Laboratory of Cellular Neurophysiology

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About the Laboratory

Research of the Laboratory of Cellular Neurophysiology focuses on the function and pharmacology of ionotropic receptors (ligand-activated ion channels), specifically ionotropic glutamate receptors (iGluRs) and transient receptor potential (TRP) channels. iGluRs mediate the majority of excitatory signaling in the central nervous system, are essential for normal brain development and function, and their dysfunction leads to serious neurological and psychiatric disorders, including many forms of neurodegeneration. TRP channels are present in both the peripheral and the central nervous system, and they play a fundamental role in the detection and transmission of painful stimuli and participate in signaling associated with chronic inflammation.

The goal of our research is to better characterize the relationship between ionotropic receptor structure and function, to identify molecular mechanisms of ionotropic receptor modulation by different chemical compounds or physical variables, and to describe the consequences of mutations of human ionotropic receptors for the function of synapses, neurons and neuronal networks. Obtained results deepen our basic understanding of the mechanisms of ionotropic receptor function, and inform the development of novel receptor modulators with therapeutic potential in the treatment of neurodevelopmental and neurodegenerative disorders.

History of the Laboratory

METHODS

Alumni list

History of the Laboratory II

Projects

TRP channel research

Glutamate receptor research

Publications

Fili; Klevinda - Kuchtiak; Viktor - Tomović; Eni - Candelas Serra; Miriam - Kubik-Zahorodna; Agnieszka - Harant; K. - Božíková; Paulína - Černý; Jiří - Kořínek; Miloslav - Hrčka Krausová; Barbora - Abramová; Vera - Dobrovolski; Mark - Abdelrahman; Fatma Elzahraa Sultan - Procházka; Jan - Balík; Aleš - Smejkalová; Tereza - Vyklický ml.; Ladislav Mice carrying a GluN2B protein-truncating variant have altered NMDA receptor subunit composition and their behavior recapitulates patient phenotypes. Cellular and Molecular Life Sciences. 2026; 83(30 Jan); 89.

IF = 6.2

Adla; Santosh Kumar - Hrčka Krausová; Barbora - Kysilov; Bohdan - Kudláček; Karel - Souček; Radko - Buděšínský; Miloš - Voldřich; Jan - Vyklický ml.; Ladislav - Kudová; Eva Positive modulators of N-methyl-d-aspartate receptor: structure–activity relationship study on steroidal C-17 and C-20 oxime ethers. RSC Advances. 2026; 16(12); 10769-10784.

IF = 4.6

Kubištová; A. - Spišská; V. - Málková; P. - Novotný; J. - Telenský; P. - Balík; Aleš - Bendová; Z. Low-Intensity Constant Light During Early Postnatal Development Induces Sex-Specific Anxiety-Like Behaviour and Region- and Sex-Specific Changes in Circadian Gene Expression and RNA Editing. Cellular and Molecular Neurobiology. 2026; 46(8 Jan); 6.

IF = 4.8

Kádková; Anna - Kosinová; Kamila - Kloučková; Markéta - Strachotová; D. - Barvík; I. - Zímová; Lucie - Vlachová; Viktorie TRPV2 and TRPC5 are potential targets for astringent phytochemicals. Current Research in Food Science. 2026; 12(Jan); 101306.

IF = 7

Abramová; Vera - Tomović; Eni - Kysilov; Bohdan - Kořínek; Miloslav - Dobrovolski; Mark - Hrčka Krausová; Barbora - Fili; Klevinda - Abdelrahman; Fatma Elzahraa Sultan - Božíková; Paulína - Černý; Jiří - Smejkalová; Tereza - Balík; Aleš - Vyklický ml.; Ladislav Disruption of grin2A; an Epilepsy-Associated Gene; Produces Altered Spontaneous Swim Behavior in Zebrafish. Journal of Neuroscience. 2025; 45(33); e0946252025.

IF = 4

Mitro; Michal - Ptáková; Alexandra - Vlachová; Viktorie - Zímová; Lucie Cytoplasmic inter-subunit interface modulates TRPC5 activity: Molecular mechanism behind intellectual disability-related R175C mutation. Neurobiology of Disease. 2025; 215(15 Oct); 107082.

IF = 5.6