{"id":24948,"date":"2024-07-22T15:27:53","date_gmt":"2024-07-22T13:27:53","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/research-and-laboratories\/research-departments\/strukturni-biologie-signalnich-proteinu\/"},"modified":"2025-12-29T12:19:54","modified_gmt":"2025-12-29T11:19:54","slug":"laboratory-of-structural-biology-of-signaling-proteins","status":"publish","type":"page","link":"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research-departments\/laboratory-of-structural-biology-of-signaling-proteins\/","title":{"rendered":"Laboratory of Structural Biology of Signaling Proteins"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"24948\" class=\"elementor elementor-24948 elementor-17862\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22f0716 e-flex e-con-boxed e-con e-parent\" data-id=\"22f0716\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2f4f528 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"2f4f528\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad6ff43 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"ad6ff43\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Laboratory of Structural Biology of Signaling Proteins<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3306453 e-flex e-con-boxed e-con e-parent\" data-id=\"3306453\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f2ab90 elementor-absolute elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"6f2ab90\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"708\" height=\"789\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp\" class=\"attachment-large size-large wp-image-51089\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp 708w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3-269x300.webp 269w\" sizes=\"(max-width: 708px) 100vw, 708px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-62ed919 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"62ed919\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-50924c1 elementor-widget elementor-widget-heading\" data-id=\"50924c1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Content of this page<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8d206bc elementor-toc--content-ellipsis elementor-widget elementor-widget-table-of-contents\" data-id=\"8d206bc\" data-element_type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;marker_view&quot;:&quot;bullets&quot;,&quot;icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-toc__8d206bc\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3c81cea e-con-full e-flex e-con e-child\" data-id=\"3c81cea\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a371a1f elementor-widget elementor-widget-image\" data-id=\"a371a1f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"667\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/0f8wysu6jh2vkmk7q2dn.jpg\" class=\"attachment-1536x1536 size-1536x1536 wp-image-17868\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/0f8wysu6jh2vkmk7q2dn.jpg 1000w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/0f8wysu6jh2vkmk7q2dn-300x200.jpg 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/0f8wysu6jh2vkmk7q2dn-768x512.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-211aab2 e-con-full e-flex e-con e-child\" data-id=\"211aab2\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-650442e elementor-widget elementor-widget-heading\" data-id=\"650442e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">About the Laboratory<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4f9d8b elementor-widget elementor-widget-text-editor\" data-id=\"b4f9d8b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Our Laboratory is focused on structural biology (the relationship between the structure and function of certain groups of proteins), particularly we focus on the proteins which participate in the signal transmission in the cell. Among methods we use are recombinant protein expression, biophysical characterization, study of intermolecular interactions, protein structure and interaction surfaces. All these methods enable us to better understand the details how the activity and function of protein-protein complexes is regulated. Our research is focused mainly on:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b55d025 elementor-widget elementor-widget-text-editor\" data-id=\"b55d025\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li>Structural biology of\u00a0<strong>14-3-3 proteins and their complexes<\/strong><\/li><li>Study of inhibition of\u00a0<strong>ubiquitin ligase Nedd4-2 by 14-3-3 protein<\/strong><\/li><li>Characterizaton of the interactions between\u00a0<strong>transcription factor FOXO4 and tumour supressor p53<\/strong><\/li><li>Mechanism of regulation of proteinkinase\u00a0<strong>ASK1 by TRX and 14-3-3 protein<\/strong><\/li><li>Mechanism of regulation of protease\u00a0<strong>caspase-2 by 14-3-3 protein<\/strong><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e720055 e-con-full e-flex e-con e-child\" data-id=\"e720055\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b62862a elementor-widget elementor-widget-heading\" data-id=\"b62862a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d01bd7 elementor-grid-1 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"0d01bd7\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:26040,&quot;columns&quot;:1,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:1,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t<style id=\"loop-26040\">.elementor-26040 .elementor-element.elementor-element-004a4b0{--display:flex;--flex-direction:column;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:initial;--container-widget-flex-grow:0;--container-widget-align-self:initial;--flex-wrap-mobile:wrap;--justify-content:space-between;--align-items:flex-start;--gap:15px 15px;--row-gap:15px;--column-gap:15px;border-style:solid;--border-style:solid;border-width:1px 1px 1px 1px;--border-top-width:1px;--border-right-width:1px;--border-bottom-width:1px;--border-left-width:1px;border-color:var( --e-global-color-d64be13 );--border-color:var( --e-global-color-d64be13 );--border-radius:10px 10px 10px 10px;box-shadow:0px 6px 10px 0px rgba(0, 0, 0, 0.1);--margin-top:0px;--margin-bottom:0px;--margin-left:0px;--margin-right:0px;--padding-top:20px;--padding-bottom:20px;--padding-left:20px;--padding-right:20px;}.elementor-26040 .elementor-element.elementor-element-004a4b0:not(.elementor-motion-effects-element-type-background), .elementor-26040 .elementor-element.elementor-element-004a4b0 > .elementor-motion-effects-container > .elementor-motion-effects-layer{background-color:var( --e-global-color-bbae344 );}.elementor-widget-heading .elementor-heading-title{font-family:var( --e-global-typography-primary-font-family ), Sans-serif;font-weight:var( --e-global-typography-primary-font-weight );line-height:var( --e-global-typography-primary-line-height );color:var( --e-global-color-primary );}.elementor-26040 .elementor-element.elementor-element-429f813 .elementor-heading-title{font-family:\"Barlow Condensed\", Sans-serif;font-size:24px;font-weight:600;text-transform:none;text-decoration:none;line-height:1.1em;}.elementor-widget-button .elementor-button{background-color:var( --e-global-color-accent );font-family:var( --e-global-typography-accent-font-family ), Sans-serif;font-size:var( --e-global-typography-accent-font-size );font-weight:var( --e-global-typography-accent-font-weight );text-decoration:var( --e-global-typography-accent-text-decoration );line-height:var( --e-global-typography-accent-line-height 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.elementor-element.elementor-element-1c3c2d8 .elementor-button:focus svg{fill:var( --e-global-color-8d600d2 );}@media(min-width:768px){.elementor-26040 .elementor-element.elementor-element-004a4b0{--width:100%;}}@media(max-width:1024px){.elementor-26040 .elementor-element.elementor-element-004a4b0{--padding-top:20px;--padding-bottom:20px;--padding-left:20px;--padding-right:20px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-26040 .elementor-element.elementor-element-429f813 .elementor-heading-title{font-size:24px;}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}@media(max-width:767px){.elementor-26040 .elementor-element.elementor-element-004a4b0{--padding-top:20px;--padding-bottom:20px;--padding-left:20px;--padding-right:20px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-26040 .elementor-element.elementor-element-429f813 .elementor-heading-title{font-size:22px;}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}\/* Start custom CSS for heading, class: .elementor-element-429f813 *\/.elementor-26040 .elementor-element.elementor-element-429f813 a {\r\n    text-decoration: none;\r\n}\/* End custom CSS *\/\n\/* Start custom CSS for container, class: .elementor-element-004a4b0 *\/.elementor-26040 .elementor-element.elementor-element-004a4b0 {\n    height: 100%;\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-30140 