Laboratory of Molecular Neurobiology

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Laboratory of Molecular Neurobiology -

Left: GFP-labeled hippocampal granule cells (green), in utero electroporated. Middle: Dendrites (arrows) and dendritic spines (inset) of cortical pyramidal neurons (red) and their 3D model. Right: NFL antibody-stained peripheral neurons in E11.5 embryos.

About the Laboratory

Defects in signaling cascades are considered to contribute to many neurodevelopmental and neurodegenerative disorders, but the exact molecular mechanisms underlying the onset of these diseases are so far largely unknown. Using mouse models and primary neuron cultures, we focus on identification of genes, molecular mechanism and signaling cascades that regulate neuron polarization, axonal/dendritic growth and guidance in the developing nervous system, and their deregulation that leads to neurodevelopmental disorders as autism spectrum disordersepilepsy or schizophrenia.

Our work focuses on:

  • the function of microtubule associated proteins of CRMP family and their isoforms in neural development
  • regulation of CRMP isoforms by prolyl isomerases during growth and guidance of axons/dendrites
  • the efect of tubulin pottranslational modifications and microtubule associated proteins on microtubule dynamics and cortical development in vitro and in vivo

Publications

Procházková; N. - Nguyenova; M.-T. - Řehořová; M. - Kudláček; J. - Chvojka; J. - Žiak; Jakub - Balaštík; Martin - Otáhal; J. - Jiruška; P. - Novák; O. NeuroPorator: An open-source; current-limited electroporator for safe in utero gene transfer. Journal of Neuroscience Methods. 2024; 406(June); 110126.

IF = 2.7

Cheema; Marie Munawar - Kotrbová Macáková; Zuzana - Hrčka Krausová; Barbora - Adla; Santosh Kumar - Slavíková; Barbora - Chodounská; Hana - Kratochvíl; Miroslav - Vondrášek; Jiří - Sedlák; David - Balaštík; Martin - Kudová; Eva 5?-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia. Journal of Steroid Biochemistry and Molecular Biology. 2024; 239(May); 106464.

IF = 2.7

Chvojka; J. - Procházková; N. - Řehořová; M. - Kudláček; J. - Kylarová; S. - Králiková; M. - Buran; Peter - Weissová; Romana - Balaštík; Martin - Jefferys; J. G. R. - Novák; O. - Jiruška; P. Mouse model of focal cortical dysplasia type II generates a wide spectrum of high-frequency activities. Neurobiology of Disease. 2024; 190(January); 106383.

IF = 5.1

Havelka; D. - Zhernov; Ilia - Teplan; M. - Lánský; Zdeněk - Chafai; Djamel Eddine - Cifra; M. Lab-on-chip microscope platform for electro-manipulation of a dense microtubules network. Scientific Reports. 2022; 12(1)); 2462.

IF = 4.6

Průša; J. - Taha Ayoub; A. - Chafai; Djamel Eddine - Havelka; D. - Cifra; M. Electro-opening of a microtubule lattice in silico. Computational and Structural Biotechnology Journal. 2021; 19(Mar 4); 1488-1496.

IF = 6.155

Maimon; R. - Ankol; L. - Pery; T. G. - Altman; T. - Ionescu; A. - Weissová; Romana - Ostrovsky; M. - Tank; E. - Alexandra; G. - Shelestovich; N. - Opatowsky; Y. - Dori; A. - Barmada; S. - Balaštík; Martin - Perlson; E. A CRMP4-dependent retrograde axon-to-soma death signal in amyotrophic lateral sclerosis. EMBO Journal. 2021; 40(17)); e107586.

IF = 13.783

People

Head of Laboratory

Vedoucí vědecký pracovník
Tel: 2822
Email: martin.balastik@fgu.cas.cz

Deputy Head of Laboratory

Tel: 2821
Email: romana.weissova@.fgu.cas.cz

Laboratory staff

Laborantka
Tel: 2821
Email: polina.belyaeva@fgu.cas.cz
Tel: 2821
Email: dominika.kubinova@fgu.cas.cz
Vědecký asistent
Tel: 2545
Email: lenka.polidarova@fgu.cas.cz
Tel: 2821
Email: pukajova.barbora@fgu.cas.cz
Doktorand
Tel: 2821
Email: maria.ruiz@fgu.cas.cz
Tel: 2821
Email: michaela.ruskova@fgu.cas.cz