{"id":25071,"date":"2024-07-17T14:42:09","date_gmt":"2024-07-17T12:42:09","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/research-and-laboratories\/research-departments\/laboratory-of-bioenergetics\/zlucove-kyseliny-brani-vzniku-obezity\/"},"modified":"2024-08-20T12:53:25","modified_gmt":"2024-08-20T10:53:25","slug":"bile-acids-prevents-the-development-of-obesity","status":"publish","type":"page","link":"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research-departments\/laboratory-of-bioenergetics\/bile-acids-prevents-the-development-of-obesity\/","title":{"rendered":"Bile acids prevents the development of obesity"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"25071\" class=\"elementor elementor-25071 elementor-17008\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-471cac8 e-flex e-con-boxed e-con e-parent\" data-id=\"471cac8\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5c83bf5 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"5c83bf5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Bile acids prevents the development of obesity<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8a15d85 e-flex e-con-boxed e-con e-parent\" data-id=\"8a15d85\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0b5d0e2 elementor-widget elementor-widget-text-editor\" data-id=\"0b5d0e2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u017dlu\u010dov\u00e9 kyseliny sni\u017euj\u00ed energetick\u00fd p\u0159\u00edjem a aktivuj\u00ed termogenn\u00ed funkci hn\u011bd\u00e9 tukov\u00e9 tk\u00e1n\u011b.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee55526 elementor-widget elementor-widget-text-editor\" data-id=\"ee55526\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>\u017dlu\u010dov\u00e9 kyseliny<\/strong> \u2013 steroidn\u00ed l\u00e1tky, kter\u00e9 vznikaj\u00ed v&nbsp;j\u00e1trech a \u017elu\u010d\u00ed se dost\u00e1vaj\u00ed do st\u0159eva, kde umo\u017e\u0148uj\u00ed tr\u00e1ven\u00ed tuk\u016f. Obyvatel\u00e9 \u0159ady asijsk\u00fdch st\u00e1t\u016f t\u011bmto l\u00e1tk\u00e1m p\u0159ipisuj\u00ed l\u00e9\u010div\u00e9 a stimula\u010dn\u00ed \u00fa\u010dinky, v&nbsp;z\u00e1padn\u00ed medic\u00edn\u011b jsou pou\u017e\u00edv\u00e1ny k&nbsp;l\u00e9\u010db\u011b choleliti\u00e1zy. Pokusy na my\u0161\u00edch krmen\u00fdch dietou s&nbsp;vysok\u00fdm obsahem tuku (proveden\u00e9 ve spolupr\u00e1ci mezi Fyziologick\u00fdm \u00fastavem a University of Coimbra v&nbsp;Portugalsku) prok\u00e1zaly, \u017ee pod\u00e1v\u00e1n\u00ed jedn\u00e9 ze \u017elu\u010dov\u00fdch kyselin (kyseliny chenodeoxycholov\u00e9; CDCA) br\u00e1n\u00ed vzniku obezity. Na tomto \u00fa\u010dinku CDCA se pod\u00edl\u00ed jak sn\u00ed\u017een\u00ed p\u0159\u00edjmu potravy, tak zv\u00fd\u0161en\u00ed energetick\u00e9ho v\u00fddeje vlivem na hn\u011bdou tukovou tk\u00e1\u0148, unik\u00e1tn\u00ed termogenn\u00ed tk\u00e1\u0148 p\u0159\u00edtomnou u savc\u016f v\u010detn\u011b \u010dlov\u011bka. Zejm\u00e9na u novorozenc\u016f br\u00e1n\u00ed hn\u011bd\u00e1 tukov\u00e1 tk\u00e1\u0148 prochladnut\u00ed a spot\u0159ebov\u00e1v\u00e1 velk\u00e9 mno\u017estv\u00ed \u017eivin. Pod vlivem p\u016fsoben\u00ed CDCA stoup\u00e1 v&nbsp;hn\u011bd\u00e9 tukov\u00e9 tk\u00e1ni obsah UCP1 proteinu, kter\u00fd zprost\u0159edkov\u00e1v\u00e1 tvorbu tepla. Nav\u00edc se bu\u0148ky s&nbsp;UCP1 objevuj\u00ed i v&nbsp;b\u00edl\u00e9 tukov\u00e9 tk\u00e1ni.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-938ac41 elementor-widget elementor-widget-text-editor\" data-id=\"938ac41\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Mikroskopick\u00fd obraz \u0159ezu podko\u017en\u00ed b\u00edl\u00e9 tukov\u00e9 tk\u00e1n\u011b my\u0161\u00ed<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ed2116 elementor-widget elementor-widget-text-editor\" data-id=\"5ed2116\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Vy\u0161\u0161\u00ed v\u00fdskyt UCP1-pozitivn\u00edch bun\u011bk (zv\u00fdrazn\u011bny \u0161ipkami) u my\u0161\u00ed krmen\u00fdch vysokotukou dietou s&nbsp;p\u0159\u00eddavkem 0,1% CDCA oproti my\u0161\u00edm krmen\u00fdm standardn\u00ed dietou (STD), nebo vysokotukou dietou (cHF), nebo vysokotukou dietou v&nbsp;mno\u017estv\u00ed odpov\u00eddaj\u00edc\u00edm spot\u0159eb\u011b potravy u CDCA skupiny (PF).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f848b0 elementor-widget elementor-widget-image\" data-id=\"0f848b0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"700\" height=\"250\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/figure-web.png\" class=\"attachment-large size-large wp-image-17012\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/figure-web.png 700w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/07\/figure-web-300x107.png 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23b8ad0 elementor-widget elementor-widget-text-editor\" data-id=\"23b8ad0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Theodoro J, Zouhar P, Flachs P, Bardova K, Janovska P, Gomes A, Duarte F, Varela A, Rolo A, Palmeira C and Kopecky J. 2014. Enhancement of brown fat ther-mogenesis using chenodeoxycholic acid in mise. International Journal of Obesity 38:1027-34. IF = 5.38<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u017dlu\u010dov\u00e9 kyseliny sni\u017euj\u00ed energetick\u00fd p\u0159\u00edjem a aktivuj\u00ed termogenn\u00ed funkci hn\u011bd\u00e9 tukov\u00e9 tk\u00e1n\u011b. \u017dlu\u010dov\u00e9 kyseliny \u2013 steroidn\u00ed l\u00e1tky, kter\u00e9 vznikaj\u00ed v&nbsp;j\u00e1trech a \u017elu\u010d\u00ed se dost\u00e1vaj\u00ed do st\u0159eva, kde umo\u017e\u0148uj\u00ed tr\u00e1ven\u00ed tuk\u016f. Obyvatel\u00e9 \u0159ady asijsk\u00fdch st\u00e1t\u016f t\u011bmto l\u00e1tk\u00e1m p\u0159ipisuj\u00ed l\u00e9\u010div\u00e9 a stimula\u010dn\u00ed \u00fa\u010dinky, v&nbsp;z\u00e1padn\u00ed medic\u00edn\u011b jsou pou\u017e\u00edv\u00e1ny k&nbsp;l\u00e9\u010db\u011b choleliti\u00e1zy. Pokusy na my\u0161\u00edch krmen\u00fdch dietou s&nbsp;vysok\u00fdm obsahem tuku [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":55280,"parent":23853,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-25071","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/25071","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/comments?post=25071"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/25071\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/23853"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/55280"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=25071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}