post-30140 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-structural-biology-of-signaling-proteins stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/structural-basis-of-the-14-3-3-protein-dependent-activation-of-ubiquitin-ligase-nedd4-2\/\">Structural basis of the 14-3-3 protein-dependent activation of ubiquitin ligase Nedd4-2<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/structural-basis-of-the-14-3-3-protein-dependent-activation-of-ubiquitin-ligase-nedd4-2\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"26040\" class=\"elementor elementor-26040 elementor-1128 e-loop-item e-loop-item-30137 post-30137 vyzkumny-projekt type-vyzkumny-projekt status-publish hentry oddeleni-structural-biology-of-signaling-proteins stav-projektu-current-projects\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-004a4b0 e-con-full e-flex e-con e-child\" data-id=\"004a4b0\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-429f813 elementor-widget elementor-widget-heading\" data-id=\"429f813\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/characterizaton-of-the-interactions-between-transcription-factor-foxo4-and-tumour-supressor-p53\/\">Characterizaton of the interactions between transcription factor FOXO4 and tumour supressor p53<\/a><\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3c2d8 elementor-align-left button__text_arrow elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"1c3c2d8\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/fgu.cas.cz\/en\/research-project\/characterizaton-of-the-interactions-between-transcription-factor-foxo4-and-tumour-supressor-p53\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dc25d5b e-con-full e-flex e-con e-child\" data-id=\"dc25d5b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8595551 elementor-widget elementor-widget-heading\" data-id=\"8595551\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Achievements<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e366542 custom_accordion  elementor-widget elementor-widget-accordion\" data-id=\"e366542\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2381\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-2381\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Otto Wichterle Prize<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2381\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-2381\"><p>Prize of Otto Wichterle for Dr. Dalibor Ko\u0161ek.<\/p><p><strong>Dalibor Kosek received the prize of Otto Wichterle for excellent young scientists of CAS in the year 2022.<\/strong><\/p><p><img decoding=\"async\" class=\"aligncenter wp-image-17875 size-large\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/wichterle-2022-dal-detail-1024x691.jpg\" alt=\"-\" width=\"1024\" height=\"691\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/wichterle-2022-dal-detail-1024x691.jpg 1024w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/wichterle-2022-dal-detail-300x202.jpg 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/wichterle-2022-dal-detail-768x518.jpg 768w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/wichterle-2022-dal-detail-1536x1036.jpg 1536w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/wichterle-2022-dal-detail.jpg 1722w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2382\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-2382\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">NEW FINDINGS ON THE STRUCTURE OF THE FOXO4: p53 COMPLEX - A KEY FACTOR IN SENESCENCE REGULATION (9.4.2022)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2382\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-2382\"><div>\n<p><strong>Transcription factor p53 protects cells against tumorigenesis when subjected to various cellular stresses. Under stress conditions, p53 interacts with another transcription factor, FOXO4 (Forkhead box O 4), and together they increase the production of p21 protein, which triggers the process of cell aging (senescence). However, the molecular mechanism of upregulation of p21 transcription is still unclear. In a work published in the Protein Science journal, scientific teams of Dr. Obsilova (IPHYS CAS), prof. Obsil (Faculty of Science, Charles University and IPHYS CAS) and their colleagues from IOCB CAS characterized interactions between p53 and FOXO4 at the molecular level. New knowledge about the structure of the complex may enable the development of specific inhibitors of the interaction between these two proteins, and subsequently in the development of new drugs aimed at the selective elimination of senescent cells.<\/strong><\/p>\n<\/div>\n<p>In this structural study, the researchers performed a detailed characterization of the interactions in the FOXO4: p53 complex using an integrated approach involving analytical ultracentrifugation, nuclear magnetic resonance, and chemical cross-linking coupled to mass spectrometry. Because both FOXO4 and p53 have multiple domains (see Figure), they studied the role of individual domains and disordered segments of both proteins and mapped their interaction interfaces. They found out that the interaction between p53 transactivation domain TAD and the FOXO4 Forkhead domain is crucial for the overall stability of the p53:FOXO4 complex. Furthermore, contacts involving the N-terminal disordered FOXO4 segment, the C-terminal negative regulatory domain of p53, and the DNA-binding domains of both proteins stabilize the complex formation. By measuring DNA binding, they further found that the p53: FOXO4 complex formation blocks p53 binding to DNA without affecting the DNA-binding properties of FOXO4.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/www.fgu.cas.cz\/upload\/files\/p53_FOXO4.jpg\" alt=\"-\" title=\"\"><\/p>\n<p>Left, sedimentation velocity analytical ultracentrifugation analysis of interaction between FOXO4 and p53. Middle, chemical shift perturbations obtained from 1H-15N HSQC spectra of 15N-labeled FOXO4 in the presence of p53 mapped onto the crystal structure of the FOXO4 DBD:DNA complex. Right, fluorescence anisotropy measurements showing that the complex formation reduces the DNA-binding affinity of p53.<\/p>\n<p>Mandal R, Kohoutova K, Petrvalska O, Horvath M, Srb P, Veverka V, Obsilova V&nbsp;and Obsil T. FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA.&nbsp;<em>Protein Sci.<\/em>&nbsp;ro\u010d.&nbsp;<strong>31<\/strong>, \u010d. 5 (2022), \u010d. \u010dl&aacute;nku e4287. IF = 6.725. DOI: 10.1002\/pro.4287.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2383\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-2383\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Our new articles in Communications Biology<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2383\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-2383\"><div><img decoding=\"async\" src=\"https:\/\/www.fgu.cas.cz\/img\/upload\/62g97p1ioq7eqr6snkof.JPG\" alt=\"Our new articles in Communications Biology\" title=\"\"><\/div><div><div><div><div><p><strong>Two accepted papers in Communications Biology: July and August 2021<\/strong><\/p><p>Pavel Pohl, Rohit Joshi, Olivia Petrvalska, Tomas Obsil and Veronika Obsilova<\/p><p><a href=\"https:\/\/www.nature.com\/articles\/s42003-021-02419-0#citeas\" target=\"_blank\" rel=\"noopener\">14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains | Communications Biology (nature.com)<\/a><\/p><p>Commun. Biol. 2021 July 22; 4(1):899.<\/p><p>Matej Horvath,\u00a0Olivia Petrvalska, Petr Herman, Tomas Obsil and Veronika Obsilova<\/p><p><a href=\"https:\/\/www.nature.com\/articles\/s42003-021-02518-y.epdf?sharing_token=Yq8vS5Plhjh4W_P1bVMDxNRgN0jAjWel9jnR3ZoTv0MO16eFJRzTBbtGdgxOdu5B-HHpzFMc-aQN7WIYRtTDXkyYIUeAym9JhL-XGo9YTsbuhIZB_XrpwXYVZYRp5zOfv9-ndv0xD4jTsXy0DVODFTu-iafBRuVpLnU_B6CtTEI%3D\" target=\"_blank\" rel=\"noopener\">14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites | Communications Biology (nature.com)<\/a><\/p><p>Commun. Biol. 2021 August 19; 4(1):986.<\/p><\/div><div><p>IF = 6.268<\/p><\/div><\/div><\/div><div><div><strong>Pohl et al. investigated the structural basis of Nedd4-2 regulation by 14-3-3 and found that phosphorylated Ser342 and Ser448 are the main residues that facilitate 14-3-3 binding to Nedd4-2. The authors propose that the Nedd4-2:14-3-3 complex then stimulates a structural rearrangement of Nedd4-2 through inhibiting interaction of its structured domains.<\/strong><\/div><div><strong><img decoding=\"async\" src=\"https:\/\/www.fgu.cas.cz\/upload\/files\/Nedd_ComBiol700x700.jpg\" alt=\"-\" title=\"\"><\/strong><\/div><\/div><div><div>Characterization of the interaction between Nedd4-2 and 14-3-3 in solution. a) Sedimentation coefficient distributions (c(s)) , b) Isotherm of weight-averaged sedimentation coefficients (sw) derived from SV-AUC analysis, c)\u00a0SAXS-based structural model of the complex with the crystal structures of the Nedd4-2 phosphopeptides (Pohl et al. 2021).