{"id":30090,"date":"2024-08-22T14:29:46","date_gmt":"2024-08-22T12:29:46","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&#038;p=30090"},"modified":"2024-09-02T07:49:12","modified_gmt":"2024-09-02T05:49:12","slug":"study-of-metabolic-and-cardiovascular-diseases-within-project-cardia","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/study-of-metabolic-and-cardiovascular-diseases-within-project-cardia\/","title":{"rendered":"Study of metabolic and cardiovascular diseases within project CarDia"},"content":{"rendered":"<div>\n<p>Our laboratory is involved in the research activities of <a href=\"https:\/\/cardia.ikem.cz\/en\/home\" target=\"_blank\" rel=\"noopener\">the <strong>CarDia<\/strong> project<\/a> (2022 \u2013 2025; see below)<\/p>\n<\/div>\n<p>In particular, we focus on the following research areas:<\/p>\n<ol>\n<li>Synthesis and study of the effects of new hepatoselective analogues of human insulin for the potential treatment of type 1 and type 2 diabetes mellitus (M. Rossmeisl in collaboration with J. Jiracek at the Institute of Organic Chemistry and Biochemistry CAS).<\/li>\n<li>Testing NRF2 activators to improve adipose tissue function and their use in stimulating the synthesis and secretion of insulin-sensitizing lipokines in the context of exercise (M. Rossmeisl in collaboration with L. Rossmeislova at the 3rd Faculty of Medicine, Charles University).<\/li>\n<li>Use of novel synthetic analogues of natural neuropeptides as potential drugs against obesity and type 2 diabetes mellitus (J. Kopecky in collaboration with L. Maletinska at the Institute of Organic Chemistry and Biochemistry CAS).<\/li>\n<li>Role of adipose tissue metabolim in development of cardiac cachexia (J. Kopecky in collaboration with V. Melenovsky and M. Haluzik at the Institute of clinical and experimental medicine).<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Related publication:\u00a0<a href=\"https:\/\/pubmed-ncbi-nlm-nih-gov.d360prx.biomed.cas.cz\/31740387\/\" target=\"_blank\" rel=\"noopener\">Brezinova et al. 2020 BBA-Mol Cell Biol L<\/a>;\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33084249\/\" target=\"_blank\" rel=\"noopener\">Janovska et al. 2020 J Cachexia, Sarcopenia Muscle<\/a><\/p>\n<p><strong>Activities:<\/strong><\/p>\n<p><a href=\"https:\/\/www.fgu.cas.cz\/en\/articles\/1143-konference-bioenergetika-2024-20-22-5\">Conference Bioenergetics 2024, May 20-22<\/a><\/p>\n<p><em>Project supported by National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) &#8211; Funded by the European Union \u2013 Next Generation EU.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our laboratory is involved in the research activities of the CarDia project (2022 \u2013 2025; see below) In particular, we focus on the following research areas: Synthesis and study of the effects of new hepatoselective analogues of human insulin for the potential treatment of type 1 and type 2 diabetes mellitus (M. Rossmeisl in collaboration [&hellip;]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[149],"poskytovatel":[],"stav-projektu":[209],"class_list":["post-30090","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-adipose-tissue-biology","stav-projektu-current-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30090","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30090\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=30090"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=30090"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=30090"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=30090"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}