension in Seoul<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2387\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-2387\"><p>Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul &#8211; Michal Behuliak was awarded by the 2nd place in the section <strong>Young Investigator Award<\/strong>, Anna Vav\u0159\u00ednov\u00e1 by <strong>Travel Grant<\/strong> and Josef Zicha was awarded by the 2nd place in the section <strong>Best Oral Presentation<\/strong> in Basic Sciences.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2388\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-2388\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Michal Behuliak was granted by the director of the Institute of Physiology the Young Investigator award for authors under 35 years<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2388\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-2388\"><p>Michal Behuliak was granted by the the director of our Institute with the award for authors under 35 years for the publication Behuliak et al: Ontogenetic changes in contribution of calcium sensitization and calcium entry to blood pressure maintenance of Wistar-Kyoto and spontaneously hypertensive rats. J Hypertens. 2015;33(12):2443-54<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2389\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-2389\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Michal Behuliak was granted by the general manager of Servier the Young Investigator award<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2389\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-2389\"><p>Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23810\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-23810\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Otto Wichterle prize was granted to Mgr. Michal Behuliak<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23810\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-23810\"><p>Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23811\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-23811\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Joint laboratory of IPHYS and IOCHB<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23811\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-23811\"><p>The joint laboratory with the group of RNDr. Lenka Malet\u00ednsk\u00e1 from the Institute of Organic Chemistry and Biochemistry was established in 2016.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9750c69 e-con-full e-flex e-con e-child\" data-id=\"9750c69\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f1379a3 elementor-widget elementor-widget-heading\" data-id=\"f1379a3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Publications<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9cb9a84 e-con-full e-flex e-con e-child\" data-id=\"9cb9a84\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-10fff63 elementor-widget__width-auto elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-facetwp-facet\" data-id=\"10fff63\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Publication year                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-rok_vydani facetwp-type-fselect\" data-name=\"rok_vydani\" data-type=\"fselect\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9ae46a elementor-widget__width-auto elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-facetwp-facet\" data-id=\"d9ae46a\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Prestigious publication                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-prestizni_publikace facetwp-type-fselect\" data-name=\"prestizni_publikace\" data-type=\"fselect\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a82dd0c elementor-widget__width-auto elementor-widget-tablet__width-inherit elementor-widget-mobile__width-initial elementor-widget elementor-widget-facetwp-facet\" data-id=\"a82dd0c\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Search publication                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-vyhledavani facetwp-type-search\" data-name=\"vyhledavani\" data-type=\"search\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"facetwp-flyout-open elementor-element elementor-element-7ad2ae1 elementor-hidden-desktop elementor-widget elementor-widget-facetwp-button\" data-id=\"7ad2ae1\" data-element_type=\"widget\" data-widget_type=\"facetwp-button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Filtration<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"facetwp-template facetwp-elementor-widget elementor-element elementor-element-b0db2bb elementor-grid-1 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"b0db2bb\" data-element_type=\"widget\" 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--e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-56175 post-56175 publikace type-publikace status-publish hentry oddeleni-biological-rhythms oddeleni-experimental-hypertension oddeleni-genetics-of-model-diseases typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 8.2<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0375982\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1161\/HYPERTENSIONAHA.125.25510\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-56176 post-56176 publikace type-publikace status-publish hentry oddeleni-experimental-hypertension typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 4.7<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0376100\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1016\/j.ejphar.2026.178542\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-53281 post-53281 publikace type-publikace status-publish hentry oddeleni-experimental-hypertension typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Arora; Mahak - Zicha; Josef - Van\u011b\u010dkov\u00e1; Ivana\u00a0<i>Pathogenic Role of mTOR Signaling in Cardiometabolic Disease: Implications for Heart; Liver; and Kidney Dysfunction<\/i>. <strong>Physiological Research.  2025; 74(6); 891-907<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 2<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0373750\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.33549\/physiolres.935677\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-53282 post-53282 publikace type-publikace status-publish hentry oddeleni-experimental-hypertension typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Hojn\u00e1; Silvie - Mr\u00e1zikov\u00e1; L. - Sh\u00e1n\u011blov\u00e1; A. - Pelantov\u00e1; Helena - Montezano; A. - Touyz; R. M. - Malet\u00ednsk\u00e1; L. - Kune\u0161; Jaroslav\u00a0<i>Oxidative Stress; Metabolic Impairment and Neuroinflammation are Associated With Target Organ Damage in SHRSP<\/i>. <strong>Physiological Research.  