<\/div><div>\u00a0<\/div><div><strong>Horvath et al. structurally and biochemically characterized the full-lenght human DAPK-14-3-3 complex to investigate the effects of binding to DAPK2 on its dimerization, activation by dephosphorylation of Ser318, and Ca<sup>2+<\/sup>\/calmodulin binding. Their results provide mechanistic insights into 14-3-3-mediated DAPK2 inhibition and highlight the potential of the DAPK2:14-3-3 complex as a target for anti-inflammatory therapies.<\/strong><\/div><\/div><\/div><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2384\" class=\"elementor-tab-title\" data-tab=\"4\" role=\"button\" aria-controls=\"elementor-tab-content-2384\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Innovative method of the Forhkead transcription factor FOXO3 regulation<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2384\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"4\" role=\"region\" aria-labelledby=\"elementor-tab-title-2384\"><div><div><p><strong>The study published in prestigious journal eLife identifies small molecule compounds that interact with the Forkhead box O3 transcription factor (FOXO3) and modulate its activity.<\/strong><\/p><p>FOXO3, with the characteristic fork head DNA-binding domain is part of the O subclass of the forkhead family of transcription factors. These transcription factors have important roles in mammalian cells in regards to regulating cell homeostasis, differentiation, longevity and steer cell death. The activity of FOXO3 in particular contributes to therapy-resistance programs that protect cancer cells during chemo and radiotherapy. Recent studies have also found the DNA-binding domain (DBD) of FOXO aid protein-protein interactions with other key regulators of longevity and death, and drug resistance. A reversible inhibition of FOXO3 activity by small compounds thereby might boost anti-tumor immune responses.<\/p><\/div><\/div><p>In order to inhibit the FOXO3 activity, it was first necessary to identify small molecule compounds that could block the interaction between FOXO3 and DNA. Using the structural data of FOXO3 DBD and FOXO4 DBD, the researchers developed six different pharmacophore models that were used for in silico screening of small molecule compound databases. Selected compounds were then tested for their ability to inhibit FOXO3 function both in vitro, and in cancer cell lines. The interactions of these compounds with FOXO3 DBD were assessed using NMR spectroscopy and docking studies.<\/p><p>The teams of Dr. V. Ob\u0161ilov\u00e1 from the\u00a0<a href=\"https:\/\/www.biocev.eu\/en\/research-program\/structural-biology-and-protein-engineering.5\/structural-biology-of-signaling-proteins.28\" target=\"_blank\" rel=\"noopener\">Institute of Physiology CAS in BIOCEV<\/a>\u00a0and prof. T. Ob\u0161il from the Faculty of Science, Charles University with the team of prof. M. J. Ausserlechner from the Medical University of Innsbruck, Austria identified the compounds S9 and its oxalate salt S9OX as compounds able to inhibit the FOXO3 activity in cancer cells. They also proposed that due to their mode of binding to FOXO3 DBD, these compounds may also interfere with protein-protein interactions of FOXO3. The advantage of these compounds is the strict control of application-dose and -time and the fact that they are not immunogenic allowing repeated applications \u2013 so dose- and application time can be adjusted to damage cancer cells or boost anti-cancer immunity, but also limit unwanted side effects of FOXO-inhibition on stem cells and other somatic tissues. Future research will be focused on investigation whether or not S9 can be used as a chemical foundation for developing FOXO-regulatory compounds that would control the functions and target gene subsets of FOXO transcription factors.<\/p><p>Original paper: Hagenbuchner J<sup>*<\/sup>,\u00a0<strong>Obsilova<\/strong>\u00a0V<sup>*<\/sup>, Kaserer T<sup>*<\/sup>, Kaiser N, Rass B,\u00a0<strong>Psenakova<\/strong>\u00a0K,\u00a0<strong>Docekal<\/strong>\u00a0V,\u00a0<strong>Alblova<\/strong>\u00a0M,\u00a0<strong>Kohoutova<\/strong>\u00a0K, Schuster D, Aneichyk T,\u00a0<strong>Vesely<\/strong>\u00a0J, Obexer P,\u00a0<strong>Obsil<\/strong>\u00a0T<sup>+<\/sup>, Ausserlechner MJ<sup>+<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31789593\" target=\"_blank\" rel=\"noopener\">. Modulating FOXO3 transcriptional activity by small, DBD-binding molecules.<\/a>\u00a0eLife. 2019, 8(Dec 4), e48876.&nbsp;doi:\u00a0<a href=\"https:\/\/doi.org\/10.7554\/eLife.48876\" target=\"_blank\" rel=\"noopener\">10.7554\/eLife.48876.<\/a>\u00a0IF = 7.551<\/p><div><sup>*<\/sup>\u00a0Equall contribution.<sup>+<\/sup>\u00a0Corresponding authors.<\/div><div><img decoding=\"async\" src=\"https:\/\/www.fgu.cas.cz\/upload\/files\/Obsilova_foxo3_s9.jpg\" alt=\"-\" title=\"\"><\/div><p>Compounds S9 blocks the DNA binding surface of Forkhead transcription factor FOXO3. The figure shows the structural model of the DNA-binding domain of FOXO3 with bound compound S9 based on data from NMR measurements and docking simulations.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2385\" class=\"elementor-tab-title\" data-tab=\"5\" role=\"button\" aria-controls=\"elementor-tab-content-2385\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">The best publication in Physiological Research with the young authors for the year 2018<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2385\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"5\" role=\"region\" aria-labelledby=\"elementor-tab-title-2385\"><p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-17901 size-full\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/gct51jf0q8oumypzz2k8.jpg\" alt=\"-\" width=\"700\" height=\"987\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/gct51jf0q8oumypzz2k8.jpg 700w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/gct51jf0q8oumypzz2k8-213x300.jpg 213w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>We obtained the first prize for the best publication in Physiological Research with the young authors from for the year 2018.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2386\" class=\"elementor-tab-title\" data-tab=\"6\" role=\"button\" aria-controls=\"elementor-tab-content-2386\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">The best publication with the authors from IP for the year 2017<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2386\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"6\" role=\"region\" aria-labelledby=\"elementor-tab-title-2386\"><p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-17909 size-full\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/il82r2mxk622nfj5noba.jpeg\" alt=\"-\" width=\"700\" height=\"990\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/il82r2mxk622nfj5noba.jpeg 700w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/il82r2mxk622nfj5noba-212x300.jpeg 212w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p>We got the prize for the best publication of the Institute of Physiology for year 2017 for the publication:<\/p>\n<p><strong>Alblova M, Smidova A<\/strong>, Docekal V, Vesely J, Herman P, <strong>Obsilova V, Obsil T<\/strong>. :<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29087344\/\" target=\"_blank\" rel=\"noopener\">Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.<\/a><\/p>\n<p>Proc Natl Acad Sci U S&nbsp;A. (2017) 114:E9811-E9820. IF = 9.504.<\/p>\n<p>\u00a0<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2387\" class=\"elementor-tab-title\" data-tab=\"7\" role=\"button\" aria-controls=\"elementor-tab-content-2387\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Our new paper in PNAS<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2387\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"7\" role=\"region\" aria-labelledby=\"elementor-tab-title-2387\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2388\" class=\"elementor-tab-title\" data-tab=\"8\" role=\"button\" aria-controls=\"elementor-tab-content-2388\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Our new paper in JBC: Structural Insight into the 14-3-3 Protein-Dependent Inhibition of Protein Kinase ASK1.<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2388\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"8\" role=\"region\" aria-labelledby=\"elementor-tab-title-2388\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-2389\" class=\"elementor-tab-title\" data-tab=\"9\" role=\"button\" aria-controls=\"elementor-tab-content-2389\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Our new publication in Journal of Biological Chemistry: Role of the EF-hand-like Motif in the 14-3-3 Protein-mediated Activation of Yeast Neutral Trehalase Nth1.<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-2389\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"9\" role=\"region\" aria-labelledby=\"elementor-tab-title-2389\"><p>Kopecka M, Kosek D, Kukacka Z, Rezabkova L, Man P, Novak P, Obsil T, Obsilova V.