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Laboratory of Molecular Physiology of Bone

Laboratory of Molecular Physiology of Bone Left: μCT analysis of bone and osmium-stained bone marrow adipose tissue (BMAT) in chow (ND) and high-fat diet (HFD) mice. Right: Isolation protocol of bone marrow skeletal stem cells and their differentiation in osteoblasts (OB) and adipocytes (AD).

In obesity, lipids are accumulated in liver, muscle or cardiovascular system, instead of adipose tissue. Recent studies have shown that bones are also affected, leading to enhanced adipocyte formation in bone marrow (BMAT). Higher BMAT is often associated with bone fragility fractures, an overlooked complication affecting the quality of life. There is limited information on a physiological role of BMAT in relation to bone and whole body energy metabolism. The major focus of the department is on the characterization of the metabolic phenotype of BMAT and its contribution to bone homeostasis and whole body energy metabolism. The research will employ murine and human cellular systems, mice biomodels, clinical studies and molecular, bioanalytical and in vivo phenotyping techniques. It will be conducted within a broad international collaboration.

The department has been newly established in 2019, based on the 5-year "Start Up Research Program" financed by IPHYS. 

We always welcome new motivated students from various scientific backgrounds, just contact us via email.



Grants awarded to the Tencerova laboratory: 2022: 3-year Research grant from Czech Science Foundation (PI: Michaela Tencerova) 2021: L’Oréal-UNESCO For Women in Science 2021: 3-year Student research grant from GAUK (PI: Andrea Benova) 2020: 5-year EFSD/Novo Nordisk Foundation Future Leaders Award (PI: Michaela Tencerova) 2020: 3-year Research grant from Czech Science Foundation (PI: Michaela Tencerova) 2019: 5-year START UP Research program supported by IPHYS (PI: Michaela Tencerova) 2022: ECTS Academy fellowship 2023: 3- year Research grant from the Ministry of Health (PI: Michaela Tencerova) More


van der Eerden; B. C. J. - Riddle; R. C. - Stegen; S. - Tencerová; Michaela . Editorial: Energy metabolism within the skeleton . Frontiers in Physiology. 2023; 14(May 22); 1205435 . IF = 4.0 [ASEP] [ doi ]
Tencerová; Michaela - Duque; G. - Beekman; K. M. - Corsi; A. - Geurts; J. - Bisschop; P. H. - Paccou; J. The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism . Nutrients. 2023; 15(21); 4601 . IF = 5.9 [ASEP] [ doi ]
Potalitsyn; Pavlo - Mrázková; Lucie - Selicharová; Irena - Tencerová; Michaela - Ferenčáková; Michaela - Chrudinová; Martina - Turnovská; Tereza - Brzozowski; A. M. - Marek; Aleš - Kaminský; Jakub - Jiráček; Jiří - Žáková; Lenka . Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2 . Communications Biology. 2023; 6); 863 . IF = 5.9 [ASEP] [ doi ]
Ferenčáková; Michaela - Beňová; Andrea - Raška Jr.; I. - Abaffy; Pavel - Šindelka; Radek - Džubanová; Martina - Pospíšilová; E. - Kolostová; K. - Čajka; Tomáš - Paclík; A. - Zikán; V. - Tencerová; Michaela . Human bone marrow stromal cells: the impact of anticoagulants on stem cell properties . Frontiers in Cell and Developmental Biology. 2023; 11(18 Sep); 1255823 . IF = 5.5 [ASEP] [ doi ]
Beňová; Andrea - Ferenčáková; Michaela - Bardová; Kristina - Funda; Jiří - Procházka; Jan - Špoutil; František - Čajka; Tomáš - Džubanová; Martina - Balcaen; T. - Kerckhofs; G. - Willekens; W. - van Lenthe; G. H. - Charyyeva; Arzuv - Alquicer; Glenda - Pecinová; Alena - Mráček; Tomáš - Horáková; Olga - Coupeau; Roman - Hansen; M. S. - Rossmeisl; Martin - Kopecký; Jan - Tencerová; Michaela . Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity . Communications Biology. 2023; 6(1); 1043 . IF = 5.9 [ASEP] [ doi ]

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Mgr. Michaela Tencerová, Ph.D.

Head of the Laboratory


Mgr. Andrea Beňová

PhD Student


RNDr. Michaela Ferenčáková, Ph.D.

Postdoctoral Fellow

Mgr. Martina Džubanová

PhD student


Ing. Michaela Vodičková

Lab technician

Kim Nguyen, Ph.D.

Postdoctoral fellow

M.Sc. Michaela Fickerova

Lab technician