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Laboratory of Developmental Cardiology

Laboratory of Developmental Cardiology

Ischemic heart disease is the main cause of mortality worldwide. We study cardiac tolerance to injury caused by acute oxygen deprivation from the molecular level to the whole organism using animal models. Our research is focused mainly on the study of mechanisms that underlie:

  • high cardiac tolerance to injury early ontogeny,
  • increased cardiac tolerance induced by adaptation to chronic hypoxia and regular exercise training,
  • permanent consequences of early developmental interventions for cardiac tolerance in adulthood,
  • and altered cardiac tolerance associated with various pathological states.

Further we study heart development with special emphasis on the cardiac conduction system. Our current research is focused on the following projects:

  • elucidating cardiac conduction system formation with phylogenetic approaches,
  • dynamic imaging methods for cardiac conduction system,
  • and development of new methods for quantitative analysis of fibrous structures to study branching patterns of the coronary vessels and cardiac conduction system.

13th conference New Frontiers in Basic Cardiovascular Research


Developmental aspects of cardiac ischemic tolerance

The immature heart is highly tolerant to ischemic injury, but chronic oxygen deficit during early ontogeny may have negative consequences that persist till adulthood. We study mechanisms responsible for developmental changes of cardiac ischemic tolerance. More

Cardiac ischemic tolerance in systemic hypertension

Systemic hypertension is a major risk factor of ischemic heart disease. However, it can also stimulate mechanisms that protect the heart against acute oxygen deprivation. We study the effects of various forms of hypertension on cardiac ischemic tolerance. More

Cardioprotective mechanism of chronic hypoxia

Prolonged exposure to hypoxic environment leads to adaptation which is associated with improved cardiac tolerance to acute oxygen deprivation. We study molecular mechanisms underlying the cardioprotective effects of chronic hypoxia on various manifestations of ischemic injury. More


Ševela; S. - Meisnerová; E. - Vecka; M. - Vávrová; J. - Rychlíková; J. - Leníček; M. - Vítek; L. - Nováková; Olga - Novák; F. High Dose Fish Oil Added to Various Lipid Emulsions Normalizes Superoxide Dismutase 1 Activity in Home Parenteral Nutrition Patients . Nutrients. 2024; 16(4); 485 . IF = 5.9 [ASEP] [ doi ]
Olejníčková; Veronika - Hamor; P. U. - Janáček; Jiří - Bartoš; M. - Zábrodská; E. - Šaňková; B. - Kvasilová; A. - Kolesová; Hana - Sedmera; David . Development of ventricular trabeculae affects electrical conduction in the early endothermic heart . Developmental Dynamics. 2024; 253(1); 78-90 . IF = 2.5 [ASEP] [ doi ]
Benák; Daniel - Holzerová; Kristýna - Hrdlička; Jaroslav - Kolář; František - Olsen; M. - Karelson; M. - Hlaváčková; Markéta . Epitranscriptomic regulation in fasting hearts: implications for cardiac health . RNA biology. 2024; 21(1); 1-14 . IF = 4.1 [ASEP] [ doi ]
Semenzato; M. - Kohr; M. J. - Quirin; Ch. - Menab?; R. - Alánová; Petra - Alán; L. - Pellattiero; A. - Murphy; E. - Di Lisa; F. - Scorrano; L. Oxidization of optic atrophy 1 cysteines occurs during heart ischemia-reperfusion and amplifies cell death by oxidative stress . Redox Biology. 2023; 63(July)); 102755 . IF = 11.4 [ASEP] [ doi ]
Ošťádal; Bohuslav - Kolář; František - Ošťádalová; Ivana - Sedmera; David - Olejníčková; Veronika - Hlaváčková; Markéta - Alánová; Petra . Developmental Aspects of Cardiac Adaptation to Increased Workload . Journal of cardiovascular development and disease. 2023; 10(5)); 205 . IF = 2.4 [ASEP] [ doi ]


RNDr. Markéta Hlaváčková, Ph.D.
Head of the Laboratory
RNDr. Petra Alánová, Ph.D.
Deputy Head of the Laboratory
Prof. RNDr. František Kolář, CSc.
Senior Researcher
RNDr. Jan Neckář, Ph.D.
Senior Researcher
Prof. MUDr. Bohuslav Ošťádal, DrSc.
Senior Researcher
Ing. František Papoušek, CSc.
Senior Researcher
RNDr. Kristýna Holzerová, Ph.D.
Postdoctoral Fellow
Mgr. Jaroslav Hrdlička, Ph.D.
Postdoctoral Fellow
MVDr. Veronika Olejníčková, Ph.D.
Postdoctoral Fellow
Mgr. Daniel Benák, Ph.D.
Postdoctoral Fellow
Mgr. Almos Boroš
PhD Student
Mgr. Miloslava Chalupová
PhD Student
Mgr. Barbora Opletalová
PhD Student
Anežka Ševčíková
Anna Jelínková-Jokelová
Ing. Miloslava Marková