<\/p>\n<p>J Biol Chem. 2014 May 16;289(20):13948-61.<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24713696\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24713696<\/a><\/p>\n<p>Trehalases hydrolyze the non-reducing disaccharide trehalose amassed by cells as a universal protectant and storage carbohydrate. Recently, it has been shown that the activity of neutral trehalase Nth1 from Saccharomyces cerevisiae is mediated by the 14-3-3 protein binding that modulates the structure of both the catalytic domain and the region containing the EF-hand-like motif, whose role in the activation of Nth1 is unclear. In this work, the structure of the Nth1\u00b714-3-3 complex and the importance of the EF-hand-like motif were investigated using site-directed mutagenesis, hydrogen\/deuterium exchange coupled to mass spectrometry, chemical cross-linking, and small angle x-ray scattering. The low resolution structural views of Nth1 alone and the Nth1\u00b714-3-3 complex show that the 14-3-3 protein binding induces a significant structural rearrangement of the whole Nth1 molecule. The EF-hand-like motif-containing region forms a separate domain that interacts with both the 14-3-3 protein and the catalytic trehalase domain. The structural integrity of the EF-hand like motif is essential for the 14-3-3 protein-mediated activation of Nth1, and calcium binding, although not required for the activation, facilitates this process by affecting its structure. Our data suggest that the EF-hand like motif-containing domain functions as the intermediary through which the 14-3-3 protein modulates the function of the catalytic domain of Nth1.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23810\" class=\"elementor-tab-title\" data-tab=\"10\" role=\"button\" aria-controls=\"elementor-tab-content-23810\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Our New Paper in JBC: Structural Characterization of Phosducin and its Complex with the 14-3-3 Protein<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23810\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"10\" role=\"region\" aria-labelledby=\"elementor-tab-title-23810\"><p><strong>Kacirova M, Kosek D, Kadek A, Man P, Vecer J, Herman P, Obsilova V&nbsp;and Obsil T<\/strong><\/p>\n<p><strong>J. Biol. Chem. jbc.M115.636563. First Published on May 13, 2015, doi:10.1074\/jbc.M115.636563<\/strong><\/p>\n<p>Kacirova M, Kosek D, Kadek A, Man P, Vecer J, Herman P, Obsilova V&nbsp;and Obsil T<\/p>\n<p>http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25971962<\/p>\n<p>Phosducin (Pdc), a highly conserved phosphoprotein involved in the regulation of retinal phototransduction cascade, transcriptional control, and modulation of blood pressure, is controlled in the phosphorylation-dependent manner including the binding to the 14-3-3 protein. However, the molecular mechanism of this regulation is largely unknown. Here, the solution structure of Pdc and its interaction with the 14-3-3 protein were investigated using small angle X-ray scattering, time-resolved fluorescence spectroscopy and hydrogen-deuterium exchange coupled to mass spectrometry. The 14-3-3 protein dimer interacts with Pdc using surfaces both inside and outside its central channel. The N-terminal domain of Pdc, where both phosphorylation sites and the 14-3-3 binding motifs are located, is intrinsically disordered protein which reduces its flexibility in several regions without undergoing dramatic disorder-to-order transition upon binding to 14-3-3. Our data also indicate that the C-terminal domain of Pdc interacts with the outside surface of the 14-3-3 dimer through region involved in Gt\u03b2\u03b3 binding. In conclusion, we show that the 14-3-3 protein interacts with and sterically occludes both the N- and C-terminal Gt\u03b2\u03b3 binding interfaces of phosphorylated Pdc, thus providing a mechanistic explanation for the 14-3-3-dependent inhibition of Pdc function.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23811\" class=\"elementor-tab-title\" data-tab=\"11\" role=\"button\" aria-controls=\"elementor-tab-content-23811\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Tom\u00e1\u0161 Ob\u0161il was awarded the title of professor<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23811\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"11\" role=\"region\" aria-labelledby=\"elementor-tab-title-23811\"><p>Prof. RNDr. Tom\u00e1\u0161 Ob\u0161il, Ph.D. was awarded by the title of professor at The Faculty of Science, Charles University, majoring in Physical Chemistry. Professors graduation will take place December 18, 2014.<\/p><p>\u00a0<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23812\" class=\"elementor-tab-title\" data-tab=\"12\" role=\"button\" aria-controls=\"elementor-tab-content-23812\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Josef Hl\u00e1vka Award and Medal for 2014<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23812\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"12\" role=\"region\" aria-labelledby=\"elementor-tab-title-23812\"><p>16.&nbsp;12.&nbsp;2014: The Foundation of Josef, Marie and Zde\u0148ek Hl\u00e1vka awarded Hana Janou\u0161kov\u00e1 for being the best graduated student from 2nd Medical Faculty, Charles University in Prague.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23813\" class=\"elementor-tab-title\" data-tab=\"13\" role=\"button\" aria-controls=\"elementor-tab-content-23813\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Our new paper in JBC: Biophysical and Structural Characterization of the Thioredoxin-binding Domain of Protein Kinase ASK1 and Its Interaction with Reduced Thioredoxin.<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23813\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"13\" role=\"region\" aria-labelledby=\"elementor-tab-title-23813\"><p>Kosek D, Kylarova S, Psenakova K, Rezabkova L, Herman P, Vecer J, Obsilova V, Obsil T.<\/p>\n<p><strong>J Biol Chem. 2014 Aug 29;289(35):24463-74.<\/strong><\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25037217\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25037217<\/a><\/p>\n<p>Apoptosis signal-regulating kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase, plays a key role in the pathogenesis of multiple diseases. Its activity is regulated by thioredoxin (TRX1) but the precise mechanism of this regulation is unclear due to the lack of structural data. Here, we performed biophysical and structural characterization of the TRX1-binding domain of ASK1 (ASK1-TBD) and its complex with reduced TRX1. ASK1-TBD is a monomeric and rigid domain that forms a stable complex with reduced TRX1 with 1:1 molar stoichiometry. The binding interaction does not involve the formation of intermolecular disulfide bonds. Residues from the catalytic WCGPC motif of TRX1 are essential for complex stability with Trp(31) being directly involved in the binding interaction as suggested by time-resolved fluorescence. Small-angle x-ray scattering data reveal a compact and slightly asymmetric shape of ASK1-TBD and suggest reduced TRX1 interacts with this domain through the large binding interface without inducing any dramatic conformational change.<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23814\" class=\"elementor-tab-title\" data-tab=\"14\" role=\"button\" aria-controls=\"elementor-tab-content-23814\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Z\u00edsk\u00e1n\u00ed grantu GA \u010cR<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23814\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"14\" role=\"region\" aria-labelledby=\"elementor-tab-title-23814\"><p>14-10061S \u2013 Mechanismus regulace kinasov\u00e9 aktivity proteinkinasy ASK1 (\u0159e\u0161itel\u00e9: <a href=\"https:\/\/fgu.cas.cz\/profil\/prof-rndr-tomas-obsil-ph-d\/\">T. Ob\u0161il<\/a>, P\u0159F UK, a <a href=\"https:\/\/fgu.cas.cz\/profil\/rndr-veronika-obsilova-ph-d\/\">V. Ob\u0161ilov\u00e1<\/a>, Fg\u00da AV \u010cR, v.v.i.)<\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-23815\" class=\"elementor-tab-title\" data-tab=\"15\" role=\"button\" aria-controls=\"elementor-tab-content-23815\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Studentsk\u00fd Velemlok pro nejlep\u0161\u00edho pedagoga<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-23815\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"15\" role=\"region\" aria-labelledby=\"elementor-tab-title-23815\"><p><strong>21.&nbsp;2.&nbsp;2014 \u2013 doc. RNDr. Tom\u00e1\u0161 Ob\u0161il ocen\u011bn studenty P\u0159F UK jako nejlep\u0161\u00ed vyu\u010duj\u00edc\u00ed v&nbsp;oboru chemie<\/strong><\/p>\n<p>Cenu Studentsk\u00fd Velemlok pro nejlep\u0161\u00edho pedagoga v&nbsp;roce 2013 p\u0159evzal docent Tom\u00e1\u0161 Ob\u0161il z&nbsp;rukou d\u011bkana P\u0159\u00edrodov\u011bdeck\u00e9 fakulty Univerzity Karlovy v&nbsp;Praze 21.