Laboratory of Molecular Physiology of Bone

Content of this page

Left: μCT analysis of bone and osmium-stained bone marrow adipose tissue (BMAT) in chow (ND) and high-fat diet (HFD) mice. Right: Isolation protocol of bone marrow skeletal stem cells and their differentiation in osteoblasts (OB) and adipocytes (AD).

About the Laboratory

In obesity, lipids are accumulated in liver, muscle or cardiovascular system, instead of adipose tissue. Recent studies have shown that bones are also affected, leading to enhanced adipocyte formation in bone marrow (BMAT). Higher BMAT is often associated with bone fragility fractures, an overlooked complication affecting the quality of life. There is limited information on a physiological role of BMAT in relation to bone and whole body energy metabolism. The major focus of the department is on the characterization of the metabolic phenotype of BMAT and its contribution to bone homeostasis and whole body energy metabolism. The research will employ murine and human cellular systems, mice biomodels, clinical studies and molecular, bioanalytical and in vivo phenotyping techniques. It will be conducted within a broad international collaboration.

The department has been newly established in 2019, based on the 5-year “Start Up Research Program” financed by IPHYS.

We always welcome new motivated students from various scientific backgrounds, just contact us via email.

Achievements

Grants awarded to the Tencerova laboratory: 2022: 3-year Research grant from Czech Science Foundation (PI: Michaela Tencerova) 2021: L’Oréal-UNESCO For Women in Science 2021: 3-year Student research grant from GAUK (PI: Andrea Benova) 2020: 5-year EFSD/Novo Nordisk Foundation Future Leaders Award (PI: Michaela Tencerova) 2020: 3-year Research grant from Czech Science Foundation (PI: Michaela Tencerova) 2019: 5-year START UP Research program supported by IPHYS (PI: Michaela Tencerova) 2022: ECTS Academy fellowship 2023: 3- year Research grant from the Ministry of Health (PI: Michaela Tencerova) More

Publications

Brejchová; Kristýna - Rahm; Michal - Beňová; Andrea - Domanská; Veronika - Reyes Gutierrez; Paul Eduardo - Džubanová; Martina - Trubačová; Radka - Vondráčková; Michaela - Čajka; Tomáš - Tencerová; Michaela - Vrábel; Milan - Kuda; Ondřej Uncovering mechanisms of thiazolidinediones on osteogenesis and adipogenesis using spatial fluxomics. Metabolism-Clinical and Experimental. 2025; 166(May); 156157.

IF = 10.9

Lems; W. F. - Anastasilakis; A. D. - Andreasen; C. M. - Paccou; J. - Rolvien; T. - Tencerová; Michaela - Tuckermann; J. - Yavropoulou; M. P. - Soe; K. Basic and Clinical Scientists Working Together-Do We Make the Best of Both Worlds?. Calcified Tissue International. 2025; 116(1); 39.

IF = 3.3

Huynh; D. V. - Nguyen; Dung Kim - Nguyen; T. V. - Bui; T. V. - Le; C. T. Maxillary osteonecrosis related to post-COVID-19: A report of case series and 6-month follow-up. Journal of Oral and Maxillofacial Surgery Medicine and Pathology. 2025; 37(1); 180-187.

IF = 0.4

Džubanová; Martina - Ferenčáková; Michaela - Beňová; Andrea - Ali; D. - Tencerová; Michaela Protocol for isolation of human bone marrow stromal cells and characterization of cellular metabolism. STAR protocols. 2025; 6(1); 103553.

IF = 1.3

Palmisano; B. - Tencerová; Michaela Abstracts BMAS Summer School 2023 – 2nd Bone Marrow Adiposity Society Summer School Meeting 2023. Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 2024; 79(5); glad282.

IF = 4.3

Mrázková; Lucie - Lubos; Marta - Voldřich; Jan - Kužmová; Erika - Zrubecká; Denisa - Gwozdiaková; Petra - Buděšínský; Miloš - Asai; Seiya - Marek; Aleš - Pícha; Jan - Tencerová; Michaela - Ferenčáková; Michaela - Barrera Alquicer; Glenda - Kaminský; Jakub - Jiráček; Jiří - Žáková; Lenka The final walk with preptin. PLoS ONE. 2024; 19(9); e0309726.

IF = 2.9