Emerging evidence suggests that both exogenous ketone supplementation and the natural accumulation of ketone bodies during fasting enhance the heart’s tolerance to acute ischemia-reperfusion injury. However, the precise mechanisms behind this protective effect remain elusive.
Our research deals with the pivotal role of the transcription factor HIF-1α in mediating the cardioprotective benefits of ketosis, induced through short- and long-term intermittent fasting. Using an experimental model of myocardial infarction, we explore the intricate interplay between ketone metabolism and heart health, with a particular focus on: i) sex-based differences in response to ketosis, ii) mitophagy, and iii) epitranscriptomic (RNA epigenetic) modifications that may regulate cellular adaptation to metabolic stress.
Supported by the Ministry of Education, Youth and Sports of the CR (grant Inter-COST LUC24089 2024-2027; PI Prof. Frantisek Kolar).
