Laboratory of Computational Neuroscience

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About the Laboratory

Research

Theoretical methods are employed to describe and understand particular processes in neural systems on the level of single cells or populations. The focus is mainly on the neural coding problem, mathematical models of neuronal activity, and biophysical modeling of axon growth and circuit formation. The results are validated by using experimental data and numerical simulations. Information theory, stochastic processes, differential equations and statistics provide the necessary tools.

We are involved in:

The Board of Directors of the Organization for Computational Neurosciences (OCNS), organization of the Prague 2015 meeting and of the annual Workshops on Methods of Information Theory in Computational Neuroscience
Organization and committee membership in the biennal Neural Coding workshop series since Prague 1995 (Prague 2012; Versailles 2014; Cologne 2016; Torino 2018; Seattle 2020)
Organization of the Information beyond Shannon 2013 workshop (Prague)
Associate and Guest editorship: Neural Processing Letters; BioSystems; Mathematical Biosciences and Engineering; Frontiers in Integrative Neuroscience

Publications

Lytvynenko; A. - Baluchová; S. - Zima; J. - Krůšek; Jan - Schwarzová-Pecková; K. Biofouling and performance of boron-doped diamond electrodes for detection of dopamine and serotonin in neuron cultivation media. Bioelectrochemistry. 2024; 158(August); 108713.

IF = 4.8

Studtmann; C. - Ladislav; M. - Safari; M. - Khondaker; R. - Chen; Y. - Vaughan; G. A. - Topolski; M. A. - Tomović; E. - Balík; Aleš - Swanger; S. A. Ventral posterolateral and ventral posteromedial thalamocortical neurons have distinct physiological properties. Journal of Neurophysiology. 2023; 130(6); 1492-1507.

IF = 2.5

Kolcheva; Marharyta - Ladislav; M. - Netolický; J. - Kortus; Š. - Řeháková; K. - Hrčka Krausová; B. - Hemelíková; K. - Misiachna; A. - Kádková; A. - Klíma; Martin - Chalupská; Dominika - Horák; M. The pathogenic N650K variant in the GluN1 subunit regulates the trafficking; conductance; and pharmacological properties of NMDA receptors. Neuropharmacology. 2023; 222(1 January)); 109297.

IF = 4.7

Cheema; Marie Munawar - Kotrbová Macáková; Zuzana - Hrčka Krausová; Barbora - Adla; Santosh Kumar - Slavíková; Barbora - Chodounská; Hana - Kratochvíl; Miroslav - Vondrášek; Jiří - Sedlák; David - Balaštík; Martin - Kudová; Eva 5?-reduced neuroactive steroids as modulators of growth and viability of postnatal neurons and glia. Journal of Steroid Biochemistry and Molecular Biology. 2024; 239(May); 106464.

IF = 4.1

Kysilov; Bohdan - Kuchtiak; Viktor - Hrčka Krausová; Barbora - Balík; Aleš - Kořínek; Miloslav - Fili; Klevinda - Dobrovolski; Mark - Abramová; Vera - Chodounská; Hana - Kudová; Eva - Božíková; Paulina - Černý; Jiří - Smejkalová; Tereza - Vyklický ml.; Ladislav Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids. Cellular and Molecular Life Sciences. 2024; 81(1); 36.

IF = 8.0

Lebedeva; M. - Kubištová; A. - Spišská; V. - Filipovská; E. - Pačesová; D. - Svobodová; I. - Kuchtiak; Viktor - Balík; Aleš - Bendová; Z. The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2R/R mice; a comparison with C57BL/6J and Adar2?/? mice strains. Brain Research. 2024; 1826(1 March); 148739.

IF = 2.9