{"id":27868,"date":"2024-08-12T10:58:12","date_gmt":"2024-08-12T08:58:12","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/about-the-institute\/o-nasem-ustavu\/"},"modified":"2025-11-18T16:01:05","modified_gmt":"2025-11-18T15:01:05","slug":"about-our-institute","status":"publish","type":"page","link":"https:\/\/fgu.cas.cz\/en\/about-the-institute\/about-our-institute\/","title":{"rendered":"About our Institute"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"27868\" class=\"elementor elementor-27868 elementor-23149\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c86234b e-flex e-con-boxed e-con e-parent\" data-id=\"c86234b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-070ab50 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"070ab50\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5c4bed2 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"5c4bed2\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">About our Institute<\/h1>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4278805 e-flex e-con-boxed e-con e-parent\" data-id=\"4278805\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5107d64 elementor-absolute elementor-hidden-tablet elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"5107d64\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"708\" height=\"789\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp\" class=\"attachment-large size-large wp-image-51089\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3.webp 708w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2025\/11\/bg-3-269x300.webp 269w\" sizes=\"(max-width: 708px) 100vw, 708px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b63dfd4 e-con-full elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child\" data-id=\"b63dfd4\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;sticky_on&quot;:[&quot;desktop&quot;],&quot;sticky_offset&quot;:80,&quot;sticky_parent&quot;:&quot;yes&quot;,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b7c0f3 elementor-widget elementor-widget-heading\" data-id=\"7b7c0f3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Content of this page\n<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6110535 elementor-toc--content-ellipsis elementor-widget elementor-widget-table-of-contents\" data-id=\"6110535\" data-element_type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;exclude_headings_by_selector&quot;:[],&quot;marker_view&quot;:&quot;bullets&quot;,&quot;icon&quot;:{&quot;value&quot;:&quot;&quot;,&quot;library&quot;:&quot;&quot;},&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:200,&quot;sizes&quot;:[]},&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t\t\t\t\t\t<div id=\"elementor-toc__6110535\" class=\"elementor-toc__body\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4d5558a e-con-full e-flex e-con e-child\" data-id=\"4d5558a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9e25496 elementor-widget elementor-widget-image\" data-id=\"9e25496\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"700\" height=\"311\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/91ak11cx4m7ama67mlhl.jpg\" class=\"attachment-1536x1536 size-1536x1536 wp-image-22985\" alt=\"-\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/91ak11cx4m7ama67mlhl.jpg 700w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/91ak11cx4m7ama67mlhl-300x133.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6eba597 e-con-full e-flex e-con e-child\" data-id=\"6eba597\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ede6843 elementor-widget elementor-widget-heading\" data-id=\"ede6843\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">About the Institute<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f46b41 elementor-widget elementor-widget-text-editor\" data-id=\"8f46b41\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Institute of Physiology of the Czech Academy of Sciences (IPHYS) is one of the leading research institutions in the Czech Republic. The Institute is engaged in research in the field of normal and pathological physiology, with the main focus on:<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27f130e custom_accordion  elementor-widget elementor-widget-accordion\" data-id=\"27f130e\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-4181\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-4181\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Nervous system and brain research<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-4181\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-4181\"><h4>Nervous system and brain research<\/h4><p><strong>DISEASES IN FOCUS<\/strong>: ALZHEIMER\u2019S DISEASE &#8211; SCHIZOPHRENIA &#8211; DEPRESSION &#8211; EPILEPSY &#8211; DISORDER