{"id":52135,"date":"2025-12-22T12:32:17","date_gmt":"2025-12-22T11:32:17","guid":{"rendered":"https:\/\/fgu.cas.cz\/?post_type=udalost&#038;p=52135"},"modified":"2026-02-13T15:51:54","modified_gmt":"2026-02-13T14:51:54","slug":"integrative-metabolomic-and-genetic-mapping-for-identification-of-genes-regulating-liver-metabolism-and-blood-pressure-in-rat-recombinant-inbred-strains","status":"publish","type":"udalost","link":"https:\/\/fgu.cas.cz\/en\/event\/integrative-metabolomic-and-genetic-mapping-for-identification-of-genes-regulating-liver-metabolism-and-blood-pressure-in-rat-recombinant-inbred-strains\/","title":{"rendered":"Integrative metabolomic and genetic mapping for identification of genes regulating liver metabolism and blood pressure in rat recombinant inbred strains"},"content":{"rendered":"<p>The spontaneously hypertensive rat (SHR) displays key features of the metabolic syndrome. To enable genetic dissection of complex traits, we developed HXB\/BXH recombinant inbred (RI) strains derived from SHR and Brown Norway rats (N=30). We performed LC-MS\u2013based metabolomic profiling of liver tissue, identifying 761 metabolites and more than 50 significant metabolomic QTLs (mQTLs; LOD &gt;4) using GeneNetwork. A prominent mQTL on chromosome 11 regulating hepatic proline levels colocalized with a cis-eQTL for Prodh1, supporting its role in proline catabolism. An mQTL for N-alpha-acetylarginine on chromosome 4 overlapped a blood pressure QTL and a cis-eQTL for Nat8f1, suggesting a link between arginine acetylation and blood pressure regulation. Lipid-associated mQTLs near Cd36 colocalized with lipolysis QTLs, implicating Cd36 in hepatic lipid metabolism. Finally, mQTLs for microbial-derived metabolites on chromosome 3 overlapped a fat mass QTL, highlighting the gut\u2013liver axis in adiposity regulation.<\/p>\n<p><strong>IPHYS contact person:<\/strong> Michal Pravenec, <a href=\"https:\/\/fgu.cas.cz\/en\/research-and-laboratories\/research-departments\/laboratory-of-genetics-of-model-diseases\/\">Laboratory of Genetics of Model Diseases<\/a>; michal.pravenec@fgu.cas.cz<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The spontaneously hypertensive rat (SHR) displays key features of the metabolic syndrome. To enable genetic dissection of complex traits, we developed HXB\/BXH recombinant inbred (RI) strains derived from SHR and Brown Norway rats (N=30). We performed LC-MS\u2013based metabolomic profiling of liver tissue, identifying 761 metabolites and more than 50 significant metabolomic QTLs (mQTLs; LOD &gt;4) [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":55280,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"kategorie-udalosti":[],"class_list":["post-52135","udalost","type-udalost","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/52135","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/udalost"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/11"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/52135\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/55280"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=52135"}],"wp:term":[{"taxonomy":"kategorie-udalosti","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/kategorie-udalosti?post=52135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}