{"id":55953,"date":"2026-04-07T14:04:38","date_gmt":"2026-04-07T12:04:38","guid":{"rendered":"https:\/\/fgu.cas.cz\/?post_type=udalost&p=55953"},"modified":"2026-04-07T14:10:50","modified_gmt":"2026-04-07T12:10:50","slug":"the-brown-fat-secretome-a-new-frontier-in-cardiometabolic-research","status":"publish","type":"udalost","link":"https:\/\/fgu.cas.cz\/en\/event\/the-brown-fat-secretome-a-new-frontier-in-cardiometabolic-research\/","title":{"rendered":"The Brown Fat Secretome: A New Frontier in Cardiometabolic Research"},"content":{"rendered":"

Annotation<\/strong>:\u00a0The adipose tissue has a high degree of plasticity, with two phenotypic extremes: white adipose tissue, specialized in the storage of metabolic energy, and brown adipose tissue, which has a thermogenic, energy expenditure, function. Rodent and human studies showed that the activity of brown adipose tissue is associated with protection against obesity, type 2 diabetes, and cardiovascular disease. Traditionally, these effects were thought to be due to the ability of brown fat to uptake glucose and lipids to sustain thermogenesis, thereby promoting a negative energy balance and protection against hyperlipidemia and hyperglycemia. However, in recent years, the beneficial health effects of active brown fat have also been attributed to a second factor: its ability to secrete signaling molecules, known as brown adipokines or batokines (distinct from the traditional adipokines secreted by white adipose tissue), which may exert systemic effects favoring cardiometabolic health. The presentation will review the evidence supporting this secretory role of brown adipose tissue, the current knowledge of the main batokines and their functions, as well as the existing limitations in fully understanding the brown adipose tissue secretome. It will also address the potential of characterizing this secretome for the identification of possible therapeutic agents and circulating biomarkers of brown adipose tissue activity. Finally, current research strategies aimed at advancing in the identification of brown adipokines in humans, an area of significant biomedical impact, will be discussed.<\/p>\n

Biography:\u00a0<\/strong>Prof. Francesc Villarroya Gombau, PhD, is a full professor of Biochemistry and Molecular Biology at the University of Barcelona in Spain. He is also a member of the International Scientific Board of the Institute of Physiology CAS.\u00a0 He is a leading Spanish biochemist and molecular biologist whose research has substantially advanced understanding of the roles of brown and white adipose tissue in regulating energy metabolism, obesity, and cardiometabolic disease. He serves as Senior Group Leader of the \u201cAdipose Tissue Molecular Biology and Gene Regulation and Associated Disorders\u201d research group at the Sant Joan de D\u00e9u Research Institute in Barcelona. His group focuses on the molecular mechanisms that control the function of brown and white adipose tissue, their inflammatory and endocrine roles, and their contributions to the pathogenesis of obesity, diabetes, lipodystrophies, and cardiovascular complications. Professor Villarroya is the author of highly influential work on brown adipose tissue as a secretory organ and on inflammation of brown\/beige adipose tissues in obesity, which rank among the most cited studies in this field. His recent publications and international collaborations also address the role of adipose tissue in the action of modern incretin- and glucagon-based anti-obesity drugs, lipid-associated immune cells in adipose depots, and the cardiometabolic impact of altered adipose tissue function, including in people living with HIV. Professor Villarroya acts as an advisor to several international research institutions and agencies and has received prestigious distinctions, including the ICREA Academia award, reflecting his long-standing scientific contributions in metabolism and endocrinology.<\/p>\n

Contact at IPHYS:<\/strong> MUDr. Jan Kopeck\u00fd, DrSc., Laboratory of Adipose Tissue Biology; jan.kopecky@fgu.cas.cz<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Annotation:\u00a0The adipose tissue has a high degree of plasticity, with two phenotypic extremes: white adipose tissue, specialized in the storage of metabolic energy, and brown adipose tissue, which has a thermogenic, energy expenditure, function. Rodent and human studies showed that the activity of brown adipose tissue is associated with protection against obesity, type 2 diabetes, […]<\/p>\n","protected":false},"author":11,"featured_media":55280,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"kategorie-udalosti":[84],"class_list":["post-55953","udalost","type-udalost","status-publish","has-post-thumbnail","hentry","kategorie-udalosti-lectures"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/55953","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/udalost"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/11"}],"version-history":[{"count":4,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/55953\/revisions"}],"predecessor-version":[{"id":55961,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/55953\/revisions\/55961"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/55280"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=55953"}],"wp:term":[{"taxonomy":"kategorie-udalosti","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/kategorie-udalosti?post=55953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}