OF BIORHYTHMS &#8211; NEUROPATHIC PAIN &#8211; NEURODEGENERATION &#8211; AUTISM &#8211; INBORN COGNITIVE DEFECTS &#8211; CHANNELOPATHIES<\/p><p>Neuroscience research covers studies aimed at understanding basic physiological and pathological processes related to human neurological and psychiatric diseases. Investigations at the system level study integrative functions of the central nervous system that include cognitive functions (memory, spatial orientation or learning), chronic pain, and epilepsy. At the cellular level circadian rhythms (i.e. processes repeated rhythmically during a 24-hour period) and pathophysiological mechanisms of drug addictions are investigated. Studies at the molecular level are aimed at revealing the biochemical principles of signal transmission from one cell to another, structural and functional correlations of neurotransmitter receptor activation and modulation by biological and pharmacological compounds. Aspects of neural transmission are studied in vivo, in vitro as well as theoretically using computer simulations and modelling.<\/p><p><a class=\"elementor-button elementor-button-link\" href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/research-topics\/#neurovedy\">More information<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-4182\" class=\"elementor-tab-title\" data-tab=\"2\" role=\"button\" aria-controls=\"elementor-tab-content-4182\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Cardiovascular system research<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-4182\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"2\" role=\"region\" aria-labelledby=\"elementor-tab-title-4182\"><h4>Cardiovascular system research<\/h4><p><strong>DISEASES IN FOCUS<\/strong>: HYPERTENSION &#8211; ISCHEMIC HEART DISEASE- CHRONIC HEART FAILURE &#8211; HEART ARRHYTHMIAS &#8211; CHRONIC KIDNEY FAILURE<\/p><p>Research in the cardiovascular field includes studies on the mechanisms of the development, therapy and prevention of serious cardiovascular diseases, such as ischemic heart disease, hypertension and chronic heart and kidney failure. Particular attention is devoted to the development of cardiac adaptation to oxygen deprivation and mechanisms of cardiac protection. Studies on the mechanisms of blood pressure regulation, vascular contractions and development of the conductive system represent a basis for new therapeutic approaches to hypertension and cardiac arrhythmias. The genetic approach deals with modifications or defects of selected genes responsible for cardiovascular diseases. Work is also being done on the development of biomaterials that may be suitable for synthetic vascular replacements.<\/p><p><a class=\"elementor-button elementor-button-link\" href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/research-topics\/#kardiofyziologie\">More information<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-4183\" class=\"elementor-tab-title\" data-tab=\"3\" role=\"button\" aria-controls=\"elementor-tab-content-4183\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Metabolism research<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-4183\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"3\" role=\"region\" aria-labelledby=\"elementor-tab-title-4183\"><h4>Metabolism research<\/h4><p><strong>DISEASES IN FOCUS<\/strong>: OBESITY AND METABOLIC SYNDROME &#8211; DIABETES MELLITUS TYPE 2 &#8211; INHERITED METABOLIC DISEASES &#8211; DISEASES OF THE INTESTINE &#8211; CANCER &#8211; INFECTIONS BY YEASTS &#8211; BONE MARROW DISEASES<\/p><p>Studies in this field cover specific aspects of metabolism from the cellular to wholebody level. The research is focused on characterisation of transport systems in cell membranes, specific signaling pathways affecting metabolism, the function of mitochondria and the impact of mitochondrial dysfunction on health, interactions between nutrition and the immune system that affect metabolism, circadian control of metabolism, genetic basis of obesity related diseases as well as the ontogenic aspects and the role of ageing in metabolic health.<\/p><p><a class=\"elementor-button elementor-button-link\" href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/research-topics\/#metabolismus\">More information<\/a><\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-08aea63 e-con-full e-flex e-con e-child\" data-id=\"08aea63\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-39657f4 elementor-widget elementor-widget-heading\" data-id=\"39657f4\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Main goal<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-33e8982 elementor-widget elementor-widget-text-editor\" data-id=\"33e8982\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Main goal of the research is to characterize mechanisms of the development of serious human diseases, such as vascular and cerebrovascular accidents, ischemic heart disease, diabetes, hereditary metabolic disorders and neurodegenerative diseases. Centre for Preclinical testing forms a part of the Institute.