Laboratory of Neurophysiology of Memory

Content of this page

About the Laboratory

Our Laboratory has been involved in learning, memory, and cognitive function studies. For instance, spatial orientation is now considered a type of so-called declarative memory (the ability to remember facts and events). This capability is dominantly affected in Alzheimer’s disease and other dementias, obsessive-compulsive disorder, or schizophrenia. These are conditions for which we do not know details of their physiology, so we actually treat only symptoms but not causes. Using neuroanatomical, neuropharmacological, cellular, molecular, and behavioral approaches, we investigate brain function in relation to behavior, both in health and disease. In an intense collaboration, we also work on the development of novel therapeutics focused on brain diseases.

EXTERNAL WEBSITE OF THE LABORATORY

Projects

Molecular and in vivo imaging, immediate-early genes, cognitive coordination and psychosis

Neuropharmacological studies, animal models of brain disorders and new therapeutics

Study of cognitive functions in humans, spatial navigation and its impairment

Integration of molecular, cellular and systems approaches in study of cognitive functions

Achievements

Publications

Dvořáková; Tereza - Lobellová; Veronika - Manubens; P. - Sanchez-Jimenez; A. - Villacorta-Atienza; J. A. - Stuchlík; Aleš - Levčík; David Spatial prediction of dynamic interactions in rats. PLoS ONE. 2025; 20(2); e0319101.

IF = 2.9

Diez-Hermano; S. - Aparicio-Rodriguez; G. - Manubens; P. - Sanchez-Jimenez; A. - Calvo-Tapia; C. - Levčík; David - Villacorta-Atienza; J. A. Minimal Neural Network Conditions for Encoding Future Interactions. International Journal of Neural Systems. 2025; 35(04); 2550016.

IF = 6.6

Černotová; Daniela - Hrůzová; Karolína - Touš; Jan - Janča; R. - Stuchlík; Aleš - Levčík; David - Svoboda; Jan Early social deficits in TgF344-AD rats are accompanied by sex-specific parvalbumin-positive interneuron reduction and altered brain oscillations in the hippocampal CA2. Neurobiology of Disease. 2025; 208(May); 106875.

IF = 5.1

Hamed; A. - Kursa; M. B. - Mrozek; W. - Piwoński; K. P. - Falińska; M. - Danielewski; K. - Rejmak; E. - Włodkowska; U. - Kubík; Štěpán - Czajkowski; R. Spatio-temporal mechanisms of consolidation; recall and reconsolidation in reward-related memory trace. Molecular Psychiatry. 2025; 30(April); 1319-1328.

IF = 9.6

Li; L. - Wu; Z. - Guarracino; A. - Villani; F. - Kong; D. - Mancieri; A. - Zhang; A. - Saba; L. - Chen; H. - Brožka; Hana - Valeš; Karel - Senko; A. N. - Kempermann; G. - Stuchlík; Aleš - Pravenec; Michal - Lechner; J. - Prins; P. - Mathur; R. - Lu; L. - Yang; K. - Peng; J. - Williams; R. W. - Wang; X. Genetic modulation of protein expression in rat brain. iScience. 2025; 28(3); 112079.

IF = 4.6

Krajčovič; Branislav - Černotová; Daniela - Buchtová; Helena - Stuchlík; Aleš - Kubík; Štěpán - Svoboda; Jan CA1 ensembles expressing immediate-early genes are driven by context switch; shrink with sustained presence; and show no effect of change of task demands. Behavioural Brain Research. 2025; 480(5 March); 115407.

IF = 2.6