{"id":30215,"date":"2025-09-10T15:11:54","date_gmt":"2025-09-10T13:11:54","guid":{"rendered":"https:\/\/fgu.antstudio.dev\/?post_type=vyzkumny-projekt&p=30215"},"modified":"2025-09-11T09:16:40","modified_gmt":"2025-09-11T07:16:40","slug":"neurosteroids-positive-and-negative-allosteric-p2x-receptor-modulators","status":"publish","type":"vyzkumny-projekt","link":"https:\/\/fgu.cas.cz\/en\/research-project\/neurosteroids-positive-and-negative-allosteric-p2x-receptor-modulators\/","title":{"rendered":"Neurosteroids: positive and negative allosteric P2X receptor modulators"},"content":{"rendered":"
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Syntetick\u00e9 deriv\u00edty testosteropnu zy\u0161uj\u00ed aktivitu P2X receptorov\u00fdch kan\u00e1l\u016f vazbou na m\u00edst\u011b, kter\u00e9 se \u010d\u00e1ste\u010dn\u011b p\u0159ekr\u00fdv\u00e1 s\u00a0vazebn\u00fdm m\u00edstem pro P2X4-specifick\u00fd alosterick\u00fd modul\u00e1tor ivermektin.<\/em><\/p>\n

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Rupert M, Bhattacharya A, Stillerova VT, Jindrichova M, Mokdad A, Boue-Grabot E, Zemkova H: Role of Conserved Residues and F322 in the Extracellular Vestibule of the Rat P2X7 Receptor in Its Expression, Function and Dye Uptake Ability. International Journal of Molecular Sciences Nov 10;21(22):E8446 (2020) DOI<\/a>,\u00a0IF=5.924<\/p>\n

Sivcev S, Slavikova B, Rupert M, Ivetic M, Nekardova M, Kudova E. Zemkova H: Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating. J Neurochem 150, 28-43 (2019) DOI<\/a>, IF=5.372<\/p>\n

Sivcev S, Slavikova B, Ivetic M, Kn\u011bz\u016f M, Kudova E, Zemkova H: Title: Lithocholic acid inhibits P2X2 and potentiates P2X4 receptor channel ating. Journal of Steroid Biochemistry and Molecular Biology 202:105725 (2020) DOI<\/a>,\u00a0IF=4.294<\/p>\n","protected":false},"excerpt":{"rendered":"

  Syntetick\u00e9 deriv\u00edty testosteropnu zy\u0161uj\u00ed aktivitu P2X receptorov\u00fdch kan\u00e1l\u016f vazbou na m\u00edst\u011b, kter\u00e9 se \u010d\u00e1ste\u010dn\u011b p\u0159ekr\u00fdv\u00e1 s\u00a0vazebn\u00fdm m\u00edstem pro P2X4-specifick\u00fd alosterick\u00fd modul\u00e1tor ivermektin.   Rupert M, Bhattacharya A, Stillerova VT, Jindrichova M, Mokdad A, Boue-Grabot E, Zemkova H: Role of Conserved Residues and F322 in the Extracellular Vestibule of the Rat P2X7 Receptor in Its […]<\/p>\n","protected":false},"author":1,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"oddeleni":[185],"poskytovatel":[],"stav-projektu":[209],"class_list":["post-30215","vyzkumny-projekt","type-vyzkumny-projekt","status-publish","hentry","oddeleni-pain-research","stav-projektu-current-projects"],"acf":[],"_links":{"self":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt"}],"about":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/types\/vyzkumny-projekt"}],"author":[{"embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":0,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/vyzkumny-projekt\/30215\/revisions"}],"wp:attachment":[{"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/media?parent=30215"}],"wp:term":[{"taxonomy":"oddeleni","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/oddeleni?post=30215"},{"taxonomy":"poskytovatel","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/poskytovatel?post=30215"},{"taxonomy":"stav-projektu","embeddable":true,"href":"https:\/\/fgu.cas.cz\/en\/wp-json\/wp\/v2\/stav-projektu?post=30215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}