Jan Krůšek

Given the importance of NMDA receptor function in physiology and pathology, we study the relationship between the receptor structure and its function.  We are particularly interested in the role of linker regions connecting the ligand-binding domain and the ion channel. Our results will contribute to a more detailed understanding of the mechanism of ion channel opening and may help identify novel regulators of NMDA receptor function.  (This project is in collaboration with Dr. J. Černý, BTU, CAS.)