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Laboratory of Experimental Hypertension

Laboratory of Experimental Hypertension

The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure  regulation and end-organ damage in rats with different types of experimental hypertension.

Our research is focused mainly on:

  • Cardiovascular effects of new antidiabetics – gliflozins in  model of experimental hypertension and chronic heart failure
  • Central and peripheral mechanisms of blood pressure regulation
  • Role of sympathetic and parasympathetic nervous system  in cardiovascular diseases
  • Cardiovascular effects  of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).

Projects

Achievements

Publications

Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef . Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats . Hypertension Research. 2022; 45(3); 414-423 . IF = 5.528 [ASEP] [ doi ]
Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances . Nutrition & Diabetes. 2022; 12(1)); 26 . IF = 4.725 [ASEP] [ doi ]
Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana . Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein . Biomedicines. 2022; 10(9)); 2066 . IF = 4.757 [ASEP] [ doi ]
Andelová; K. - Szeiffová Bačová; B. - Sýkora; M. - Pavelka; Stanislav - Rauchová; Hana - Tribulová; N. Cardiac Cx43 Signaling Is Enhanced and TGF-beta 1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHRM . Biomedicines. 2022; 10(7)); 1707 . IF = 4.757 [ASEP] [ doi ]
Zicha; Josef - Behuliak; Michal - Vavřínová; Anna - Dobešová; Zdenka - Kuneš; Jaroslav - Rauchová; Hana - Vaněčková; Ivana . Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats . Hypertension Research. 2021; 44(9); 1067-1078 . IF = 5.528 [ASEP] [ doi ]
Zicha; Josef . Contribution of Sympathetic Nervous System to High Blood Pressure in Salt Hypertensive Dahl Rats . Physiological Research. 2021; 70(2); 117-118 . IF = 2.139 [ASEP] [ doi ]
Vavřínová; Anna - Behuliak; Michal - Vaněčková; Ivana - Zicha; Josef . The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure . Physiological Research. 2021; 70(3); 307-326 . IF = 2.139 [ASEP] [ doi ]
Rauchová; Hana . Coenzyme Q10 Effects in Neurological Diseases . Physiological Research. 2021; 70(Suppl.4); S683-S714 . IF = 2.139 [ASEP] [ doi ]
Pražienková; V. - Funda; Jiří - Pirník; Z. - Karnošová; A. - Hrubá; L. - Kořínková; L. - Neprašová; B. - Janovská; Petra - Bencze; Michal - Kadlecová; Michaela - Blahoš; J. - Kopecký; Jan - Železná; B. - Kuneš; Jaroslav - Bardová; Kristina - Maletínská; L. GPR10 gene deletion in mice increases basal neuronal activity; disturbs insulin sensitivity and alters lipid homeostasis . Gene. 2021; 774(Mar 30)); 145427 . IF = 3.913 [ASEP] [ doi ]
Pirník; Z. - Kořínková; L. - Osacká; J. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Cholecystokinin System Is Involved in the Anorexigenic Effect of Peripherally Applied Palmitoylated Prolactin-Releasing Peptide in Fasted Mice . Physiological Research. 2021; 70(4); 579-590 . IF = 2.139 [ASEP] [ doi ]
Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František . Excess ischemic tachyarrhythmias trigger protection infarction in rats . Clinical science. 2021; 135(17); 2143-2163 . IF = 6.876 [ASEP] [ doi ]
Mráziková; L. - Neprašová; Barbora - Mengr; A. - Popelová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models . Frontiers in Pharmacology. 2021; 12(Nov 18)); 779962 . IF = 5.988 [ASEP] [ doi ]
Mengr; A. - Hrubá; L. - Exnerová; A. - Holubová; M. - Popelová; A. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylated Prolactin-releasing Peptide Reduced A? Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study . Current Alzheimer Research. 2021; 18(8); 607-622 . IF = 3.040 [ASEP] [ doi ]
Karnošová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L. Palmitoylation of Prolactin-Releasing Peptide Increased Affinity for and Activation of the GPR10; NPFF-R2 and NPFF-R1 Receptors: In Vitro Study . International Journal of Molecular Sciences. 2021; 22(16)); 8904 . IF = 6.208 [ASEP] [ doi ]
Kacířová; M. - Železná; B. - Blažková; M. - Holubová; M. - Popelová; A. - Kuneš; Jaroslav - Šedivá; B. - Maletínská; L. Aging and high-fat diet feeding lead to peripheral insulin resistance and sex-dependent changes in brain of mouse model of tau pathology THY-Tau22 . Journal of Neuroinflammation. 2021; 18(1)); 141 . IF = 9.587 [ASEP] [ doi ]

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People

  RNDr. Ivana Vaněčková, DSc.
Head of the Laboratory
  MUDr. Josef Zicha, DrSc.
Deputy Head of the Laboratory
  RNDr. Jaroslav Kuneš, DrSc.
Senior Researcher
  MUDr. Hana Rauchová, CSc.
Senior Researcher
  RNDr. Milada Dobiášová, DrSc.
Senior Researcher
  Mgr. Michal Behuliak, Ph.D.
Senior Researcher
  RNDr. Michaela Kadlecová, Ph.D.
Junior Researcher
  Mgr. Silvie Hojná, Ph.D.
Junior Researcher
  RNDr. Lenka Řezáčová, Ph.D.
Junior Researcher
  Bc. Martina Sabolová
Pregradual student
  Alena Charvátová
Technician
  Zdeňka Kopecká
Technician