{"id":6915,"date":"2019-07-09T00:00:00","date_gmt":"2019-07-08T22:00:00","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/2019\/07\/a-promising-pharmacological-approach-in-cardiovascular-disease-prevention\/"},"modified":"2024-08-29T12:19:07","modified_gmt":"2024-08-29T10:19:07","slug":"a-promising-pharmacological-approach-in-cardiovascular-disease-prevention","status":"publish","type":"post","link":"https:\/\/fgu.cas.cz\/en\/2019\/07\/a-promising-pharmacological-approach-in-cardiovascular-disease-prevention\/","title":{"rendered":"A promising pharmacological approach in cardiovascular disease prevention"},"content":{"rendered":"

Epoxyeicosatrienoic acids (EETs), cytochrome P450 epoxygenase metabolites of arachidonic acid, represent a promising pharmacological approach in cardiovascular disease prevention. In our study, cardioprotective effects of a novel, stable and orally active agonistic 14,15-EET analog\u00a0EET-B on the progression of post-ischemic heart failure\u00a0 was examined in spontaneously hypertensive rats (SHR), a pre-clinical rodent model of human essential hypertension. SHR were subjected to myocardial infarction and the effects of continuous EET-B treatment before and after MI on post-ischemic left ventricular function, myocardial fibrosis and inflammation were analyzed. As EET-based therapies can attenuate the progression of HF by mechanisms involving activation of heme oxygenase-1, its immunopositivity\u00a0in viable myocytes of\u00a0the ischemic myocardium was also determined. We demonstrated that EET-B treatment improved post-ischemic left ventricular function, markedly increased heme oxygenase-1 immunopositivity in cardiomyocytes subjected myocardial infarction and reduced cardiac inflammation and fibrosis. These findings suggest that EET analog EET-B\u00a0has beneficial therapeutic actions to reduce remodeling in SHR subjected to myocardial infarction.<\/p>\n

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Neck\u00e1r, Jan – Khan, M. A. H. – Gross, G. J. – Cyprov\u00e1, Michaela – Hrdlicka, Jaroslav – Kvasilov\u00e1, A. – Falck, J. R. – Campbell, W. B. – Sedl\u00e1kov\u00e1, Lenka – \u0160kutov\u00e1, \u0160\u00e1rka – Olejn\u00edckov\u00e1, Veronika – Gregorovicov\u00e1, Martina – Sedmera, David – Kol\u00e1r, Franti\u0161ek – Imig, J. D. Epoxyeicosatrienoic acid analog EET-B attenuates post-myocardial infarction remodeling in spontaneously hypertensive rats. Clinical science. Roc. 133, c. 8 (2019), s. 939-951. ISSN 0143-5221, IF: 5,237\u00a0DOI<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Epoxyeicosatrienoic acids (EETs), cytochrome P450 epoxygenase metabolites of arachidonic acid, represent a promising pharmacological approach in cardiovascular disease prevention. In our study, cardioprotective effects of a novel, stable and orally active agonistic 14,15-EET analog\u00a0EET-B on the progression of post-ischemic heart failure\u00a0 was examined in spontaneously hypertensive rats (SHR), a pre-clinical rodent model of human essential […]<\/p>\n","protected":false},"author":1,"featured_media":6419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[113],"tags":[],"class_list":["post-6915","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-important-success"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/posts\/6915","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/comments?post=6915"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/posts\/6915\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/6419"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=6915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/categories?post=6915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/tags?post=6915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}