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Laboratory of Biological Rhythms

Laboratory of Biological Rhythms From the left: Central clock in the brain - the suprachiasmatic nucleus (SCN); glial cells in the SCN; lcocomotor activity records of rats; neurons in hippocampus; clock gene expression in the SCN with a phase plot.

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In the center of our interest is the endogenous time-keeping system, circadian clock of mammals, including humans. The system temporally regulates rhythmic processes in our body so that they take place at the proper time of day and are optimally synchronized relative to each other.

A failure of the temporal regulation has a negative impact on human health. Using in vivo and in vitro models, we study the molecular mechanisms underlying the circadian clock as well as the resulting physiological and behavioral rhythms.

We focus on the following questions:

  • What are the mechanisms for entraining (synchronizing) the circadian system and what are the consequences of its failure?
  • How does the circadian system develop and how is it being entrained during ontogeny?
  • How is the circadian system of humans entrained in real life conditions, both in health and in disease?

 

          

Fig. PER2 protein in the SCN, 7 days ex vivo recording.

Projects

The ontogenesis of the biological clock of laboratory rat

The mammalian biological clock initiates its ontogenesis already during embryonic development in the maternal uterus. Newborn mammals are equipped with clock running in accordance with the maternal clock. We focus on investigating when and how do the newborn clock develop and entrain.  More