2025; 74(5); 779-795<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 2<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0373752\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.33549\/physiolres.935659\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-49404 post-49404 publikace type-publikace status-publish hentry oddeleni-experimental-hypertension typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Baranowska; I. - Walkowska; A. - Badzy\u0144ska; B. - Van\u011b\u010dkov\u00e1; Ivana - Gawrys; O. - \u010cervenka; L. - Kompanowska - Jezierska; E.\u00a0<i>14;15-Epoxyeicosatrienoic acid analog augments hypotensive effect of en endothelin-A receptor blocker antrasentan and prevents oedema and organ hypertrophy in spontaneously hypertensive rats<\/i>. <strong>Journal of Physiology and Pharmacology.  2025; 76(3); 259-268<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 1.7<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0368875\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.26402\/jpp.2025.3.03\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-41334 post-41334 publikace type-publikace status-publish hentry oddeleni-experimental-hypertension typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Mr\u00e1zikov\u00e1; L. - Hojn\u00e1; Silvie - Sh\u00e1n\u011blov\u00e1; A. - \u017delezn\u00e1; B. - Kune\u0161; Jaroslav - Malet\u00ednsk\u00e1; L.\u00a0<i>Anti-inflammatory effects of palm11-PrRP31 in a rat model of lipopolysaccharide-induced acute inflammation<\/i>. <strong>Journal of Molecular Endocrinology.  2025; 74(3);  e240090<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 3.8<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0365081\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1530\/JME-24-0090\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-68ba3c9 elementor-widget elementor-widget-facetwp-facet\" data-id=\"68ba3c9\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                        <div class=\"facetwp-facet facetwp-facet-strankovani facetwp-type-pager\" data-name=\"strankovani\" data-type=\"pager\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-864c9ef e-con-full e-flex e-con e-child\" data-id=\"864c9ef\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba5ec6c elementor-widget elementor-widget-heading\" data-id=\"ba5ec6c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Photogallery<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6441e84 elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"6441e84\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;3&quot;,&quot;slides_to_scroll&quot;:&quot;1&quot;,&quot;slides_to_show_tablet&quot;:&quot;3&quot;,&quot;slides_to_show_mobile&quot;:&quot;1&quot;,&quot;lazyload&quot;:&quot;yes&quot;,&quot;image_spacing_custom_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]}}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-carousel-wrapper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Obr\u00e1zkov\u00fd koloto\u010d\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper swiper-image-stretch\" aria-live=\"off\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"1 of 5\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"57b3409ac224abehuliak-jh-2015-scheme-color\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTM0NSwidXJsIjoiaHR0cHM6XC9cL2ZndS5jYXMuY3pcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjRcLzA3XC81N2IzNDA5YWMyMjRhYmVodWxpYWstamgtMjAxNS1zY2hlbWUtY29sb3IuanBnIiwic2xpZGVzaG93IjoiNjQ0MWU4NCJ9\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/57b3409ac224abehuliak-jh-2015-scheme-color.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/57b3409ac224abehuliak-jh-2015-scheme-color.jpg\" alt=\"Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA\/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA\/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"2 of 5\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"531208f5c0682obr7\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTM0MywidXJsIjoiaHR0cHM6XC9cL2ZndS5jYXMuY3pcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjRcLzA3XC81MzEyMDhmNWMwNjgyb2JyNy5wbmciLCJzbGlkZXNob3ciOiI2NDQxZTg0In0%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f5c0682obr7.png\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f5c0682obr7.png\" alt=\"Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"3 of 5\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"531208f5148c3obr6\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTM0MSwidXJsIjoiaHR0cHM6XC9cL2ZndS5jYXMuY3pcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjRcLzA3XC81MzEyMDhmNTE0OGMzb2JyNi5wbmciLCJzbGlkZXNob3ciOiI2NDQxZTg0In0%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f5148c3obr6.png\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f5148c3obr6.png\" alt=\"Aorta section \u2013 \u03b1-actin (red), nuclei (blue) and autofluorescence (green).\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Aorta section \u2013 \u03b1-actin (red), nuclei (blue) and autofluorescence (green).<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"4 of 5\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"531208f3c648fobr5\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTMzOSwidXJsIjoiaHR0cHM6XC9cL2ZndS5jYXMuY3pcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjRcLzA3XC81MzEyMDhmM2M2NDhmb2JyNS5wbmciLCJzbGlkZXNob3ciOiI2NDQxZTg0In0%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f3c648fobr5.png\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f3c648fobr5.png\" alt=\"531208f3c648fobr5\" \/><div class=\"swiper-lazy-preloader\"><\/div><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"5 of 5\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"531208f1b6078tlak\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NTMzNywidXJsIjoiaHR0cHM6XC9cL2ZndS5jYXMuY3pcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjRcLzA3XC81MzEyMDhmMWI2MDc4dGxhay5wbmciLCJzbGlkZXNob3ciOiI2NDQxZTg0In0%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f1b6078tlak.png\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/531208f1b6078tlak.png\" alt=\"531208f1b6078tlak\" \/><div class=\"swiper-lazy-preloader\"><\/div><\/figure><\/a><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"8\" height=\"12.453\" viewBox=\"0 0 8 12.453\"><g id=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24_5\" data-name=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24 5\" transform=\"translate(-8.959 -6)\"><path id=\"Vector\" d=\"M8.958,12.227,15.445,6l1.513,1.453-4.973,4.774L16.958,17l-1.513,1.453Z\" transform=\"translate(0 0)\" fill=\"#6c90c0\"><\/path><\/g><\/svg>\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"8\" height=\"12.453\" viewBox=\"0 0 8 12.453\"><g