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Laboratory of Experimental Hypertension

Laboratory of Experimental Hypertension

The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure  regulation and end-organ damage in rats with different types of experimental hypertension.

Our research is focused mainly on:

  • Cardiovascular effects of new antidiabetics – gliflozins in  model of experimental hypertension and chronic heart failure
  • Central and peripheral mechanisms of blood pressure regulation
  • Role of sympathetic and parasympathetic nervous system  in cardiovascular diseases
  • Cardiovascular effects  of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).

Projects

Achievements

Publications

Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef . Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats . Hypertension Research. 2022; 45(3); 414-423 . IF = 5.528 [ASEP] [ doi ]
Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances . Nutrition & Diabetes. 2022; 12(1)); 26 . IF = 4.725 [ASEP] [ doi ]
Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana . Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein . Biomedicines. 2022; 10(9)); 2066 . IF = 4.757 [ASEP] [ doi ]
Andelová; K. - Szeiffová Bačová; B. - Sýkora; M. - Pavelka; Stanislav - Rauchová; Hana - Tribulová; N. Cardiac Cx43 Signaling Is Enhanced and TGF-beta 1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHRM . Biomedicines. 2022; 10(7)); 1707 . IF = 4.757 [ASEP] [ doi ]
Zicha; Josef - Behuliak; Michal - Vavřínová; Anna - Dobešová; Zdenka - Kuneš; Jaroslav - Rauchová; Hana - Vaněčková; Ivana . Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats . Hypertension Research. 2021; 44(9); 1067-1078 . IF = 5.528 [ASEP] [ doi ]

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The entire photogallery

People

  RNDr. Ivana Vaněčková, DSc.
Head of the Laboratory
  MUDr. Josef Zicha, DrSc.
Deputy Head of the Laboratory
  RNDr. Jaroslav Kuneš, DrSc.
Senior Researcher
  MUDr. Hana Rauchová, CSc.
Senior Researcher
  RNDr. Milada Dobiášová, DrSc.
Senior Researcher
  Mgr. Michal Behuliak, Ph.D.
Senior Researcher
  RNDr. Michaela Kadlecová, Ph.D.
Junior Researcher
  Mgr. Silvie Hojná, Ph.D.
Junior Researcher
  RNDr. Lenka Řezáčová, Ph.D.
Junior Researcher
  Bc. Martina Sabolová
Pregradual student
  Alena Charvátová
Technician
  Zdeňka Kopecká
Technician