{"id":29689,"date":"2024-08-23T10:54:40","date_gmt":"2024-08-23T08:54:40","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&#038;p=29689"},"modified":"2024-10-21T12:10:52","modified_gmt":"2024-10-21T10:10:52","slug":"obesity-type-2-diabetes-and-neurodegeneration-crosstalk-new-therapeutic-potential-of-prolactin-releasing-peptide-analogs","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/obesity-type-2-diabetes-and-neurodegeneration-crosstalk-new-therapeutic-potential-of-prolactin-releasing-peptide-analogs\/","title":{"rendered":"Obesity, type 2 diabetes and neurodegeneration crosstalk: New therapeutic potential of prolactin-releasing peptide analogs &#8220;completed project&#8221;"},"content":{"rendered":"<div id=\"rightCol\" class=\"articleDetail\">\n<div class=\"content full\">\n<p>Obesity, diabetes, cardiovascular and neurodegenerative diseases (so-called civilization diseases) &#8211; are the world&#8217;s&nbsp;leading causes of morbidity and mortality and are responsible for60% of all deaths. It appears that obesity, type 2 diabetes (T2DM) and neurodegeneration have a common etiopathogenesis involving subclinical inflammation and insulin resistance. In the proposed project, we will explore the efficacy of new lipidized analogs of anorexigenic prolactinreleasing peptide as a complex therapy that simultaneously affects obesity, T2DM and neurodegeneration in mouse and rat models. In parallel, in these models peripheral biomarkers or panel of biomarkers of neurodegeneration development and long-term monitoring of its progression and treatment will be identified using of a comprehensive methodological portfolio including metabolomics in urine and plasma and advanced mass spectrometry imaging methods. Results of this project could help to find a common denominator of these major civilization diseases and open new possibilities for their comprehensive treatment.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Obesity, diabetes, cardiovascular and neurodegenerative diseases (so-called civilization diseases) &#8211; are the world&#8217;s&nbsp;leading causes of morbidity and mortality and are responsible for60% of all deaths. It appears that obesity, type 2 diabetes (T2DM) and neurodegeneration have a common etiopathogenesis involving subclinical inflammation and insulin resistance. In the proposed project, we will explore the efficacy of [&hellip;]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[155],"poskytovatel":[],"stav-projektu":[209],"class_list":["post-29689","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-experimental-hypertension","stav-projektu-current-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/29689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/29689\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=29689"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=29689"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=29689"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=29689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}