Jan Krůšek, Ivan Dittert

Boron-doped diamond (BDD) is a promising material in constructing conductive biocompatible devices, such as multielectrode arrays for recording of neuronal electric activity, or electrochemical detectors for neurotransmitter release detection. Cultivation and recording of  neuronal network activity depends on longterm survival of neurons which is improved by boron-doped diamond surface modification by poly-L-lysine. (This project is in collaboration with  IP CAS, CTU and Charles University).

Boron-doped diamond-covered multielectrode chamber with a gas-permeable lid.  Recording of spontaneous hippocampal neuronal activity on day 14 in vitro on 5 boron-doped diamond electrodes.