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Laboratory of Experimental Hypertension

Laboratory of Experimental Hypertension

The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure  regulation and end-organ damage in rats with different types of experimental hypertension.

Our research is focused mainly on:

  • Study of the central mechanisms of blood pressure regulation in rats with hypertension with a focus on the brain renin-angiotensin system, oxidative stress and baroreflex control of sympathetic tone – cooperation with the Institute for Translational Research in Biomedicine, Kaohsiung, Taiwan and Institute for Clinical and Experimental Medicine, Prague.
  • Search for the cardiovascular, renal and metabolic mechanisms of gliflozins, a new group of antidiabetics, in experimental hypertension and chronic kidney disease –  cooperation with Institute for Clinical and Experimental Medicine, Prague.
  • Investigation on the cardiovascular effects of new analogs of neuropeptides regulating food intake in rats in connection with their neuroprotective effects in Alzheimer disease – cooperation with IOCHB CAS, Prague.
  • Study of the role of sympathetic nervous system, renin-angiotensin system and glucocorticoids in modulation of cardiovascular stress response.

Projects

Achievements

Publications

Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef . Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats . Hypertension Research. 2022; 45(3); 414-423 . IF = 5.528 [ASEP] [ doi ]
Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances . Nutrition & Diabetes. 2022; 12(1)); 26 . IF = 4.725 [ASEP] [ doi ]
Zicha; Josef - Behuliak; Michal - Vavřínová; Anna - Dobešová; Zdenka - Kuneš; Jaroslav - Rauchová; Hana - Vaněčková; Ivana . Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats . Hypertension Research. 2021; 44(9); 1067-1078 . IF = 5.528 [ASEP] [ doi ]
Zicha; Josef . Contribution of Sympathetic Nervous System to High Blood Pressure in Salt Hypertensive Dahl Rats . Physiological Research. 2021; 70(2); 117-118 . IF = 2.139 [ASEP] [ doi ]
Vavřínová; Anna - Behuliak; Michal - Vaněčková; Ivana - Zicha; Josef . The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure . Physiological Research. 2021; 70(3); 307-326 . IF = 2.139 [ASEP] [ doi ]
Rauchová; Hana . Coenzyme Q10 Effects in Neurological Diseases . Physiological Research. 2021; 70(Suppl.4); S683-S714 . IF = 2.139 [ASEP] [ doi ]
Pražienková; V. - Funda; Jiří - Pirník; Z. - Karnošová; A. - Hrubá; L. - Kořínková; L. - Neprašová; B. - Janovská; Petra - Bencze; Michal - Kadlecová; Michaela - Blahoš; J. - Kopecký; Jan - Železná; B. - Kuneš; Jaroslav - Bardová; Kristina - Maletínská; L. GPR10 gene deletion in mice increases basal neuronal activity; disturbs insulin sensitivity and alters lipid homeostasis . Gene. 2021; 774(Mar 30)); 145427 . IF = 3.913 [ASEP] [ doi ]
Pirník; Z. - Kořínková; L. - Osacká; J. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Cholecystokinin System Is Involved in the Anorexigenic Effect of Peripherally Applied Palmitoylated Prolactin-Releasing Peptide in Fasted Mice . Physiological Research. 2021; 70(4); 579-590 . IF = 2.139 [ASEP] [ doi ]
Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František . Excess ischemic tachyarrhythmias trigger protection infarction in rats . Clinical science. 2021; 135(17); 2143-2163 . IF = 6.876 [ASEP] [ doi ]
Mráziková; L. - Neprašová; Barbora - Mengr; A. - Popelová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models . Frontiers in Pharmacology. 2021; 12(Nov 18)); 779962 . IF = 5.988 [ASEP] [ doi ]