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-07daedc custom_accordion  elementor-widget elementor-widget-accordion\" data-id=\"07daedc\" data-element_type=\"widget\" data-widget_type=\"accordion.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion\">\n\t\t\t\t\t\t\t<div class=\"elementor-accordion-item\">\n\t\t\t\t\t<h5 id=\"elementor-tab-title-8231\" class=\"elementor-tab-title\" data-tab=\"1\" role=\"button\" aria-controls=\"elementor-tab-content-8231\" aria-expanded=\"false\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon elementor-accordion-icon-right\" aria-hidden=\"true\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-closed\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(-6.691 -4)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t<span class=\"elementor-accordion-icon-opened\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10.617\" height=\"16\" viewBox=\"0 0 10.617 16\"><g id=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24_1\" data-name=\"keyboard_backspace_24dp_FILL0_wght200_GRAD0_opsz24 1\" transform=\"translate(17.309 20) rotate(180)\"><path id=\"Vector\" d=\"M17.308,14.692,12,20,6.692,14.692l.708-.708,4.1,4.1V4h1V18.084l4.1-4.1Z\" fill=\"#1d1d1b\"><\/path><\/g><\/svg><\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-accordion-title\" tabindex=\"0\">Centre for Preclinical Testing (CPT)<\/a>\n\t\t\t\t\t<\/h5>\n\t\t\t\t\t<div id=\"elementor-tab-content-8231\" class=\"elementor-tab-content elementor-clearfix\" data-tab=\"1\" role=\"region\" aria-labelledby=\"elementor-tab-title-8231\"><p><img decoding=\"async\" class=\"alignnone wp-image-23019 size-full\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/slider05.jpg\" alt=\"-\" width=\"1920\" height=\"700\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/slider05.jpg 1920w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/slider05-300x109.jpg 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/slider05-1024x373.jpg 1024w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/slider05-768x280.jpg 768w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/slider05-1536x560.jpg 1536w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-23021\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/1920x700-prekliniky-web-front-page-figure-e1622295895139.jpg\" alt=\"-\" width=\"1920\" height=\"700\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/1920x700-prekliniky-web-front-page-figure-e1622295895139.jpg 1920w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/1920x700-prekliniky-web-front-page-figure-e1622295895139-300x109.jpg 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/1920x700-prekliniky-web-front-page-figure-e1622295895139-1024x373.jpg 1024w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/1920x700-prekliniky-web-front-page-figure-e1622295895139-768x280.jpg 768w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/1920x700-prekliniky-web-front-page-figure-e1622295895139-1536x560.jpg 1536w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><\/p><h4>COMPLETE SERVICES FOR THE IMPLEMENTATION OF PRECLINICAL STUDIES<\/h4><p>Successful completion of preclinical studies is an essential prerequisite for starting clinical trials on humans. Preclinical testing on animals under the strict GLP conditions (GLP \u2013 Good Laboratory Practice) is a key and indispensable element in the development of new pharmaceuticals. Centre for Preclinical Testing was founded with the support of Czech Academy of Sciences and it is closely linked with CAS program \u201e<a href=\"https:\/\/strategie.avcr.cz\/en\/o-strategii\" target=\"_blank\" rel=\"noopener\">Preclinical Testing of Potential Pharmaceuticals\u201c within Strategy AV21<\/a>. The Centre offers a <a href=\"http:\/\/www.prekliniky.cz\/en\/services\/\" target=\"_blank\" rel=\"noopener\">complete service<\/a> for preclinical studies with candidate substances on turnkey basis.<\/p><p>It uses a wide infrastructure and know-how of selected <a href=\"http:\/\/www.prekliniky.cz\/en\/facilities\/\" target=\"_blank\" rel=\"noopener\">specialised laboratories within the CAS<\/a>. It provides standard and custom tailored studies to support CTA\/MA processes and meet the needs of our clients in pharma (human and veterinary medicinal products), food, medical devices. Non-clinical safety studies and analytical chemistry testing can be performed under GLP requirements. Since its founding in 2017, dozens of pharmacological and toxicological in-vivo studies have been conducted at CPT, helping medicines on their long journey from test tube to patient.