Achievements

Publications

Vejražková; D. - Vaňková; M. - Včelák; J. - Krejčí; H. - Anderlová; K. - Tura; A. - Pacini; G. - Sumová; Alena - Sládek; Martin - Bendlová; B. The rs10830963 Polymorphism of the MTNR1B Gene: Association With Abnormal Glucose; Insulin and C-peptide Kinetics . Frontiers in Endocrinology. 2022; 13); 868364 . IF = 6.055 [ASEP] [ doi ]
Shi; S.-Q. - Mahoney; C. E. - Houdek; Pavel - Zhao; W. - Anderson; M. P. - Zhuo; X. - Beaudet; A. - Sumová; Alena - Scammell; T. E. - Johnson; C. H. Circadian Rhythms and Sleep Are Dependent Upon Expression Levels of Key Ubiquitin Ligase Ube3a . Frontiers in Behavioral Neuroscience. 2022; 16(Mar 23)); 837523 . IF = 3.617 [ASEP] [ doi ]
Liška; Karolína - Sládek; Martin - Houdek; Pavel - Shrestha; N. - Lužná; Vendula - Ralph; M. R. - Sumová; Alena . High Sensitivity of the Circadian Clock in the Hippocampal Dentate Gyrus to Glucocorticoid- and GSK3-Beta-Dependent Signals . Neuroendocrinology. 2022; 112(4); 384-398 . IF = 5.135 [ASEP] [ doi ]
Honzlová; Petra - Novosadová; Zuzana - Houdek; Pavel - Sládek; Martin - Sumová; Alena . Misaligned feeding schedule elicits divergent circadian reorganizations in endo- and exocrine pancreas clocks . Cellular and Molecular Life Sciences. 2022; 79(6)); 318 . IF = 9.207 [ASEP] [ doi ]
Greiner; Philipp - Houdek; Pavel - Sládek; Martin - Sumová; Alena . Early rhythmicity in the fetal suprachiasmatic nuclei in response to maternal signals detected by omics approach . PLOS Biology. 2022; 20(5)); e3001637 . IF = 9.593 [ASEP] [ doi ]
Abbondanza; Alice - Bas; Irina Ribeiro - Modrák; Martin - Čapek; Martin - Minich; Jessica - Tyshkevich; Alexandra - Naser; Shahed - Rangotis; Revan - Houdek; Pavel - Sumová; Alena - Dumas; S. - Bernard; V. - Janíčková; Helena . Nicotinic Acetylcholine Receptors Expressed by Striatal Interneurons Inhibit Striatal Activity and Control Striatal-Dependent Behaviors . Journal of Neuroscience. 2022; 42(13); 2786-2803 . IF = 6.709 [ASEP] [ doi ]
Sládek; Martin - Liška; Karolína - Houdek; Pavel - Sumová; Alena . Modulation of single cell circadian response to NMDA by diacylglycerol lipase inhibition reveals a role of endocannabinoids in light entrainment of the suprachiasmatic nucleus . Neuropharmacology. 2021; 185(Mar 1)); 108455 . IF = 5.273 [ASEP] [ doi ]
Ralph; M. R. - Shi; S.-Q. - Johnson; C. H. - Houdek; Pavel - Shrestha; T. C. - Crosby; P. - O´Neill; J. S. - Sládek; Martin - Stinchcombe; A. R. - Sumová; Alena . Targeted modification of the Per2 clock gene alters circadian function in mPer2(luciferase) (mPer2(Luc)) mice . PLoS Computational Biology. 2021; 17(5)); e1008987 . IF = 4.779 [ASEP] [ doi ]
Lužná; Vendula - Liška; Karolína - Sládek; Martin - Sumová; Alena . Hormonal fine-tuning of clock in decidual region of mouse placenta by dopamine; melatonin; insulin; leptin and ghrelin . Placenta. 2021; 108(May); 55-63 . IF = 3.287 [ASEP] [ doi ]
Lužná; Vendula - Houdek; Pavel - Liška; Karolína - Sumová; Alena . Challenging the Integrity of Rhythmic Maternal Signals Revealed Gene-Specific Responses in the Fetal Suprachiasmatic Nuclei . Frontiers in Neuroscience. 2021; 14(Jan 7)); 613531 . IF = 5.152 [ASEP] [ doi ]
Liška; Karolína - Sládek; Martin - Čečmanová; Vendula - Sumová; Alena . Glucocorticoids reset circadian clock in choroid plexus via period genes . Journal of Endocrinology. 2021; 248(2); 155-166 . IF = 4.669 [ASEP] [ doi ]
Sumová; Alena - Čečmanová; Vendula . Mystery of rhythmic signal emergence within the suprachiasmatic nuclei . European Journal of Neuroscience. 2020; 51(1); 300-309 . IF = 3.386 [ASEP] [ doi ]
Sládek; Martin - Röschová; Michaela - Adámková; V. - Hamplová; Dana - Sumová; Alena . Chronotype assessment via a large scale socio-demographic survey favours yearlong Standard time over Daylight Saving Time in central Europe . Scientific Reports. 2020; 10(1)); 1419 . IF = 4.379 [ASEP] [ doi ]
Dodge; A. - Peters; M. M. - Greene; H. E. - Dietrick; C. - Botelho; R. - Chung; D. - Willman; J. - Nenninger; A. W. - Ciarlone; S. - Kamath; S. G. - Houdek; Pavel - Sumová; Alena - Anderson; A. E. - Dindot; S. V. - Berg; E. L. - O´Geeen; H. - Segal; D. J. - Silverman; J. L. - Weeber; E. J. - Nash; K. R. Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion . Autism Research. 2020; 13(3); 397-409 . IF = 5.216 [ASEP] [ doi ]
Sládek; Martin - Houdek; Pavel - Sumová; Alena . Circadian profiling reveals distinct regulation of endocannabinoid system in the rat plasma; liver and adrenal glands by light-dark and feeding cycles . Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. 2019; 1864(12)); 158533 . IF = 3.367 [ASEP] [ doi ]
Sládek, Martin - Sumová, Alena . Modulation of NMDA-Mediated Clock Resetting in the Suprachiasmatic Nuclei of mPer2(Luc) Mouse by Endocannabinoids . Frontiers in physiology 2019, 10(Mar 29)), 361 . IF = 4.519 [ASEP] [ doi ]
Čečmanová; Vendula - Houdek; Pavel - Šuchmanová; Karolína - Sládek; Martin - Sumová; Alena . Development and Entrainment of the Fetal Clock in the Suprachiasmatic Nuclei: The Role of Glucocorticoids . Journal of Biological Rhythms. 2019; 34(3); 307-322 . IF = 3.122 [ASEP] [ doi ]
Shrestha, T. C. - Šuchmanová, Karolína - Houdek, Pavel - Sumová, Alena - Ralph, M. R. Implicit time-place conditioning alters Per2 mRNA expression selectively in striatum without shifting its circadian clocks . Scientific Reports 2018, 8(Oct 19)), 15547 . IF = 4.011 [ASEP] [ doi ]
Petrásek, Tomáš - Vojtěchová, Iveta - Lobellová, Veronika - Popelíková, Anna - Janíková, Martina - Brožka, Hana - Houdek, Pavel - Sládek, Martin - Sumová, Alena - Krištofíková, Z. - Valeš, Karel - Stuchlík, Aleš . The McGill Transgenic Rat Model of Alzheimer's Disease Displays Cognitive and Motor Impairments, Changes in Anxiety and Social Behavior, and Altered Circadian Activity . Frontiers in Aging Neuroscience 2018, roč. 10, Aug 28, článku 250 . IF = 3.633 [ASEP] [ doi ]
Olejníková, Lucie - Polidarová, Lenka - Sumová, Alena . Stress affects expression of the clock gene Bmal1 in the suprachiasmatic nucleus of neonatal rats via glucocorticoid‐dependent mechanism . Acta Physiologica 2018, roč. 223, 1, článku e13020 . IF = 5.868 [ASEP] [ doi ]

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People

Prof. PharmDr. Alena Sumová, DSc.

Head of the Laboratory

Martin Sládek, PhD.

Deputy Head of the Laboratory

prof. Helena Illnerová

professor emeritus

Lenka Polidarová, PhD.

postdoc on maternal leave

RNDr. Pavel Houdek

scientist

Kateryna Semenovykh

grad student

Milica Drapšin

grad student

Saba Selvi

grad student

Michaela Kudrnáčová

grad student

Tereza Mičkerová

grad student

Eva Tlustá

technician