The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.
Our research is focused mainly on:
- Cardiovascular effects of new antidiabetics – gliflozins in model of experimental hypertension and chronic heart failure
- Central and peripheral mechanisms of blood pressure regulation
- Role of sympathetic and parasympathetic nervous system in cardiovascular diseases
- Cardiovascular effects of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).
Projects
Achievements
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Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.
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Publications
Mráziková; L. - Hojná; Silvie - Vaculová; P. - Strnad; Š. - Vrkoslav; V. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance
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Nutrients. 2023; 15(2)); 280
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IF = 6.706
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Kala; P. - Vaňourková; Z. - Škaroupková; P. - Kompanowska - Jezierska; E. - Sadowski; J. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L.
Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula
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Biomedicine & Pharmacotherapy. 2023; 158(February)); 114157
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IF = 7.419
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Kala; P. - Gawrys; O. - Miklovic; M. - Vaňourková; Z. - Škaroupková; P. - Jíchová; Š. - Sadowski; J. - Kompanowska - Jezierska; E. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L.
Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension
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Journal of Hypertension. 2023; 41(1); 99-114
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IF = 4.776
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Zicha; Josef - Řezáčová; Lenka - Behuliak; Michal - Vaněčková; Ivana
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Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension
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Physiological Research. 2022; 71(6); 763-770
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IF = 2.139
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doi
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Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef
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Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats
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Hypertension Research. 2022; 45(3); 414-423
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IF = 5.528
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doi
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Pačesová; A. - Holubová; M. - Hrubá; L. - Strnadová; V. - Neprašová; B. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Age-related metabolic and neurodegenerative changes in SAMP8 mice
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Aging. 2022; 14(18); 7300-7327
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IF = 5.955
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Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances
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Nutrition & Diabetes. 2022; 12(1)); 26
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IF = 4.725
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Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana
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Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
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Biomedicines. 2022; 10(9)); 2066
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IF = 4.757
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doi
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Chao; YM. - Rauchová; Hana - Chan; J. Y. H.
Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic l-NAME Treatment in Rats
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Biomedicines. 2022; 10(9)); 2232
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IF = 4.757
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doi
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Holá; L. - Železná; B. - Karnošová; A. - Kuneš; Jaroslav - Fehrentz; J. A. - Denoyelle; S. - Cantel; S. - Blechová; M. - Sýkora; D. - Myšková; A. - Maletínská; L.
A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin
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Journal of Pharmacology and Experimental Therapeutics. 2022; 383(2); 129-136
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IF = 4.404
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doi
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Hojná; Silvie - Kotsaridou; Zoe - Vaňourková; Z. - Rauchová; Hana - Behuliak; Michal - Kujal; P. - Kadlecová; Michaela - Zicha; Josef - Vaněčková; Ivana
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Empagliflozin Is Not Renoprotective in Non-Diabetic Rat Models of Chronic Kidney Disease
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Biomedicines. 2022; 10(10)); 2509
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IF = 4.757
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doi
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Andelová; K. - Szeiffová Bačová; B. - Sýkora; M. - Pavelka; Stanislav - Rauchová; Hana - Tribulová; N.
Cardiac Cx43 Signaling Is Enhanced and TGF-beta 1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHRM
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Biomedicines. 2022; 10(7)); 1707
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IF = 4.757
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doi
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Zicha; Josef - Behuliak; Michal - Vavřínová; Anna - Dobešová; Zdenka - Kuneš; Jaroslav - Rauchová; Hana - Vaněčková; Ivana
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Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats
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Hypertension Research. 2021; 44(9); 1067-1078
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IF = 5.525
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doi
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Zicha; Josef
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Contribution of Sympathetic Nervous System to High Blood Pressure in Salt Hypertensive Dahl Rats
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Physiological Research. 2021; 70(2); 117-118
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IF = 2.139
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doi
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Vavřínová; Anna - Behuliak; Michal - Vaněčková; Ivana - Zicha; Josef
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The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure
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Physiological Research. 2021; 70(3); 307-326
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IF = 2.139
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doi
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Rauchová; Hana
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Coenzyme Q10 Effects in Neurological Diseases
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Physiological Research. 2021; 70(Suppl.4); S683-S714
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IF = 2.139
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doi
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Pražienková; V. - Funda; Jiří - Pirník; Z. - Karnošová; A. - Hrubá; L. - Kořínková; L. - Neprašová; B. - Janovská; Petra - Bencze; Michal - Kadlecová; Michaela - Blahoš; J. - Kopecký; Jan - Železná; B. - Kuneš; Jaroslav - Bardová; Kristina - Maletínská; L.