&nbsp;2.&nbsp;2014. Pedagogov\u00e9 jsou na toto ocen\u011bn\u00ed navrhov\u00e1ni studenty na z\u00e1klad\u011b v\u00fdsledk\u016f hodnocen\u00ed jejich v\u00fduky ve studentsk\u00e9 anket\u011b.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-17942 size-full\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/velemlok.jpg\" alt=\"-\" width=\"960\" height=\"720\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/velemlok.jpg 960w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/velemlok-300x225.jpg 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/velemlok-768x576.jpg 768w\" sizes=\"(max-width: 960px) 100vw, 960px\" \/><\/p>\n<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9750c69 e-con-full e-flex e-con e-child\" data-id=\"9750c69\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f1379a3 elementor-widget elementor-widget-heading\" data-id=\"f1379a3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Publications<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-92d0150 e-con-full e-flex e-con e-child\" data-id=\"92d0150\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9a9a39d elementor-widget__width-auto elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-facetwp-facet\" data-id=\"9a9a39d\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Publication year                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-rok_vydani facetwp-type-fselect\" data-name=\"rok_vydani\" data-type=\"fselect\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-778414f elementor-widget__width-auto elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-facetwp-facet\" data-id=\"778414f\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Prestigious publication                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-prestizni_publikace facetwp-type-fselect\" data-name=\"prestizni_publikace\" data-type=\"fselect\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a655a89 elementor-widget__width-auto elementor-widget-tablet__width-inherit elementor-widget-mobile__width-initial elementor-widget elementor-widget-facetwp-facet\" data-id=\"a655a89\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                            <h4>\n                    Search publication                <\/h4>\n                        <div class=\"facetwp-facet facetwp-facet-vyhledavani facetwp-type-search\" data-name=\"vyhledavani\" data-type=\"search\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"facetwp-flyout-open elementor-element elementor-element-80fa84a elementor-hidden-desktop elementor-widget elementor-widget-facetwp-button\" data-id=\"80fa84a\" data-element_type=\"widget\" data-widget_type=\"facetwp-button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Filtration<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"facetwp-template facetwp-elementor-widget elementor-element elementor-element-b0db2bb elementor-grid-1 elementor-grid-tablet-1 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"b0db2bb\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1140,&quot;columns&quot;:1,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:1,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t<style id=\"loop-1140\">.elementor-1140 .elementor-element.elementor-element-fdfbca6{--display:flex;--flex-direction:row;--container-widget-width:initial;--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--gap:10px 10px;--row-gap:10px;--column-gap:10px;--padding-top:0px;--padding-bottom:0px;--padding-left:0px;--padding-right:0px;}.elementor-widget-icon.elementor-view-stacked .elementor-icon{background-color:var( --e-global-color-primary );}.elementor-widget-icon.elementor-view-framed .elementor-icon, .elementor-widget-icon.elementor-view-default .elementor-icon{color:var( --e-global-color-primary );border-color:var( --e-global-color-primary );}.elementor-widget-icon.elementor-view-framed .elementor-icon, .elementor-widget-icon.elementor-view-default .elementor-icon svg{fill:var( --e-global-color-primary );}.elementor-1140 .elementor-element.elementor-element-01e22d5{width:var( --container-widget-width, auto );max-width:auto;--container-widget-width:auto;--container-widget-flex-grow:0;}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-element{--flex-grow:0;--flex-shrink:0;}.elementor-1140 .elementor-element.elementor-element-01e22d5 .elementor-icon-wrapper{text-align:center;}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-view-framed .elementor-icon{background-color:var( --e-global-color-34f6237 );}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-view-stacked .elementor-icon{color:var( --e-global-color-34f6237 );}.elementor-1140 .elementor-element.elementor-element-01e22d5.elementor-view-stacked .elementor-icon svg{fill:var( --e-global-color-34f6237 );}.elementor-1140 .elementor-element.elementor-element-01e22d5 .elementor-icon{font-size:14px;padding:8px;border-width:0px 0px 0px 0px;border-radius:100px 100px 100px 100px;}.elementor-1140 .elementor-element.elementor-element-01e22d5 .elementor-icon svg{height:14px;}.elementor-1140 .elementor-element.elementor-element-7f15758{--display:flex;--flex-direction:row;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--justify-content:flex-start;--align-items:flex-start;--gap:2px 30px;--row-gap:2px;--column-gap:30px;--flex-wrap:wrap;--padding-top:0px;--padding-bottom:0px;--padding-left:0px;--padding-right:0px;}.elementor-widget-heading .elementor-heading-title{font-family:var( --e-global-typography-primary-font-family ), Sans-serif;font-weight:var( --e-global-typography-primary-font-weight );line-height:var( --e-global-typography-primary-line-height );color:var( --e-global-color-primary );}.elementor-1140 .elementor-element.elementor-element-d82d22b{width:100%;max-width:100%;margin:-4px 0px calc(var(--kit-widget-spacing, 0px) + 0px) 0px;text-align:left;}.elementor-1140 .elementor-element.elementor-element-d82d22b .elementor-heading-title{font-family:var( --e-global-typography-text-font-family ), Sans-serif;font-size:var( --e-global-typography-text-font-size );font-weight:var( --e-global-typography-text-font-weight );line-height:var( --e-global-typography-text-line-height );color:var( --e-global-color-text );}.elementor-1140 .elementor-element.elementor-element-f26a1ac{margin:0px 0px calc(var(--kit-widget-spacing, 0px) + 0px) 0px;text-align:left;}.elementor-1140 .elementor-element.elementor-element-f26a1ac .elementor-heading-title{font-family:var( --e-global-typography-text-font-family ), Sans-serif;font-size:var( --e-global-typography-text-font-size );font-weight:var( --e-global-typography-text-font-weight );line-height:var( --e-global-typography-text-line-height );color:var( --e-global-color-text );}.elementor-widget-button .elementor-button{background-color:var( --e-global-color-accent );font-family:var( --e-global-typography-accent-font-family ), Sans-serif;font-size:var( --e-global-typography-accent-font-size );font-weight:var( --e-global-typography-accent-font-weight );text-decoration:var( --e-global-typography-accent-text-decoration );line-height:var( --e-global-typography-accent-line-height );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button{background-color:#00000000;font-family:var( --e-global-typography-accent-font-family ), Sans-serif;font-size:var( --e-global-typography-accent-font-size );font-weight:var( --e-global-typography-accent-font-weight );text-decoration:var( --e-global-typography-accent-text-decoration );line-height:var( --e-global-typography-accent-line-height );fill:var( --e-global-color-primary );color:var( --e-global-color-primary );transition-duration:0.3s;border-style:solid;border-width:0px 0px 1px 0px;border-color:var( --e-global-color-text );border-radius:0px 0px 0px 0px;padding:0px 0px 0px 0px;}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:hover, .elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:focus{background-color:#00000000;color:var( --e-global-color-8d600d2 );border-color:var( --e-global-color-8d600d2 );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button-content-wrapper{flex-direction:row-reverse;}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button .elementor-button-content-wrapper{gap:6px;}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:hover svg, .elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button:focus svg{fill:var( --e-global-color-8d600d2 );}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button{background-color:#00000000;fill:var( --e-global-color-primary );color:var( --e-global-color-primary );transition-duration:0.3s;border-style:solid;border-width:0px 0px 1px 0px;border-color:var( --e-global-color-text );border-radius:0px 0px 0px 0px;padding:0px 0px 0px 0px;}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:hover, .elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:focus{background-color:#00000000;color:var( --e-global-color-8d600d2 );border-color:var( --e-global-color-8d600d2 );}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button-content-wrapper{flex-direction:row-reverse;}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button .elementor-button-content-wrapper{gap:6px;}.elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:hover svg, .elementor-1140 .elementor-element.elementor-element-bdfa0a7 .elementor-button:focus svg{fill:var( --e-global-color-8d600d2 );}@media(max-width:1024px){.elementor-1140 .elementor-element.elementor-element-7f15758{--gap:2px 20px;--row-gap:2px;--column-gap:20px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1140 .elementor-element.elementor-element-d82d22b .