<\/p><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22fb214 e-con-full e-flex e-con e-child\" data-id=\"22fb214\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-29f2903 elementor-widget elementor-widget-heading\" data-id=\"29f2903\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research and education<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3cb805c e-con-full e-flex e-con e-child\" data-id=\"3cb805c\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-26e92e2 elementor-widget elementor-widget-text-editor\" data-id=\"26e92e2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Knowledge of scientists from the Institute of Physiology and <strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/important-success\/\" target=\"_blank\" rel=\"noopener\">their discoveries<\/a><\/strong> represent a theoretical basis for the development of new therapies. <\/p><p>Institute holds an important role in the <strong><a href=\"https:\/\/fgu.cas.cz\/en\/students-and-career\/ph-d-studies\/\">education<\/a> <\/strong>of students and current health care workers.<\/p><p>Institute of Physiology is consisted of a number of <strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research-departments\/\">scientific laboratories<\/a><\/strong> and <strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/service-departments\/\">service departments<\/a><\/strong>. Insitute use the top <strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/devices-and-equipment\/\">equipment<\/a><\/strong> for the research.<\/p><p>There are a wide range of world-renowned experts who regularly gain recognition for their scientific work of major domestic and foreign <a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/awards\/\"><strong>awards<\/strong><\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-57fc844 e-grid e-con-full e-con e-child\" data-id=\"57fc844\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-8cf6b41 e-con-full e-flex e-con e-child\" data-id=\"8cf6b41\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f227f24 elementor-widget elementor-widget-heading\" data-id=\"f227f24\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Institute employees<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ac9bf0 elementor-widget elementor-widget-text-editor\" data-id=\"5ac9bf0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Institute\u00b4s scientists have worked and still are working on a major social and manager positions (eg. <strong><a href=\"https:\/\/fgu.cas.cz\/en\/profil\/prof-rndr-helena-illnerova-drsc\/\">prof. Helena Illnerov\u00e1<\/a><\/strong> &#8211; president of The Czech Academy of Sciences 2001 &#8211; 2005), including significant positions in the international scientific societies (eg. prof. Bohuslav O\u0161\u0165\u00e1dal &#8211; president of the International Academy of Cardiovascular Sciences)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9c52492 e-con-full e-flex e-con e-child\" data-id=\"9c52492\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f001d64 elementor-widget elementor-widget-heading\" data-id=\"f001d64\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Lectures and popularization events<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c87d3cd elementor-widget elementor-widget-text-editor\" data-id=\"c87d3cd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The Institute organise a range of <strong><a href=\"https:\/\/fgu.cas.cz\/en\/public-and-media\/popularization\/\">popularization activities<\/a><\/strong> for the general and expert public. It has been organizing the <strong><a href=\"https:\/\/fgu.cas.cz\/en\/public-and-media\/lectures-and-seminars\/\">series of lectures and seminars<\/a><\/strong> (among others <a href=\"https:\/\/fgu.cas.cz\/en\/public-and-media\/lectures-and-seminars\/bures-lectures\/\"><strong>Bure\u0161 lectures series<\/strong><\/a> and the popularisation lectures <a href=\"https:\/\/fgu.cas.cz\/en\/public-and-media\/lectures-and-seminars\/the-human-body-in-health-and-disease\/\"><strong>The human body in health and disease<\/strong><\/a>). <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c105bfd e-con-full e-flex e-con e-child\" data-id=\"c105bfd\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b16c597 elementor-widget elementor-widget-heading\" data-id=\"b16c597\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Grants and research projects<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63cf028 elementor-widget elementor-widget-text-editor\" data-id=\"63cf028\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The Institute has been successful in attracting\u00a0<strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/research-projects\/\">research funding\u00a0<\/a><\/strong>at both national and international level. It participates also in research projects in the\u00a0<strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/research-projects\/\">centers of excellence\u00a0<\/a><\/strong>and is also a recipient of\u00a0<strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research\/research-projects\/\">EU Structural Funds\u00a0<\/a><\/strong>support.