The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.
Our research is focused mainly on:
- Cardiovascular effects of new antidiabetics – gliflozins in model of experimental hypertension and chronic heart failure
- Central and peripheral mechanisms of blood pressure regulation
- Role of sympathetic and parasympathetic nervous system in cardiovascular diseases
- Cardiovascular effects of new analogs of neuropeptides regulating food intake in rats and their relation to neuroprotection in Alzheimer disease (cooperation with IOCHB CAS).
Projects
Achievements
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Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Mgr. Michal Behuliak, PhD. was granted with Otto Wicherle prize from the President of Czech Academy of Sciences on Monday, May 30, 2016.
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Publications
Zicha; Josef - Řezáčová; Lenka - Vaněčková; Ivana
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Nitric Oxide and Salt Resistance in Dahl Rats: No Role of Inducible NO Synthase
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Physiological Research. 2023; 72(1); 123-127
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IF = 2.1
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doi
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Strnadová; V. - Karnošová; A. - Blechová; M. - Neprašová; B. - Holá; L. - Němcová; A. - Myšková; A. - Sýkora; D. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Search for lipidized PrRP analogs with strong anorexigenic effect: In vitro and in vivo studies
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Neuropeptides. 2023; 98(April)); 102319
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IF = 2.9
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doi
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Rauchová; Hana - Hojná; Silvie - Kadlecová; Michaela - Vaněčková; Ivana - Chao; YM. - Chan; J. Y. H. - Zicha; Josef
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Sex differences in blood pressure; free radicals and plasma cholesterol fractions in Ren-2 transgenic rats of various ages
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Physiological Research. 2023; 72(2); 167-175
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IF = 2.1
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doi
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Pelantová; H. - Tomášová; P. - Šedivá; B. - Neprašová; B. - Mráziková; L. - Kuneš; Jaroslav - Železná; B. - Maletínská; L. - Kuzma; M.
Metabolomic Study of Aging in fa/fa Rats: Multiplatform Urine and Serum Analysis
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Metabolites. 2023; 13(4)); 552
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IF = 4.1
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doi
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Mráziková; L. - Hojná; Silvie - Vaculová; P. - Strnad; Š. - Vrkoslav; V. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Lipidized PrRP Analog Exhibits Strong Anti-Obesity and Antidiabetic Properties in Old WKY Rats with Obesity and Glucose Intolerance
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Nutrients. 2023; 15(2)); 280
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IF = 5.9
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doi
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Karnošová; A. - Strnadová; V. - Železná; B. - Kuneš; Jaroslav - Kašpárek; P. - Maletínská; L.
NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose
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Clinical science. 2023; 137(10); 847-862
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IF = 6.0
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doi
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Kala; P. - Vaňourková; Z. - Škaroupková; P. - Kompanowska - Jezierska; E. - Sadowski; J. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L.
Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula
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Biomedicine & Pharmacotherapy. 2023; 158(February)); 114157
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IF = 7.5
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doi
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Kala; P. - Gawrys; O. - Miklovic; M. - Vaňourková; Z. - Škaroupková; P. - Jíchová; Š. - Sadowski; J. - Kompanowska - Jezierska; E. - Walkowska; A. - Veselka; J. - Táborský; M. - Maxová; H. - Vaněčková; Ivana - Červenka; L.
Endothelin type A receptor blockade attenuates aorto-caval fistula-induced heart failure in rats with angiotensin II-dependent hypertension
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Journal of Hypertension. 2023; 41(1); 99-114
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IF = 4.9
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doi
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Freitas-Lima; L. C. - Pačesová; A. - Staňurová; J. - Šácha; P. - Marek; A. - Hubálek; M. - Kuneš; Jaroslav - Železná; B. - Maletínská; L.
GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript peptide
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European Journal of Pharmacology. 2023; 949(15 June)); 175713
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IF = 5.0
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doi
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Zicha; Josef - Řezáčová; Lenka - Behuliak; Michal - Vaněčková; Ivana
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Blood pressure reduction induced by chronic intracerebroventricular or peroral clonidine administration in rats with salt-dependent or angiotensin II-dependent hypertension
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Physiological Research. 2022; 71(6); 763-770
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IF = 2.1
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doi
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Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef
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Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats
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Hypertension Research. 2022; 45(3); 414-423
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IF = 5.4
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doi
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Pačesová; A. - Holubová; M. - Hrubá; L. - Strnadová; V. - Neprašová; B. - Pelantová; H. - Kuzma; M. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Age-related metabolic and neurodegenerative changes in SAMP8 mice
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Aging. 2022; 14(18); 7300-7327
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IF = 5.2
[ASEP]
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doi
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Mráziková; L. - Hojná; Silvie - Pačesová; A. - Hrubá; L. - Strnadová; V. - Neprašová; Barbora - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Palmitoylated prolactin-releasing peptide treatment had neuroprotective but not anti-obesity effect in fa/fa rats with leptin signaling disturbances
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Nutrition & Diabetes. 2022; 12(1)); 26
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IF = 6.1
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doi
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Malínská; H. - Hüttl; M. - Marková; I. - Miklánková; D. - Hojná; Silvie - Papoušek; František - Šilhavý; Jan - Mlejnek; Petr - Zicha; Josef - Hrdlička; Jaroslav - Pravenec; Michal - Vaněčková; Ivana
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Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
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Biomedicines. 2022; 10(9)); 2066
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IF = 4.7
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doi
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Chao; YM. - Rauchová; Hana - Chan; J. Y. H.
Disparate Roles of Oxidative Stress in Rostral Ventrolateral Medulla in Age-Dependent Susceptibility to Hypertension Induced by Systemic l-NAME Treatment in Rats
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Biomedicines. 2022; 10(9)); 2232
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IF = 4.7
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doi
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Holá; L. - Železná; B. - Karnošová; A. - Kuneš; Jaroslav - Fehrentz; J. A. - Denoyelle; S. - Cantel; S. - Blechová; M. - Sýkora; D. - Myšková; A. - Maletínská; L.
A Novel Truncated Liver Enriched Antimicrobial Peptide-2 Palmitoylated at its N-Terminal Antagonizes Effects of Ghrelin
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Journal of Pharmacology and Experimental Therapeutics. 2022; 383(2); 129-136
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IF = 3.5
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doi
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Hojná; Silvie - Kotsaridou; Zoe - Vaňourková; Z. - Rauchová; Hana - Behuliak; Michal - Kujal; P. - Kadlecová; Michaela - Zicha; Josef - Vaněčková; Ivana
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Empagliflozin Is Not Renoprotective in Non-Diabetic Rat Models of Chronic Kidney Disease
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Biomedicines. 2022; 10(10)); 2509
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IF = 4.7
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doi
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Andelová; K. - Szeiffová Bačová; B. - Sýkora; M. - Pavelka; Stanislav - Rauchová; Hana - Tribulová; N.
Cardiac Cx43 Signaling Is Enhanced and TGF-beta 1/SMAD2/3 Suppressed in Response to Cold Acclimation and Modulated by Thyroid Status in Hairless SHRM
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Biomedicines. 2022; 10(7)); 1707
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IF = 4.7
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doi
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Zicha; Josef - Behuliak; Michal - Vavřínová; Anna - Dobešová; Zdenka - Kuneš; Jaroslav - Rauchová; Hana - Vaněčková; Ivana
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Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats
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Hypertension Research. 2021; 44(9); 1067-1078
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IF = 5.525
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doi
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Zicha; Josef
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Contribution of Sympathetic Nervous System to High Blood Pressure in Salt Hypertensive Dahl Rats
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Physiological Research. 2021; 70(2); 117-118
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IF = 2.139
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doi
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Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.
