Laboratory of Neurophysiology of Memory

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About the Laboratory

Our Laboratory has been involved in learning, memory, and cognitive function studies. For instance, spatial orientation is now considered a type of so-called declarative memory (the ability to remember facts and events). This capability is dominantly affected in Alzheimer’s disease and other dementias, obsessive-compulsive disorder, or schizophrenia. These are conditions for which we do not know details of their physiology, so we actually treat only symptoms but not causes. Using neuroanatomical, neuropharmacological, cellular, molecular, and behavioral approaches, we investigate brain function in relation to behavior, both in health and disease. In an intense collaboration, we also work on the development of novel therapeutics focused on brain diseases.

EXTERNAL WEBSITE OF THE LABORATORY

Projects

Disruption of Spatiotemporal Coordination as an Early Marker of Schizophrenia – A Translational Study of Frontotemporal Interaction

An Animal Model of Schizophrenia Based on Chemogenetically Induced Sensory Noise During Adolescence

The role of parvalbumin-positive interneurons in a rat model of schizophrenia induced by maternal immune activation

Navigating the Social Memories: Oxytocin’s Multifaceted Role in Alzheimer’s Disease

Study of cognitive functions in humans, spatial navigation and its impairment

Achievements

Publications

Kunčická; Daniela - Ondráčková; Simona - Estoková; Simona - Radostová; Dominika - Černotová; Daniela - Štaud; F. - Brožka; Hana - Stuchlík; Aleš Prenatal exposure to high- but not low-molecular-weight poly(I:C) produces selective sociability deficits in offspring. Behavioural Brain Research. 2026; 514(2 Oct); 116357.

IF = 2.9

Gunia; Anna - Kalina; A. - Javůrková; A. - Vlček; Kamil The behavioral evidence of processing congruences and incongruences between Self- and Other-perspective-related representations during both perspective judgments. Psychological Research-Psychologische Forschung. 2026; 90(4); 134.

IF = 2.1

Adámek; P. - Rudolfová; V. - Malenínská; Kristýna - Horáček; J. Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory. Biological Psychiatry. Global Open Science. 2026; 6(5); 100764.

IF = 4

Hrčka Krausová; Barbora - Radostová; Dominika - Malenínská; Kristýna - Škodová; T. - Valeš; K. - Vítků; J. - Brožka; Hana Acute inhibition of NMDA receptor function by bisphenol A and bisphenol F in adult rat brain. Neurotoxicology. 2026; 114(May); 103430.

IF = 3.8

Laczó; M. - Malenínská; Kristýna - Khazaalova; Natalie - Borovská; Š. - Vyhnálek; M. - Hort; J. - Stuchlík; Aleš - Svoboda; Jan - Laczó; J. Spatial pattern separation deficits in early Alzheimer’s disease are comparable in humans and animal models. Scientific Reports. 2026; 16(1); 6020.

IF = 4.9

Hrůza; Karolína - Černotová; Daniela - Malenínská; Kristýna - Svoboda; Jan - Levčík; David - Stuchlík; Aleš Task-specific effects of mGlu2/3 receptor agonist LY379268 on MK-801-induced behavioral and neural dysfunctions in rats. Physiological Research. 2026; 75(1); 149-166.

IF = 2.8