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-1140 .elementor-element.elementor-element-f26a1ac .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}@media(max-width:767px){.elementor-1140 .elementor-element.elementor-element-fdfbca6{--flex-direction:row;--container-widget-width:calc( ( 1 - var( --container-widget-flex-grow ) ) * 100% );--container-widget-height:100%;--container-widget-flex-grow:1;--container-widget-align-self:stretch;--flex-wrap-mobile:wrap;--justify-content:flex-start;--align-items:flex-start;--flex-wrap:nowrap;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1140 .elementor-element.elementor-element-d82d22b .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-1140 .elementor-element.elementor-element-f26a1ac .elementor-heading-title{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-widget-button .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}.elementor-1140 .elementor-element.elementor-element-ea5608b .elementor-button{font-size:var( --e-global-typography-accent-font-size );line-height:var( --e-global-typography-accent-line-height );}}<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-46182 post-46182 publikace type-publikace status-publish hentry oddeleni-structural-biology-of-signaling-proteins typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Jano\u0161ev; Ma\u0161a - Ko\u0161ek; Dalibor - Tekel; Andrej - Joshi; Rohit - Honzejkov\u00e1; K. - Pohl; Pavel - Ob\u0161il; Tom\u00e1\u0161 - Ob\u0161ilov\u00e1; Veronika\u00a0<i>Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins<\/i>. <strong>Nature Communications.  2025; 16(26 May);  4875<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 15.7<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0366759\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1038\/s41467-025-60207-4\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-46183 post-46183 publikace type-publikace status-publish hentry oddeleni-structural-biology-of-signaling-proteins typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Kohoutov\u00e1; Kl\u00e1ra - Srb; Pavel - Ob\u0161ilov\u00e1; Veronika - Veverka; V\u00e1clav - Ob\u0161il; Tom\u00e1\u0161\u00a0<i>Structural plasticity of the FOXO-DBD:p53-TAD interaction<\/i>. <strong>Nature Communications.  2025; 16(27 May);  4907<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 15.7<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0366760\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1038\/s41467-025-59106-5\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-34162 post-34162 publikace type-publikace status-publish hentry oddeleni-structural-biology-of-signaling-proteins typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Ob\u0161ilov\u00e1; Veronika - Ob\u0161il; Tom\u00e1\u0161\u00a0<i>Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins.<\/i>. <strong>Physiological Research.  2024; 73(Suppl.1); S401-S412<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 2.0<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0355969\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.33549\/physiolres.935306\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-34148 post-34148 publikace type-publikace status-publish hentry oddeleni-structural-biology-of-signaling-proteins typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Kumar; J. P. - Ko\u0161ek; Dalibor - Durell; S. R. - Miller Jenkins; L. M. - Debnath; S. - Coussens; N. P. - Hall; M. D. - Appella; D. H. - Dyda; F. - Mazur; S. J. - Appella; E.\u00a0<i>Crystal structure and mechanistic studies of the PPM1D serine\/threonine phosphatase catalytic domain<\/i>. <strong>Journal of Biological Chemistry.  2024; 300(8);  107561<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 3.9<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0355413\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.1016\/j.jbc.2024.107561\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-4285 post-4285 publikace type-publikace status-publish hentry oddeleni-structural-biology-of-signaling-proteins typ-publikace-prestizni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honzejkov\u00e1; K. - Ko\u0161ek; Dalibor - Ob\u0161ilov\u00e1; Veronika - Ob\u0161il; Tom\u00e1\u0161\u00a0<i>The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1<\/i>. <strong>eLife.  2024; 13(Mar 27);  RP95199<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 6.4<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0353047\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">ASEP<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bdfa0a7 elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"bdfa0a7\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/dx.doi.org\/10.7554\/eLife.95199.2\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1140\" class=\"elementor elementor-1140 e-loop-item e-loop-item-4127 post-4127 publikace type-publikace status-publish hentry oddeleni-structural-biology-of-signaling-proteins typ-publikace-standardni-publikace\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-fdfbca6 e-con-full e-flex e-con e-parent\" data-id=\"fdfbca6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-01e22d5 elementor-view-framed elementor-widget__width-initial elementor-shape-circle elementor-widget elementor-widget-icon\" data-id=\"01e22d5\" data-element_type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"14\" height=\"14\" viewBox=\"0 0 14 14\" fill=\"none\"><path d=\"M3.50016 12.8333C3.17933 12.8333 2.90468 12.7191 2.6762 12.4906C2.44773 12.2621 2.3335 11.9875 2.3335 11.6666V2.33329C2.3335 2.01246 2.44773 1.73781 2.6762 1.50933C2.90468 1.28086 3.17933 1.16663 3.50016 1.16663H10.5002C10.821 1.16663 11.0956 1.28086 11.3241 1.50933C11.5526 1.73781 11.6668 2.01246 11.6668 2.33329V11.6666C11.6668 11.9875 11.5526 12.2621 11.3241 12.4906C11.0956 12.7191 10.821 12.8333 10.5002 12.8333H3.50016ZM3.50016 11.6666H10.5002V2.33329H9.3335V6.41663L7.87516 5.54163L6.41683 6.41663V2.33329H3.50016V11.6666Z\" fill=\"white\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f15758 e-con-full e-flex e-con e-child\" data-id=\"7f15758\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d82d22b elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d82d22b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Ob\u0161ilov\u00e1; Veronika - Ob\u0161il; T.\u00a0<i>The yeast 14-3-3 proteins Bmh1 and Bmh2 regulate key signaling pathways<\/i>. <strong>Frontiers in molecular biosciences.  2024; 11(Jan 24);  1327014<\/strong>. <\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f26a1ac elementor-widget elementor-widget-heading\" data-id=\"f26a1ac\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">IF = 4.0<\/p>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea5608b elementor-align-center button__text_arrow_large elementor-widget elementor-widget-button\" data-id=\"ea5608b\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/hdl.handle.net\/11104\/0351172\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16\" height=\"16\" viewBox=\"0 0 16 16\" fill=\"none\"><g id=\"arrow_forward_FILL0_wght400_GRAD0_opsz24 1\"><path id=\"Vector\" d=\"M10.7832 8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 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8.66663H2.6665V7.33329H10.7832L7.04984 3.59996L7.99984 2.66663L13.3332 7.99996L7.99984 13.3333L7.04984 12.4L10.7832 8.66663Z\" fill=\"black\"><\/path><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">DOI<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4def725 elementor-widget elementor-widget-facetwp-facet\" data-id=\"4def725\" data-element_type=\"widget\" data-widget_type=\"facetwp-facet.