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INSTITUTE OF PHYSIOLOGY CAS

Cutting-edge science for health

Laboratory of Experimental Hypertension

Laboratory of Experimental Hypertension

The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure  regulation and end-organ damage in rats with different types of experimental hypertension.

Our research is focused mainly on:

  • Study of the central mechanisms of blood pressure regulation in rats with hypertension with a focus on the brain renin-angiotensin system, oxidative stress and baroreflex control of sympathetic tone – cooperation with the Institute for Translational Research in Biomedicine, Kaohsiung, Taiwan and Institute for Clinical and Experimental Medicine, Prague.
  • Search for the cardiovascular, renal and metabolic mechanisms of gliflozins, a new group of antidiabetics, in experimental hypertension and chronic kidney disease –  cooperation with Institute for Clinical and Experimental Medicine, Prague.
  • Elucidation of the mechanisms by which renin-angiotensin and endothelin systems participate  in renal damage in transgenic rats with inserted mouse renin gene (Ren-2 TGR) – cooperation with  Mossakowski Medical Research Centre, Warsaw, Poland.
  • Investigation of the cardiovascular effects of new analogs of neuropeptides regulating food intake in rats – cooperation with IOCHB CAS, Prague.

Projects

Achievements

Publications

Rauchová; Hana - Hojná; Silvie - Kadlecová; Michaela - Vaněčková; Ivana - Zicha; Josef . Sex differences in blood pressure of aged Ren-2 transgenic rats . Physiological Research. 2020; 69(2); 245-252 . IF = 1.655 [ASEP] [ doi ]
Kořínková; L. - Holubová; M. - Neprašová; B. - Hrubá; L. - Pražienková; V. - Bencze; Michal - Haluzík; M. - Kuneš; Jaroslav - Maletínská; L. - Železná; B. Synergistic effect of leptin and lipidized PrRP on metabolic pathways in ob/ob mice . Journal of Molecular Endocrinology. 2020; 64(2); 77-90 . IF = 3.562 [ASEP] [ doi ]
Zicha, Josef - Hojná, Silvie - Kopkan, L. - Červenka, L. - Vaněčková, Ivana . The Absence of Sympathoexcitation During the Development of Hypertension in Cyp1a1 Ren-2 Transgenic Rats . Physiological Research 2019, 68(2), 329-334 . IF = 1.655 [ASEP] [ doi ]
Walkowska; A. - Vaněčková; Ivana - Sadowski; J. - Kompanowska - Jezierska; E. Rapid blood pressure increase after renal denervation in anaesthetized rats: interaction of oxidative stress and neuronal nitric oxide synthase . JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2019; 70(4); 613-618 . IF = 2.644 [ASEP] [ doi ]
Vavřínová; Anna - Behuliak; Michal - Bencze; Michal - Vodička; Martin - Ergang; Peter - Vaněčková; Ivana - Zicha; Josef . Sympathectomy-induced blood pressure reduction in adult normotensive and hypertensive rats is counteracted by enhanced cardiovascular sensitivity to vasoconstrictors . Hypertension Research. 2019; 42; 1872-1882 . IF = 2.941 [ASEP] [ doi ]

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People

  RNDr. Ivana Vaněčková, DSc.
Head of the Laboratory
  MUDr. Josef Zicha, DrSc.
Deputy Head of the Laboratory
  RNDr. Jaroslav Kuneš, DrSc.
Senior Researcher
  RNDr. Milada Dobiášová, DrSc.
Senior Researcher
  MUDr. Hana Rauchová, CSc.
Senior Researcher
  RNDr. Michaela Kadlecová, Ph.D.
Junior Researcher
  Mgr. Michal Behuliak, Ph.D.
Junior Researcher
  Mgr. Silvie Hojná, Ph.D.
Junior Researcher
  RNDr. Lenka Řezáčová, Ph.D.
Postdoctoral Fellow
  Mgr. Michal Bencze, Ph.D.
Postdoctoral Fellow
  Mgr. Anna Vavřínová
PhD Student
  Bc. Natálie Drábková
Undergraduate Student
  Alena Charvátová
Technician
  Zdeňka Kopecká
Technician