{"id":30111,"date":"2024-08-22T15:57:12","date_gmt":"2024-08-22T13:57:12","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&#038;p=30111"},"modified":"2024-09-02T08:03:21","modified_gmt":"2024-09-02T06:03:21","slug":"the-role-of-the-endocannabinoid-system-in-metabolic-effects-of-marine-omega-3-phospholipids-concluded-project","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/the-role-of-the-endocannabinoid-system-in-metabolic-effects-of-marine-omega-3-phospholipids-concluded-project\/","title":{"rendered":"The role of the endocannabinoid system in metabolic effects of marine omega-3 phospholipids (concluded project)"},"content":{"rendered":"<div>\n<p><strong>Metabolic disturbances in obesity are associated with dysregulation of the endocannabinoid (EC) system. We have shown in mice fed an obesogenic high-fat diet that metabolic effects of long-chain omega-3 fatty acids were stronger when supplied in the phospholipid form (omega-3 PL) as compared with triacylglycerols (<a href=\"http:\/\/www.plosone.org\/article\/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0038834&amp;representation=PDF\" target=\"_blank\" rel=\"noopener\">Rossmeisl et al. 2012. PloS One<\/a>). These effects were associated with a more efficient modulation of major EC molecules in white adipose tissue (WAT).<\/strong><\/p>\n<\/div>\n<p>In this project, we will characterize<\/p>\n<ol>\n<li>omega-3-induced changes in the content of EPA, DHA and other omega-3 fatty acids in relevant lipid fractions from WAT, liver and plasma, and their relationship to the levels of EC molecules and metabolic profile during obesity development<\/li>\n<li>mechanisms, by which omega-3 PL affect insulin sensitivity of the organism<\/li>\n<li>changes in lipid metabolism of hepatocytes due to the modulation of the EC system in WAT by omega-3 PL<\/li>\n<li>metabolic effects of omega-3 in transgenic mice carrying human PPARalpha.<\/li>\n<\/ol>\n<p>Our results will help to clarify, how modulation of the EC system by omega-3 contributes to their beneficial effects in obesity.<\/p>\n<p>Main publication outputs of the research team at IPHYS (<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29626526\/\" target=\"_blank\" rel=\"noopener\">Rossmeisl et al. 2018. BBA-Mol Cell Biol Lipids<\/a>; <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32371092\/\" target=\"_blank\" rel=\"noopener\">Rossmeisl et al. 2020. BBA-Mol Cell Biol Lipids<\/a>)<\/p>\n<p><em>Supported by the CSF projects (no. 14-09347S; 2014-2016; and no. 17-11027S, 2017-2019) PI: Martin Rossmeisl, MD, PhD.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Metabolic disturbances in obesity are associated with dysregulation of the endocannabinoid (EC) system. We have shown in mice fed an obesogenic high-fat diet that metabolic effects of long-chain omega-3 fatty acids were stronger when supplied in the phospholipid form (omega-3 PL) as compared with triacylglycerols (Rossmeisl et al. 2012. PloS One). These effects were associated [&hellip;]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[149],"poskytovatel":[],"stav-projektu":[210],"class_list":["post-30111","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-adipose-tissue-biology","stav-projektu-finished-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30111","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30111\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=30111"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=30111"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=30111"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=30111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}