{"id":30108,"date":"2024-08-22T15:51:25","date_gmt":"2024-08-22T13:51:25","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&#038;p=30108"},"modified":"2024-09-02T08:02:12","modified_gmt":"2024-09-02T06:02:12","slug":"the-role-of-intestine-in-the-metabolic-effects-of-dietary-supplementation-with-omega-3-fatty-acids-concluded-project","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/the-role-of-intestine-in-the-metabolic-effects-of-dietary-supplementation-with-omega-3-fatty-acids-concluded-project\/","title":{"rendered":"The role of intestine in the metabolic effects of dietary supplementation with omega-3 fatty acids (concluded project)"},"content":{"rendered":"<div>\n<p>Dietary supplementation with Omega-3 such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may protect against obesity while exerting hypolipidemic and anti-inflammatory effects. While the effects of omega-3 on lipid metabolism in the liver are relatively well known, changes in intestinal metabolism due to omega-3 administration have not yet been explored in detail. Our previous studies showed that metabolic effects are stronger when omega-3 are administered as phospholipids (Rossmeisl et al., PlosOne 2012). The main goal of this project is to identify the nature of metabolic effects of omega-3 administered in different lipid forms (triacylglycerols, phospholipids, wax esters), mainly with regard to the possible involvement of the intestine in these effects.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<p>Experiments will be performed in mice under obesogenic conditions induced by high-fat feeding, with the following specific aims:<\/p>\n<ol>\n<li>to assess the bioavailability of EPA and DHA using the so-called Omega-3 index as well as at the level of intestine;<\/li>\n<li>to identify the most regulated cellular processes that are affected in the intestine by dietary interventions with novel omega-3 concentrates;<\/li>\n<li>to compare lipid transport capacity and chylomicron secretion in mice previously fed high-fat diets supplemented with different lipid forms of omega-3;<\/li>\n<li>to reveal potential effects of chronic dietary intake of omega-3 with regard to modulation of endocrine function of the gastrointestinal system.<\/li>\n<\/ol>\n<p>Main publication output of the research team at IPHYS (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32660007\/\" target=\"_blank\" rel=\"noopener\">Kroupova et al. 2020. Nutrients<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<p><em>Supported by the CSF project no. 16-08124S (2016-2018, PI: Olga Horakova, PhD)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dietary supplementation with Omega-3 such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may protect against obesity while exerting hypolipidemic and anti-inflammatory effects. While the effects of omega-3 on lipid metabolism in the liver are relatively well known, changes in intestinal metabolism due to omega-3 administration have not yet been explored in detail. Our previous [&hellip;]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[149],"poskytovatel":[],"stav-projektu":[210],"class_list":["post-30108","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-adipose-tissue-biology","stav-projektu-finished-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30108\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=30108"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=30108"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=30108"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=30108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}