{"id":30116,"date":"2024-08-23T19:59:19","date_gmt":"2024-08-23T17:59:19","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&p=30116"},"modified":"2024-09-02T08:05:27","modified_gmt":"2024-09-02T06:05:27","slug":"effects-of-omega-3-in-type-2-diabetic-patients-new-mechanisms-for-targeted-therapy-concluded-project","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/effects-of-omega-3-in-type-2-diabetic-patients-new-mechanisms-for-targeted-therapy-concluded-project\/","title":{"rendered":"Effects of omega-3 in type 2 diabetic patients \u2013 new mechanisms for targeted therapy (concluded project)"},"content":{"rendered":"
\n

Minor dietary components with proven biological effects play an important role in the complex treatment strategy of obesity-related diseases, however our knowledge regarding the mechanisms of their action is relatively limited. The aim of this project is to identify novel mechanisms behind the beneficial effects of omega-3 in patients with type 2 diabetes mellitus (DM), i.e. the only dietary component with clearly demonstrated beneficial effects on dyslipidemia and cardiovascular mortality and morbidity in the diabetic patients.\u00a0<\/strong><\/p>\n<\/div>\n

Based on our results in a mouse model of metabolic syndrome (Kuda et al. 2009. Diabetologia<\/a>;\u00a0Horakova et al. 2012. PLoS One<\/a>;\u00a0Kus et al. 2011. PLoS One<\/a>), and by taking advantage of available clinical\u00a0 data and biological materials (plasma, adipose and muscle tissue) collected during the previous randomized, placebo-controlled, intervention study in DM patients treated with metformin (6-month-long intervention; groups, n=15: placebo, omega-3, placebo+pioglitazone, omega-3+pioglitazone), we focus on:<\/p>\n

    \n
  1. novel regulatory mechanisms (adipokines\/cytokines, lipid mediators, endocannabinoids), through which omega-3 affect lipid metabolism and mitigate low-grade chronic inflammation and accumulation of adipose tissue<\/li>\n
  2. mechanisms, which differentiate the effects of\u00a0 omega-3 and pioglitazone on insulin sensitivity in patients; and possible improvements of glucose homeostasis in response to a modulation of incretin system by omega-3<\/li>\n
  3. identification of novel markers of sensitivity to treatment, based on targeted metabolomic analysis in plasma of patients.<\/li>\n<\/ol>\n

     <\/p>\n

    Project will help to understand the mechanisms, by which omega-3\u00a0 normalize lipid metabolism and mitigate low-grade inflammation in patients with DM, specifically in those treated with metformin (or metformin + pioglitazone). The results will help to<\/p>\n

      \n
    1. rationalize the use of omega-3 in the treatment of DM patients and in the prevention of cardiovascular diseases in these patients<\/li>\n
    2. establish a personalized treatment of the patients.<\/li>\n<\/ol>\n

       <\/p>\n

      Supported by the Ministry of Health of the Czech Republic (NT13763-4;\u00a0 2012-2015; PI: Jan Kopeck\u00fd, MD, DSc;\u00a0 collaborator: prof. Terezie Pelik\u00e1nov\u00e1, MD, DSc, Diabetes Centre, IKEM, Prague).<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

      Minor dietary components with proven biological effects play an important role in the complex treatment strategy of obesity-related diseases, however our knowledge regarding the mechanisms of their action is relatively limited. The aim of this project is to identify novel mechanisms behind the beneficial effects of omega-3 in patients with type 2 diabetes mellitus (DM), […]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[149],"poskytovatel":[],"stav-projektu":[210],"class_list":["post-30116","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-adipose-tissue-biology","stav-projektu-finished-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30116\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=30116"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=30116"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=30116"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=30116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}