Mengr; A. - Hrubá; L. - Exnerová; A. - Holubová; M. - Popelová; A. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated Prolactin-releasing Peptide Reduced A? Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study . Current Alzheimer Research. 2021; 18(8); 607-622 . IF = 3.040 [ASEP] [ doi ]
Karnošová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10; NPFF-R2 and NPFF-R1 Receptors: In Vitro Study . International Journal of Molecular Sciences. 2021; 22(16)); 8904 . IF = 6.208 [ASEP] [ doi ]
Kacířová; M. - Železná; B. - Blažková; M. - Holubová; M. - Popelová; A. - Kuneš; Jaroslav - Šedivá; B. - Maletínská; L. Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22 . Journal of Neuroinflammation. 2021; 18(1)); 141 . IF = 9.587 [ASEP] [ doi ]
Hüttl; M. - Marková; I. - Miklánková; D. - Zapletalová; I. - Poruba; M. - Haluzík; M. - Vaněčková; Ivana - Malínská; H. In a Prediabetic Model; Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia . International Journal of Molecular Sciences. 2021; 22(21)); 11513 . IF = 6.208 [ASEP] [ doi ]
Hojná; Silvie - Rauchová; Hana - Malínská; H. - Marková; I. - Hüttl; M. - Papoušek; František - Behuliak; Michal - Miklánková; D. - Vaňourková; Z. - Neckář; Jan - Kadlecová; Michaela - Kujal; P. - Zicha; Josef - Vaněčková; Ivana . Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats; an experimental non-diabetic model of hypertension . Biomedicine & Pharmacotherapy. 2021; 144(Dec)); 112246 . IF = 7.419 [ASEP] [ doi ]
Dobiášová; Milada . Correspondence to: “Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors” . Atherosclerosis. 2021; 335(October); 148-148 . IF = 6.847 [ASEP] [ doi ]
Zmeškalová; A. - Popelová; A. - Exnerová; A. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Cellular Signaling and Anti-Apoptotic Effects of Prolactin-Releasing Peptide and Its Analog on SH-SY5Y Cells . International Journal of Molecular Sciences. 2020; 21(17)); 6343 . IF = 5.923 [ASEP] [ doi ]
Vodička; Martin - Vavřínová; Anna - Mikulecká; Anna - Zicha; Josef - Behuliak; Michal . Hyper-reactivity of HPA axis in Fischer 344 rats is associated with impaired cardiovascular and behavioral adaptation to repeated restraint stress . STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS. 2020; 23(6); 667-677 . IF = 3.493 [ASEP] [ doi ]
Strnad; Š. - Pražienková; V. - Holubová; M. - Sýkora; D. - Cvačka; J. - Maletínská; L. - Železná; B. - Kuneš; Jaroslav - Vrkoslav; V. Mass spectrometry imaging of free-floating brain sections detects pathological lipid distribution in a mouse model of Alzheimer's-like pathology . Analyst. 2020; 145(13); 4595-4605 . IF = 4.616 [ASEP] [ doi ]
Rauchová; Hana - Hojná; Silvie - Kadlecová; Michaela - Vaněčková; Ivana - Zicha; Josef . Sex differences in blood pressure of aged Ren-2 transgenic rats . Physiological Research. 2020; 69(2); 245-252 . IF = 1.881 [ASEP] [ doi ]

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People

  RNDr. Ivana Vaněčková, DSc.
Head of the Laboratory
  MUDr. Josef Zicha, DrSc.
Deputy Head of the Laboratory
  RNDr. Jaroslav Kuneš, DrSc.
Senior Researcher
  MUDr. Hana Rauchová, CSc.
Senior Researcher
  RNDr. Milada Dobiášová, DrSc.
Senior Researcher
  Mgr. Michal Behuliak, Ph.D.
Senior Researcher
  RNDr. Michaela Kadlecová, Ph.D.
Junior Researcher
  Mgr. Silvie Hojná, Ph.D.
Junior Researcher
  Mgr. Anna Vavřínová, Ph.D.
Postdoctoral Fellow
  Mgr. Pavol Valovič
PhD Student
  Alena Charvátová
Technician
  Zdeňka Kopecká
Technician