Premature birth and its complications are the number one cause of death among children under 5 years of age and could impose long-term developmental and health problems. To improve the prognosis of premature newborns, it is necessary to understand the causes of their insufficient postnatal adaptation that depends on the changes in energy metabolism and other mechanisms. However, this research is limited by the lack of clinical materials.
The project characterizes perinatal and especially early postnatal development using a unique biobank of
In the heart, skeletal muscle and liver, the whole transcriptome will be characterized using RNA sequencing, mitochondrial DNA will be quantified and levels of selected proteins will be evaluated using immunohistochemistry
Supported by the Ministry of health of the Czech Republic project no. NU20-07-00026 (2020-2024, PI: Jan Kopecký, MD, DSc., IPHYS)