Laboratory of Developmental Epileptology

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About the Laboratory

The research at our Laboratory focuses on the pathophysiology of epilepsy and epileptic seizures in adulthood and particularly in the developing brain. In our research we are utilizing modern electrophysiological, imaging, biochemical and pharmacological techniques. To elucidate the cellular and network mechanisms involved in epilepsy and to increase the translational potential of new observations we are using extensively chronic models of acquired epilepsy and also genetic models and also collaborate with leading epilepsy centres.

Pro náš výzkum požíváme interdisciplinární přístup zahrnující postupy molekulární biologie, neuropatologie, elektrofyziologie i behaviorální metody.

Our primary research topics are:

Consequences of brain injury during early stages of the brain development
Mechanisms responsible for seizure initiation and termination.
Impact of seizures on the developing brain
Development of new diagnostic techniques of epilepsy
Cognitive and behavioural consequences of epilepsy
The role of oxidative stress in pathogenesis of epilepsy and seizures during the development
Impact of antiepileptic therapy of the brain development
Age-specific mechanisms of seizure initiation and propagation

Projects

Cognitive and behavioural consequences of epilepsy

Mechanisms responsible for seizure initiation and termination

Development of new diagnostic techniques of epilepsy

The role of oxidative stress in pathogenesis of epilepsy and seizures in immature brain

Impact of antiepileptic therapy on the brain development

Impact of seizures on the developing brain

Consequences of brain injury during early stages of the brain development

Achievements

European Epileptology Award 2016 for prof. Pavel Mareš

Epileptology European Award 2016 was awarded prof. Pavel Mareš.

The European Epileptology Award is awarded every two years by the ILAE Commission on European Affairs (CEA) to European epileptologists in recognition of their outstanding contributions to European epileptology. It´s awarded to one clinical and one experimental epileptologist. Award-winning clinical epileptologist is prof. Federico Vigevano (Italy).

Collaborators

19.3. 2014

Centrum pro epilepsie Motol (doc. Marusič, doc. Kršek)

Fakulta elektrotechnická ČVUT (doc. Čmejla, doc. Lhotská, Ing. Klíma)

Ústav informatiky AV ČR (dr. Paluš, dr. Hlinka)

Ústřední vojenská nemocnice (prof. Beneš, dr. Vaněk)

ISARG Prague

Mayo Clinic, USA (prof. Worrell)

University of Birmingham, UK (prof. Jefferys)

Technische Universität Berlin (prof. Schoell)

Institute fo Neurophysiology, Charite, Berlin (Assoc. Prof. Kovacs, Prof. Heinemann)

The Chaim Sheba Medical Center (Dr. Maggio)

University of Eastern Finland (prof. Pitkanen)

David Geffen School of Medicine at UCLA, USA (prof. Wasterlain, prof. Sankar)

Center for Research and Advanced Studies, Mexico (dr. Rocha)

Institute of Neurobiology, Bulgarian Academy of Sciences (assoc.prof.Tchekalarova)

Publications

Danačíková; Šárka - Straka; B. - Daněk; Jan - Kořínek; V. - Otáhal; Jakub In vitro human cell culture models in a bench-to-bedside approach to epilepsy. Epilepsia Open. 2024; 9(3); 865-890.

IF = 2.8

Al-Redouan; A. - Salaj; M. - Kubová; Hana - Druga; Rastislav Compartmental neuronal degeneration in the ventral striatum induced by status epilepticus in young rats’ brain in comparison with adults. International Journal of Developmental Neuroscience. 2024; 84(4); 328-341.

IF = 1.7

Tefr Faridová; A. - Heřman; H. - Danačíková; Šárka - Svoboda; Jan - Otáhal; Jakub Serum biomarkers of hypoxic-ischemic brain injury. Physiological Research. 2023; 72(Suppl.5); S461-S474.

IF = 2.1

Rehák Bučková; Barbora - Kala; David - Kořenek; Jakub - Matušková; V. - Kumpošt; Vojtěch - Svobodová; L. - Otáhal; Jakub - Škoch; A. - Šulc; V. - Olšerová; A. - Vyhnálek; M. - Janský; P. - Tomek; A. - Marusič; P. - Jiruška; P. - Hlinka; Jaroslav Structural connectivity-based predictors of cognitive impairment in stroke patients attributable to aging. PLoS ONE. 2023; 18(4)); e0280892.

IF = 3.7

Pokošová; P. - Kala; David - Šanda; J. - Ježdík; P. - Prysiazhniuk; Y. - Faridová; A. - Jahodová; A. - Bělohlávková; A. - Kalina; A. - Holubová; Z. - Jurášek; B. - Kynčl; M. - Otáhal; Jakub Magnetic resonance imaging techniques for indirect assessment of myelin content in the brain using standard T1w and T2w MRI sequences and postprocessing analysis. Physiological Research. 2023; 72(Suppl.5); S573-S585.

IF = 2.1

Kubová; Hana - Mikulecká; Anna - Mareš; Pavel The outcome of early life status epilepticus-lessons from laboratory animals. Epilepsia Open. 2023; 8(Suppl.1); S90-S109.

IF = 3.0