Laboratory of Molecular Physiology of Bone

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Left: μCT analysis of bone and osmium-stained bone marrow adipose tissue (BMAT) in chow (ND) and high-fat diet (HFD) mice. Right: Isolation protocol of bone marrow skeletal stem cells and their differentiation in osteoblasts (OB) and adipocytes (AD).

About the Laboratory

In obesity, lipids are accumulated in liver, muscle or cardiovascular system, instead of adipose tissue. Recent studies have shown that bones are also affected, leading to enhanced adipocyte formation in bone marrow (BMAT). Higher BMAT is often associated with bone fragility fractures, an overlooked complication affecting the quality of life. There is limited information on a physiological role of BMAT in relation to bone and whole body energy metabolism. The major focus of the department is on the characterization of the metabolic phenotype of BMAT and its contribution to bone homeostasis and whole body energy metabolism. The research will employ murine and human cellular systems, mice biomodels, clinical studies and molecular, bioanalytical and in vivo phenotyping techniques. It will be conducted within a broad international collaboration.

The department has been newly established in 2019, based on the 5-year “Start Up Research Program” financed by IPHYS.

We always welcome new motivated students from various scientific backgrounds, just contact us via email.

Achievements

Grants awarded to the Tencerova laboratory: 2022: 3-year Research grant from Czech Science Foundation (PI: Michaela Tencerova) 2021: L’Oréal-UNESCO For Women in Science 2021: 3-year Student research grant from GAUK (PI: Andrea Benova) 2020: 5-year EFSD/Novo Nordisk Foundation Future Leaders Award (PI: Michaela Tencerova) 2020: 3-year Research grant from Czech Science Foundation (PI: Michaela Tencerova) 2019: 5-year START UP Research program supported by IPHYS (PI: Michaela Tencerova) 2022: ECTS Academy fellowship 2023: 3- year Research grant from the Ministry of Health (PI: Michaela Tencerova) More

Publications

Mrázková; Lucie - Lubos; Marta - Voldřich; Jan - Kužmová; Erika - Zrubecká; Denisa - Gwozdiaková; Petra - Buděšínský; Miloš - Asai; Seiya - Marek; Aleš - Pícha; Jan - Tencerová; Michaela - Ferenčáková; Michaela - Barrera Alquicer; Glenda - Kaminský; Jakub - Jiráček; Jiří - Žáková; Lenka The final walk with preptin. PLoS ONE. 2024; 19(9); e0309726.

IF = 2.9

Džubanová; Martina - Beňová; Andrea - Ferenčáková; Michaela - Coupeau; Roman - Tencerová; Michaela Nutrition and Bone Marrow Adiposity in Relation to Bone Health. Physiological Research. 2024; 73(Suppl.1); S107-S138.

IF = 1.9

Džubanová; Martina - Bond; J. M. - Craige; S. M. - Tencerová; Michaela NOX4-reactive oxygen species axis: critical regulators of bone health and metabolism. Frontiers in Cell and Developmental Biology. 2024; 12(12 AUG); 1432668.

IF = 4.6

Balcaen; T. - Beňová; Andrea - de Jong; F. - Silva; R. O. - Čajka; Tomáš - Sakellariou; D. - Tencerová; Michaela - Kerckhofs; G. - De Borggraeve; W. M. Exploring contrast-enhancing staining agents for studying adipose tissue through contrast-enhanced computed tomography. Journal of Lipid Research. 2024; 65(7); 100572.

IF = 5.0

Tencerová; Michaela - Duque; G. - Beekman; K. M. - Corsi; A. - Geurts; J. - Bisschop; P. H. - Paccou; J. The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism. Nutrients. 2023; 15(21); 4601.

IF = 4.8

van der Eerden; B. C. J. - Riddle; R. C. - Stegen; S. - Tencerová; Michaela Editorial: Energy metabolism within the skeleton. Frontiers in Physiology. 2023; 14(May 22); 1205435.

IF = 3.2