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n        <div class=\"facet-wrap\">\n                        <div class=\"facetwp-facet facetwp-facet-strankovani facetwp-type-pager\" data-name=\"strankovani\" data-type=\"pager\"><\/div>        <\/div>\n\n        \t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-864c9ef e-con-full e-flex e-con e-child\" data-id=\"864c9ef\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ba5ec6c elementor-widget elementor-widget-heading\" data-id=\"ba5ec6c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Photogallery<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6441e84 elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"6441e84\" data-element_type=\"widget\" data-settings=\"{&quot;slides_to_show&quot;:&quot;3&quot;,&quot;slides_to_scroll&quot;:&quot;1&quot;,&quot;slides_to_show_tablet&quot;:&quot;3&quot;,&quot;slides_to_show_mobile&quot;:&quot;1&quot;,&quot;lazyload&quot;:&quot;yes&quot;,&quot;image_spacing_custom_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;navigation&quot;:&quot;both&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;,&quot;speed&quot;:500,&quot;image_spacing_custom&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]}}\" data-widget_type=\"image-carousel.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-image-carousel-wrapper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Image Carousel\" dir=\"ltr\">\n\t\t\t<div class=\"elementor-image-carousel swiper-wrapper swiper-image-stretch\" aria-live=\"off\">\n\t\t\t\t\t\t\t\t<div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"1 of 3\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"5a22c3004e28ecm3-ajleg\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTc5NTEsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI0XC8wN1wvNWEyMmMzMDA0ZTI4ZWNtMy1hamxlZy5qcGciLCJzbGlkZXNob3ciOiI2NDQxZTg0In0%3D\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/5a22c3004e28ecm3-ajleg.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/5a22c3004e28ecm3-ajleg-1009x1024.jpg\" alt=\"Detailed insight on structure of the complex 14-3-3:Nth1 (PDB 5M4A). Alblova et al. (2017).\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Detailed insight on structure of the complex 14-3-3:Nth1 (PDB 5M4A). Alblova et al. (2017).<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"2 of 3\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"583d5c962ff1dnth-abc\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTc5NTMsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI0XC8wN1wvNTgzZDVjOTYyZmYxZG50aC1hYmMuanBnIiwic2xpZGVzaG93IjoiNjQ0MWU4NCJ9\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/583d5c962ff1dnth-abc.jpg\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/583d5c962ff1dnth-abc.jpg\" alt=\"A) Identification of key phosphorylation sites responsible for 14-3-3-dependent activation of neutral trehalase Nth1. B) Decrease of H\/D kinetics for a peptide in Ca-binding domain which lies on the interface between the two proteins induced by Bmh1. C) SAXS low resolution structure of the Nth1:Bmh1 complex. Veisova et al. (2012), Macakova et al. (2013), Kopecka et al. (2014).\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">A) Identification of key phosphorylation sites responsible for 14-3-3-dependent activation of neutral trehalase Nth1. B) Decrease of H\/D kinetics for a peptide in Ca-binding domain which lies on the interface between the two proteins induced by Bmh1. C) SAXS low resolution structure of the Nth1:Bmh1 complex. Veisova et al. (2012), Macakova et al. (2013), Kopecka et al. (2014).<\/figcaption><\/figure><\/a><\/div><div class=\"swiper-slide\" role=\"group\" aria-roledescription=\"slide\" aria-label=\"3 of 3\"><a data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"6441e84\" data-elementor-lightbox-title=\"583c0d33920fbobr3\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MTc5NTUsInVybCI6Imh0dHBzOlwvXC9mZ3UuY2FzLmN6XC93cC1jb250ZW50XC91cGxvYWRzXC8yMDI0XC8wN1wvNTgzYzBkMzM5MjBmYm9icjMucG5nIiwic2xpZGVzaG93IjoiNjQ0MWU4NCJ9\" href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/583c0d33920fbobr3.png\"><figure class=\"swiper-slide-inner\"><img class=\"swiper-slide-image swiper-lazy\" data-src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/583c0d33920fbobr3.png\" alt=\"Protein 14-3-3 interacts with N- and C-termini of Gt\u03b2\u03b3 binding interfaces of phosducinu. Kacirova et al. (2015).\" \/><div class=\"swiper-lazy-preloader\"><\/div><figcaption class=\"elementor-image-carousel-caption\">Protein 14-3-3 interacts with N- and C-termini of Gt\u03b2\u03b3 binding interfaces of phosducinu. Kacirova et al. (2015).<\/figcaption><\/figure><\/a><\/div>\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-prev\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"8\" height=\"12.453\" viewBox=\"0 0 8 12.453\"><g id=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24_5\" data-name=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24 5\" transform=\"translate(-8.959 -6)\"><path id=\"Vector\" d=\"M8.958,12.227,15.445,6l1.513,1.453-4.973,4.774L16.958,17l-1.513,1.453Z\" transform=\"translate(0 0)\" fill=\"#6c90c0\"><\/path><\/g><\/svg>\t\t\t\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-swiper-button elementor-swiper-button-next\" role=\"button\" tabindex=\"0\">\n\t\t\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"8\" height=\"12.453\" viewBox=\"0 0 8 12.453\"><g id=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24_5\" data-name=\"keyboard_arrow_down_24dp_FILL0_wght400_GRAD0_opsz24 5\" 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);line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-0a8af6b{--gap:15px 15px;--row-gap:15px;--column-gap:15px;}.elementor-1210 .elementor-element.elementor-element-63f4a74 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-54c1327 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}}@media(min-width:768px){.elementor-1210 .elementor-element.elementor-element-237f3e9{--width:100%;}}@media(max-width:767px){.elementor-1210 .elementor-element.elementor-element-237f3e9{--gap:0px 0px;--row-gap:0px;--column-gap:0px;--flex-wrap:nowrap;}.elementor-widget-image .widget-image-caption{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-1210 .elementor-element.elementor-element-0040c42{--padding-top:2px;--padding-bottom:2px;--padding-left:5px;--padding-right:0px;}.elementor-widget-heading .elementor-heading-title{line-height:var( --e-global-typography-primary-line-height );}.elementor-1210 .elementor-element.elementor-element-ad7a981 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-551f794 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-0a8af6b{--gap:0px 10px;--row-gap:0px;--column-gap:10px;}.elementor-1210 .elementor-element.elementor-element-63f4a74 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}.elementor-1210 .elementor-element.elementor-element-54c1327 .elementor-heading-title{font-size:var( --e-global-typography-74d688f-font-size );line-height:var( --e-global-typography-74d688f-line-height );}}\/* Start custom CSS for image, class: .elementor-element-9ce683f *\/.elementor-1210 .elementor-element.elementor-element-9ce683f a {\n    width: 100%;\n}\/* End custom CSS *\/\n\/* Start custom CSS for container, class: .elementor-element-237f3e9 *\/.elementor-1210 .elementor-element.elementor-element-237f3e9 {\n    height: 100%;\n}\/* End custom CSS *\/<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-36027 post-36027 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins typ-pozice-vedouci-oddeleni ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-veronika-obsilova-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/veru-ks07044-crop-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21808\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/rndr-veronika-obsilova-ph-d\/\">Veronika Ob\u0161ilov\u00e1, D.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Head of lab.; Senior research scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873513<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: veronika.obsilova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9beb24a e-con-full e-flex e-con e-child\" data-id=\"9beb24a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fd5993c dual__bold elementor-widget elementor-widget-heading\" data-id=\"fd5993c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Deputy Head of Laboratory<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7daf823 elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"7daf823\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1210,&quot;columns&quot;:2,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:2,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35917 post-35917 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins typ-pozice-zastupce-vedouciho ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/prof-rndr-tomas-obsil-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/tom-foto-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21813\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/prof-rndr-tomas-obsil-ph-d\/\">Tom\u00e1\u0161 Ob\u0161il, Prof.  D.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Deputy head of lab.; Research Scientist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 221951303<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: obsil@natur.cuni.