id=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24_5\" data-name=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24 5\" transform=\"translate(16.959 18.453) rotate(180)\"><path id=\"Vector\" d=\"M8.958,12.227,15.445,6l1.513,1.453-4.973,4.774L16.958,17l-1.513,1.453Z\" transform=\"translate(0 0)\" fill=\"#6c90c0\"><\/path><\/g><\/svg>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1768751 e-con-full e-flex e-con e-child\" data-id=\"1768751\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e36700f elementor-widget elementor-widget-heading\" data-id=\"e36700f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">People<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9f71d8d e-con-full e-flex e-con e-child\" data-id=\"9f71d8d\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aa7451a dual__bold elementor-widget elementor-widget-heading\" data-id=\"aa7451a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Head of Laboratory<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db884dd elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget 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.elementor-heading-title{font-family:var( --e-global-typography-74d688f-font-family ), Sans-serif;font-size:var( --e-global-typography-74d688f-font-size );font-weight:var( --e-global-typography-74d688f-font-weight );text-decoration:var( --e-global-typography-74d688f-text-decoration );line-height:var( --e-global-typography-74d688f-line-height );}@media(max-width:1024px){.elementor-widget-image .widget-image-caption{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1210 .elementor-element.elementor-element-ad7a981 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-551f794 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-0a8af6b{--gap:15px 15px;--row-gap:15px;--column-gap:15px;}.elementor-1210 .elementor-element.elementor-element-63f4a74 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-54c1327 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}}@media(min-width:768px){.elementor-1210 .elementor-element.elementor-element-237f3e9{--width:100%;}}@media(max-width:767px){.elementor-1210 .elementor-element.elementor-element-237f3e9{--gap:0px 0px;--row-gap:0px;--column-gap:0px;--flex-wrap:nowrap;}.elementor-widget-image .widget-image-caption{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-1210 .elementor-element.elementor-element-0040c42{--padding-top:2px;--padding-bottom:2px;--padding-left:5px;--padding-right:0px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1210 .elementor-element.elementor-element-ad7a981 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-551f794 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-0a8af6b{--gap:0px 10px;--row-gap:0px;--column-gap:10px;}.elementor-1210 .elementor-element.elementor-element-63f4a74 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-54c1327 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}}\/* Start custom CSS for image, class: .elementor-element-9ce683f *\/.elementor-1210 .elementor-element.elementor-element-9ce683f a {\n    width: 100%;\n}\/* End custom CSS *\/\n\/* Start custom CSS for container, class: .elementor-element-237f3e9 *\/.elementor-1210 .elementor-element.elementor-element-237f3e9 {\n    height: 100%;\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35929 post-35929 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension typ-pozice-vedouci-oddeleni ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-ivana-vaneckova-csc\/\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/ivana-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21551\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-ivana-vaneckova-csc\/\">Ivana Van\u011b\u010dkov\u00e1, D.Sc., Ph.D., DSc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Head of lab.; Senior research scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2592<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: ivana.vaneckova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-013daae e-con-full e-flex e-con e-child\" data-id=\"013daae\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ae16f6e dual__bold elementor-widget elementor-widget-heading\" data-id=\"ae16f6e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Deputy Head of Laboratory<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a9910a0 elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"a9910a0\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1210,&quot;columns&quot;:2,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:2,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35754 post-35754 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension oddeleni-magazine-editorial-staff typ-pozice-zastupce-vedouciho ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mudr-josef-zicha-drsc\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/pepik-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21554\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mudr-josef-zicha-drsc\/\">Josef Zicha, M.D., D.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Deputy head of lab; Head of lab.; Senior research scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2438<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: josef.zicha@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0ed1201 e-con-full e-flex e-con e-child\" data-id=\"0ed1201\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a03dec0 dual__bold elementor-widget elementor-widget-heading\" data-id=\"a03dec0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Laboratory staff<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db57bce elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"db57bce\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1210,&quot;columns&quot;:2,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:2,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35732 post-35732 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/msc-mahak-arora\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/04\/mahak-1-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-41878\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/msc-mahak-arora\/\">Mahak Arora, M.