\u00a0It is the part of a\u00a0<strong><a href=\"http:\/\/www.mediaim.cz\/en\" target=\"_blank\" rel=\"noopener\">Translational Research Project MediAim<\/a>\u00a0<\/strong>that is\u00a0dedicated to the\u00a0development of new therapeutic agents and strategies to fight certain serious noncommunicable diseases and selected viral\u00a0diseases. It\u00b4s included three institutions:\u00a0<strong><a href=\"https:\/\/www.ikem.cz\/en\/\" target=\"_blank\" rel=\"noopener\">IKEM<\/a><\/strong>,\u00a0<strong><a href=\"https:\/\/www.uochb.cz\/en\" target=\"_blank\" rel=\"noopener\">IOCB<\/a>\u00a0<\/strong>and IPHYS.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2f7a97f e-con-full e-flex e-con e-child\" data-id=\"2f7a97f\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-407a07b elementor-widget elementor-widget-text-editor\" data-id=\"407a07b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The Institute is a co-recipient of the\u00a0<strong><a href=\"https:\/\/www.planobnovycr.cz\/\" target=\"_blank\" rel=\"noopener\">National Recovery Plan<\/a><\/strong>\u00a0(2022 \u2013 2025)\u00a0in the\u00a0<a href=\"https:\/\/cardia.ikem.cz\/en\/home\" target=\"_blank\" rel=\"noopener\"><strong>National Institute for Metabolic and Cardiovascular Disease Research (CarDia)<\/strong><\/a>\u00a0project, whose main goal is to contribute to more effective management of the epidemic of civilization\u00a0diseases, and in the\u00a0<strong><a href=\"https:\/\/fgu.cas.cz\/en\/research-project\/national-institute-for-neurological-research-neur-in-2022-2025\/\">National Institute for Neurological Research (NPO-NEURO-D)<\/a><\/strong>\u00a0project\u00a0which focuses on excellent research of disorders of brain development and aging.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e1cd9a3 e-con-full e-flex e-con e-child\" data-id=\"e1cd9a3\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b1b2a1d elementor-widget elementor-widget-text-editor\" data-id=\"b1b2a1d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/IPHYS-brochure-2024-web2.pdf\" target=\"_blank\" rel=\"noopener\">Presentation institute\u00b4s brochure (2024)<\/a>, <a href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/BROZURA-FGU-2020.pdf\" target=\"_blank\" rel=\"noopener\">presentation institute\u00b4s brochure (2020)<\/a>,\u00a0<a href=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/BROZURA-FGU-2017small.pdf\" target=\"_blank\" rel=\"noopener\">presentation institute\u00b4s brochure (2017)<\/a>.\u00a0<\/p><p><a href=\"https:\/\/fgu.cas.cz\/en\/about-the-institute\/general-information\/facts-and-figures\/\">Facts and Figures<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e8b0b45 e-con-full e-flex e-con e-child\" data-id=\"e8b0b45\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e8ada7b elementor-widget elementor-widget-heading\" data-id=\"e8ada7b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Gallery of the Institute<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87ee2b0 elementor-arrows-position-inside elementor-pagination-position-outside elementor-widget elementor-widget-image-carousel\" data-id=\"87ee2b0\" data-element_type=\"widget\" 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class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Content of this page About the Institute Institute of Physiology of the Czech Academy of Sciences (IPHYS) is one of the leading research institutions in the Czech Republic. The Institute is engaged in research in the field of normal and pathological physiology, with the main focus on: Nervous system and brain research Nervous system and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":55280,"parent":27083,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-27868","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/27868","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/comments?post=27868"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/27868\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/pages\/27083"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/55280"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=27868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}