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c6eb248 e-con-full e-flex e-con e-child\" data-id=\"c6eb248\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cbbe66e dual__bold elementor-widget elementor-widget-heading\" data-id=\"cbbe66e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Laboratory staff<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3ee5d9 elementor-grid-2 elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-loop-grid\" data-id=\"c3ee5d9\" data-element_type=\"widget\" data-settings=\"{&quot;template_id&quot;:1210,&quot;columns&quot;:2,&quot;row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:20,&quot;sizes&quot;:[]},&quot;columns_tablet&quot;:2,&quot;row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;_skin&quot;:&quot;post&quot;,&quot;columns_mobile&quot;:&quot;1&quot;,&quot;edit_handle_selector&quot;:&quot;[data-elementor-type=\\&quot;loop-item\\&quot;]&quot;,&quot;row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"loop-grid.post\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-loop-container elementor-grid\" role=\"list\">\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35730 post-35730 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/msc-jayashri-bhosale\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/bhosale-jayashri-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21823\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/msc-jayashri-bhosale\/\">Jayashri Babaji Bhosale, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">PhD student<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873506<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: jayashri.bhosale@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-53128 post-53128 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-adam-brzezina\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/default-people-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-image-4890\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/default-people-150x150.png 150w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/default-people-300x300.png 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/default-people-768x768.png 768w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/default-people.png 904w\" sizes=\"(max-width: 150px) 100vw, 150px\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-adam-brzezina\/\">Adam Brzezina, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Research Specialist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873506<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: adam.brzezina@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-39653 post-39653 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/39653\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/02\/janacova-klara-150x150.png\" class=\"attachment-thumbnail size-thumbnail wp-image-39652\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/39653\/\">Kl\u00e1ra Jan\u00e1\u010dov\u00e1, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Research Specialist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873512<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: klara.janacova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35321 post-35321 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-dana-kalabova-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/dana-foto-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21832\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-dana-kalabova-ph-d\/\">Dana Kal\u00e1bov\u00e1, M.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Research Specialist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873501<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: dana.kalabova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-34860 post-34860 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/bc-gabriela-kocarova\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/kocarova-small1-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21837\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/bc-gabriela-kocarova\/\">Gabriela Ko\u010d\u00e1rov\u00e1, B.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Research Specialist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873501<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: gabriela.kocarova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-45149 post-45149 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-klara-kohoutova\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/07\/klara-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-45157\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-klara-kohoutova\/\">Kl\u00e1ra Kohoutov\u00e1, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Postdoctoral researcher<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873506<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: klara.kohoutova@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-35320 post-35320 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-dalibor-kosek-ph-d\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/kosek-small-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-21816\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/mgr-dalibor-kosek-ph-d\/\">Dalibor Ko\u0161ek, M.Sc., Ph.D.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Scientific Assistant<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873512<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: dalibor.kosek@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-41204 post-41204 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/ing-kseniia-kostyleva\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/04\/kostyleva-kseniia-small-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-41200\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/ing-kseniia-kostyleva\/\">Kseniia Kostyleva, M.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Research Specialist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873506<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: kseniia.kostyleva@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"1210\" class=\"elementor elementor-1210 e-loop-item e-loop-item-42926 post-42926 profil type-profil status-publish has-post-thumbnail hentry oddeleni-structural-biology-of-signaling-proteins ustav-biocev\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-237f3e9 e-con-full e-flex e-con e-child\" data-id=\"237f3e9\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce683f elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"9ce683f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fgu.cas.cz\/en\/profil\/bc-martin-slavik\/\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/08\/martin-slavik-150x150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-47961\" alt=\"-\" title=\"\">\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0040c42 e-flex e-con-boxed e-con e-child\" data-id=\"0040c42\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7229714 e-con-full e-flex e-con e-child\" data-id=\"7229714\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d364753 elementor-widget__width-inherit elementor-widget elementor-widget-heading\" data-id=\"d364753\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/bc-martin-slavik\/\">Martin Slav\u00edk, B.Sc.<\/a><\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ad7a981 position-info elementor-widget elementor-widget-heading\" data-id=\"ad7a981\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Specialist<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a8af6b e-con-full contact-info e-flex e-con e-child\" data-id=\"0a8af6b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63f4a74 elementor-widget elementor-widget-heading\" data-id=\"63f4a74\" data-element_type=\"widget\" id=\"phone-orefix\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Tel: 325873506<\/span>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54c1327 elementor-widget elementor-widget-heading\" data-id=\"54c1327\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<span class=\"elementor-heading-title elementor-size-default\">Email: martin.slavik@fgu.cas.cz<\/span>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Content of this page About the Laboratory Our Laboratory is focused on structural biology (the relationship between the structure and function of certain groups of proteins), particularly we focus on the proteins which participate in the signal transmission in the cell. Among methods we use are recombinant protein expression, biophysical characterization, study of intermolecular interactions, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":22745,"parent":24807,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-24948","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/comments?post=24948"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24948\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24807"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/22745"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=24948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}