{"id":30147,"date":"2024-08-22T10:28:33","date_gmt":"2024-08-22T08:28:33","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&#038;p=30147"},"modified":"2024-09-02T08:39:32","modified_gmt":"2024-09-02T06:39:32","slug":"impact-of-antiepileptic-therapy-on-the-brain-development","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/impact-of-antiepileptic-therapy-on-the-brain-development\/","title":{"rendered":"Impact of antiepileptic therapy on the brain development"},"content":{"rendered":"<div>\n<p><strong>Period of perinatal and early postnatal development represents critical time for future brain functions and capabilities, as brain plasticity permits experiences to shape the immature brain.\u00a0<\/strong><\/p>\n<\/div>\n<p><span class=\"Normal_0020_0028Web_0029__Char\">The immature brain differs from the adult brain in its response to antiepileptic drugs. Experimental evidence from animal models has revealed that treatment with antiepileptic drugs can alter normal brain development. The immature brain also shows greater variability in pharmacological responses and cognitive or behavioral side effects. The aim of our research is to detect age related differences in pharmacodynamics of antiepileptic drugs and identify possible adverse effects of both clinically used and potential antiepileptic drugs on the brain development and functions later in life. In future, our research can help to develop new, age specific and safe antiepileptic drugs for pediatric patients with epilepsy.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-26171 aligncenter\" src=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/fig-3.jpg\" alt=\"-\" width=\"978\" height=\"688\" title=\"\" srcset=\"https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/fig-3.jpg 978w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/fig-3-300x211.jpg 300w, https:\/\/fgu.cas.cz\/wp-content\/uploads\/2024\/08\/fig-3-768x540.jpg 768w\" sizes=\"(max-width: 978px) 100vw, 978px\" \/><\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19146832\" target=\"_blank\" rel=\"noopener\"><strong>Tsenov et al, Brain Res, 2009<\/strong><\/a><\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21130691\" target=\"_blank\" rel=\"noopener\"><strong>Mikuleck\u00e1 et al, Epilepsy Behav, 2011<\/strong><\/a><\/p>\n<p class=\"Normal\"><span class=\"Normal__Char\">Mikuleck\u00e1 et al, <\/span><span class=\"Normal__Char\">Front Behav Neurosci. 2014a<\/span><\/p>\n<p class=\"Normal\"><span class=\"Normal__Char\">Mikuleck\u00e1 et al, <\/span><span class=\"Normal__Char\">Front Behav Neurosci. 2014b<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Period of perinatal and early postnatal development represents critical time for future brain functions and capabilities, as brain plasticity permits experiences to shape the immature brain.\u00a0 The immature brain differs from the adult brain in its response to antiepileptic drugs. Experimental evidence from animal models has revealed that treatment with antiepileptic drugs can alter normal [&hellip;]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[145],"poskytovatel":[],"stav-projektu":[209],"class_list":["post-30147","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-developmental-epileptology","stav-projektu-current-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30147\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=30147"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=30147"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=30147"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=30147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}