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Postdoctoral researcher<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2135<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: mahak.arora@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35309 post-35309 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-almos-boros\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"60\" height=\"80\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/obrazek.png\" class=\"attachment-thumbnail size-thumbnail wp-image-21902\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-almos-boros\/\">Almos Boro\u0161, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">PhD student<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2135<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: almos.boros@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-34783 post-34783 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/alena-charvatova\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/alca-copy-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21585\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/alena-charvatova\/\">Alena Charv\u00e1tov\u00e1<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Laboratory technician<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2432<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: alena.charvatova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35589 post-35589 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-silvie-hojna-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/silva-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21571\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-silvie-hojna-ph-d\/\">Silvie Hojn\u00e1, M.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Scientific Assistant<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2666<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: silvie.hojna@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35107 post-35107 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/ing-michaela-kadlecova-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/misa-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21566\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/ing-michaela-kadlecova-ph-d\/\">Michaela Kadlecov\u00e1, M.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Scientific Assistant<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2427<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: michaela.kadlecova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-36082 post-36082 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/zdenka-kopecka\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/zdenka-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21590\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/zdenka-kopecka\/\">Zde\u0148ka Kopeck\u00e1<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Laboratory technician<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2420<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: zdenka.kopecka@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35937 post-35937 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension typ-pozice-reditele-ustavu ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-jaroslav-kunes-drsc\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/kunes-foto-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21557\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-jaroslav-kunes-drsc\/\">Jaroslav Kune\u0161, D.Sc., D.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Emeritus<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-551f794 note-info elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-heading\" data-id=\"551f794\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Institute Director (2003\u20132010)<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2420<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: jaroslav.kunes@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35932 post-35932 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-jan-neckar-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/neckar-j-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21879\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-jan-neckar-ph-d\/\">Jan Neck\u00e1\u0159, D.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Senior research scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2666<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: jan.neckar@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35821 post-35821 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mvdr-veronika-olejnickova-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/olejnickova-v-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21896\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mvdr-veronika-olejnickova-ph-d\/\">Veronika Olejn\u00ed\u010dkov\u00e1, D.V.M., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Scientific Assistant<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2427<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: veronika.olejnickova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35718 post-35718 profil type-profil status-publish has-post-thumbnail hentry oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mudr-hana-rauchova-csc\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/hanka-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21563\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mudr-hana-rauchova-csc\/\">Hana Rauchov\u00e1, M.D., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Research Scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2432<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: hana.rauchova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35909 post-35909 profil type-profil status-publish has-post-thumbnail hentry oddeleni-biological-controls oddeleni-experimental-hypertension ustav-fgu\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-lenka-rezacova-ph-d-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/lenka-150x150.gif\" class=\"attachment-thumbnail size-thumbnail wp-image-21577\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-lenka-rezacova-ph-d-ph-d\/\">Lenka \u0158ez\u00e1\u010dov\u00e1, D.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Scientific Assistant<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 2427<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: lenka.rezacova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Content of this page About the Laboratory The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension. Our research is focused mainly on: Cardiovascular effects of new antidiabetics \u2013 gliflozins in model of experimental hypertension and chronic heart failure Central and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22745,"parent":24807,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-24872","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/comments?post=24872"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24872\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24807"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/22745"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=24872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}