GPR10 gene deletion in mice increases basal neuronal activity; disturbs insulin sensitivity and alters lipid homeostasis
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Gene. 2021; 774(Mar 30)); 145427
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IF = 3.913
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doi
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Pirník; Z. - Kořínková; L. - Osacká; J. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Cholecystokinin System Is Involved in the Anorexigenic Effect of Peripherally Applied Palmitoylated Prolactin-Releasing Peptide in Fasted Mice
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Physiological Research. 2021; 70(4); 579-590
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IF = 2.139
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doi
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Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František
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Excess ischemic tachyarrhythmias trigger protection infarction in rats
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Clinical science. 2021; 135(17); 2143-2163
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IF = 6.876
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doi
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Mráziková; L. - Neprašová; Barbora - Mengr; A. - Popelová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models
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Frontiers in Pharmacology. 2021; 12(Nov 18)); 779962
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IF = 5.988
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doi
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Mengr; A. - Hrubá; L. - Exnerová; A. - Holubová; M. - Popelová; A. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Palmitoylated Prolactin-releasing Peptide Reduced A? Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study
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Current Alzheimer Research. 2021; 18(8); 607-622
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IF = 3.040
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doi
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Karnošová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10; NPFF-R2 and NPFF-R1 Receptors: In Vitro Study
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International Journal of Molecular Sciences. 2021; 22(16)); 8904
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IF = 6.208
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doi
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Kacířová; M. - Železná; B. - Blažková; M. - Holubová; M. - Popelová; A. - Kuneš; Jaroslav - Šedivá; B. - Maletínská; L.
Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22
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Journal of Neuroinflammation. 2021; 18(1)); 141
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IF = 9.587
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doi
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Hüttl; M. - Marková; I. - Miklánková; D. - Zapletalová; I. - Poruba; M. - Haluzík; M. - Vaněčková; Ivana - Malínská; H.
In a Prediabetic Model; Empagliflozin Improves Hepatic Lipid Metabolism Independently of Obesity and before Onset of Hyperglycemia
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International Journal of Molecular Sciences. 2021; 22(21)); 11513
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IF = 6.208
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doi
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Hojná; Silvie - Rauchová; Hana - Malínská; H. - Marková; I. - Hüttl; M. - Papoušek; František - Behuliak; Michal - Miklánková; D. - Vaňourková; Z. - Neckář; Jan - Kadlecová; Michaela - Kujal; P. - Zicha; Josef - Vaněčková; Ivana
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Antihypertensive and metabolic effects of empagliflozin in Ren-2 transgenic rats; an experimental non-diabetic model of hypertension
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Biomedicine & Pharmacotherapy. 2021; 144(Dec)); 112246
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IF = 7.419
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doi
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Dobiášová; Milada
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Correspondence to: “Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors”
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Atherosclerosis. 2021; 335(October); 148-148
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IF = 6.851
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doi
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Badzyńska; B. - Vaněčková; Ivana - Sadowski; J. - Hojná; Silvie - Kompanowska - Jezierska; E.
Effects of systemic and renal intramedullary endothelin-1 receptor blockade on tissue NO and intrarenal hemodynamics in normotensive and hypertensive rats
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European Journal of Pharmacology. 2021; 910(5 Nov)); 174445
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IF = 5.195
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doi
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Zmeškalová; A. - Popelová; A. - Exnerová; A. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Cellular Signaling and Anti-Apoptotic Effects of Prolactin-Releasing Peptide and Its Analog on SH-SY5Y Cells
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International Journal of Molecular Sciences. 2020; 21(17)); 6343
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IF = 5.923
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doi
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Zemančíková; A. - Török; J. - Bališ; P. - Valovič; Pavol - Uličná; O. - Chomová; M.
MODULATION OF SYMPATHOADRENERGIC CONTRACTIONS BY PERIVASCULAR ADIPOSE TISSUE IN MESENTERIC ARTERIES OF RATS WITH DIFFERENT LEVEL OF BODY ADIPOSITY
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Journal of Physiology and Pharmacology. 2020; 71(4); 589-596
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IF = 3.011
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doi
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Vodička; Martin - Vavřínová; Anna - Mikulecká; Anna - Zicha; Josef - Behuliak; Michal
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Hyper-reactivity of HPA axis in Fischer 344 rats is associated with impaired cardiovascular and behavioral adaptation to repeated restraint stress
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STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS. 2020; 23(6); 667-677
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IF = 3.493
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Show more
Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.
