Laboratory of Cellular Neurophysiology
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About the Laboratory
Research of the Laboratory of Cellular Neurophysiology focuses on the function and pharmacology of ionotropic receptors (ligand-activated ion channels), specifically ionotropic glutamate receptors (iGluRs) and transient receptor potential (TRP) channels. iGluRs mediate the majority of excitatory signaling in the central nervous system, are essential for normal brain development and function, and their dysfunction leads to serious neurological and psychiatric disorders, including many forms of neurodegeneration. TRP channels are present in both the peripheral and the central nervous system, and they play a fundamental role in the detection and transmission of painful stimuli and participate in signaling associated with chronic inflammation.
The goal of our research is to better characterize the relationship between ionotropic receptor structure and function, to identify molecular mechanisms of ionotropic receptor modulation by different chemical compounds or physical variables, and to describe the consequences of mutations of human ionotropic receptors for the function of synapses, neurons and neuronal networks. Obtained results deepen our basic understanding of the mechanisms of ionotropic receptor function, and inform the development of novel receptor modulators with therapeutic potential in the treatment of neurodevelopmental and neurodegenerative disorders.
Publications
Studtmann; C. - Ladislav; M. - Safari; M. - Khondaker; R. - Chen; Y. - Vaughan; G. A. - Topolski; M. A. - Tomović; E. - Balík; Aleš - Swanger; S. A. Ventral posterolateral and ventral posteromedial thalamocortical neurons have distinct physiological properties. Journal of Neurophysiology. 2023; 130(6); 1492-1507.
IF = 2.5
Kolcheva; Marharyta - Ladislav; M. - Netolický; J. - Kortus; Š. - Řeháková; K. - Hrčka Krausová; B. - Hemelíková; K. - Misiachna; A. - Kádková; A. - Klíma; Martin - Chalupská; Dominika - Horák; M. The pathogenic N650K variant in the GluN1 subunit regulates the trafficking; conductance; and pharmacological properties of NMDA receptors. Neuropharmacology. 2023; 222(1 January)); 109297.
IF = 4.7
Kysilov; Bohdan - Kuchtiak; Viktor - Hrčka Krausová; Barbora - Balík; Aleš - Kořínek; Miloslav - Fili; Klevinda - Dobrovolski; Mark - Abramová; Vera - Chodounská; Hana - Kudová; Eva - Božíková; Paulina - Černý; Jiří - Smejkalová; Tereza - Vyklický ml.; Ladislav Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids. Cellular and Molecular Life Sciences. 2024; 81(1); 36.
IF = 8.0
Lebedeva; M. - Kubištová; A. - Spišská; V. - Filipovská; E. - Pačesová; D. - Svobodová; I. - Kuchtiak; Viktor - Balík; Aleš - Bendová; Z. The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2R/R mice; a comparison with C57BL/6J and Adar2?/? mice strains. Brain Research. 2024; 1826(1 March); 148739.
IF = 2.9
Cheema; Marie Munawar - Kotrbová Macáková; Zuzana - Hrčka Krausová; Barbora - Adla; Santosh Kumar - Slavíková; Barbora - Chodounská; Hana - Kratochvíl; Miroslav - Vondrášek; Jiří - Sedlák; David - Balaštík; Martin - Kudová; Eva 5?-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia. Journal of Steroid Biochemistry and Molecular Biology. 2024; 239(May); 106464.
IF = 4.1
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