Neuroepigenetics

Non-coding RNAs, once considered mere transcriptional byproducts, are now recognized as pivotal regulators of gene expression and cellular function. Among them, circular RNAs (circRNAs) and tRNA-derived fragments (tRFs) have emerged as key players in maintaining neuronal health and disease progression. Despite their immense potential, their roles in neurodegenerative and psychiatric disorders remain insufficiently understood. This presents an exciting opportunity to unravel how these RNA species—along with their epitranscriptomic modifications, such as m6A methylation—impact brain function in conditions like Alzheimer’s Disease, Schizophrenia, and stress-related psychiatric disorders.

At the Laboratory of Neuroepigenetics, we investigate the intricate roles of non-coding RNAs and epigenetic modifications in brain disorders, with a primary focus on Alzheimer’s Disease (AD), Schizophrenia, and stress-related psychiatric conditions. By integrating cutting-edge transcriptomics, functional genomics, and disease modeling, we aim to bridge the gap between molecular alterations and disease phenotypes, ultimately paving the way for novel RNA-based therapeutic interventions.