Exploring the role of circular RNAs and m6A methylation in early life stress-induced psychiatric disorders
Description: Early life stress (ELS) is a major risk factor for psychiatric disorders such as schizophrenia and depression, with long-lasting effects on brain function. Emerging evidence suggests that circRNAs are highly responsive to stress, with altered expression and m6A modifications potentially mediating the link between ELS and synaptic dysfunction. This project will investigate the differential […]
M.A. Lalit Kaurani Ph.D.
Profiling tRNA-derived fragments (tRFs) and their functional role in Schizophrenia
Description: tRNA-derived fragments (tRFs) are newly recognized regulators of gene expression, translation, and stress responses. This project will profile tRFs in schizophrenia using RNA sequencing and investigate their roles in neuroinflammation and synaptic dysfunction—key features of the disorder. By integrating human neuronal and glial co-culture systems with murine schizophrenia models, the study aims to elucidate […]
Investigating the role of circular RNAs and their m6A methylation in synaptic dysregulation in Alzheimer’s Disease
Description: Circular RNAs (circRNAs) are emerging as crucial regulators of synaptic plasticity and neuronal health. This project aims to uncover how circRNA expression and their m6A methylation patterns are altered in Alzheimer’s Disease (AD). By employing high-throughput RNA sequencing, m6A profiling, and advanced computational analyses, the study will identify circRNAs critical to synaptic function and […]
