{"id":30126,"date":"2024-08-23T20:09:45","date_gmt":"2024-08-23T18:09:45","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&#038;p=30126"},"modified":"2024-09-02T08:09:47","modified_gmt":"2024-09-02T06:09:47","slug":"modified-lignin-as-a-potential-new-food-supplement-with-antioxidant-effects-concluded-project","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/modified-lignin-as-a-potential-new-food-supplement-with-antioxidant-effects-concluded-project\/","title":{"rendered":"Modified lignin as a potential new food supplement with antioxidant effects (concluded project)"},"content":{"rendered":"<div>\n<p><strong>This project focuses on biological activity of modified lignin that can be isolated from a by-product of paper and cellulose production. Modified lignin could apply to biomedicine as a food supplement with antioxidant effects, which could protect organism against negative environmental factors and diseases of affluence.\u00a0<\/strong><\/p>\n<\/div>\n<p>Effects of lignin will be characterized:<\/p>\n<ol>\n<li><em>in vitro <\/em>by testing cytotoxicity, genotoxicity, antioxidant effects, and occurrence of DNA modifications; as well as<\/li>\n<li><em>in vivo<\/em> using an animal experimental model of diet-induced obesity and metabolic syndrome to reveal potential protective effects on tissue damage, low-grade chronic inflammation, and oxidative stress. Furthermore, we will characterize the effects of lignin on lipid and glucose homeostasis by quantification of appropriate metabolites levels in plasma.<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>This project is based on our unique collaboration with commercial company <a href=\"http:\/\/www.vidia.cz\/index.php?lang=en\" target=\"_blank\" rel=\"noopener\">VIDIA Inc.<\/a> (Vestec), which focuses on a development of diagnostics in human medicine and environment. The results should help to introduce new nutritional supplements to protect humans against diseases of affluence, such as obesity, type 2 diabetes, and cardiovascular disease.<\/p>\n<p>&nbsp;<\/p>\n<p><em>Supported by the Technology Agency of the Czech Republic (TA03010581; 2013-2015, PI: Ing. Michaela Pol\u00e1kov\u00e1, VIDIA Inc.; co-PI:<\/em><em> Martin Rossmeisl, MD, PhD, Institute of Physiology, CAS.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This project focuses on biological activity of modified lignin that can be isolated from a by-product of paper and cellulose production. Modified lignin could apply to biomedicine as a food supplement with antioxidant effects, which could protect organism against negative environmental factors and diseases of affluence.\u00a0 Effects of lignin will be characterized: in vitro by [&hellip;]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[149],"poskytovatel":[],"stav-projektu":[210],"class_list":["post-30126","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-adipose-tissue-biology","stav-projektu-finished-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30126","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30126\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=30126"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=30126"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=30126"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=30126"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}