The Bureš Lectures are a series of publicly accessible colloquia given by world-renowned scientific personalities. The lecture series was initiated in 2013 as part of the celebration of the 60th anniversary of the Institute of Physiology. It is named in the honor of Dr. Jan Bureš (13. 6. 1926 – 24. 8. 2012), an outstanding neuroscientist who worked in the Institute of Physiology starting in the 1950s. During his illustrious career in the institute, he investigated especially the mechanisms of cortical spreading depression in brain activity, as well as the neural mechanisms of memory, spatial perception and orientation.
Date: 17. 4. 2023, 3 PM
Place: IPHYS Lecture hall, Vídeňská 1083
Lecture topic: "Circadian Clocks The genes, cells and circuits that time our lives"
IPHYS Contact Person: Alena Sumová, alena.sumova@fgu.cas.cz
Date: 19. 11. 2018, 3 PM
Place: IPHYS Lecture hall, Vídeňská 1083
Lecture topic: Molecular checkpoints in the development and treatment of metabolic disorders
IPHYS Contact Person: Jan Kopecky (jan.kopecky@fgu.cas.cz)
Date: 19. 11. 2018, 15,00 hod.
Place: kinosál FGÚ, Vídeňská 1083
Lecture topic: Neuroinflammation in epilepsy: mechanisms and therapeutic perspectives
IPHYS Contact Person: Jakub Otáhak (jakub.otahal@fgu.cas.cz)
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Japan
Date: 2. 10. 2017, 3 PM
Place: IPHYS Lecture hall, Vídeňská 1083
Lecture topic: "Towards the mysteries of sleep: Forward genetic analysis of sleep behavior in mice"
The mechanism of sleep represents one of the greatest mysteries in today's neuroscience. The simple question as to why we have to sleep, as well as what is the physical substrate for "sleepiness," still remain unanswered. We tackle these problems by using a non-hypothesis-based exploratory approach through a large-scale, forward genetic screen of randomly mutagenized mice with EEG/EMG-based sleep/wake recording.
The University of Texas Southwestern Medical Center, USA
Date: 21. 10. 2016, 2 PM
Place: Milan Hasek Auditorium, IMG building, Vídeňská 1083
Lecture topic: "The Multifaceted Roles of Adipose Tissue: Therapeutic Targets for Diabetes, Cancer and Beyond"
Philipp Scherer is Professor and Director of the Touchstone Diabetes Center at the University of Texas Southwestern Medical Center in Dallas. Dr. Scherer received his Ph.D. degree from the University of Basel, Switzerland, followed by post-doctoral training the Whitehead Institute at MIT in Cambridge. In 1997, he joined the faculty of the Albert Einstein College of Medicine where he was a Professor for Cell Biology and Medicine. Throughout his career, he has maintained an interest in processes related to cellular and systemic energy homeostasis. During his Ph.D., he identified several components of the mitochondrial protein import machinery. While a post-doc, he identified adiponectin, one of the first secretory factors to be described that almost exclusively originate in adipose tissue and which is currently widely studied by many different research groups. Current efforts in his laboratory are focused on the identification and physiological characterization of novel proteins that serve as potential links between the adipocyte, liver, the pancreatic beta cell and the processes of whole body energy homeostasis, inflammation, cancer and cardiovascular disease. His research team aims to identify novel targets for pharmacological intervention and to further define the role of adipose tissue as an endocrine organ.
Prof. Scherer is the recipient of numerous scientific honors, including the O´Donnell Award in Medicine (2012) and the Banting Medal – the highest award of the American Diabetes Association (2015). To date, his publications have recived over 35 000 citations in the scientific literature (h-index 97).
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. An overview will be provided of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beigin/britening as well as reduction of inflammation and fibrosis.
Partners of the lecture:
Mc Gill University, Canada
Lecture "The role of mitochondrial RNA granules in mitochondrial biogenesis", December 14, 2015
The University of Arizona, USA
Lecture: "New Approaches to Drug Design: Multivalency in Drug Design for the Disease State", June 10, 2015
University of Massachusetts Medical School, USA
Lecture: "Insulin in Control of Energy Expenditure", May 11, 2015
Programme and the nformation about the speaker
University of Manitoba, Winnipeg, Canada
Lecture: "The unique challenges of a clinical trial focused on the impact of natural health products on cardiovascular disease", February 9, 2015
University of Stockholm, Sweden
Lecture: "Brown adipose tissue: the mammalian prerogative", February 14, 2014
University of Eastern Finland, Finland
Lecture" "Preventing the development of epilepsy after brain injury – How far are we in 2014?", April 10, 2014
University of Virginia, USA
Lecture: „The Promise of Circadian Biology“, July 2, 2014
Universität Leipzig, Germany
Lecture: „Purinergic regulation of neural progenitor cell functions in the brain“, September 25, 2014
Virginia Tech Carilion Research Institute, USA
Lecture: „Multiple Roles of Connexins in Biology and Medicine“, October 13, 2014
Janelia Research Campus, USA
Lecture: „Hippocampus and episodic memory“, December 17, 2014
University of Arizona, USA
Lecture: "Memory and Context: The Role of the Hippocampus", September 11, 2013
Sars International Centre for Marine Molecular Biology, Norway
Lecture: "From Genomes to Morphology – The Evolution of Developmental Diversity", December 16, 2013
Scientific part: RNDr. Martin Zápotocký, PhD. tel. +420 241 062 708, zapotocky@biomed.cas.cz
Organizational part: Diana Moosová, tel. +420 241 062 413, diana.moosova@fgu.cas.cz
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