{"id":25079,"date":"2024-07-17T14:16:58","date_gmt":"2024-07-17T12:16:58","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/research-and-laboratories\/research-departments\/laboratory-of-biomaterials-and-tissue-engineering\/tkanove-nahrady\/"},"modified":"2024-08-20T13:04:05","modified_gmt":"2024-08-20T11:04:05","slug":"tissue-substitution","status":"publish","type":"page","link":"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research-departments\/laboratory-of-biomaterials-and-tissue-engineering\/tissue-substitution\/","title":{"rendered":"Tissue substitution"},"content":{"rendered":"\t\t
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Tissue substitution<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Fotogalerie \u010dl\u00e1nku<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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\"Klinicky
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Klinicky u\u017e\u00edvan\u00e9 n\u00e1hrady srde\u010dn\u00edch chlopn\u00ed. A: N\u00e1hrada z pyrolytick\u00e9ho uhl\u00edku, vy\u017eaduj\u00edc\u00ed u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f proti sr\u00e1\u017een\u00ed krve. B: N\u00e1hrada z biologick\u00e9ho materi\u00e1lu, ov\u0161em z ciz\u00edho d\u00e1rce (lidsk\u00e9ho \u010di zv\u00ed\u0159ec\u00edho), co\u017e navozuje imunitn\u00ed reakci.<\/figcaption><\/figure><\/a><\/div>
\"Klinicky
<\/div>
Klinicky u\u017e\u00edvan\u00e9 c\u00e9vn\u00ed prot\u00e9zy vyroben\u00e9 z expandovan\u00e9ho polytetrafluoroethyl\u00e9nu (ePTFE) a z polyethyl\u00e9n tereftal\u00e1tu (PET). Materi\u00e1l prot\u00e9z je vysoce hydrofobn\u00ed a v tom stavu, v jak\u00e9m vych\u00e1z\u00ed z v\u00fdroby, neumo\u017e\u0148uje rekonstrukci p\u0159irozen\u00fdch bun\u011b\u010dn\u00fdch vrstev c\u00e9vn\u00ed st\u011bny.<\/figcaption><\/figure><\/a><\/div>
\"530669b04980aklouby\"
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Star\u0161\u00ed generace tk\u00e1\u0148ov\u00fdch n\u00e1hrad<\/b> obsahovala prakticky pouze um\u011bl\u00fd materi\u00e1l. Tento materi\u00e1l musel b\u00fdt tzv. biokompatibiln\u00ed, tj. s vhodn\u00fdmi mechanick\u00fdmi vlastnostmi a bez cytotoxick\u00e9ho, mutagenn\u00edho a imunogenn\u00edho p\u016fsoben\u00ed. Ji\u017e se v\u0161ak ne\u0159e\u0161ila ot\u00e1zka, zda podporuje os\u00eddlen\u00ed bu\u0148kami nahrazovan\u00e9 tk\u00e1n\u011b a jej\u00ed regeneraci. N\u00e1hrady tohoto typu se dosud u\u017e\u00edvaj\u00ed i v sou\u010dasn\u00e9 klinick\u00e9 praxi a jsou p\u0159edstavov\u00e1ny nap\u0159. syntetick\u00fdmi polymern\u00edmi c\u00e9vn\u00edmi prot\u00e9zami, n\u00e1hradami srde\u010dn\u00edch chlopn\u00ed \u010di kloubn\u00edmi n\u00e1hradami (viz fotogalerie).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Modern\u00ed generace tk\u00e1\u0148ov\u00fdch n\u00e1hrad<\/strong> by m\u011bla obsahovat nejen um\u011bl\u00fd materi\u00e1l, ale i p\u0159irozen\u00e9 bun\u011b\u010dn\u00e9 slo\u017eky nahrazovan\u00e9 tk\u00e1n\u011b. Um\u011bl\u00fd materi\u00e1l v nich nen\u00ed pouze pasivn\u011b tolerov\u00e1n bu\u0148kami, ale slou\u017e\u00ed jako analog extracelul\u00e1rn\u00ed matrix (mezibun\u011b\u010dn\u00e9 hmoty) tk\u00e1n\u011b. To znamen\u00e1, \u017ee podobn\u011b jako p\u0159irozen\u00e1 mezibun\u011b\u010dn\u00e1 hmota \u0159\u00edd\u00ed bun\u011b\u010dn\u00e9 funkce, nap\u0159\u00edklad stupe\u0148 jejich adheze, r\u016fstov\u00e1 aktivita, p\u0159epnut\u00ed mezi r\u016fstem a diferenciac\u00ed, vyzr\u00e1v\u00e1n\u00ed bun\u011b\u010dn\u00e9ho fenotypu, produkce r\u016fzn\u00fdch biologicky aktivn\u00edch molekul bu\u0148kami.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Fotogalerie \u010dl\u00e1nku   Klinicky u\u017e\u00edvan\u00e9 n\u00e1hrady srde\u010dn\u00edch chlopn\u00ed. A: N\u00e1hrada z pyrolytick\u00e9ho uhl\u00edku, vy\u017eaduj\u00edc\u00ed u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f proti sr\u00e1\u017een\u00ed krve. B: N\u00e1hrada z biologick\u00e9ho materi\u00e1lu, ov\u0161em z ciz\u00edho d\u00e1rce (lidsk\u00e9ho \u010di zv\u00ed\u0159ec\u00edho), co\u017e navozuje imunitn\u00ed reakci.   Klinicky u\u017e\u00edvan\u00e9 c\u00e9vn\u00ed prot\u00e9zy vyroben\u00e9 z expandovan\u00e9ho polytetrafluoroethyl\u00e9nu (ePTFE) a z polyethyl\u00e9n tereftal\u00e1tu (PET). Materi\u00e1l prot\u00e9z je vysoce hydrofobn\u00ed a v tom stavu, v jak\u00e9m vych\u00e1z\u00ed […]<\/p>\n","protected":false},"author":1,"featured_media":55280,"parent":24861,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-25079","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/25079","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/comments?post=25079"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/25079\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/24861"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/55280"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=25079"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}