{"id":56590,"date":"2026-05-27T14:33:30","date_gmt":"2026-05-27T12:33:30","guid":{"rendered":"https:\/\/fgu.cas.cz\/?post_type=udalost&#038;p=56590"},"modified":"2026-05-27T14:36:00","modified_gmt":"2026-05-27T12:36:00","slug":"multi-tissue-metabolic-reprogramming-in-cachexia-the-role-of-one-carbon-metabolism","status":"publish","type":"udalost","link":"https:\/\/fgu.cas.cz\/en\/event\/multi-tissue-metabolic-reprogramming-in-cachexia-the-role-of-one-carbon-metabolism\/","title":{"rendered":"Multi-Tissue Metabolic Reprogramming in Cachexia: The Role of One-Carbon Metabolism"},"content":{"rendered":"<p><strong>Annotation:\u00a0<\/strong>Cachexia is a debilitating wasting syndrome that drives high rates of morbidity and mortality among cancer patients. Although tumor\u2013host interactions and maladaptive metabolic reprogramming are known to play major roles, their mechanisms remain incompletely understood. Here, we present a detailed picture of spatio-temporal metabolic alterations that occur during cachexia, combining untargeted metabolomics with \u00b9\u00b3C\u2011glucose tracing across a range of organs and tumors from male tumor-bearing mice at early, intermediate, and late disease stages. We identified one-carbon metabolism as a tissue-overarching pathway characteristic for metabolic wasting in mice, which is linked to inflammation, glucose hypermetabolism, and muscle atrophy. Notably, the same rewiring of one\u2011carbon metabolism was recapitulated in several additional mouse models of cachexia. Altogether, these findings establish a molecular framework for the coordinated, multi\u2011tissue metabolic response that underlies cancer\u2011induced cachexia, highlighting one\u2011carbon metabolism as a central, tissue-overarching driver of the wasting phenotype.<\/p>\n<p><strong>IPHYS contact:<\/strong> Krist\u00fdna Brejchov\u00e1, Laboratory of Bioactive Lipids, IPHYS; kristyna.brejchova@fgu.cas.cz<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Annotation:\u00a0Cachexia is a debilitating wasting syndrome that drives high rates of morbidity and mortality among cancer patients. Although tumor\u2013host interactions and maladaptive metabolic reprogramming are known to play major roles, their mechanisms remain incompletely understood. Here, we present a detailed picture of spatio-temporal metabolic alterations that occur during cachexia, combining untargeted metabolomics with \u00b9\u00b3C\u2011glucose tracing [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":55280,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"kategorie-udalosti":[84],"class_list":["post-56590","udalost","type-udalost","status-publish","has-post-thumbnail","hentry","kategorie-udalosti-lectures"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/56590","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/udalost"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/11"}],"version-history":[{"count":3,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/56590\/revisions"}],"predecessor-version":[{"id":56597,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/udalost\/56590\/revisions\/56597"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media\/55280"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=56590"}],"wp:term":[{"taxonomy":"kategorie-udalosti","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/kategorie-udalosti?post=56590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}